PH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X3F2_LEIDO

TriTrypDb:

LdBPK_301600.1 , LdCL_300021300 , LDHU3_30.2080

Length:

846

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X3F2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3F2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	682	686	PF00656	0.758
CLV_C14_Caspase3-7	690	694	PF00656	0.636
CLV_NRD_NRD_1	152	154	PF00675	0.763
CLV_NRD_NRD_1	179	181	PF00675	0.809
CLV_NRD_NRD_1	304	306	PF00675	0.589
CLV_NRD_NRD_1	643	645	PF00675	0.656
CLV_NRD_NRD_1	676	678	PF00675	0.688
CLV_NRD_NRD_1	772	774	PF00675	0.765
CLV_NRD_NRD_1	789	791	PF00675	0.412
CLV_PCSK_KEX2_1	304	306	PF00082	0.526
CLV_PCSK_KEX2_1	530	532	PF00082	0.723
CLV_PCSK_KEX2_1	643	645	PF00082	0.656
CLV_PCSK_KEX2_1	676	678	PF00082	0.688
CLV_PCSK_KEX2_1	771	773	PF00082	0.810
CLV_PCSK_KEX2_1	789	791	PF00082	0.412
CLV_PCSK_PC1ET2_1	530	532	PF00082	0.723
CLV_PCSK_SKI1_1	304	308	PF00082	0.510
CLV_PCSK_SKI1_1	330	334	PF00082	0.592
CLV_PCSK_SKI1_1	373	377	PF00082	0.587
CLV_PCSK_SKI1_1	381	385	PF00082	0.625
CLV_PCSK_SKI1_1	457	461	PF00082	0.447
CLV_PCSK_SKI1_1	588	592	PF00082	0.595
CLV_PCSK_SKI1_1	8	12	PF00082	0.515
CLV_PCSK_SKI1_1	842	846	PF00082	0.487
CLV_PCSK_SKI1_1	86	90	PF00082	0.512
DEG_SIAH_1	418	426	PF03145	0.543
DEG_SPOP_SBC_1	522	526	PF00917	0.575
DOC_CYCLIN_RxL_1	298	310	PF00134	0.471
DOC_CYCLIN_RxL_1	322	333	PF00134	0.678
DOC_CYCLIN_RxL_1	836	846	PF00134	0.531
DOC_CYCLIN_yCln2_LP_2	409	415	PF00134	0.468
DOC_CYCLIN_yCln2_LP_2	589	595	PF00134	0.581
DOC_CYCLIN_yCln2_LP_2	837	843	PF00134	0.515
DOC_MAPK_gen_1	230	238	PF00069	0.555
DOC_MAPK_gen_1	48	56	PF00069	0.612
DOC_MAPK_gen_1	586	595	PF00069	0.544
DOC_MAPK_gen_1	789	799	PF00069	0.511
DOC_MAPK_MEF2A_6	355	364	PF00069	0.551
DOC_MAPK_MEF2A_6	750	757	PF00069	0.492
DOC_MAPK_MEF2A_6	792	800	PF00069	0.532
DOC_MAPK_MEF2A_6	806	814	PF00069	0.432
DOC_MAPK_MEF2A_6	836	845	PF00069	0.476
DOC_PP1_RVXF_1	455	462	PF00149	0.489
DOC_PP1_RVXF_1	589	596	PF00149	0.542
DOC_SPAK_OSR1_1	285	289	PF12202	0.465
DOC_USP7_MATH_1	106	110	PF00917	0.705
DOC_USP7_MATH_1	112	116	PF00917	0.697
DOC_USP7_MATH_1	176	180	PF00917	0.823
DOC_USP7_MATH_1	309	313	PF00917	0.605
DOC_USP7_MATH_1	323	327	PF00917	0.486
DOC_USP7_MATH_1	521	525	PF00917	0.600
DOC_USP7_MATH_1	574	578	PF00917	0.651
DOC_USP7_MATH_1	692	696	PF00917	0.724
DOC_WW_Pin1_4	1	6	PF00397	0.748
DOC_WW_Pin1_4	132	137	PF00397	0.827
DOC_WW_Pin1_4	166	171	PF00397	0.835
DOC_WW_Pin1_4	179	184	PF00397	0.755
DOC_WW_Pin1_4	264	269	PF00397	0.483
DOC_WW_Pin1_4	446	451	PF00397	0.686
DOC_WW_Pin1_4	706	711	PF00397	0.702
LIG_14-3-3_CanoR_1	298	303	PF00244	0.471
LIG_14-3-3_CanoR_1	330	337	PF00244	0.580
LIG_14-3-3_CanoR_1	36	40	PF00244	0.448
LIG_14-3-3_CanoR_1	428	434	PF00244	0.477
LIG_14-3-3_CanoR_1	531	540	PF00244	0.584
LIG_14-3-3_CanoR_1	776	785	PF00244	0.733
LIG_Actin_WH2_2	70	88	PF00022	0.497
LIG_AP2alpha_2	57	59	PF02296	0.641
LIG_APCC_ABBA_1	383	388	PF00400	0.582
LIG_APCC_ABBA_1	812	817	PF00400	0.417
LIG_APCC_ABBAyCdc20_2	304	310	PF00400	0.490
LIG_Clathr_ClatBox_1	757	761	PF01394	0.496
LIG_deltaCOP1_diTrp_1	20	23	PF00928	0.562
LIG_deltaCOP1_diTrp_1	224	231	PF00928	0.545
LIG_deltaCOP1_diTrp_1	273	278	PF00928	0.531
LIG_deltaCOP1_diTrp_1	310	315	PF00928	0.489
LIG_deltaCOP1_diTrp_1	369	376	PF00928	0.510
LIG_deltaCOP1_diTrp_1	475	480	PF00928	0.477
LIG_deltaCOP1_diTrp_1	640	649	PF00928	0.549
LIG_FHA_1	100	106	PF00498	0.547
LIG_FHA_1	108	114	PF00498	0.715
LIG_FHA_1	127	133	PF00498	0.508
LIG_FHA_1	206	212	PF00498	0.735
LIG_FHA_1	391	397	PF00498	0.592
LIG_FHA_1	540	546	PF00498	0.457
LIG_FHA_1	614	620	PF00498	0.487
LIG_FHA_1	707	713	PF00498	0.568
LIG_FHA_1	72	78	PF00498	0.481
LIG_FHA_1	809	815	PF00498	0.420
LIG_FHA_1	87	93	PF00498	0.514
LIG_FHA_2	169	175	PF00498	0.804
LIG_FHA_2	331	337	PF00498	0.634
LIG_FHA_2	564	570	PF00498	0.593
LIG_FHA_2	676	682	PF00498	0.807
LIG_GBD_Chelix_1	11	19	PF00786	0.562
LIG_HCF-1_HBM_1	26	29	PF13415	0.416
LIG_Integrin_isoDGR_2	769	771	PF01839	0.712
LIG_Integrin_RGD_1	161	163	PF01839	0.788
LIG_LIR_Gen_1	273	280	PF02991	0.373
LIG_LIR_Gen_1	310	319	PF02991	0.478
LIG_LIR_Gen_1	334	344	PF02991	0.530
LIG_LIR_Gen_1	535	545	PF02991	0.482
LIG_LIR_Gen_1	554	563	PF02991	0.538
LIG_LIR_Gen_1	817	826	PF02991	0.544
LIG_LIR_Nem_3	20	24	PF02991	0.545
LIG_LIR_Nem_3	26	32	PF02991	0.465
LIG_LIR_Nem_3	273	278	PF02991	0.473
LIG_LIR_Nem_3	284	290	PF02991	0.424
LIG_LIR_Nem_3	310	316	PF02991	0.500
LIG_LIR_Nem_3	334	340	PF02991	0.513
LIG_LIR_Nem_3	47	53	PF02991	0.608
LIG_LIR_Nem_3	535	541	PF02991	0.502
LIG_LIR_Nem_3	554	559	PF02991	0.497
LIG_LIR_Nem_3	646	652	PF02991	0.645
LIG_LIR_Nem_3	817	821	PF02991	0.515
LIG_NRBOX	96	102	PF00104	0.556
LIG_PAM2_1	374	386	PF00658	0.612
LIG_Pex14_1	21	25	PF04695	0.539
LIG_Pex14_1	231	235	PF04695	0.510
LIG_Pex14_2	10	14	PF04695	0.485
LIG_SH2_CRK	469	473	PF00017	0.564
LIG_SH2_SRC	415	418	PF00017	0.636
LIG_SH2_SRC	469	472	PF00017	0.573
LIG_SH2_STAP1	25	29	PF00017	0.469
LIG_SH2_STAP1	556	560	PF00017	0.464
LIG_SH2_STAP1	93	97	PF00017	0.587
LIG_SH2_STAT5	259	262	PF00017	0.517
LIG_SH2_STAT5	29	32	PF00017	0.438
LIG_SH2_STAT5	300	303	PF00017	0.526
LIG_SH2_STAT5	363	366	PF00017	0.461
LIG_SH2_STAT5	71	74	PF00017	0.462
LIG_SH2_STAT5	756	759	PF00017	0.444
LIG_SH2_STAT5	818	821	PF00017	0.441
LIG_SH3_3	100	106	PF00018	0.547
LIG_SH3_3	133	139	PF00018	0.789
LIG_SH3_3	435	441	PF00018	0.523
LIG_SH3_3	510	516	PF00018	0.458
LIG_SH3_3	627	633	PF00018	0.521
LIG_SH3_3	743	749	PF00018	0.562
LIG_SH3_3	760	766	PF00018	0.575
LIG_SUMO_SIM_anti_2	616	621	PF11976	0.480
LIG_SUMO_SIM_par_1	101	111	PF11976	0.607
LIG_SUMO_SIM_par_1	206	212	PF11976	0.737
LIG_SUMO_SIM_par_1	397	402	PF11976	0.585
LIG_SUMO_SIM_par_1	756	761	PF11976	0.562
LIG_TRAF2_1	292	295	PF00917	0.490
LIG_TRAF2_1	414	417	PF00917	0.629
LIG_TYR_ITIM	288	293	PF00017	0.579
LIG_UBA3_1	216	223	PF00899	0.501
LIG_WRC_WIRS_1	350	355	PF05994	0.518
LIG_WRC_WIRS_1	53	58	PF05994	0.521
MOD_CDK_SPxxK_3	1	8	PF00069	0.737
MOD_CK1_1	107	113	PF00069	0.785
MOD_CK1_1	179	185	PF00069	0.815
MOD_CK1_1	248	254	PF00069	0.564
MOD_CK1_1	389	395	PF00069	0.527
MOD_CK2_1	10	16	PF00069	0.576
MOD_CK2_1	119	125	PF00069	0.678
MOD_CK2_1	168	174	PF00069	0.805
MOD_CK2_1	216	222	PF00069	0.505
MOD_CK2_1	249	255	PF00069	0.544
MOD_CK2_1	289	295	PF00069	0.483
MOD_CK2_1	675	681	PF00069	0.806
MOD_CK2_1	827	833	PF00069	0.674
MOD_CMANNOS	477	480	PF00535	0.468
MOD_Cter_Amidation	769	772	PF01082	0.758
MOD_GlcNHglycan	110	113	PF01048	0.713
MOD_GlcNHglycan	116	119	PF01048	0.743
MOD_GlcNHglycan	140	143	PF01048	0.749
MOD_GlcNHglycan	166	169	PF01048	0.827
MOD_GlcNHglycan	248	251	PF01048	0.555
MOD_GlcNHglycan	333	336	PF01048	0.585
MOD_GlcNHglycan	345	348	PF01048	0.585
MOD_GlcNHglycan	388	391	PF01048	0.503
MOD_GlcNHglycan	443	446	PF01048	0.776
MOD_GlcNHglycan	464	467	PF01048	0.644
MOD_GlcNHglycan	481	484	PF01048	0.331
MOD_GlcNHglycan	576	579	PF01048	0.686
MOD_GlcNHglycan	678	681	PF01048	0.808
MOD_GlcNHglycan	778	781	PF01048	0.612
MOD_GSK3_1	104	111	PF00069	0.654
MOD_GSK3_1	120	127	PF00069	0.724
MOD_GSK3_1	145	152	PF00069	0.746
MOD_GSK3_1	164	171	PF00069	0.748
MOD_GSK3_1	179	186	PF00069	0.608
MOD_GSK3_1	203	210	PF00069	0.678
MOD_GSK3_1	245	252	PF00069	0.523
MOD_GSK3_1	331	338	PF00069	0.547
MOD_GSK3_1	345	352	PF00069	0.481
MOD_GSK3_1	354	361	PF00069	0.506
MOD_GSK3_1	386	393	PF00069	0.614
MOD_GSK3_1	395	402	PF00069	0.455
MOD_GSK3_1	446	453	PF00069	0.666
MOD_GSK3_1	471	478	PF00069	0.533
MOD_GSK3_1	572	579	PF00069	0.690
MOD_GSK3_1	664	671	PF00069	0.750
MOD_GSK3_1	700	707	PF00069	0.597
MOD_GSK3_1	772	779	PF00069	0.632
MOD_LATS_1	529	535	PF00433	0.559
MOD_N-GLC_1	203	208	PF02516	0.690
MOD_N-GLC_1	446	451	PF02516	0.577
MOD_N-GLC_1	664	669	PF02516	0.650
MOD_N-GLC_2	673	675	PF02516	0.746
MOD_NEK2_1	10	15	PF00069	0.476
MOD_NEK2_1	149	154	PF00069	0.785
MOD_NEK2_1	203	208	PF00069	0.752
MOD_NEK2_1	216	221	PF00069	0.448
MOD_NEK2_1	276	281	PF00069	0.464
MOD_NEK2_1	32	37	PF00069	0.475
MOD_NEK2_1	399	404	PF00069	0.586
MOD_NEK2_1	539	544	PF00069	0.458
MOD_NEK2_1	704	709	PF00069	0.678
MOD_NEK2_2	323	328	PF00069	0.688
MOD_PIKK_1	168	174	PF00454	0.845
MOD_PIKK_1	694	700	PF00454	0.638
MOD_PIKK_1	744	750	PF00454	0.577
MOD_PK_1	124	130	PF00069	0.678
MOD_PK_1	289	295	PF00069	0.490
MOD_PKA_1	643	649	PF00069	0.660
MOD_PKA_1	676	682	PF00069	0.682
MOD_PKA_1	772	778	PF00069	0.744
MOD_PKA_2	246	252	PF00069	0.519
MOD_PKA_2	35	41	PF00069	0.462
MOD_PKA_2	572	578	PF00069	0.732
MOD_PKA_2	643	649	PF00069	0.660
MOD_PKA_2	675	681	PF00069	0.804
MOD_PKA_2	772	778	PF00069	0.744
MOD_PKB_1	328	336	PF00069	0.581
MOD_Plk_1	124	130	PF00069	0.831
MOD_Plk_1	309	315	PF00069	0.493
MOD_Plk_2-3	79	85	PF00069	0.606
MOD_Plk_4	10	16	PF00069	0.476
MOD_Plk_4	216	222	PF00069	0.466
MOD_Plk_4	345	351	PF00069	0.453
MOD_Plk_4	358	364	PF00069	0.378
MOD_Plk_4	49	55	PF00069	0.612
MOD_Plk_4	613	619	PF00069	0.498
MOD_Plk_4	92	98	PF00069	0.564
MOD_Plk_4	99	105	PF00069	0.507
MOD_ProDKin_1	1	7	PF00069	0.744
MOD_ProDKin_1	132	138	PF00069	0.826
MOD_ProDKin_1	166	172	PF00069	0.835
MOD_ProDKin_1	179	185	PF00069	0.754
MOD_ProDKin_1	264	270	PF00069	0.495
MOD_ProDKin_1	446	452	PF00069	0.676
MOD_ProDKin_1	706	712	PF00069	0.704
MOD_SUMO_rev_2	13	19	PF00179	0.462
MOD_SUMO_rev_2	42	50	PF00179	0.634
MOD_SUMO_rev_2	747	755	PF00179	0.638
TRG_DiLeu_BaEn_1	240	245	PF01217	0.493
TRG_DiLeu_BaEn_2	25	31	PF01217	0.459
TRG_DiLeu_BaEn_2	794	800	PF01217	0.541
TRG_DiLeu_BaEn_4	584	590	PF01217	0.647
TRG_DiLeu_BaLyEn_6	302	307	PF01217	0.472
TRG_ENDOCYTIC_2	235	238	PF00928	0.464
TRG_ENDOCYTIC_2	29	32	PF00928	0.438
TRG_ENDOCYTIC_2	290	293	PF00928	0.551
TRG_ENDOCYTIC_2	337	340	PF00928	0.529
TRG_ENDOCYTIC_2	556	559	PF00928	0.399
TRG_ENDOCYTIC_2	818	821	PF00928	0.388
TRG_ER_diArg_1	227	230	PF00400	0.647
TRG_ER_diArg_1	304	306	PF00400	0.526
TRG_ER_diArg_1	327	330	PF00400	0.577
TRG_ER_diArg_1	549	552	PF00400	0.495
TRG_ER_diArg_1	586	589	PF00400	0.651
TRG_ER_diArg_1	642	644	PF00400	0.644
TRG_ER_diArg_1	771	773	PF00400	0.774
TRG_ER_diArg_1	789	792	PF00400	0.429
TRG_Pf-PMV_PEXEL_1	305	310	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	842	846	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8V2	Leptomonas seymouri	59%	96%
A4HIA3	Leishmania braziliensis	79%	100%
A4I5I7	Leishmania infantum	100%	100%
E9B0T2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q7E6	Leishmania major	92%	100%