Splicing factor 3a, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

splicing factor 3a, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X3F0_LEIDO

TriTrypDb:

LdBPK_301820.1 , LdCL_300023500 , LDHU3_30.2530

Length:

621

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0140513	nuclear protein-containing complex	2	11
GO:1990904	ribonucleoprotein complex	2	11

Expansion

Sequence features

A0A3S7X3F0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3F0

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	11
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	11
GO:0000398	mRNA splicing, via spliceosome	8	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008380	RNA splicing	7	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0008270	zinc ion binding	6	10
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	10
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	431	435	PF00656	0.522
CLV_C14_Caspase3-7	593	597	PF00656	0.366
CLV_C14_Caspase3-7	599	603	PF00656	0.304
CLV_NRD_NRD_1	210	212	PF00675	0.412
CLV_NRD_NRD_1	235	237	PF00675	0.537
CLV_NRD_NRD_1	439	441	PF00675	0.588
CLV_NRD_NRD_1	470	472	PF00675	0.676
CLV_NRD_NRD_1	553	555	PF00675	0.335
CLV_NRD_NRD_1	587	589	PF00675	0.394
CLV_PCSK_KEX2_1	235	237	PF00082	0.504
CLV_PCSK_KEX2_1	470	472	PF00082	0.676
CLV_PCSK_KEX2_1	553	555	PF00082	0.335
CLV_PCSK_KEX2_1	589	591	PF00082	0.335
CLV_PCSK_KEX2_1	619	621	PF00082	0.593
CLV_PCSK_PC1ET2_1	589	591	PF00082	0.335
CLV_PCSK_PC7_1	615	621	PF00082	0.449
CLV_PCSK_SKI1_1	39	43	PF00082	0.432
CLV_PCSK_SKI1_1	408	412	PF00082	0.440
CLV_PCSK_SKI1_1	460	464	PF00082	0.628
DEG_COP1_1	113	120	PF00400	0.579
DEG_Nend_UBRbox_3	1	3	PF02207	0.656
DEG_SPOP_SBC_1	305	309	PF00917	0.805
DEG_SPOP_SBC_1	368	372	PF00917	0.680
DOC_CYCLIN_RxL_1	36	46	PF00134	0.485
DOC_CYCLIN_RxL_1	405	415	PF00134	0.442
DOC_CYCLIN_yClb1_LxF_4	187	192	PF00134	0.545
DOC_CYCLIN_yCln2_LP_2	218	224	PF00134	0.452
DOC_MAPK_DCC_7	340	349	PF00069	0.596
DOC_MAPK_MEF2A_6	197	204	PF00069	0.510
DOC_PP1_RVXF_1	187	193	PF00149	0.542
DOC_PP1_RVXF_1	210	217	PF00149	0.515
DOC_PP2B_LxvP_1	115	118	PF13499	0.540
DOC_PP2B_LxvP_1	329	332	PF13499	0.572
DOC_USP7_MATH_1	161	165	PF00917	0.627
DOC_USP7_MATH_1	277	281	PF00917	0.657
DOC_USP7_MATH_1	304	308	PF00917	0.808
DOC_USP7_MATH_1	367	371	PF00917	0.751
DOC_WW_Pin1_4	116	121	PF00397	0.546
DOC_WW_Pin1_4	172	177	PF00397	0.601
DOC_WW_Pin1_4	481	486	PF00397	0.584
DOC_WW_Pin1_4	77	82	PF00397	0.668
LIG_14-3-3_CanoR_1	145	151	PF00244	0.508
LIG_14-3-3_CanoR_1	440	447	PF00244	0.503
LIG_14-3-3_CanoR_1	54	61	PF00244	0.558
LIG_14-3-3_CanoR_1	560	565	PF00244	0.309
LIG_Actin_WH2_2	444	462	PF00022	0.615
LIG_APCC_ABBA_1	61	66	PF00400	0.458
LIG_BIR_III_4	602	606	PF00653	0.355
LIG_CtBP_PxDLS_1	332	336	PF00389	0.605
LIG_FHA_1	1	7	PF00498	0.633
LIG_FHA_1	151	157	PF00498	0.546
LIG_FHA_1	194	200	PF00498	0.496
LIG_FHA_1	381	387	PF00498	0.441
LIG_FHA_2	126	132	PF00498	0.481
LIG_FHA_2	153	159	PF00498	0.547
LIG_FHA_2	279	285	PF00498	0.671
LIG_FHA_2	399	405	PF00498	0.461
LIG_FHA_2	415	421	PF00498	0.394
LIG_FHA_2	579	585	PF00498	0.453
LIG_FHA_2	593	599	PF00498	0.276
LIG_FHA_2	607	613	PF00498	0.249
LIG_KLC1_Yacidic_2	62	66	PF13176	0.458
LIG_LIR_Apic_2	343	348	PF02991	0.610
LIG_LIR_Apic_2	531	536	PF02991	0.312
LIG_LIR_Gen_1	100	109	PF02991	0.580
LIG_LIR_Gen_1	257	268	PF02991	0.469
LIG_LIR_Gen_1	397	404	PF02991	0.428
LIG_LIR_Nem_3	100	104	PF02991	0.454
LIG_LIR_Nem_3	140	146	PF02991	0.381
LIG_LIR_Nem_3	191	195	PF02991	0.405
LIG_LIR_Nem_3	231	237	PF02991	0.484
LIG_LIR_Nem_3	257	263	PF02991	0.463
LIG_LIR_Nem_3	397	403	PF02991	0.427
LIG_LIR_Nem_3	563	567	PF02991	0.355
LIG_LIR_Nem_3	612	616	PF02991	0.480
LIG_NRBOX	394	400	PF00104	0.387
LIG_NRP_CendR_1	619	621	PF00754	0.671
LIG_Pex14_2	539	543	PF04695	0.335
LIG_RPA_C_Fungi	206	218	PF08784	0.525
LIG_SH2_CRK	234	238	PF00017	0.390
LIG_SH2_CRK	533	537	PF00017	0.447
LIG_SH2_SRC	229	232	PF00017	0.467
LIG_SH2_STAP1	146	150	PF00017	0.387
LIG_SH2_STAP1	414	418	PF00017	0.507
LIG_SH2_STAT5	229	232	PF00017	0.357
LIG_SH2_STAT5	400	403	PF00017	0.573
LIG_SH2_STAT5	613	616	PF00017	0.480
LIG_SH2_STAT5	64	67	PF00017	0.464
LIG_SH3_1	236	242	PF00018	0.554
LIG_SH3_3	114	120	PF00018	0.565
LIG_SH3_3	170	176	PF00018	0.623
LIG_SH3_3	236	242	PF00018	0.554
LIG_SH3_3	479	485	PF00018	0.772
LIG_SH3_3	487	493	PF00018	0.789
LIG_TRAF2_1	417	420	PF00917	0.515
LIG_TRAF2_1	428	431	PF00917	0.479
LIG_TRAF2_1	435	438	PF00917	0.453
LIG_TRAF2_1	493	496	PF00917	0.693
LIG_TRFH_1	342	346	PF08558	0.471
LIG_TYR_ITIM	398	403	PF00017	0.470
LIG_WRC_WIRS_1	192	197	PF05994	0.470
LIG_WRPW_2	219	222	PF00400	0.449
MOD_CDK_SPK_2	116	121	PF00069	0.509
MOD_CK1_1	175	181	PF00069	0.589
MOD_CK1_1	361	367	PF00069	0.745
MOD_CK1_1	443	449	PF00069	0.524
MOD_CK1_1	466	472	PF00069	0.696
MOD_CK2_1	125	131	PF00069	0.409
MOD_CK2_1	152	158	PF00069	0.534
MOD_CK2_1	251	257	PF00069	0.473
MOD_CK2_1	259	265	PF00069	0.520
MOD_CK2_1	278	284	PF00069	0.410
MOD_CK2_1	398	404	PF00069	0.461
MOD_CK2_1	414	420	PF00069	0.404
MOD_CK2_1	432	438	PF00069	0.454
MOD_CK2_1	52	58	PF00069	0.496
MOD_CK2_1	578	584	PF00069	0.474
MOD_CK2_1	592	598	PF00069	0.457
MOD_CK2_1	606	612	PF00069	0.249
MOD_GlcNHglycan	146	149	PF01048	0.499
MOD_GlcNHglycan	163	166	PF01048	0.638
MOD_GlcNHglycan	360	363	PF01048	0.704
MOD_GlcNHglycan	442	445	PF01048	0.517
MOD_GlcNHglycan	477	480	PF01048	0.769
MOD_GlcNHglycan	584	587	PF01048	0.397
MOD_GSK3_1	306	313	PF00069	0.770
MOD_GSK3_1	369	376	PF00069	0.619
MOD_GSK3_1	394	401	PF00069	0.488
MOD_GSK3_1	402	409	PF00069	0.435
MOD_GSK3_1	443	450	PF00069	0.474
MOD_GSK3_1	578	585	PF00069	0.378
MOD_N-GLC_1	406	411	PF02516	0.584
MOD_NEK2_1	150	155	PF00069	0.427
MOD_NEK2_1	180	185	PF00069	0.622
MOD_NEK2_1	193	198	PF00069	0.397
MOD_NEK2_1	394	399	PF00069	0.412
MOD_NEK2_1	403	408	PF00069	0.424
MOD_NEK2_1	447	452	PF00069	0.568
MOD_NEK2_1	463	468	PF00069	0.632
MOD_NEK2_2	528	533	PF00069	0.312
MOD_NEK2_2	566	571	PF00069	0.335
MOD_PKA_1	340	346	PF00069	0.552
MOD_PKA_1	440	446	PF00069	0.539
MOD_PKA_2	144	150	PF00069	0.415
MOD_PKA_2	298	304	PF00069	0.779
MOD_PKA_2	53	59	PF00069	0.553
MOD_PKA_2	578	584	PF00069	0.344
MOD_PKB_1	590	598	PF00069	0.482
MOD_Plk_1	268	274	PF00069	0.628
MOD_Plk_1	406	412	PF00069	0.555
MOD_Plk_2-3	125	131	PF00069	0.529
MOD_Plk_2-3	251	257	PF00069	0.512
MOD_Plk_4	175	181	PF00069	0.629
MOD_Plk_4	19	25	PF00069	0.464
MOD_Plk_4	259	265	PF00069	0.595
MOD_Plk_4	394	400	PF00069	0.443
MOD_Plk_4	406	412	PF00069	0.420
MOD_Plk_4	528	534	PF00069	0.312
MOD_ProDKin_1	116	122	PF00069	0.541
MOD_ProDKin_1	172	178	PF00069	0.607
MOD_ProDKin_1	481	487	PF00069	0.583
MOD_ProDKin_1	77	83	PF00069	0.663
MOD_SUMO_for_1	111	114	PF00179	0.561
MOD_SUMO_for_1	167	170	PF00179	0.607
MOD_SUMO_for_1	266	269	PF00179	0.569
MOD_SUMO_rev_2	262	268	PF00179	0.522
MOD_SUMO_rev_2	377	384	PF00179	0.472
MOD_SUMO_rev_2	464	469	PF00179	0.598
MOD_SUMO_rev_2	90	96	PF00179	0.552
TRG_DiLeu_BaEn_1	497	502	PF01217	0.695
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.582
TRG_DiLeu_BaLyEn_6	345	350	PF01217	0.595
TRG_ENDOCYTIC_2	101	104	PF00928	0.534
TRG_ENDOCYTIC_2	105	108	PF00928	0.545
TRG_ENDOCYTIC_2	146	149	PF00928	0.388
TRG_ENDOCYTIC_2	219	222	PF00928	0.384
TRG_ENDOCYTIC_2	234	237	PF00928	0.388
TRG_ENDOCYTIC_2	400	403	PF00928	0.573
TRG_ENDOCYTIC_2	564	567	PF00928	0.355
TRG_ENDOCYTIC_2	613	616	PF00928	0.355
TRG_ER_diArg_1	234	236	PF00400	0.535
TRG_ER_diArg_1	37	40	PF00400	0.455
TRG_ER_diArg_1	470	473	PF00400	0.688
TRG_ER_diArg_1	552	554	PF00400	0.335
TRG_ER_diArg_1	587	590	PF00400	0.335
TRG_ER_diArg_1	619	621	PF00400	0.669
TRG_NES_CRM1_1	565	578	PF08389	0.417
TRG_NLS_MonoExtC_3	587	592	PF00514	0.355
TRG_Pf-PMV_PEXEL_1	10	15	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	154	158	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	416	420	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	511	515	PF00026	0.408
TRG_PTS2	1	45	PF00400	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5M4	Leptomonas seymouri	62%	97%
A0A1X0P1R3	Trypanosomatidae	42%	100%
A0A422P3I2	Trypanosoma rangeli	44%	100%
A4H930	Leishmania braziliensis	84%	100%
A4I5K9	Leishmania infantum	100%	100%
C9ZQY7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B0V4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q7B2	Leishmania major	95%	100%
V5DQL3	Trypanosoma cruzi	43%	100%