Splicing factor 3a, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

splicing factor 3a, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X3F0_LEIDO

TriTrypDb:

LdBPK_301820.1 , LdCL_300023500 , LDHU3_30.2530

Length:

621

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0140513	nuclear protein-containing complex	2	11
GO:1990904	ribonucleoprotein complex	2	11

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Expansion

Sequence features

A0A3S7X3F0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3F0

Function

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Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	11
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	11
GO:0000398	mRNA splicing, via spliceosome	8	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008380	RNA splicing	7	11

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0008270	zinc ion binding	6	10
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	10
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	431	435	PF00656	0.522
CLV_C14_Caspase3-7	593	597	PF00656	0.366
CLV_C14_Caspase3-7	599	603	PF00656	0.304
CLV_NRD_NRD_1	210	212	PF00675	0.412
CLV_NRD_NRD_1	235	237	PF00675	0.537
CLV_NRD_NRD_1	439	441	PF00675	0.588
CLV_NRD_NRD_1	470	472	PF00675	0.676
CLV_NRD_NRD_1	553	555	PF00675	0.335
CLV_NRD_NRD_1	587	589	PF00675	0.394
CLV_PCSK_KEX2_1	235	237	PF00082	0.504

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5M4	Leptomonas seymouri	62%	97%
A0A1X0P1R3	Trypanosomatidae	42%	100%
A0A422P3I2	Trypanosoma rangeli	44%	100%
A4H930	Leishmania braziliensis	84%	100%
A4I5K9	Leishmania infantum	100%	100%
C9ZQY7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B0V4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q7B2	Leishmania major	95%	100%
V5DQL3	Trypanosoma cruzi	43%	100%

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