Adenylate kinase isoenzyme 6 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Adenylate kinase, nuclear

Species:

Leishmania donovani

UniProt:

A0A3S7X3E3_LEIDO

TriTrypDb:

LdBPK_301880.1 , LdCL_300024100 , LDHU3_30.2590

Length:

180

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0042995	cell projection	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0099080	supramolecular complex	2	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3S7X3E3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3E3

PDB structure(s): 1y63_A

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0044237	cellular metabolic process	2	11
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006979	response to oxidative stress	3	1
GO:0007154	cell communication	2	1
GO:0009267	cellular response to starvation	4	1
GO:0009605	response to external stimulus	2	1
GO:0009991	response to extracellular stimulus	3	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0030490	maturation of SSU-rRNA	9	1
GO:0031667	response to nutrient levels	4	1
GO:0031668	cellular response to extracellular stimulus	3	1
GO:0031669	cellular response to nutrient levels	4	1
GO:0033554	cellular response to stress	3	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0042594	response to starvation	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071496	cellular response to external stimulus	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004017	adenylate kinase activity	6	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0016887	ATP hydrolysis activity	7	11
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0019205	nucleobase-containing compound kinase activity	5	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0050145	nucleoside monophosphate kinase activity	5	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0019843	rRNA binding	5	1
GO:0042134	rRNA primary transcript binding	6	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.563
CLV_PCSK_KEX2_1	116	118	PF00082	0.278
CLV_PCSK_KEX2_1	123	125	PF00082	0.210
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.278
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.210
CLV_PCSK_SKI1_1	40	44	PF00082	0.262
DEG_APCC_KENBOX_2	42	46	PF00400	0.262
DEG_Nend_UBRbox_2	1	3	PF02207	0.575
DOC_MAPK_gen_1	168	176	PF00069	0.618
DOC_MAPK_MEF2A_6	95	103	PF00069	0.244
DOC_PP1_RVXF_1	65	72	PF00149	0.260
DOC_PP4_FxxP_1	71	74	PF00568	0.260
DOC_WW_Pin1_4	11	16	PF00397	0.242
LIG_BRCT_BRCA1_1	88	92	PF00533	0.243
LIG_eIF4E_1	86	92	PF01652	0.260
LIG_FHA_1	105	111	PF00498	0.259
LIG_FHA_1	55	61	PF00498	0.242
LIG_FHA_2	103	109	PF00498	0.260
LIG_FHA_2	161	167	PF00498	0.513
LIG_FHA_2	47	53	PF00498	0.278
LIG_LIR_Apic_2	70	74	PF02991	0.286
LIG_LIR_Gen_1	108	119	PF02991	0.184
LIG_LIR_Gen_1	31	41	PF02991	0.260
LIG_LIR_Gen_1	94	103	PF02991	0.288
LIG_LIR_Nem_3	108	114	PF02991	0.184
LIG_LIR_Nem_3	31	36	PF02991	0.239
LIG_LIR_Nem_3	94	100	PF02991	0.288
LIG_Pex14_2	92	96	PF04695	0.242
LIG_SH2_STAP1	144	148	PF00017	0.541
LIG_SH2_STAP1	51	55	PF00017	0.260
LIG_SH2_STAT5	48	51	PF00017	0.260
LIG_SUMO_SIM_anti_2	145	153	PF11976	0.539
LIG_SUMO_SIM_anti_2	169	175	PF11976	0.522
LIG_SUMO_SIM_par_1	145	153	PF11976	0.534
LIG_SUMO_SIM_par_1	73	78	PF11976	0.307
LIG_SUMO_SIM_par_1	99	108	PF11976	0.260
LIG_TRAF2_1	163	166	PF00917	0.610
LIG_UBA3_1	110	116	PF00899	0.285
MOD_CK2_1	102	108	PF00069	0.260
MOD_CK2_1	160	166	PF00069	0.561
MOD_CK2_1	18	24	PF00069	0.283
MOD_GSK3_1	14	21	PF00069	0.242
MOD_GSK3_1	46	53	PF00069	0.241
MOD_N-GLC_1	153	158	PF02516	0.502
MOD_PKA_2	112	118	PF00069	0.268
MOD_Plk_1	153	159	PF00069	0.508
MOD_Plk_2-3	153	159	PF00069	0.493
MOD_Plk_2-3	50	56	PF00069	0.359
MOD_ProDKin_1	11	17	PF00069	0.242
MOD_SUMO_for_1	174	177	PF00179	0.519
MOD_SUMO_rev_2	120	125	PF00179	0.307
TRG_DiLeu_BaEn_1	37	42	PF01217	0.320
TRG_DiLeu_BaLyEn_6	64	69	PF01217	0.242
TRG_NES_CRM1_1	165	177	PF08389	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I331	Leptomonas seymouri	86%	100%
A0A0S4JFJ5	Bodo saltans	64%	100%
A0A1X0P236	Trypanosomatidae	79%	100%
A0A3R7N3J3	Trypanosoma rangeli	73%	100%
A4HIC3	Leishmania braziliensis	90%	100%
A4I5L5	Leishmania infantum	100%	100%
A4YIQ9	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	32%	99%
A5PJA1	Bos taurus	40%	100%
A6VHC3	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	29%	99%
B6YUL3	Thermococcus onnurineus (strain NA1)	32%	100%
C3MQV5	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	34%	96%
C3MWU3	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	34%	96%
C3N6L0	Sulfolobus islandicus (strain M.16.27)	34%	96%
C3N6Z8	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	34%	96%
C3NGL3	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	34%	96%
C4KI81	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	34%	96%
C5A628	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	31%	100%
C9ZQZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	80%
E9B0W0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O27656	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	34%	100%
O28278	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	30%	100%
O58998	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	31%	100%
Q09527	Caenorhabditis elegans	47%	99%
Q12055	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	91%
Q46FV0	Methanosarcina barkeri (strain Fusaro / DSM 804)	33%	99%
Q4Q7A6	Leishmania major	99%	100%
Q54Y03	Dictyostelium discoideum	44%	100%
Q58450	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	34%	100%
Q5EB68	Rattus norvegicus	41%	100%
Q5JG26	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	31%	100%
Q7JYV7	Drosophila melanogaster	41%	100%
Q8I236	Plasmodium falciparum (isolate 3D7)	29%	97%
Q8PZ69	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	34%	92%
Q8TG40	Candida albicans (strain SC5314 / ATCC MYA-2876)	40%	73%
Q8TJQ0	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	32%	97%
Q8TWH4	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	32%	95%
Q8U1S1	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	35%	100%
Q8VCP8	Mus musculus	41%	100%
Q8ZU30	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	33%	93%
Q976L5	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	30%	96%
Q97ZW3	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	34%	96%
Q9FJI1	Arabidopsis thaliana	40%	100%
Q9TTU2	Oryctolagus cuniculus	40%	100%
Q9UU88	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	100%
Q9UZK4	Pyrococcus abyssi (strain GE5 / Orsay)	38%	100%
Q9Y3D8	Homo sapiens	41%	100%