Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7X3E1_LEIDO

TriTrypDb:

LdBPK_301850.1 , LdCL_300023800 , LDHU3_30.2560

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X3E1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3E1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.706
CLV_C14_Caspase3-7	295	299	PF00656	0.738
CLV_NRD_NRD_1	19	21	PF00675	0.655
CLV_NRD_NRD_1	264	266	PF00675	0.718
CLV_NRD_NRD_1	30	32	PF00675	0.516
CLV_NRD_NRD_1	309	311	PF00675	0.705
CLV_NRD_NRD_1	480	482	PF00675	0.654
CLV_PCSK_KEX2_1	108	110	PF00082	0.709
CLV_PCSK_KEX2_1	19	21	PF00082	0.655
CLV_PCSK_KEX2_1	264	266	PF00082	0.778
CLV_PCSK_KEX2_1	30	32	PF00082	0.516
CLV_PCSK_KEX2_1	309	311	PF00082	0.727
CLV_PCSK_KEX2_1	360	362	PF00082	0.643
CLV_PCSK_KEX2_1	462	464	PF00082	0.743
CLV_PCSK_KEX2_1	480	482	PF00082	0.654
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.709
CLV_PCSK_PC1ET2_1	360	362	PF00082	0.643
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.690
CLV_PCSK_SKI1_1	13	17	PF00082	0.677
CLV_PCSK_SKI1_1	20	24	PF00082	0.560
CLV_PCSK_SKI1_1	254	258	PF00082	0.461
CLV_PCSK_SKI1_1	52	56	PF00082	0.585
DEG_COP1_1	282	293	PF00400	0.728
DEG_SPOP_SBC_1	203	207	PF00917	0.615
DOC_CKS1_1	365	370	PF01111	0.688
DOC_CKS1_1	429	434	PF01111	0.611
DOC_CYCLIN_RxL_1	446	456	PF00134	0.679
DOC_MAPK_DCC_7	264	272	PF00069	0.748
DOC_MAPK_gen_1	264	272	PF00069	0.789
DOC_MAPK_gen_1	30	39	PF00069	0.485
DOC_MAPK_MEF2A_6	264	272	PF00069	0.748
DOC_MAPK_MEF2A_6	437	446	PF00069	0.654
DOC_PP1_RVXF_1	231	237	PF00149	0.620
DOC_PP1_RVXF_1	447	454	PF00149	0.679
DOC_PP4_FxxP_1	429	432	PF00568	0.583
DOC_USP7_MATH_1	177	181	PF00917	0.722
DOC_USP7_MATH_1	187	191	PF00917	0.620
DOC_USP7_MATH_1	203	207	PF00917	0.620
DOC_USP7_MATH_1	293	297	PF00917	0.746
DOC_USP7_MATH_1	371	375	PF00917	0.721
DOC_USP7_MATH_1	381	385	PF00917	0.679
DOC_USP7_MATH_1	50	54	PF00917	0.723
DOC_WW_Pin1_4	180	185	PF00397	0.761
DOC_WW_Pin1_4	248	253	PF00397	0.698
DOC_WW_Pin1_4	289	294	PF00397	0.682
DOC_WW_Pin1_4	333	338	PF00397	0.782
DOC_WW_Pin1_4	364	369	PF00397	0.712
DOC_WW_Pin1_4	403	408	PF00397	0.733
DOC_WW_Pin1_4	418	423	PF00397	0.615
DOC_WW_Pin1_4	428	433	PF00397	0.599
DOC_WW_Pin1_4	461	466	PF00397	0.637
DOC_WW_Pin1_4	471	476	PF00397	0.789
LIG_14-3-3_CanoR_1	13	19	PF00244	0.734
LIG_14-3-3_CanoR_1	221	227	PF00244	0.614
LIG_14-3-3_CanoR_1	449	454	PF00244	0.752
LIG_14-3-3_CanoR_1	52	57	PF00244	0.760
LIG_FHA_2	174	180	PF00498	0.674
LIG_FHA_2	19	25	PF00498	0.696
LIG_FHA_2	199	205	PF00498	0.768
LIG_FHA_2	223	229	PF00498	0.695
LIG_FHA_2	303	309	PF00498	0.644
LIG_FHA_2	396	402	PF00498	0.730
LIG_FHA_2	419	425	PF00498	0.700
LIG_FHA_2	53	59	PF00498	0.758
LIG_LIR_Apic_2	347	352	PF02991	0.611
LIG_LIR_Gen_1	126	137	PF02991	0.653
LIG_LIR_Gen_1	214	224	PF02991	0.575
LIG_LIR_Gen_1	40	51	PF02991	0.687
LIG_LIR_Gen_1	469	476	PF02991	0.576
LIG_LIR_Nem_3	126	132	PF02991	0.658
LIG_LIR_Nem_3	214	219	PF02991	0.584
LIG_LIR_Nem_3	40	46	PF02991	0.679
LIG_LIR_Nem_3	469	473	PF02991	0.661
LIG_PCNA_yPIPBox_3	80	91	PF02747	0.526
LIG_SH2_CRK	349	353	PF00017	0.614
LIG_SH2_CRK	470	474	PF00017	0.659
LIG_SH2_NCK_1	470	474	PF00017	0.611
LIG_SH2_PTP2	43	46	PF00017	0.586
LIG_SH2_STAT5	14	17	PF00017	0.598
LIG_SH2_STAT5	248	251	PF00017	0.701
LIG_SH2_STAT5	43	46	PF00017	0.697
LIG_SH3_1	334	340	PF00018	0.775
LIG_SH3_2	337	342	PF14604	0.763
LIG_SH3_3	148	154	PF00018	0.757
LIG_SH3_3	246	252	PF00018	0.702
LIG_SH3_3	287	293	PF00018	0.727
LIG_SH3_3	308	314	PF00018	0.732
LIG_SH3_3	334	340	PF00018	0.775
LIG_SH3_3	362	368	PF00018	0.691
LIG_SH3_3	380	386	PF00018	0.506
LIG_SH3_3	41	47	PF00018	0.661
LIG_SH3_3	430	436	PF00018	0.683
LIG_SUMO_SIM_par_1	73	79	PF11976	0.670
LIG_TRAF2_1	124	127	PF00917	0.670
LIG_TRAF2_1	176	179	PF00917	0.679
LIG_TRAF2_1	206	209	PF00917	0.725
LIG_TRAF2_1	387	390	PF00917	0.780
LIG_TRFH_1	43	47	PF08558	0.602
LIG_UBA3_1	15	23	PF00899	0.666
LIG_WW_3	310	314	PF00397	0.728
MOD_CDC14_SPxK_1	251	254	PF00782	0.690
MOD_CDK_SPK_2	289	294	PF00069	0.793
MOD_CDK_SPxK_1	248	254	PF00069	0.697
MOD_CK1_1	180	186	PF00069	0.783
MOD_CK1_1	191	197	PF00069	0.664
MOD_CK1_1	222	228	PF00069	0.656
MOD_CK1_1	279	285	PF00069	0.788
MOD_CK1_1	292	298	PF00069	0.622
MOD_CK1_1	299	305	PF00069	0.570
MOD_CK1_1	354	360	PF00069	0.718
MOD_CK1_1	369	375	PF00069	0.652
MOD_CK1_1	406	412	PF00069	0.705
MOD_CK1_1	418	424	PF00069	0.699
MOD_CK1_1	471	477	PF00069	0.681
MOD_CK2_1	121	127	PF00069	0.699
MOD_CK2_1	152	158	PF00069	0.678
MOD_CK2_1	173	179	PF00069	0.671
MOD_CK2_1	18	24	PF00069	0.705
MOD_CK2_1	202	208	PF00069	0.805
MOD_CK2_1	222	228	PF00069	0.691
MOD_CK2_1	247	253	PF00069	0.619
MOD_CK2_1	283	289	PF00069	0.748
MOD_CK2_1	318	324	PF00069	0.779
MOD_CK2_1	395	401	PF00069	0.772
MOD_Cter_Amidation	262	265	PF01082	0.707
MOD_GlcNHglycan	104	107	PF01048	0.724
MOD_GlcNHglycan	154	157	PF01048	0.682
MOD_GlcNHglycan	279	282	PF01048	0.661
MOD_GlcNHglycan	295	298	PF01048	0.667
MOD_GlcNHglycan	34	37	PF01048	0.585
MOD_GlcNHglycan	368	371	PF01048	0.726
MOD_GlcNHglycan	408	411	PF01048	0.684
MOD_GlcNHglycan	469	473	PF01048	0.697
MOD_GSK3_1	117	124	PF00069	0.748
MOD_GSK3_1	14	21	PF00069	0.691
MOD_GSK3_1	167	174	PF00069	0.712
MOD_GSK3_1	187	194	PF00069	0.542
MOD_GSK3_1	198	205	PF00069	0.706
MOD_GSK3_1	272	279	PF00069	0.787
MOD_GSK3_1	285	292	PF00069	0.617
MOD_GSK3_1	296	303	PF00069	0.650
MOD_GSK3_1	347	354	PF00069	0.726
MOD_GSK3_1	377	384	PF00069	0.728
MOD_GSK3_1	392	399	PF00069	0.648
MOD_LATS_1	343	349	PF00433	0.670
MOD_N-GLC_2	80	82	PF02516	0.531
MOD_NEK2_1	18	23	PF00069	0.676
MOD_NEK2_1	32	37	PF00069	0.523
MOD_NEK2_1	377	382	PF00069	0.746
MOD_NEK2_1	90	95	PF00069	0.719
MOD_NEK2_2	14	19	PF00069	0.677
MOD_PIKK_1	272	278	PF00454	0.762
MOD_PIKK_1	280	286	PF00454	0.710
MOD_PIKK_1	371	377	PF00454	0.687
MOD_PKA_1	108	114	PF00069	0.769
MOD_PKA_2	108	114	PF00069	0.680
MOD_PKA_2	18	24	PF00069	0.660
MOD_PKA_2	187	193	PF00069	0.660
MOD_PKA_2	293	299	PF00069	0.791
MOD_Plk_1	109	115	PF00069	0.601
MOD_Plk_1	125	131	PF00069	0.660
MOD_Plk_1	354	360	PF00069	0.669
MOD_Plk_1	468	474	PF00069	0.583
MOD_Plk_2-3	204	210	PF00069	0.650
MOD_ProDKin_1	180	186	PF00069	0.761
MOD_ProDKin_1	248	254	PF00069	0.697
MOD_ProDKin_1	289	295	PF00069	0.684
MOD_ProDKin_1	333	339	PF00069	0.780
MOD_ProDKin_1	364	370	PF00069	0.712
MOD_ProDKin_1	403	409	PF00069	0.733
MOD_ProDKin_1	418	424	PF00069	0.617
MOD_ProDKin_1	428	434	PF00069	0.597
MOD_ProDKin_1	461	467	PF00069	0.637
MOD_ProDKin_1	471	477	PF00069	0.790
MOD_SUMO_rev_2	205	215	PF00179	0.636
TRG_ENDOCYTIC_2	43	46	PF00928	0.681
TRG_ENDOCYTIC_2	470	473	PF00928	0.663
TRG_ER_diArg_1	18	20	PF00400	0.674
TRG_ER_diArg_1	233	236	PF00400	0.628
TRG_ER_diArg_1	264	266	PF00400	0.735
TRG_ER_diArg_1	29	31	PF00400	0.522
TRG_ER_diArg_1	309	311	PF00400	0.705
TRG_ER_diArg_1	479	481	PF00400	0.655
TRG_Pf-PMV_PEXEL_1	449	454	PF00026	0.752

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H927	Leishmania braziliensis	58%	100%
A4I5L2	Leishmania infantum	99%	100%
E9B0V7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q7A9	Leishmania major	88%	100%