Cupin-like_domain/JmjC_domain_hydroxylase_putativ e/Pfam:PF13621/Pfam:PF02373

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cupin-like domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X3C6_LEIDO

TriTrypDb:

LdBPK_301250.1 , LdCL_300017700 , LDHU3_30.1630

Length:

618

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X3C6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3C6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.580
CLV_C14_Caspase3-7	505	509	PF00656	0.368
CLV_NRD_NRD_1	280	282	PF00675	0.669
CLV_NRD_NRD_1	317	319	PF00675	0.465
CLV_NRD_NRD_1	359	361	PF00675	0.385
CLV_NRD_NRD_1	376	378	PF00675	0.419
CLV_NRD_NRD_1	406	408	PF00675	0.311
CLV_NRD_NRD_1	593	595	PF00675	0.455
CLV_NRD_NRD_1	602	604	PF00675	0.391
CLV_NRD_NRD_1	66	68	PF00675	0.509
CLV_NRD_NRD_1	97	99	PF00675	0.575
CLV_PCSK_FUR_1	278	282	PF00082	0.547
CLV_PCSK_KEX2_1	280	282	PF00082	0.623
CLV_PCSK_KEX2_1	317	319	PF00082	0.477
CLV_PCSK_KEX2_1	359	361	PF00082	0.322
CLV_PCSK_KEX2_1	376	378	PF00082	0.286
CLV_PCSK_KEX2_1	470	472	PF00082	0.382
CLV_PCSK_KEX2_1	595	597	PF00082	0.453
CLV_PCSK_KEX2_1	602	604	PF00082	0.419
CLV_PCSK_KEX2_1	97	99	PF00082	0.575
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.382
CLV_PCSK_PC1ET2_1	595	597	PF00082	0.434
CLV_PCSK_PC7_1	591	597	PF00082	0.435
CLV_PCSK_SKI1_1	403	407	PF00082	0.382
CLV_PCSK_SKI1_1	439	443	PF00082	0.382
CLV_PCSK_SKI1_1	470	474	PF00082	0.382
CLV_PCSK_SKI1_1	534	538	PF00082	0.332
DEG_APCC_DBOX_1	221	229	PF00400	0.633
DEG_MDM2_SWIB_1	74	82	PF02201	0.515
DOC_CKS1_1	333	338	PF01111	0.284
DOC_CYCLIN_RxL_1	199	207	PF00134	0.633
DOC_CYCLIN_RxL_1	64	73	PF00134	0.485
DOC_CYCLIN_yCln2_LP_2	191	197	PF00134	0.594
DOC_CYCLIN_yCln2_LP_2	221	227	PF00134	0.658
DOC_MAPK_gen_1	317	323	PF00069	0.608
DOC_MAPK_gen_1	602	613	PF00069	0.464
DOC_MAPK_gen_1	94	104	PF00069	0.560
DOC_MAPK_MEF2A_6	193	201	PF00069	0.626
DOC_MAPK_MEF2A_6	606	615	PF00069	0.474
DOC_PP2B_LxvP_1	221	224	PF13499	0.653
DOC_PP2B_LxvP_1	302	305	PF13499	0.576
DOC_PP2B_LxvP_1	474	477	PF13499	0.354
DOC_PP2B_LxvP_1	549	552	PF13499	0.284
DOC_PP2B_LxvP_1	58	61	PF13499	0.568
DOC_PP2B_LxvP_1	613	616	PF13499	0.525
DOC_PP2B_PxIxI_1	60	66	PF00149	0.560
DOC_PP4_FxxP_1	220	223	PF00568	0.653
DOC_USP7_MATH_1	111	115	PF00917	0.568
DOC_USP7_MATH_1	172	176	PF00917	0.617
DOC_USP7_MATH_1	179	183	PF00917	0.571
DOC_USP7_MATH_1	445	449	PF00917	0.382
DOC_USP7_MATH_1	511	515	PF00917	0.382
DOC_WW_Pin1_4	13	18	PF00397	0.470
DOC_WW_Pin1_4	145	150	PF00397	0.622
DOC_WW_Pin1_4	2	7	PF00397	0.643
DOC_WW_Pin1_4	332	337	PF00397	0.284
DOC_WW_Pin1_4	447	452	PF00397	0.382
LIG_14-3-3_CanoR_1	123	128	PF00244	0.499
LIG_14-3-3_CanoR_1	229	236	PF00244	0.656
LIG_14-3-3_CanoR_1	237	245	PF00244	0.590
LIG_14-3-3_CanoR_1	272	282	PF00244	0.571
LIG_14-3-3_CanoR_1	318	324	PF00244	0.473
LIG_14-3-3_CanoR_1	377	386	PF00244	0.356
LIG_14-3-3_CanoR_1	407	416	PF00244	0.378
LIG_14-3-3_CanoR_1	471	475	PF00244	0.382
LIG_14-3-3_CanoR_1	97	103	PF00244	0.652
LIG_Actin_RPEL_3	15	34	PF02755	0.415
LIG_APCC_ABBA_1	236	241	PF00400	0.656
LIG_BRCT_BRCA1_1	113	117	PF00533	0.555
LIG_BRCT_BRCA1_1	574	578	PF00533	0.331
LIG_Clathr_ClatBox_1	536	540	PF01394	0.311
LIG_deltaCOP1_diTrp_1	344	352	PF00928	0.382
LIG_deltaCOP1_diTrp_1	38	44	PF00928	0.523
LIG_FHA_1	14	20	PF00498	0.590
LIG_FHA_1	196	202	PF00498	0.631
LIG_FHA_1	248	254	PF00498	0.621
LIG_FHA_1	277	283	PF00498	0.615
LIG_FHA_1	287	293	PF00498	0.655
LIG_FHA_1	333	339	PF00498	0.357
LIG_FHA_1	40	46	PF00498	0.580
LIG_FHA_1	563	569	PF00498	0.382
LIG_FHA_1	99	105	PF00498	0.661
LIG_FHA_2	33	39	PF00498	0.622
LIG_FHA_2	349	355	PF00498	0.382
LIG_FHA_2	390	396	PF00498	0.382
LIG_FHA_2	429	435	PF00498	0.382
LIG_FHA_2	503	509	PF00498	0.382
LIG_Integrin_isoDGR_2	369	371	PF01839	0.382
LIG_Integrin_RGD_1	506	508	PF01839	0.368
LIG_LIR_Apic_2	217	223	PF02991	0.642
LIG_LIR_Apic_2	329	333	PF02991	0.382
LIG_LIR_Apic_2	415	419	PF02991	0.382
LIG_LIR_Gen_1	114	125	PF02991	0.539
LIG_LIR_Gen_1	350	358	PF02991	0.382
LIG_LIR_Gen_1	38	45	PF02991	0.523
LIG_LIR_Gen_1	424	434	PF02991	0.382
LIG_LIR_Gen_1	437	445	PF02991	0.263
LIG_LIR_Gen_1	459	466	PF02991	0.382
LIG_LIR_Gen_1	553	562	PF02991	0.522
LIG_LIR_Nem_3	114	120	PF02991	0.552
LIG_LIR_Nem_3	240	245	PF02991	0.630
LIG_LIR_Nem_3	350	355	PF02991	0.382
LIG_LIR_Nem_3	38	44	PF02991	0.523
LIG_LIR_Nem_3	384	388	PF02991	0.382
LIG_LIR_Nem_3	423	429	PF02991	0.380
LIG_LIR_Nem_3	437	443	PF02991	0.256
LIG_LIR_Nem_3	459	465	PF02991	0.382
LIG_LIR_Nem_3	50	56	PF02991	0.424
LIG_LIR_Nem_3	553	559	PF02991	0.382
LIG_LIR_Nem_3	575	581	PF02991	0.433
LIG_LYPXL_SIV_4	61	69	PF13949	0.558
LIG_MYND_1	6	10	PF01753	0.606
LIG_Pex14_2	357	361	PF04695	0.382
LIG_Pex14_2	422	426	PF04695	0.382
LIG_Pex14_2	74	78	PF04695	0.516
LIG_REV1ctd_RIR_1	355	364	PF16727	0.311
LIG_REV1ctd_RIR_1	41	50	PF16727	0.532
LIG_SH2_CRK	416	420	PF00017	0.382
LIG_SH2_NCK_1	330	334	PF00017	0.382
LIG_SH2_NCK_1	388	392	PF00017	0.382
LIG_SH2_NCK_1	416	420	PF00017	0.382
LIG_SH2_PTP2	62	65	PF00017	0.544
LIG_SH2_SRC	27	30	PF00017	0.505
LIG_SH2_SRC	416	419	PF00017	0.354
LIG_SH2_SRC	62	65	PF00017	0.544
LIG_SH2_STAP1	80	84	PF00017	0.505
LIG_SH2_STAT5	127	130	PF00017	0.470
LIG_SH2_STAT5	203	206	PF00017	0.648
LIG_SH2_STAT5	213	216	PF00017	0.631
LIG_SH2_STAT5	23	26	PF00017	0.516
LIG_SH2_STAT5	27	30	PF00017	0.468
LIG_SH2_STAT5	385	388	PF00017	0.382
LIG_SH2_STAT5	399	402	PF00017	0.254
LIG_SH2_STAT5	421	424	PF00017	0.382
LIG_SH2_STAT5	62	65	PF00017	0.544
LIG_SH2_STAT5	80	83	PF00017	0.345
LIG_SH3_1	330	336	PF00018	0.382
LIG_SH3_3	191	197	PF00018	0.594
LIG_SH3_3	253	259	PF00018	0.617
LIG_SH3_3	330	336	PF00018	0.382
LIG_SH3_3	476	482	PF00018	0.382
LIG_SUMO_SIM_par_1	32	39	PF11976	0.490
LIG_SUMO_SIM_par_1	335	340	PF11976	0.382
LIG_SUMO_SIM_par_1	564	569	PF11976	0.382
LIG_TRAF2_1	185	188	PF00917	0.551
LIG_TYR_ITIM	201	206	PF00017	0.634
LIG_UBA3_1	252	260	PF00899	0.522
LIG_WRC_WIRS_1	71	76	PF05994	0.545
MOD_CDK_SPK_2	13	18	PF00069	0.570
MOD_CK1_1	158	164	PF00069	0.671
MOD_CK1_1	276	282	PF00069	0.613
MOD_CK1_1	4	10	PF00069	0.547
MOD_CK1_1	428	434	PF00069	0.354
MOD_CK1_1	509	515	PF00069	0.382
MOD_CK1_1	574	580	PF00069	0.442
MOD_CK2_1	32	38	PF00069	0.621
MOD_CK2_1	389	395	PF00069	0.382
MOD_CK2_1	529	535	PF00069	0.382
MOD_Cter_Amidation	374	377	PF01082	0.382
MOD_GlcNHglycan	130	133	PF01048	0.584
MOD_GlcNHglycan	165	168	PF01048	0.589
MOD_GlcNHglycan	174	177	PF01048	0.533
MOD_GlcNHglycan	206	209	PF01048	0.598
MOD_GlcNHglycan	380	383	PF01048	0.382
MOD_GlcNHglycan	446	450	PF01048	0.382
MOD_GlcNHglycan	459	462	PF01048	0.263
MOD_GlcNHglycan	466	469	PF01048	0.199
MOD_GlcNHglycan	511	514	PF01048	0.382
MOD_GlcNHglycan	531	534	PF01048	0.199
MOD_GlcNHglycan	552	555	PF01048	0.382
MOD_GSK3_1	128	135	PF00069	0.545
MOD_GSK3_1	141	148	PF00069	0.485
MOD_GSK3_1	151	158	PF00069	0.581
MOD_GSK3_1	272	279	PF00069	0.643
MOD_GSK3_1	32	39	PF00069	0.462
MOD_GSK3_1	447	454	PF00069	0.382
MOD_GSK3_1	502	509	PF00069	0.382
MOD_GSK3_1	562	569	PF00069	0.382
MOD_GSK3_1	70	77	PF00069	0.540
MOD_GSK3_1	93	100	PF00069	0.646
MOD_N-GLC_2	571	573	PF02516	0.408
MOD_NEK2_1	104	109	PF00069	0.633
MOD_NEK2_1	204	209	PF00069	0.682
MOD_NEK2_1	228	233	PF00069	0.678
MOD_NEK2_1	267	272	PF00069	0.774
MOD_NEK2_1	292	297	PF00069	0.643
MOD_NEK2_1	36	41	PF00069	0.480
MOD_NEK2_1	378	383	PF00069	0.382
MOD_NEK2_1	406	411	PF00069	0.375
MOD_NEK2_1	74	79	PF00069	0.523
MOD_NEK2_2	111	116	PF00069	0.569
MOD_NEK2_2	179	184	PF00069	0.512
MOD_NEK2_2	273	278	PF00069	0.539
MOD_NEK2_2	589	594	PF00069	0.539
MOD_NEK2_2	70	75	PF00069	0.543
MOD_PIKK_1	141	147	PF00454	0.570
MOD_PIKK_1	228	234	PF00454	0.630
MOD_PKA_1	407	413	PF00069	0.311
MOD_PKA_1	470	476	PF00069	0.382
MOD_PKA_1	97	103	PF00069	0.569
MOD_PKA_2	228	234	PF00069	0.669
MOD_PKA_2	319	325	PF00069	0.469
MOD_PKA_2	348	354	PF00069	0.487
MOD_PKA_2	378	384	PF00069	0.382
MOD_PKA_2	406	412	PF00069	0.378
MOD_PKA_2	470	476	PF00069	0.382
MOD_PKA_2	74	80	PF00069	0.527
MOD_PKA_2	93	99	PF00069	0.477
MOD_PKB_1	504	512	PF00069	0.382
MOD_Plk_1	111	117	PF00069	0.561
MOD_Plk_1	158	164	PF00069	0.647
MOD_Plk_1	179	185	PF00069	0.585
MOD_Plk_1	589	595	PF00069	0.472
MOD_Plk_2-3	133	139	PF00069	0.580
MOD_Plk_2-3	32	38	PF00069	0.488
MOD_Plk_4	123	129	PF00069	0.446
MOD_Plk_4	186	192	PF00069	0.502
MOD_Plk_4	216	222	PF00069	0.782
MOD_Plk_4	470	476	PF00069	0.382
MOD_Plk_4	98	104	PF00069	0.665
MOD_ProDKin_1	13	19	PF00069	0.463
MOD_ProDKin_1	145	151	PF00069	0.626
MOD_ProDKin_1	2	8	PF00069	0.636
MOD_ProDKin_1	332	338	PF00069	0.284
MOD_ProDKin_1	447	453	PF00069	0.382
TRG_ENDOCYTIC_2	203	206	PF00928	0.648
TRG_ENDOCYTIC_2	27	30	PF00928	0.505
TRG_ENDOCYTIC_2	438	441	PF00928	0.382
TRG_ENDOCYTIC_2	62	65	PF00928	0.544
TRG_ER_diArg_1	278	281	PF00400	0.606
TRG_ER_diArg_1	317	319	PF00400	0.465
TRG_ER_diArg_1	358	360	PF00400	0.318
TRG_ER_diArg_1	376	378	PF00400	0.280
TRG_ER_diArg_1	503	506	PF00400	0.382
TRG_ER_diArg_1	593	596	PF00400	0.450
TRG_ER_diArg_1	601	603	PF00400	0.396
TRG_ER_diArg_1	97	99	PF00400	0.575
TRG_NLS_MonoExtN_4	591	598	PF00514	0.460
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I5F0	Leishmania infantum	100%	100%
E9B0P8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q7I4	Leishmania major	93%	100%