Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X3C2_LEIDO

TriTrypDb:

LdBPK_301610.1 , LdCL_300021400 , LDHU3_30.2100

Length:

382

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3S7X3C2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3C2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.689
CLV_NRD_NRD_1	312	314	PF00675	0.614
CLV_NRD_NRD_1	347	349	PF00675	0.411
CLV_PCSK_KEX2_1	346	348	PF00082	0.382
CLV_PCSK_PC1ET2_1	346	348	PF00082	0.393
CLV_PCSK_SKI1_1	269	273	PF00082	0.617
CLV_PCSK_SKI1_1	308	312	PF00082	0.662
DEG_APCC_DBOX_1	153	161	PF00400	0.393
DEG_Nend_Nbox_1	1	3	PF02207	0.568
DOC_MAPK_gen_1	151	160	PF00069	0.335
DOC_MAPK_gen_1	313	320	PF00069	0.401
DOC_MAPK_JIP1_4	154	160	PF00069	0.339
DOC_MAPK_MEF2A_6	151	159	PF00069	0.418
DOC_PP2B_LxvP_1	24	27	PF13499	0.469
DOC_PP2B_LxvP_1	367	370	PF13499	0.591
DOC_USP7_MATH_1	227	231	PF00917	0.418
DOC_USP7_MATH_1	242	246	PF00917	0.541
DOC_USP7_MATH_1	304	308	PF00917	0.449
DOC_WW_Pin1_4	72	77	PF00397	0.332
LIG_14-3-3_CanoR_1	107	112	PF00244	0.419
LIG_14-3-3_CanoR_1	115	123	PF00244	0.296
LIG_14-3-3_CanoR_1	269	276	PF00244	0.307
LIG_14-3-3_CanoR_1	98	102	PF00244	0.400
LIG_BRCT_BRCA1_1	142	146	PF00533	0.531
LIG_BRCT_BRCA1_1	62	66	PF00533	0.405
LIG_BRCT_BRCA1_1	74	78	PF00533	0.283
LIG_Clathr_ClatBox_1	157	161	PF01394	0.318
LIG_eIF4E_1	178	184	PF01652	0.394
LIG_FHA_1	106	112	PF00498	0.391
LIG_FHA_1	171	177	PF00498	0.334
LIG_FHA_1	279	285	PF00498	0.434
LIG_FHA_2	270	276	PF00498	0.396
LIG_FHA_2	291	297	PF00498	0.385
LIG_LIR_Apic_2	175	180	PF02991	0.323
LIG_LIR_Gen_1	277	284	PF02991	0.322
LIG_LIR_Nem_3	273	279	PF02991	0.287
LIG_Pex14_1	299	303	PF04695	0.295
LIG_Pex14_2	46	50	PF04695	0.398
LIG_SH2_CRK	303	307	PF00017	0.316
LIG_SH2_NCK_1	303	307	PF00017	0.345
LIG_SH2_PTP2	279	282	PF00017	0.265
LIG_SH2_SRC	178	181	PF00017	0.391
LIG_SH2_STAT5	178	181	PF00017	0.394
LIG_SH2_STAT5	279	282	PF00017	0.346
LIG_SH3_1	73	79	PF00018	0.339
LIG_SH3_2	76	81	PF14604	0.409
LIG_SH3_3	277	283	PF00018	0.350
LIG_SH3_3	73	79	PF00018	0.339
LIG_SUMO_SIM_par_1	156	161	PF11976	0.349
LIG_UBA3_1	86	93	PF00899	0.353
MOD_CK1_1	117	123	PF00069	0.425
MOD_CK1_1	240	246	PF00069	0.557
MOD_CK1_1	340	346	PF00069	0.526
MOD_CK1_1	57	63	PF00069	0.327
MOD_CK2_1	134	140	PF00069	0.513
MOD_CK2_1	269	275	PF00069	0.304
MOD_CK2_1	290	296	PF00069	0.433
MOD_Cter_Amidation	344	347	PF01082	0.392
MOD_GlcNHglycan	116	119	PF01048	0.606
MOD_GlcNHglycan	139	143	PF01048	0.741
MOD_GlcNHglycan	195	199	PF01048	0.620
MOD_GlcNHglycan	200	203	PF01048	0.578
MOD_GlcNHglycan	215	218	PF01048	0.589
MOD_GlcNHglycan	230	233	PF01048	0.562
MOD_GlcNHglycan	239	242	PF01048	0.650
MOD_GlcNHglycan	254	259	PF01048	0.722
MOD_GlcNHglycan	275	279	PF01048	0.584
MOD_GlcNHglycan	29	32	PF01048	0.671
MOD_GlcNHglycan	339	342	PF01048	0.404
MOD_GlcNHglycan	37	40	PF01048	0.693
MOD_GlcNHglycan	4	7	PF01048	0.615
MOD_GlcNHglycan	62	65	PF01048	0.514
MOD_GSK3_1	134	141	PF00069	0.490
MOD_GSK3_1	194	201	PF00069	0.364
MOD_GSK3_1	228	235	PF00069	0.364
MOD_GSK3_1	240	247	PF00069	0.482
MOD_GSK3_1	254	261	PF00069	0.361
MOD_GSK3_1	274	281	PF00069	0.305
MOD_GSK3_1	285	292	PF00069	0.406
MOD_GSK3_1	35	42	PF00069	0.491
MOD_GSK3_1	50	57	PF00069	0.255
MOD_GSK3_1	93	100	PF00069	0.477
MOD_N-GLC_1	66	71	PF02516	0.507
MOD_NEK2_1	105	110	PF00069	0.286
MOD_NEK2_1	119	124	PF00069	0.333
MOD_NEK2_1	127	132	PF00069	0.403
MOD_NEK2_1	170	175	PF00069	0.343
MOD_NEK2_1	19	24	PF00069	0.375
MOD_NEK2_1	2	7	PF00069	0.673
MOD_NEK2_1	50	55	PF00069	0.308
MOD_NEK2_1	59	64	PF00069	0.287
MOD_NEK2_1	66	71	PF00069	0.264
MOD_NEK2_2	172	177	PF00069	0.341
MOD_NEK2_2	306	311	PF00069	0.397
MOD_PIKK_1	57	63	PF00454	0.386
MOD_PIKK_1	93	99	PF00454	0.387
MOD_PK_1	244	250	PF00069	0.465
MOD_PKA_1	134	140	PF00069	0.507
MOD_PKA_2	114	120	PF00069	0.261
MOD_PKA_2	153	159	PF00069	0.368
MOD_PKA_2	164	170	PF00069	0.357
MOD_PKA_2	375	381	PF00069	0.704
MOD_PKA_2	97	103	PF00069	0.401
MOD_Plk_1	274	280	PF00069	0.273
MOD_Plk_1	66	72	PF00069	0.307
MOD_Plk_2-3	207	213	PF00069	0.385
MOD_Plk_4	153	159	PF00069	0.316
MOD_Plk_4	172	178	PF00069	0.298
MOD_Plk_4	19	25	PF00069	0.398
MOD_Plk_4	306	312	PF00069	0.444
MOD_Plk_4	54	60	PF00069	0.290
MOD_Plk_4	97	103	PF00069	0.384
MOD_ProDKin_1	72	78	PF00069	0.333
MOD_SUMO_for_1	365	368	PF00179	0.601
MOD_SUMO_rev_2	351	359	PF00179	0.610
MOD_SUMO_rev_2	85	94	PF00179	0.352
TRG_DiLeu_BaEn_1	153	158	PF01217	0.342
TRG_DiLeu_BaLyEn_6	367	372	PF01217	0.611
TRG_ENDOCYTIC_2	279	282	PF00928	0.275
TRG_ENDOCYTIC_2	324	327	PF00928	0.415
TRG_ER_diArg_1	70	73	PF00400	0.322
TRG_ER_diLys_1	379	382	PF00400	0.604
TRG_NLS_MonoCore_2	131	136	PF00514	0.459
TRG_NLS_MonoExtC_3	345	351	PF00514	0.645
TRG_NLS_MonoExtN_4	129	136	PF00514	0.456
TRG_Pf-PMV_PEXEL_1	109	113	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	269	273	PF00026	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMH7	Leptomonas seymouri	53%	99%
A0A1X0P321	Trypanosomatidae	31%	100%
A0A422P4W9	Trypanosoma rangeli	31%	100%
A4HIA4	Leishmania braziliensis	68%	97%
A4I5I8	Leishmania infantum	99%	100%
C9ZQS4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B0T3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4Q7E5	Leishmania major	89%	100%
V5BPM9	Trypanosoma cruzi	32%	100%