Pyridoxal kinase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Pyridoxal kinase

Gene product:

pyridoxal kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X3C0_LEIDO

TriTrypDb:

LdBPK_301310.1 , LdCL_300018300 , LDHU3_30.1690

Length:

302

Annotations

Annotations by Jardim et al.

Protein kinase, Pyridoxal kinase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7X3C0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3C0

PDB structure(s): 6k8z_A , 6k8z_B , 6k90_A , 6k90_B , 6k91_A , 6k91_B , 6k92_A , 6k92_B

Function

Biological processes
Term	Name	Level	Count
GO:0006081	cellular aldehyde metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006766	vitamin metabolic process	3	12
GO:0006767	water-soluble vitamin metabolic process	4	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009110	vitamin biosynthetic process	4	12
GO:0009443	pyridoxal 5'-phosphate salvage	4	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0018130	heterocycle biosynthetic process	4	12
GO:0019438	aromatic compound biosynthetic process	4	12
GO:0019637	organophosphate metabolic process	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0042364	water-soluble vitamin biosynthetic process	5	12
GO:0042816	vitamin B6 metabolic process	5	12
GO:0042819	vitamin B6 biosynthetic process	6	12
GO:0042822	pyridoxal phosphate metabolic process	4	12
GO:0042823	pyridoxal phosphate biosynthetic process	5	12
GO:0043094	cellular metabolic compound salvage	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0044281	small molecule metabolic process	2	12
GO:0044283	small molecule biosynthetic process	3	12
GO:0046184	aldehyde biosynthetic process	4	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0072524	pyridine-containing compound metabolic process	4	12
GO:0072525	pyridine-containing compound biosynthetic process	5	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12
GO:1901615	organic hydroxy compound metabolic process	3	12
GO:1901617	organic hydroxy compound biosynthetic process	4	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008478	pyridoxal kinase activity	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	213	215	PF00082	0.319
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.365
CLV_PCSK_SKI1_1	139	143	PF00082	0.369
CLV_PCSK_SKI1_1	199	203	PF00082	0.385
CLV_PCSK_SKI1_1	22	26	PF00082	0.393
CLV_PCSK_SKI1_1	5	9	PF00082	0.401
DOC_CKS1_1	147	152	PF01111	0.479
DOC_CKS1_1	179	184	PF01111	0.556
DOC_CKS1_1	297	302	PF01111	0.530
DOC_CYCLIN_RxL_1	136	146	PF00134	0.528
DOC_CYCLIN_RxL_1	196	206	PF00134	0.565
DOC_MAPK_gen_1	108	117	PF00069	0.503
DOC_PP4_FxxP_1	117	120	PF00568	0.565
DOC_USP7_MATH_1	208	212	PF00917	0.500
DOC_USP7_UBL2_3	108	112	PF12436	0.503
DOC_WW_Pin1_4	146	151	PF00397	0.479
DOC_WW_Pin1_4	178	183	PF00397	0.584
DOC_WW_Pin1_4	296	301	PF00397	0.587
LIG_14-3-3_CanoR_1	281	286	PF00244	0.530
LIG_APCC_ABBA_1	218	223	PF00400	0.487
LIG_CaM_IQ_9	254	269	PF13499	0.584
LIG_CtBP_PxDLS_1	245	249	PF00389	0.565
LIG_FHA_1	158	164	PF00498	0.575
LIG_FHA_1	179	185	PF00498	0.514
LIG_FHA_1	214	220	PF00498	0.496
LIG_FHA_1	227	233	PF00498	0.451
LIG_FHA_1	23	29	PF00498	0.384
LIG_FHA_1	38	44	PF00498	0.346
LIG_FHA_1	81	87	PF00498	0.335
LIG_FHA_2	141	147	PF00498	0.586
LIG_FHA_2	62	68	PF00498	0.421
LIG_FHA_2	96	102	PF00498	0.490
LIG_LIR_Gen_1	60	69	PF02991	0.421
LIG_LIR_Gen_1	76	86	PF02991	0.471
LIG_LIR_Nem_3	136	141	PF02991	0.487
LIG_LIR_Nem_3	212	218	PF02991	0.569
LIG_LIR_Nem_3	47	52	PF02991	0.460
LIG_LIR_Nem_3	60	65	PF02991	0.427
LIG_LIR_Nem_3	76	81	PF02991	0.473
LIG_LYPXL_yS_3	49	52	PF13949	0.459
LIG_NRBOX	197	203	PF00104	0.565
LIG_Rb_LxCxE_1	124	146	PF01857	0.565
LIG_SH2_CRK	215	219	PF00017	0.584
LIG_SH2_CRK	78	82	PF00017	0.344
LIG_SH2_GRB2like	85	88	PF00017	0.490
LIG_SH2_SRC	78	81	PF00017	0.492
LIG_SH2_STAP1	78	82	PF00017	0.429
LIG_SH2_STAT5	129	132	PF00017	0.494
LIG_SH2_STAT5	152	155	PF00017	0.544
LIG_SH2_STAT5	18	21	PF00017	0.372
LIG_SH2_STAT5	215	218	PF00017	0.510
LIG_SH2_STAT5	226	229	PF00017	0.439
LIG_SH2_STAT5	80	83	PF00017	0.347
LIG_SH2_STAT5	85	88	PF00017	0.475
LIG_SH3_3	144	150	PF00018	0.487
LIG_SUMO_SIM_anti_2	293	299	PF11976	0.557
LIG_SUMO_SIM_par_1	159	165	PF11976	0.584
LIG_SUMO_SIM_par_1	181	188	PF11976	0.519
LIG_SUMO_SIM_par_1	39	44	PF11976	0.419
LIG_SUMO_SIM_par_1	6	12	PF11976	0.375
LIG_WRC_WIRS_1	186	191	PF05994	0.479
MOD_CK1_1	156	162	PF00069	0.490
MOD_CK1_1	44	50	PF00069	0.438
MOD_CK1_1	9	15	PF00069	0.394
MOD_CK2_1	156	162	PF00069	0.538
MOD_CK2_1	165	171	PF00069	0.493
MOD_CK2_1	273	279	PF00069	0.578
MOD_CK2_1	61	67	PF00069	0.419
MOD_CK2_1	95	101	PF00069	0.490
MOD_Cter_Amidation	109	112	PF01082	0.339
MOD_GlcNHglycan	167	170	PF01048	0.324
MOD_GlcNHglycan	269	272	PF01048	0.595
MOD_GlcNHglycan	46	49	PF01048	0.437
MOD_GSK3_1	153	160	PF00069	0.519
MOD_GSK3_1	209	216	PF00069	0.566
MOD_GSK3_1	267	274	PF00069	0.601
MOD_GSK3_1	37	44	PF00069	0.391
MOD_N-GLC_1	44	49	PF02516	0.415
MOD_NEK2_1	153	158	PF00069	0.539
MOD_NEK2_1	200	205	PF00069	0.502
MOD_NEK2_1	233	238	PF00069	0.507
MOD_NEK2_1	280	285	PF00069	0.476
MOD_PIKK_1	175	181	PF00454	0.519
MOD_PKA_1	213	219	PF00069	0.519
MOD_PKA_2	213	219	PF00069	0.490
MOD_PKA_2	224	230	PF00069	0.490
MOD_PKA_2	280	286	PF00069	0.498
MOD_Plk_1	153	159	PF00069	0.487
MOD_Plk_1	60	66	PF00069	0.454
MOD_Plk_2-3	61	67	PF00069	0.435
MOD_Plk_4	153	159	PF00069	0.490
MOD_Plk_4	180	186	PF00069	0.539
MOD_Plk_4	233	239	PF00069	0.519
MOD_Plk_4	61	67	PF00069	0.429
MOD_ProDKin_1	146	152	PF00069	0.479
MOD_ProDKin_1	178	184	PF00069	0.584
MOD_ProDKin_1	296	302	PF00069	0.601
MOD_SUMO_rev_2	156	166	PF00179	0.569
TRG_DiLeu_BaEn_3	60	66	PF01217	0.513
TRG_ENDOCYTIC_2	138	141	PF00928	0.479
TRG_ENDOCYTIC_2	215	218	PF00928	0.584
TRG_ENDOCYTIC_2	49	52	PF00928	0.443
TRG_ENDOCYTIC_2	78	81	PF00928	0.345
TRG_NES_CRM1_1	244	259	PF08389	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMQ2	Leptomonas seymouri	75%	100%
A0A0S4IJ51	Bodo saltans	41%	90%
A0A1X0P263	Trypanosomatidae	61%	98%
A0A422P4Z2	Trypanosoma rangeli	62%	100%
A1ADT5	Escherichia coli O1:K1 / APEC	30%	100%
A4HI77	Leishmania braziliensis	88%	100%
A4I5F6	Leishmania infantum	100%	100%
A5UA83	Haemophilus influenzae (strain PittEE)	29%	100%
A6VNE5	Actinobacillus succinogenes (strain ATCC 55618 / DSM 22257 / CCUG 43843 / 130Z)	34%	100%
A7ZPL9	Escherichia coli O139:H28 (strain E24377A / ETEC)	30%	100%
A8A2R4	Escherichia coli O9:H4 (strain HS)	30%	100%
B0UUD2	Histophilus somni (strain 2336)	31%	100%
B1IX53	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	30%	100%
B1LML3	Escherichia coli (strain SMS-3-5 / SECEC)	30%	100%
B1XA89	Escherichia coli (strain K12 / DH10B)	30%	100%
B2JCI0	Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815)	29%	100%
B2TX08	Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)	30%	100%
B5YZW5	Escherichia coli O157:H7 (strain EC4115 / EHEC)	30%	100%
B6I4Z5	Escherichia coli (strain SE11)	30%	100%
B7LCG3	Escherichia coli (strain 55989 / EAEC)	30%	100%
B7LL66	Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)	30%	100%
B7M6S8	Escherichia coli O8 (strain IAI1)	30%	100%
B7MHS2	Escherichia coli O45:K1 (strain S88 / ExPEC)	30%	100%
B7MY71	Escherichia coli O81 (strain ED1a)	30%	100%
B7N609	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	30%	100%
B7NPV5	Escherichia coli O7:K1 (strain IAI39 / ExPEC)	30%	100%
B7UGB9	Escherichia coli O127:H6 (strain E2348/69 / EPEC)	30%	100%
C4ZVU9	Escherichia coli (strain K12 / MC4100 / BW2952)	30%	100%
C9ZQU3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9B0Q4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O00764	Homo sapiens	36%	97%
O01824	Caenorhabditis elegans	38%	94%
O14242	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	98%
O35331	Rattus norvegicus	38%	97%
O46560	Sus scrofa	36%	94%
O74860	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	89%
P39988	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	97%
P40191	Escherichia coli (strain K12)	30%	100%
P44690	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	29%	100%
P44697	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	30%	100%
P53727	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	95%
P77150	Escherichia coli (strain K12)	30%	100%
P82197	Ovis aries	38%	97%
Q0BSF0	Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)	32%	100%
Q0I3D2	Haemophilus somnus (strain 129Pt)	31%	100%
Q0II59	Bos taurus	38%	97%
Q0TF48	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	30%	100%
Q0THJ1	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	30%	100%
Q141E8	Paraburkholderia xenovorans (strain LB400)	30%	100%
Q1AYE5	Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129 / PRD-1)	36%	100%
Q1BXQ7	Burkholderia cenocepacia (strain AU 1054)	28%	100%
Q1C792	Yersinia pestis bv. Antiqua (strain Antiqua)	31%	100%
Q1CIM6	Yersinia pestis bv. Antiqua (strain Nepal516)	31%	100%
Q1J237	Deinococcus geothermalis (strain DSM 11300 / AG-3a)	33%	100%
Q1LFU5	Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)	32%	100%
Q1PCB1	Bombyx mori	36%	100%
Q1R8V2	Escherichia coli (strain UTI89 / UPEC)	30%	100%
Q1RBF9	Escherichia coli (strain UTI89 / UPEC)	30%	100%
Q2L1P5	Bordetella avium (strain 197N)	33%	100%
Q2SXQ4	Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)	29%	100%
Q320Z3	Shigella boydii serotype 4 (strain Sb227)	30%	100%
Q32DD5	Shigella dysenteriae serotype 1 (strain Sd197)	30%	100%
Q32FD7	Shigella dysenteriae serotype 1 (strain Sd197)	29%	100%
Q39I40	Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)	28%	100%
Q3JQA6	Burkholderia pseudomallei (strain 1710b)	28%	100%
Q3K4B8	Pseudomonas fluorescens (strain Pf0-1)	25%	100%
Q3YZC3	Shigella sonnei (strain Ss046)	30%	100%
Q3Z1Z2	Shigella sonnei (strain Ss046)	30%	100%
Q4Q7H9	Leishmania major	97%	100%
Q51892	Proteus mirabilis	28%	100%
Q55EK9	Dictyostelium discoideum	35%	100%
Q57PI7	Salmonella choleraesuis (strain SC-B67)	28%	100%
Q5E345	Aliivibrio fischeri (strain ATCC 700601 / ES114)	30%	100%
Q5PIK8	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	28%	100%
Q62LP6	Burkholderia mallei (strain ATCC 23344)	28%	100%
Q63SC2	Burkholderia pseudomallei (strain K96243)	28%	100%
Q65UE8	Mannheimia succiniciproducens (strain MBEL55E)	31%	100%
Q66A50	Yersinia pseudotuberculosis serotype I (strain IP32953)	31%	100%
Q6AFC1	Leifsonia xyli subsp. xyli (strain CTCB07)	30%	100%
Q6NG19	Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)	30%	100%
Q7CIR8	Yersinia pestis	31%	100%
Q7MGA4	Vibrio vulnificus (strain YJ016)	33%	100%
Q7N3W7	Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)	28%	100%
Q7VYK4	Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)	32%	100%
Q7W6K7	Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)	31%	100%
Q7WII1	Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)	31%	100%
Q83K78	Shigella flexneri	30%	100%
Q83KY1	Shigella flexneri	29%	100%
Q8D4Q2	Vibrio vulnificus (strain CMCP6)	33%	100%
Q8FFB5	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	30%	100%
Q8FH89	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	30%	100%
Q8K183	Mus musculus	38%	97%
Q8W1X2	Arabidopsis thaliana	36%	98%
Q8X649	Escherichia coli O157:H7	30%	100%
Q8XBL0	Escherichia coli O157:H7	30%	100%
Q8ZPM8	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	28%	100%
Q9CNY1	Pasteurella multocida (strain Pm70)	31%	100%
Q9RYX0	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	31%	100%
V5BPL8	Trypanosoma cruzi	63%	100%