MA3 domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MA3 domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X3B0_LEIDO

TriTrypDb:

LdBPK_301210.1 , LdCL_300017300 , LDHU3_30.1580

Length:

860

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X3B0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3B0

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0022613	ribonucleoprotein complex biogenesis	4	1
GO:0042274	ribosomal small subunit biogenesis	5	1
GO:0044085	cellular component biogenesis	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	328	332	PF00656	0.551
CLV_C14_Caspase3-7	815	819	PF00656	0.792
CLV_MEL_PAP_1	263	269	PF00089	0.360
CLV_NRD_NRD_1	185	187	PF00675	0.360
CLV_NRD_NRD_1	382	384	PF00675	0.428
CLV_NRD_NRD_1	412	414	PF00675	0.473
CLV_NRD_NRD_1	416	418	PF00675	0.484
CLV_NRD_NRD_1	448	450	PF00675	0.482
CLV_NRD_NRD_1	49	51	PF00675	0.495
CLV_NRD_NRD_1	54	56	PF00675	0.414
CLV_NRD_NRD_1	616	618	PF00675	0.329
CLV_NRD_NRD_1	737	739	PF00675	0.392
CLV_NRD_NRD_1	806	808	PF00675	0.525
CLV_NRD_NRD_1	95	97	PF00675	0.455
CLV_PCSK_KEX2_1	114	116	PF00082	0.533
CLV_PCSK_KEX2_1	185	187	PF00082	0.374
CLV_PCSK_KEX2_1	382	384	PF00082	0.430
CLV_PCSK_KEX2_1	416	418	PF00082	0.438
CLV_PCSK_KEX2_1	448	450	PF00082	0.402
CLV_PCSK_KEX2_1	452	454	PF00082	0.361
CLV_PCSK_KEX2_1	53	55	PF00082	0.421
CLV_PCSK_KEX2_1	547	549	PF00082	0.487
CLV_PCSK_KEX2_1	571	573	PF00082	0.334
CLV_PCSK_KEX2_1	616	618	PF00082	0.294
CLV_PCSK_KEX2_1	737	739	PF00082	0.392
CLV_PCSK_KEX2_1	755	757	PF00082	0.411
CLV_PCSK_KEX2_1	806	808	PF00082	0.556
CLV_PCSK_KEX2_1	846	848	PF00082	0.290
CLV_PCSK_KEX2_1	97	99	PF00082	0.438
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.549
CLV_PCSK_PC1ET2_1	452	454	PF00082	0.372
CLV_PCSK_PC1ET2_1	547	549	PF00082	0.487
CLV_PCSK_PC1ET2_1	571	573	PF00082	0.337
CLV_PCSK_PC1ET2_1	755	757	PF00082	0.411
CLV_PCSK_PC1ET2_1	846	848	PF00082	0.304
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.445
CLV_PCSK_PC7_1	448	454	PF00082	0.458
CLV_PCSK_PC7_1	50	56	PF00082	0.417
CLV_PCSK_SKI1_1	103	107	PF00082	0.511
CLV_PCSK_SKI1_1	120	124	PF00082	0.551
CLV_PCSK_SKI1_1	309	313	PF00082	0.511
CLV_PCSK_SKI1_1	365	369	PF00082	0.330
CLV_PCSK_SKI1_1	389	393	PF00082	0.454
CLV_PCSK_SKI1_1	417	421	PF00082	0.434
CLV_PCSK_SKI1_1	442	446	PF00082	0.422
CLV_PCSK_SKI1_1	449	453	PF00082	0.377
CLV_PCSK_SKI1_1	520	524	PF00082	0.437
CLV_PCSK_SKI1_1	572	576	PF00082	0.330
CLV_PCSK_SKI1_1	699	703	PF00082	0.269
CLV_PCSK_SKI1_1	704	708	PF00082	0.271
CLV_PCSK_SKI1_1	737	741	PF00082	0.358
CLV_PCSK_SKI1_1	825	829	PF00082	0.517
CLV_PCSK_SKI1_1	853	857	PF00082	0.337
DEG_APCC_DBOX_1	698	706	PF00400	0.475
DEG_APCC_KENBOX_2	513	517	PF00400	0.734
DEG_Nend_UBRbox_1	1	4	PF02207	0.706
DEG_SCF_FBW7_1	207	213	PF00400	0.566
DEG_SPOP_SBC_1	165	169	PF00917	0.737
DEG_SPOP_SBC_1	235	239	PF00917	0.661
DEG_SPOP_SBC_1	332	336	PF00917	0.511
DOC_CKS1_1	207	212	PF01111	0.567
DOC_CYCLIN_RxL_1	306	316	PF00134	0.471
DOC_CYCLIN_RxL_1	448	458	PF00134	0.644
DOC_CYCLIN_RxL_1	633	646	PF00134	0.540
DOC_CYCLIN_RxL_1	680	690	PF00134	0.513
DOC_CYCLIN_RxL_1	734	741	PF00134	0.614
DOC_MAPK_DCC_7	477	485	PF00069	0.681
DOC_MAPK_gen_1	448	456	PF00069	0.598
DOC_MAPK_gen_1	58	66	PF00069	0.679
DOC_MAPK_MEF2A_6	477	485	PF00069	0.681
DOC_MAPK_MEF2A_6	699	707	PF00069	0.489
DOC_PP1_RVXF_1	264	270	PF00149	0.570
DOC_PP1_RVXF_1	636	643	PF00149	0.540
DOC_PP2B_LxvP_1	707	710	PF13499	0.476
DOC_USP7_MATH_1	104	108	PF00917	0.712
DOC_USP7_MATH_1	165	169	PF00917	0.774
DOC_USP7_MATH_1	210	214	PF00917	0.597
DOC_USP7_MATH_1	31	35	PF00917	0.790
DOC_USP7_MATH_1	327	331	PF00917	0.555
DOC_USP7_MATH_1	332	336	PF00917	0.507
DOC_USP7_MATH_1	381	385	PF00917	0.569
DOC_USP7_MATH_1	510	514	PF00917	0.766
DOC_USP7_MATH_1	83	87	PF00917	0.700
DOC_WW_Pin1_4	171	176	PF00397	0.710
DOC_WW_Pin1_4	206	211	PF00397	0.622
DOC_WW_Pin1_4	29	34	PF00397	0.671
DOC_WW_Pin1_4	334	339	PF00397	0.543
DOC_WW_Pin1_4	367	372	PF00397	0.625
DOC_WW_Pin1_4	468	473	PF00397	0.616
DOC_WW_Pin1_4	820	825	PF00397	0.707
LIG_14-3-3_CanoR_1	2	8	PF00244	0.747
LIG_14-3-3_CanoR_1	214	218	PF00244	0.505
LIG_14-3-3_CanoR_1	266	272	PF00244	0.575
LIG_14-3-3_CanoR_1	382	391	PF00244	0.586
LIG_14-3-3_CanoR_1	416	426	PF00244	0.648
LIG_14-3-3_CanoR_1	448	452	PF00244	0.584
LIG_14-3-3_CanoR_1	453	461	PF00244	0.521
LIG_14-3-3_CanoR_1	565	574	PF00244	0.554
LIG_14-3-3_CanoR_1	576	585	PF00244	0.507
LIG_14-3-3_CanoR_1	65	72	PF00244	0.684
LIG_14-3-3_CanoR_1	713	719	PF00244	0.588
LIG_14-3-3_CanoR_1	806	813	PF00244	0.742
LIG_Actin_WH2_2	352	370	PF00022	0.373
LIG_Actin_WH2_2	841	858	PF00022	0.518
LIG_APCC_ABBA_1	590	595	PF00400	0.514
LIG_BIR_III_2	39	43	PF00653	0.631
LIG_BRCT_BRCA1_1	744	748	PF00533	0.579
LIG_CaM_IQ_9	89	105	PF13499	0.654
LIG_EH1_1	620	628	PF00400	0.530
LIG_eIF4E_1	621	627	PF01652	0.540
LIG_FAT_LD_1	426	434	PF03623	0.581
LIG_FHA_1	165	171	PF00498	0.690
LIG_FHA_1	198	204	PF00498	0.571
LIG_FHA_1	207	213	PF00498	0.526
LIG_FHA_1	237	243	PF00498	0.569
LIG_FHA_1	284	290	PF00498	0.563
LIG_FHA_1	314	320	PF00498	0.409
LIG_FHA_1	455	461	PF00498	0.522
LIG_FHA_1	654	660	PF00498	0.485
LIG_FHA_1	691	697	PF00498	0.499
LIG_FHA_1	731	737	PF00498	0.536
LIG_FHA_2	326	332	PF00498	0.552
LIG_FHA_2	370	376	PF00498	0.594
LIG_FHA_2	426	432	PF00498	0.577
LIG_FHA_2	468	474	PF00498	0.609
LIG_FHA_2	528	534	PF00498	0.679
LIG_FHA_2	578	584	PF00498	0.626
LIG_FHA_2	65	71	PF00498	0.569
LIG_FHA_2	767	773	PF00498	0.533
LIG_FHA_2	813	819	PF00498	0.645
LIG_IBAR_NPY_1	619	621	PF08397	0.460
LIG_Integrin_isoDGR_2	21	23	PF01839	0.400
LIG_Integrin_isoDGR_2	516	518	PF01839	0.469
LIG_LIR_Gen_1	394	404	PF02991	0.534
LIG_LIR_Gen_1	465	472	PF02991	0.545
LIG_LIR_Gen_1	586	596	PF02991	0.532
LIG_LIR_Gen_1	599	609	PF02991	0.460
LIG_LIR_Gen_1	741	749	PF02991	0.608
LIG_LIR_Gen_1	760	767	PF02991	0.476
LIG_LIR_Nem_3	241	247	PF02991	0.500
LIG_LIR_Nem_3	394	400	PF02991	0.537
LIG_LIR_Nem_3	465	469	PF02991	0.571
LIG_LIR_Nem_3	573	578	PF02991	0.523
LIG_LIR_Nem_3	586	591	PF02991	0.489
LIG_LIR_Nem_3	595	601	PF02991	0.517
LIG_LIR_Nem_3	615	621	PF02991	0.327
LIG_LIR_Nem_3	646	651	PF02991	0.455
LIG_LIR_Nem_3	741	746	PF02991	0.607
LIG_LIR_Nem_3	760	765	PF02991	0.446
LIG_MLH1_MIPbox_1	744	748	PF16413	0.579
LIG_NRBOX	307	313	PF00104	0.465
LIG_NRBOX	735	741	PF00104	0.586
LIG_OCRL_FandH_1	6	18	PF00620	0.750
LIG_PCNA_yPIPBox_3	649	662	PF02747	0.484
LIG_Pex14_1	757	761	PF04695	0.524
LIG_PTB_Apo_2	616	623	PF02174	0.460
LIG_PTB_Phospho_1	616	622	PF10480	0.460
LIG_SH2_CRK	852	856	PF00017	0.570
LIG_SH2_GRB2like	661	664	PF00017	0.475
LIG_SH2_NCK_1	762	766	PF00017	0.517
LIG_SH2_PTP2	622	625	PF00017	0.530
LIG_SH2_SRC	479	482	PF00017	0.663
LIG_SH2_STAP1	762	766	PF00017	0.517
LIG_SH2_STAT3	621	624	PF00017	0.460
LIG_SH2_STAT5	294	297	PF00017	0.332
LIG_SH2_STAT5	321	324	PF00017	0.343
LIG_SH2_STAT5	479	482	PF00017	0.636
LIG_SH2_STAT5	598	601	PF00017	0.563
LIG_SH2_STAT5	622	625	PF00017	0.475
LIG_SH2_STAT5	661	664	PF00017	0.464
LIG_SH2_STAT5	747	750	PF00017	0.510
LIG_SH3_2	472	477	PF14604	0.527
LIG_SH3_3	466	472	PF00018	0.599
LIG_SH3_3	521	527	PF00018	0.752
LIG_SH3_3	818	824	PF00018	0.612
LIG_Sin3_3	397	404	PF02671	0.592
LIG_SUMO_SIM_anti_2	213	219	PF11976	0.615
LIG_SUMO_SIM_anti_2	286	291	PF11976	0.563
LIG_SUMO_SIM_par_1	195	200	PF11976	0.560
LIG_TRAF2_1	277	280	PF00917	0.594
LIG_TRAF2_1	377	380	PF00917	0.619
LIG_TRAF2_1	438	441	PF00917	0.668
LIG_TRAF2_1	612	615	PF00917	0.494
LIG_TRAF2_1	799	802	PF00917	0.720
LIG_TYR_ITIM	850	855	PF00017	0.562
LIG_WW_3	474	478	PF00397	0.592
MOD_CDC14_SPxK_1	471	474	PF00782	0.518
MOD_CDK_SPK_2	820	825	PF00069	0.607
MOD_CDK_SPxK_1	468	474	PF00069	0.502
MOD_CK1_1	213	219	PF00069	0.567
MOD_CK1_1	330	336	PF00069	0.565
MOD_CK1_1	337	343	PF00069	0.281
MOD_CK1_1	462	468	PF00069	0.568
MOD_CK1_1	487	493	PF00069	0.699
MOD_CK1_1	5	11	PF00069	0.796
MOD_CK1_1	525	531	PF00069	0.716
MOD_CK1_1	712	718	PF00069	0.583
MOD_CK1_1	833	839	PF00069	0.677
MOD_CK2_1	104	110	PF00069	0.706
MOD_CK2_1	367	373	PF00069	0.627
MOD_CK2_1	374	380	PF00069	0.622
MOD_CK2_1	425	431	PF00069	0.563
MOD_CK2_1	467	473	PF00069	0.617
MOD_CK2_1	487	493	PF00069	0.634
MOD_CK2_1	64	70	PF00069	0.569
MOD_Cter_Amidation	112	115	PF01082	0.556
MOD_GlcNHglycan	339	342	PF01048	0.406
MOD_GlcNHglycan	384	387	PF01048	0.400
MOD_GlcNHglycan	461	464	PF01048	0.442
MOD_GlcNHglycan	486	489	PF01048	0.534
MOD_GlcNHglycan	496	500	PF01048	0.560
MOD_GlcNHglycan	506	509	PF01048	0.467
MOD_GlcNHglycan	561	564	PF01048	0.415
MOD_GlcNHglycan	630	633	PF01048	0.251
MOD_GlcNHglycan	724	727	PF01048	0.480
MOD_GlcNHglycan	772	776	PF01048	0.503
MOD_GlcNHglycan	787	790	PF01048	0.399
MOD_GlcNHglycan	794	799	PF01048	0.460
MOD_GlcNHglycan	807	810	PF01048	0.466
MOD_GlcNHglycan	818	821	PF01048	0.501
MOD_GlcNHglycan	832	835	PF01048	0.482
MOD_GSK3_1	197	204	PF00069	0.516
MOD_GSK3_1	206	213	PF00069	0.542
MOD_GSK3_1	234	241	PF00069	0.570
MOD_GSK3_1	303	310	PF00069	0.346
MOD_GSK3_1	327	334	PF00069	0.548
MOD_GSK3_1	443	450	PF00069	0.644
MOD_GSK3_1	455	462	PF00069	0.499
MOD_GSK3_1	483	490	PF00069	0.665
MOD_GSK3_1	495	502	PF00069	0.706
MOD_GSK3_1	506	513	PF00069	0.723
MOD_GSK3_1	738	745	PF00069	0.589
MOD_GSK3_1	812	819	PF00069	0.752
MOD_GSK3_1	826	833	PF00069	0.709
MOD_N-GLC_1	389	394	PF02516	0.447
MOD_N-GLC_1	677	682	PF02516	0.371
MOD_N-GLC_1	690	695	PF02516	0.309
MOD_N-GLC_1	751	756	PF02516	0.402
MOD_N-GLC_2	135	137	PF02516	0.551
MOD_NEK2_1	236	241	PF00069	0.580
MOD_NEK2_1	3	8	PF00069	0.813
MOD_NEK2_1	303	308	PF00069	0.315
MOD_NEK2_1	374	379	PF00069	0.644
MOD_NEK2_1	454	459	PF00069	0.538
MOD_NEK2_1	484	489	PF00069	0.586
MOD_NEK2_1	64	69	PF00069	0.638
MOD_NEK2_1	687	692	PF00069	0.533
MOD_NEK2_1	771	776	PF00069	0.656
MOD_NEK2_1	785	790	PF00069	0.752
MOD_NEK2_1	816	821	PF00069	0.672
MOD_NEK2_1	828	833	PF00069	0.679
MOD_PIKK_1	443	449	PF00454	0.718
MOD_PIKK_1	64	70	PF00454	0.677
MOD_PIKK_1	712	718	PF00454	0.592
MOD_PK_1	647	653	PF00069	0.548
MOD_PKA_1	382	388	PF00069	0.649
MOD_PKA_2	130	136	PF00069	0.772
MOD_PKA_2	213	219	PF00069	0.557
MOD_PKA_2	265	271	PF00069	0.570
MOD_PKA_2	381	387	PF00069	0.590
MOD_PKA_2	447	453	PF00069	0.653
MOD_PKA_2	64	70	PF00069	0.685
MOD_PKA_2	712	718	PF00069	0.592
MOD_PKA_2	785	791	PF00069	0.777
MOD_PKA_2	805	811	PF00069	0.542
MOD_PKA_2	83	89	PF00069	0.593
MOD_Plk_1	138	144	PF00069	0.618
MOD_Plk_1	374	380	PF00069	0.651
MOD_Plk_1	677	683	PF00069	0.586
MOD_Plk_1	690	696	PF00069	0.507
MOD_Plk_1	731	737	PF00069	0.566
MOD_Plk_2-3	369	375	PF00069	0.615
MOD_Plk_2-3	532	538	PF00069	0.694
MOD_Plk_4	147	153	PF00069	0.675
MOD_Plk_4	213	219	PF00069	0.525
MOD_Plk_4	283	289	PF00069	0.556
MOD_Plk_4	303	309	PF00069	0.127
MOD_Plk_4	425	431	PF00069	0.526
MOD_Plk_4	432	438	PF00069	0.522
MOD_Plk_4	677	683	PF00069	0.595
MOD_Plk_4	731	737	PF00069	0.606
MOD_Plk_4	742	748	PF00069	0.588
MOD_Plk_4	812	818	PF00069	0.774
MOD_ProDKin_1	171	177	PF00069	0.702
MOD_ProDKin_1	206	212	PF00069	0.618
MOD_ProDKin_1	29	35	PF00069	0.671
MOD_ProDKin_1	334	340	PF00069	0.535
MOD_ProDKin_1	367	373	PF00069	0.627
MOD_ProDKin_1	468	474	PF00069	0.614
MOD_ProDKin_1	820	826	PF00069	0.703
MOD_SUMO_for_1	546	549	PF00179	0.631
MOD_SUMO_rev_2	45	52	PF00179	0.729
MOD_SUMO_rev_2	57	64	PF00179	0.561
TRG_DiLeu_BaLyEn_6	314	319	PF01217	0.420
TRG_DiLeu_BaLyEn_6	701	706	PF01217	0.486
TRG_DiLeu_BaLyEn_6	735	740	PF01217	0.588
TRG_ENDOCYTIC_2	598	601	PF00928	0.591
TRG_ENDOCYTIC_2	622	625	PF00928	0.449
TRG_ENDOCYTIC_2	661	664	PF00928	0.464
TRG_ENDOCYTIC_2	762	765	PF00928	0.538
TRG_ENDOCYTIC_2	852	855	PF00928	0.562
TRG_ER_diArg_1	184	186	PF00400	0.561
TRG_ER_diArg_1	53	55	PF00400	0.621
TRG_ER_diArg_1	616	618	PF00400	0.411
TRG_ER_diArg_1	736	738	PF00400	0.591
TRG_ER_diArg_1	805	807	PF00400	0.726
TRG_NLS_MonoExtC_3	412	417	PF00514	0.703
TRG_NLS_MonoExtC_3	95	100	PF00514	0.684
TRG_NLS_MonoExtN_4	411	417	PF00514	0.698
TRG_NLS_MonoExtN_4	94	101	PF00514	0.680
TRG_Pf-PMV_PEXEL_1	309	314	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.330
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	683	688	PF00026	0.316
TRG_Pf-PMV_PEXEL_1	704	708	PF00026	0.276
TRG_Pf-PMV_PEXEL_1	756	760	PF00026	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8W4	Leptomonas seymouri	62%	99%
A0A1X0P271	Trypanosomatidae	43%	100%
A0A422P4Z6	Trypanosoma rangeli	40%	100%
A4HI69	Leishmania braziliensis	77%	100%
A4I5E6	Leishmania infantum	99%	100%
C9ZQT3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B0P4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q7I8	Leishmania major	91%	100%
Q5C9Z4	Homo sapiens	22%	100%
V5BPM5	Trypanosoma cruzi	39%	100%