LeishMANIAdb
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Importin subunit alpha

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Importin subunit alpha
Gene product:
importin alpha, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X3A8_LEIDO
TriTrypDb:
LdBPK_301180.1 , LdCL_300017000 , LDHU3_30.1540
Length:
539

Annotations

Annotations by Jardim et al.

Nuclear proteins, Importin subunit alpha

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 0
Pissara et al. no yes: 3
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 12
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0005634 nucleus 5 1
GO:0005730 nucleolus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3S7X3A8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3A8

Function

Biological processes
Term Name Level Count
GO:0006606 protein import into nucleus 5 12
GO:0006810 transport 3 12
GO:0006886 intracellular protein transport 4 12
GO:0006913 nucleocytoplasmic transport 5 12
GO:0008104 protein localization 4 12
GO:0009987 cellular process 1 12
GO:0015031 protein transport 4 12
GO:0033036 macromolecule localization 2 12
GO:0033365 protein localization to organelle 5 12
GO:0034504 protein localization to nucleus 6 12
GO:0045184 establishment of protein localization 3 12
GO:0046907 intracellular transport 3 12
GO:0051169 nuclear transport 4 12
GO:0051170 import into nucleus 6 12
GO:0051179 localization 1 12
GO:0051234 establishment of localization 2 12
GO:0051641 cellular localization 2 12
GO:0051649 establishment of localization in cell 3 12
GO:0070727 cellular macromolecule localization 3 12
GO:0071702 organic substance transport 4 12
GO:0071705 nitrogen compound transport 4 12
GO:0072594 establishment of protein localization to organelle 4 12
GO:0006607 NLS-bearing protein import into nucleus 6 1
Molecular functions
Term Name Level Count
GO:0061608 nuclear import signal receptor activity 3 12
GO:0140104 molecular carrier activity 1 12
GO:0140142 nucleocytoplasmic carrier activity 2 12
GO:0005048 signal sequence binding 4 1
GO:0005488 binding 1 1
GO:0008139 nuclear localization sequence binding 5 1
GO:0033218 amide binding 2 1
GO:0042277 peptide binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 108 110 PF00675 0.300
CLV_NRD_NRD_1 22 24 PF00675 0.468
CLV_NRD_NRD_1 355 357 PF00675 0.286
CLV_NRD_NRD_1 397 399 PF00675 0.386
CLV_PCSK_KEX2_1 22 24 PF00082 0.468
CLV_PCSK_KEX2_1 352 354 PF00082 0.259
CLV_PCSK_PC1ET2_1 352 354 PF00082 0.274
CLV_PCSK_SKI1_1 109 113 PF00082 0.267
CLV_PCSK_SKI1_1 232 236 PF00082 0.293
CLV_PCSK_SKI1_1 352 356 PF00082 0.361
CLV_PCSK_SKI1_1 439 443 PF00082 0.342
CLV_PCSK_SKI1_1 8 12 PF00082 0.477
CLV_PCSK_SKI1_1 99 103 PF00082 0.398
CLV_Separin_Metazoa 346 350 PF03568 0.404
DEG_Nend_Nbox_1 1 3 PF02207 0.582
DEG_SPOP_SBC_1 122 126 PF00917 0.404
DOC_CDC14_PxL_1 423 431 PF14671 0.445
DOC_CDC14_PxL_1 82 90 PF14671 0.495
DOC_MAPK_gen_1 22 30 PF00069 0.483
DOC_MAPK_MEF2A_6 138 146 PF00069 0.274
DOC_MAPK_MEF2A_6 418 425 PF00069 0.398
DOC_MAPK_MEF2A_6 491 500 PF00069 0.528
DOC_MAPK_RevD_3 385 399 PF00069 0.293
DOC_PP2B_LxvP_1 306 309 PF13499 0.353
DOC_PP2B_LxvP_1 390 393 PF13499 0.404
DOC_PP2B_PxIxI_1 315 321 PF00149 0.404
DOC_USP7_MATH_1 157 161 PF00917 0.274
DOC_USP7_MATH_1 60 64 PF00917 0.542
DOC_USP7_UBL2_3 7 11 PF12436 0.596
DOC_WW_Pin1_4 178 183 PF00397 0.318
DOC_WW_Pin1_4 73 78 PF00397 0.524
LIG_14-3-3_CanoR_1 109 115 PF00244 0.343
LIG_14-3-3_CanoR_1 232 237 PF00244 0.293
LIG_14-3-3_CanoR_1 25 31 PF00244 0.497
LIG_Actin_WH2_2 216 234 PF00022 0.353
LIG_APCC_ABBAyCdc20_2 31 37 PF00400 0.494
LIG_BRCT_BRCA1_1 533 537 PF00533 0.569
LIG_deltaCOP1_diTrp_1 400 410 PF00928 0.404
LIG_EH1_1 371 379 PF00400 0.404
LIG_eIF4E_1 372 378 PF01652 0.427
LIG_FHA_1 103 109 PF00498 0.333
LIG_FHA_1 161 167 PF00498 0.293
LIG_FHA_1 233 239 PF00498 0.293
LIG_FHA_1 330 336 PF00498 0.259
LIG_FHA_1 440 446 PF00498 0.323
LIG_FHA_2 257 263 PF00498 0.404
LIG_FHA_2 485 491 PF00498 0.543
LIG_FHA_2 504 510 PF00498 0.364
LIG_FHA_2 95 101 PF00498 0.416
LIG_LIR_Gen_1 117 128 PF02991 0.404
LIG_LIR_Nem_3 117 123 PF02991 0.398
LIG_LIR_Nem_3 139 144 PF02991 0.355
LIG_LYPXL_yS_3 141 144 PF13949 0.353
LIG_MAD2 110 118 PF02301 0.445
LIG_MAD2 301 309 PF02301 0.404
LIG_MYND_3 247 251 PF01753 0.465
LIG_NRBOX 131 137 PF00104 0.353
LIG_NRBOX 259 265 PF00104 0.274
LIG_PDZ_Class_2 534 539 PF00595 0.585
LIG_Pex14_1 277 281 PF04695 0.259
LIG_Pex14_2 146 150 PF04695 0.259
LIG_PTB_Apo_2 404 411 PF02174 0.404
LIG_SH2_CRK 120 124 PF00017 0.398
LIG_SH2_NCK_1 120 124 PF00017 0.404
LIG_SH2_STAP1 494 498 PF00017 0.475
LIG_SH2_STAT5 281 284 PF00017 0.274
LIG_SH2_STAT5 419 422 PF00017 0.306
LIG_SH3_1 243 249 PF00018 0.347
LIG_SH3_3 243 249 PF00018 0.347
LIG_SH3_3 310 316 PF00018 0.362
LIG_SH3_3 379 385 PF00018 0.432
LIG_SH3_3 422 428 PF00018 0.323
LIG_SUMO_SIM_anti_2 259 269 PF11976 0.425
LIG_SUMO_SIM_par_1 110 115 PF11976 0.332
LIG_SUMO_SIM_par_1 219 225 PF11976 0.404
LIG_SUMO_SIM_par_1 304 311 PF11976 0.366
LIG_SUMO_SIM_par_1 441 446 PF11976 0.309
LIG_UBA3_1 107 116 PF00899 0.395
LIG_UBA3_1 217 224 PF00899 0.324
LIG_WRC_WIRS_1 501 506 PF05994 0.528
MOD_CK1_1 160 166 PF00069 0.314
MOD_CK1_1 280 286 PF00069 0.259
MOD_CK1_1 307 313 PF00069 0.321
MOD_CK1_1 461 467 PF00069 0.553
MOD_CK2_1 219 225 PF00069 0.404
MOD_CK2_1 388 394 PF00069 0.404
MOD_CK2_1 504 510 PF00069 0.488
MOD_CK2_1 60 66 PF00069 0.600
MOD_CK2_1 94 100 PF00069 0.383
MOD_GlcNHglycan 125 128 PF01048 0.274
MOD_GlcNHglycan 147 150 PF01048 0.347
MOD_GlcNHglycan 188 192 PF01048 0.404
MOD_GlcNHglycan 197 200 PF01048 0.462
MOD_GlcNHglycan 337 340 PF01048 0.302
MOD_GlcNHglycan 390 393 PF01048 0.404
MOD_GlcNHglycan 460 463 PF01048 0.555
MOD_GlcNHglycan 533 536 PF01048 0.636
MOD_GSK3_1 156 163 PF00069 0.280
MOD_GSK3_1 232 239 PF00069 0.303
MOD_GSK3_1 304 311 PF00069 0.291
MOD_GSK3_1 325 332 PF00069 0.390
MOD_GSK3_1 406 413 PF00069 0.447
MOD_GSK3_1 457 464 PF00069 0.442
MOD_GSK3_1 500 507 PF00069 0.446
MOD_GSK3_1 72 79 PF00069 0.488
MOD_N-GLC_1 195 200 PF02516 0.404
MOD_N-GLC_1 232 237 PF02516 0.293
MOD_N-GLC_1 264 269 PF02516 0.357
MOD_N-GLC_1 406 411 PF02516 0.343
MOD_N-GLC_1 55 60 PF02516 0.675
MOD_N-GLC_2 240 242 PF02516 0.293
MOD_N-GLC_2 381 383 PF02516 0.392
MOD_N-GLC_2 90 92 PF02516 0.480
MOD_NEK2_1 102 107 PF00069 0.362
MOD_NEK2_1 377 382 PF00069 0.352
MOD_NEK2_1 410 415 PF00069 0.484
MOD_NEK2_1 429 434 PF00069 0.392
MOD_NEK2_1 514 519 PF00069 0.638
MOD_PIKK_1 329 335 PF00454 0.261
MOD_PK_1 110 116 PF00069 0.359
MOD_PKA_1 356 362 PF00069 0.274
MOD_Plk_1 160 166 PF00069 0.320
MOD_Plk_1 187 193 PF00069 0.404
MOD_Plk_1 232 238 PF00069 0.293
MOD_Plk_1 329 335 PF00069 0.404
MOD_Plk_1 406 412 PF00069 0.293
MOD_Plk_2-3 67 73 PF00069 0.488
MOD_Plk_4 102 108 PF00069 0.214
MOD_Plk_4 160 166 PF00069 0.341
MOD_Plk_4 256 262 PF00069 0.383
MOD_Plk_4 500 506 PF00069 0.451
MOD_Plk_4 84 90 PF00069 0.469
MOD_ProDKin_1 178 184 PF00069 0.318
MOD_ProDKin_1 73 79 PF00069 0.520
MOD_SUMO_rev_2 431 441 PF00179 0.345
MOD_SUMO_rev_2 456 461 PF00179 0.413
TRG_DiLeu_BaEn_1 37 42 PF01217 0.476
TRG_ENDOCYTIC_2 120 123 PF00928 0.384
TRG_ENDOCYTIC_2 141 144 PF00928 0.366
TRG_ER_diArg_1 22 25 PF00400 0.481
TRG_ER_diArg_1 30 33 PF00400 0.434
TRG_NES_CRM1_1 373 388 PF08389 0.404
TRG_Pf-PMV_PEXEL_1 353 358 PF00026 0.404

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PFK7 Leptomonas seymouri 84% 100%
A0A0S4KNG1 Bodo saltans 50% 100%
A0A1X0P216 Trypanosomatidae 57% 100%
A0A3R7LEH1 Trypanosoma rangeli 54% 100%
A2VE08 Bos taurus 43% 100%
A4HI66 Leishmania braziliensis 95% 100%
A4I5E3 Leishmania infantum 100% 100%
A9QM74 Homo sapiens 41% 100%
B6HJ92 Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) 41% 98%
C0LLJ0 Mus musculus 37% 100%
C1JZ66 Bos taurus 41% 100%
C6K7I2 Sus scrofa 41% 100%
C9ZQT2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 100%
E9B0P1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
F4JL11 Arabidopsis thaliana 43% 100%
F4KF65 Arabidopsis thaliana 28% 100%
G5EB89 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 39% 97%
O00505 Homo sapiens 39% 100%
O00629 Homo sapiens 43% 100%
O04294 Arabidopsis thaliana 41% 100%
O14063 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 40% 99%
O15131 Homo sapiens 42% 100%
O22478 Solanum lycopersicum 40% 100%
O35343 Mus musculus 42% 100%
O35344 Mus musculus 39% 100%
O35345 Mus musculus 41% 100%
O60684 Homo sapiens 41% 100%
O80480 Arabidopsis thaliana 40% 100%
O94374 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 46% 100%
P52170 Xenopus laevis 36% 100%
P52171 Xenopus laevis 38% 100%
P52292 Homo sapiens 45% 100%
P52293 Mus musculus 44% 100%
P52294 Homo sapiens 43% 100%
P52295 Drosophila melanogaster 38% 100%
P83953 Rattus norvegicus 43% 100%
P91276 Caenorhabditis elegans 31% 100%
Q02821 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 41% 99%
Q0V7M0 Bos taurus 41% 100%
Q19969 Caenorhabditis elegans 39% 100%
Q4Q7J1 Leishmania major 99% 100%
Q4WVW4 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 24% 93%
Q503E9 Danio rerio 42% 100%
Q557F4 Dictyostelium discoideum 31% 98%
Q56R16 Rattus norvegicus 42% 100%
Q5R909 Pongo abelii 43% 100%
Q5RBV0 Pongo abelii 41% 100%
Q5ZML1 Gallus gallus 43% 100%
Q60960 Mus musculus 43% 100%
Q71VM4 Oryza sativa subsp. japonica 41% 100%
Q76P29 Dictyostelium discoideum 39% 100%
Q96321 Arabidopsis thaliana 42% 100%
Q9FJ09 Arabidopsis thaliana 41% 100%
Q9FJ92 Arabidopsis thaliana 37% 100%
Q9FWY7 Arabidopsis thaliana 41% 100%
Q9FYP9 Oryza sativa subsp. japonica 25% 100%
Q9M9X7 Arabidopsis thaliana 38% 100%
Q9SLX0 Oryza sativa subsp. japonica 42% 100%
V5B924 Trypanosoma cruzi 52% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS