LeishMANIAdb
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Importin subunit alpha

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Importin subunit alpha
Gene product:
importin alpha, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X3A8_LEIDO
TriTrypDb:
LdBPK_301180.1 , LdCL_300017000 , LDHU3_30.1540
Length:
539

Annotations

Annotations by Jardim et al.

Nuclear proteins, Importin subunit alpha

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 0
Pissara et al. no yes: 3
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 12
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0005634 nucleus 5 1
GO:0005730 nucleolus 5 1
GO:0005737 cytoplasm 2 12
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 12
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Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3S7X3A8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3A8

Function

Biological processes
TermNameLevelCount
GO:0006606 protein import into nucleus 5 12
GO:0006607 NLS-bearing protein import into nucleus 6 1
GO:0006810 transport 3 12
GO:0006886 intracellular protein transport 4 12
GO:0006913 nucleocytoplasmic transport 5 12
GO:0008104 protein localization 4 12
GO:0009987 cellular process 1 12
GO:0015031 protein transport 4 12
GO:0033036 macromolecule localization 2 12
GO:0033365 protein localization to organelle 5 12
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Molecular functions
TermNameLevelCount
GO:0005048 signal sequence binding 4 1
GO:0005488 binding 1 1
GO:0008139 nuclear localization sequence binding 5 1
GO:0033218 amide binding 2 1
GO:0042277 peptide binding 3 1
GO:0061608 nuclear import signal receptor activity 3 12
GO:0140104 molecular carrier activity 1 12
GO:0140142 nucleocytoplasmic carrier activity 2 12
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 108 110 PF00675 0.300
CLV_NRD_NRD_1 22 24 PF00675 0.468
CLV_NRD_NRD_1 355 357 PF00675 0.286
CLV_NRD_NRD_1 397 399 PF00675 0.386
CLV_PCSK_KEX2_1 22 24 PF00082 0.468
CLV_PCSK_KEX2_1 352 354 PF00082 0.259
CLV_PCSK_PC1ET2_1 352 354 PF00082 0.274
CLV_PCSK_SKI1_1 109 113 PF00082 0.267
CLV_PCSK_SKI1_1 232 236 PF00082 0.293
CLV_PCSK_SKI1_1 352 356 PF00082 0.361
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1PFK7 Leptomonas seymouri 84% 100%
A0A0S4KNG1 Bodo saltans 50% 100%
A0A1X0P216 Trypanosomatidae 57% 100%
A0A3R7LEH1 Trypanosoma rangeli 54% 100%
A2VE08 Bos taurus 43% 100%
A4HI66 Leishmania braziliensis 95% 100%
A4I5E3 Leishmania infantum 100% 100%
A9QM74 Homo sapiens 41% 100%
B6HJ92 Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) 41% 98%
C0LLJ0 Mus musculus 37% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS