Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X3A4_LEIDO

TriTrypDb:

LdBPK_301050.1 , LdCL_300015700 , LDHU3_30.1370

Length:

572

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X3A4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3A4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.664
CLV_C14_Caspase3-7	517	521	PF00656	0.668
CLV_C14_Caspase3-7	98	102	PF00656	0.792
CLV_NRD_NRD_1	135	137	PF00675	0.584
CLV_NRD_NRD_1	238	240	PF00675	0.798
CLV_NRD_NRD_1	292	294	PF00675	0.819
CLV_NRD_NRD_1	295	297	PF00675	0.773
CLV_NRD_NRD_1	333	335	PF00675	0.698
CLV_NRD_NRD_1	375	377	PF00675	0.660
CLV_NRD_NRD_1	479	481	PF00675	0.523
CLV_NRD_NRD_1	56	58	PF00675	0.771
CLV_PCSK_FUR_1	293	297	PF00082	0.821
CLV_PCSK_KEX2_1	135	137	PF00082	0.630
CLV_PCSK_KEX2_1	238	240	PF00082	0.798
CLV_PCSK_KEX2_1	276	278	PF00082	0.630
CLV_PCSK_KEX2_1	292	294	PF00082	0.722
CLV_PCSK_KEX2_1	295	297	PF00082	0.725
CLV_PCSK_KEX2_1	333	335	PF00082	0.698
CLV_PCSK_KEX2_1	375	377	PF00082	0.660
CLV_PCSK_KEX2_1	479	481	PF00082	0.523
CLV_PCSK_KEX2_1	56	58	PF00082	0.771
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.630
CLV_PCSK_SKI1_1	175	179	PF00082	0.766
CLV_PCSK_SKI1_1	266	270	PF00082	0.607
CLV_PCSK_SKI1_1	375	379	PF00082	0.607
CLV_PCSK_SKI1_1	42	46	PF00082	0.597
CLV_PCSK_SKI1_1	479	483	PF00082	0.452
DEG_SPOP_SBC_1	12	16	PF00917	0.726
DEG_SPOP_SBC_1	21	25	PF00917	0.739
DEG_SPOP_SBC_1	319	323	PF00917	0.800
DEG_SPOP_SBC_1	81	85	PF00917	0.626
DOC_CKS1_1	1	6	PF01111	0.683
DOC_CKS1_1	302	307	PF01111	0.752
DOC_CKS1_1	409	414	PF01111	0.741
DOC_CYCLIN_yCln2_LP_2	379	385	PF00134	0.697
DOC_MAPK_gen_1	135	142	PF00069	0.561
DOC_MAPK_gen_1	292	303	PF00069	0.826
DOC_MAPK_gen_1	333	340	PF00069	0.684
DOC_MAPK_gen_1	73	81	PF00069	0.620
DOC_MAPK_MEF2A_6	29	36	PF00069	0.695
DOC_MAPK_MEF2A_6	333	340	PF00069	0.684
DOC_MAPK_RevD_3	122	136	PF00069	0.588
DOC_PP1_RVXF_1	374	381	PF00149	0.662
DOC_PP1_RVXF_1	40	47	PF00149	0.587
DOC_PP2B_LxvP_1	379	382	PF13499	0.734
DOC_PP2B_LxvP_1	394	397	PF13499	0.520
DOC_USP7_MATH_1	12	16	PF00917	0.816
DOC_USP7_MATH_1	307	311	PF00917	0.781
DOC_USP7_MATH_1	319	323	PF00917	0.663
DOC_USP7_MATH_1	348	352	PF00917	0.740
DOC_USP7_MATH_1	368	372	PF00917	0.404
DOC_USP7_MATH_1	490	494	PF00917	0.617
DOC_USP7_MATH_1	553	557	PF00917	0.746
DOC_USP7_MATH_1	88	92	PF00917	0.776
DOC_USP7_MATH_1	97	101	PF00917	0.673
DOC_WW_Pin1_4	181	186	PF00397	0.777
DOC_WW_Pin1_4	199	204	PF00397	0.755
DOC_WW_Pin1_4	242	247	PF00397	0.791
DOC_WW_Pin1_4	301	306	PF00397	0.737
DOC_WW_Pin1_4	34	39	PF00397	0.693
DOC_WW_Pin1_4	344	349	PF00397	0.625
DOC_WW_Pin1_4	408	413	PF00397	0.771
DOC_WW_Pin1_4	8	13	PF00397	0.814
LIG_14-3-3_CanoR_1	175	182	PF00244	0.749
LIG_14-3-3_CanoR_1	238	242	PF00244	0.752
LIG_14-3-3_CanoR_1	295	305	PF00244	0.716
LIG_14-3-3_CanoR_1	524	533	PF00244	0.526
LIG_14-3-3_CanoR_1	66	71	PF00244	0.808
LIG_BIR_III_4	115	119	PF00653	0.724
LIG_eIF4E_1	560	566	PF01652	0.704
LIG_FHA_1	1	7	PF00498	0.697
LIG_FHA_1	214	220	PF00498	0.675
LIG_FHA_1	259	265	PF00498	0.683
LIG_FHA_1	322	328	PF00498	0.763
LIG_FHA_1	357	363	PF00498	0.592
LIG_FHA_1	365	371	PF00498	0.639
LIG_FHA_1	372	378	PF00498	0.655
LIG_FHA_1	509	515	PF00498	0.608
LIG_FHA_1	82	88	PF00498	0.810
LIG_FHA_2	188	194	PF00498	0.717
LIG_FHA_2	541	547	PF00498	0.633
LIG_LIR_Gen_1	128	137	PF02991	0.716
LIG_LIR_Gen_1	353	363	PF02991	0.617
LIG_LIR_Gen_1	484	490	PF02991	0.614
LIG_LIR_Nem_3	128	133	PF02991	0.602
LIG_LIR_Nem_3	353	358	PF02991	0.604
LIG_LIR_Nem_3	484	488	PF02991	0.610
LIG_MYND_1	414	418	PF01753	0.751
LIG_NBox_RRM_1	339	349	PF00076	0.643
LIG_NRBOX	264	270	PF00104	0.598
LIG_NRBOX	357	363	PF00104	0.683
LIG_NRBOX	40	46	PF00104	0.589
LIG_PCNA_TLS_4	333	340	PF02747	0.609
LIG_RPA_C_Fungi	168	180	PF08784	0.632
LIG_SH2_GRB2like	70	73	PF00017	0.724
LIG_SH2_PTP2	485	488	PF00017	0.537
LIG_SH2_SRC	560	563	PF00017	0.645
LIG_SH2_STAP1	70	74	PF00017	0.675
LIG_SH2_STAP1	77	81	PF00017	0.598
LIG_SH2_STAT5	485	488	PF00017	0.455
LIG_SH3_2	51	56	PF14604	0.734
LIG_SH3_3	179	185	PF00018	0.658
LIG_SH3_3	299	305	PF00018	0.776
LIG_SH3_3	379	385	PF00018	0.600
LIG_SH3_3	406	412	PF00018	0.700
LIG_SH3_3	48	54	PF00018	0.660
LIG_SUMO_SIM_anti_2	193	198	PF11976	0.724
LIG_SUMO_SIM_par_1	225	232	PF11976	0.707
LIG_SUMO_SIM_par_1	32	37	PF11976	0.660
LIG_TRAF2_1	313	316	PF00917	0.743
LIG_TRAF2_2	109	114	PF00917	0.741
LIG_TYR_ITIM	483	488	PF00017	0.534
MOD_CDK_SPK_2	181	186	PF00069	0.659
MOD_CDK_SPxxK_3	199	206	PF00069	0.684
MOD_CDK_SPxxK_3	242	249	PF00069	0.693
MOD_CK1_1	11	17	PF00069	0.737
MOD_CK1_1	167	173	PF00069	0.675
MOD_CK1_1	184	190	PF00069	0.594
MOD_CK1_1	202	208	PF00069	0.801
MOD_CK1_1	211	217	PF00069	0.625
MOD_CK1_1	22	28	PF00069	0.825
MOD_CK1_1	232	238	PF00069	0.740
MOD_CK1_1	310	316	PF00069	0.800
MOD_CK1_1	321	327	PF00069	0.613
MOD_CK1_1	351	357	PF00069	0.711
MOD_CK1_1	366	372	PF00069	0.483
MOD_CK1_1	407	413	PF00069	0.749
MOD_CK1_1	491	497	PF00069	0.629
MOD_CK1_1	507	513	PF00069	0.614
MOD_CK1_1	55	61	PF00069	0.770
MOD_CK1_1	95	101	PF00069	0.798
MOD_CK2_1	187	193	PF00069	0.713
MOD_CK2_1	310	316	PF00069	0.741
MOD_CK2_1	491	497	PF00069	0.610
MOD_CK2_1	80	86	PF00069	0.728
MOD_DYRK1A_RPxSP_1	408	412	PF00069	0.751
MOD_GlcNHglycan	104	107	PF01048	0.770
MOD_GlcNHglycan	15	18	PF01048	0.774
MOD_GlcNHglycan	166	169	PF01048	0.677
MOD_GlcNHglycan	198	202	PF01048	0.791
MOD_GlcNHglycan	210	213	PF01048	0.690
MOD_GlcNHglycan	231	234	PF01048	0.682
MOD_GlcNHglycan	282	285	PF01048	0.728
MOD_GlcNHglycan	298	301	PF01048	0.608
MOD_GlcNHglycan	350	353	PF01048	0.698
MOD_GlcNHglycan	371	374	PF01048	0.630
MOD_GlcNHglycan	497	500	PF01048	0.710
MOD_GlcNHglycan	57	60	PF01048	0.740
MOD_GSK3_1	213	220	PF00069	0.621
MOD_GSK3_1	228	235	PF00069	0.521
MOD_GSK3_1	307	314	PF00069	0.813
MOD_GSK3_1	344	351	PF00069	0.621
MOD_GSK3_1	362	369	PF00069	0.535
MOD_GSK3_1	404	411	PF00069	0.699
MOD_GSK3_1	491	498	PF00069	0.583
MOD_GSK3_1	504	511	PF00069	0.563
MOD_GSK3_1	8	15	PF00069	0.744
MOD_GSK3_1	88	95	PF00069	0.696
MOD_N-GLC_1	504	509	PF02516	0.658
MOD_NEK2_1	164	169	PF00069	0.675
MOD_NEK2_1	229	234	PF00069	0.718
MOD_NEK2_1	488	493	PF00069	0.508
MOD_NEK2_1	525	530	PF00069	0.628
MOD_NEK2_2	307	312	PF00069	0.732
MOD_NEK2_2	444	449	PF00069	0.658
MOD_OFUCOSY	489	495	PF10250	0.619
MOD_PIKK_1	107	113	PF00454	0.773
MOD_PIKK_1	217	223	PF00454	0.600
MOD_PIKK_1	237	243	PF00454	0.539
MOD_PIKK_1	488	494	PF00454	0.500
MOD_PIKK_1	508	514	PF00454	0.535
MOD_PKA_2	237	243	PF00069	0.739
MOD_PKA_2	407	413	PF00069	0.741
MOD_PKA_2	55	61	PF00069	0.770
MOD_PKB_1	173	181	PF00069	0.693
MOD_Plk_1	217	223	PF00069	0.588
MOD_Plk_1	504	510	PF00069	0.670
MOD_Plk_4	321	327	PF00069	0.772
MOD_Plk_4	356	362	PF00069	0.693
MOD_Plk_4	444	450	PF00069	0.655
MOD_Plk_4	564	570	PF00069	0.602
MOD_ProDKin_1	181	187	PF00069	0.776
MOD_ProDKin_1	199	205	PF00069	0.757
MOD_ProDKin_1	242	248	PF00069	0.792
MOD_ProDKin_1	301	307	PF00069	0.737
MOD_ProDKin_1	34	40	PF00069	0.687
MOD_ProDKin_1	344	350	PF00069	0.623
MOD_ProDKin_1	408	414	PF00069	0.769
MOD_ProDKin_1	8	14	PF00069	0.814
MOD_SUMO_for_1	62	65	PF00179	0.702
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.717
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.527
TRG_DiLeu_BaLyEn_6	427	432	PF01217	0.621
TRG_DiLeu_LyEn_5	35	40	PF01217	0.713
TRG_ENDOCYTIC_2	485	488	PF00928	0.612
TRG_ER_diArg_1	122	125	PF00400	0.614
TRG_ER_diArg_1	291	293	PF00400	0.813
TRG_ER_diArg_1	375	377	PF00400	0.657
TRG_ER_diArg_1	478	480	PF00400	0.524
TRG_Pf-PMV_PEXEL_1	480	484	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFA3	Leptomonas seymouri	43%	82%
A4HI54	Leishmania braziliensis	71%	99%
A4I5D0	Leishmania infantum	99%	100%
E9B0M8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4Q7K4	Leishmania major	92%	100%