RNA-binding protein, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X388_LEIDO

TriTrypDb:

LdBPK_301170.1 , LdCL_300016900 , LDHU3_30.1510

Length:

619

Annotations

Annotations by Jardim et al.

Nucleic acid binding, RNA-binding

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X388

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X388

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.723
CLV_NRD_NRD_1	144	146	PF00675	0.733
CLV_NRD_NRD_1	355	357	PF00675	0.640
CLV_NRD_NRD_1	427	429	PF00675	0.743
CLV_NRD_NRD_1	50	52	PF00675	0.667
CLV_NRD_NRD_1	617	619	PF00675	0.698
CLV_PCSK_FUR_1	614	618	PF00082	0.731
CLV_PCSK_KEX2_1	112	114	PF00082	0.723
CLV_PCSK_KEX2_1	144	146	PF00082	0.723
CLV_PCSK_KEX2_1	354	356	PF00082	0.650
CLV_PCSK_KEX2_1	429	431	PF00082	0.751
CLV_PCSK_KEX2_1	50	52	PF00082	0.667
CLV_PCSK_KEX2_1	504	506	PF00082	0.505
CLV_PCSK_KEX2_1	515	517	PF00082	0.498
CLV_PCSK_KEX2_1	614	616	PF00082	0.655
CLV_PCSK_KEX2_1	617	619	PF00082	0.692
CLV_PCSK_PC1ET2_1	429	431	PF00082	0.751
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.505
CLV_PCSK_PC1ET2_1	515	517	PF00082	0.498
CLV_PCSK_SKI1_1	150	154	PF00082	0.857
CLV_PCSK_SKI1_1	20	24	PF00082	0.661
CLV_PCSK_SKI1_1	484	488	PF00082	0.617
CLV_PCSK_SKI1_1	504	508	PF00082	0.355
CLV_PCSK_SKI1_1	515	519	PF00082	0.447
DEG_APCC_DBOX_1	591	599	PF00400	0.507
DEG_Nend_UBRbox_1	1	4	PF02207	0.660
DOC_MAPK_gen_1	188	196	PF00069	0.642
DOC_MAPK_gen_1	213	222	PF00069	0.642
DOC_MAPK_gen_1	601	610	PF00069	0.570
DOC_MAPK_MEF2A_6	215	224	PF00069	0.754
DOC_MAPK_MEF2A_6	334	342	PF00069	0.565
DOC_PP1_RVXF_1	337	343	PF00149	0.623
DOC_PP1_RVXF_1	561	567	PF00149	0.567
DOC_PP2B_LxvP_1	140	143	PF13499	0.726
DOC_PP2B_LxvP_1	292	295	PF13499	0.630
DOC_PP2B_LxvP_1	404	407	PF13499	0.745
DOC_USP7_MATH_1	16	20	PF00917	0.618
DOC_USP7_MATH_1	182	186	PF00917	0.626
DOC_USP7_MATH_1	237	241	PF00917	0.779
DOC_USP7_MATH_1	475	479	PF00917	0.684
DOC_USP7_MATH_1	492	496	PF00917	0.419
DOC_WW_Pin1_4	267	272	PF00397	0.577
DOC_WW_Pin1_4	333	338	PF00397	0.642
DOC_WW_Pin1_4	457	462	PF00397	0.524
DOC_WW_Pin1_4	488	493	PF00397	0.513
LIG_14-3-3_CanoR_1	339	343	PF00244	0.506
LIG_14-3-3_CanoR_1	440	445	PF00244	0.543
LIG_14-3-3_CanoR_1	563	567	PF00244	0.568
LIG_Actin_WH2_2	480	496	PF00022	0.652
LIG_BIR_III_4	235	239	PF00653	0.720
LIG_BRCT_BRCA1_1	42	46	PF00533	0.528
LIG_DLG_GKlike_1	440	448	PF00625	0.541
LIG_EH1_1	544	552	PF00400	0.556
LIG_eIF4E_1	545	551	PF01652	0.472
LIG_FHA_1	204	210	PF00498	0.551
LIG_FHA_1	270	276	PF00498	0.498
LIG_FHA_1	3	9	PF00498	0.499
LIG_FHA_1	384	390	PF00498	0.752
LIG_FHA_1	522	528	PF00498	0.478
LIG_FHA_1	530	536	PF00498	0.562
LIG_FHA_1	563	569	PF00498	0.539
LIG_FHA_2	348	354	PF00498	0.573
LIG_FHA_2	80	86	PF00498	0.689
LIG_LIR_Gen_1	174	183	PF02991	0.644
LIG_LIR_Gen_1	43	53	PF02991	0.561
LIG_LIR_Nem_3	174	180	PF02991	0.545
LIG_LIR_Nem_3	254	258	PF02991	0.764
LIG_LIR_Nem_3	290	296	PF02991	0.540
LIG_LIR_Nem_3	43	49	PF02991	0.639
LIG_LIR_Nem_3	531	537	PF02991	0.573
LIG_NRBOX	440	446	PF00104	0.542
LIG_NRBOX	545	551	PF00104	0.565
LIG_Pex14_1	9	13	PF04695	0.633
LIG_SH2_CRK	255	259	PF00017	0.771
LIG_SH2_CRK	44	48	PF00017	0.497
LIG_SH2_CRK	490	494	PF00017	0.519
LIG_SH2_NCK_1	13	17	PF00017	0.689
LIG_SH2_NCK_1	199	203	PF00017	0.642
LIG_SH2_NCK_1	349	353	PF00017	0.709
LIG_SH2_SRC	13	16	PF00017	0.682
LIG_SH2_STAP1	587	591	PF00017	0.603
LIG_SH2_STAT3	587	590	PF00017	0.602
LIG_SH2_STAT5	167	170	PF00017	0.600
LIG_SH2_STAT5	276	279	PF00017	0.551
LIG_SH2_STAT5	349	352	PF00017	0.709
LIG_SH2_STAT5	534	537	PF00017	0.573
LIG_SH2_STAT5	545	548	PF00017	0.435
LIG_SH2_STAT5	81	84	PF00017	0.687
LIG_SH3_1	136	142	PF00018	0.778
LIG_SH3_1	507	513	PF00018	0.560
LIG_SH3_2	139	144	PF14604	0.838
LIG_SH3_2	510	515	PF14604	0.564
LIG_SH3_3	136	142	PF00018	0.821
LIG_SH3_3	176	182	PF00018	0.642
LIG_SH3_3	507	513	PF00018	0.560
LIG_SH3_3	86	92	PF00018	0.713
LIG_SH3_3	97	103	PF00018	0.730
LIG_SH3_CIN85_PxpxPR_1	139	144	PF14604	0.821
LIG_SUMO_SIM_par_1	547	554	PF11976	0.510
LIG_TRAF2_1	82	85	PF00917	0.695
LIG_TYR_ITIM	197	202	PF00017	0.642
LIG_WRC_WIRS_1	568	573	PF05994	0.568
LIG_WW_3	141	145	PF00397	0.828
MOD_CDC14_SPxK_1	491	494	PF00782	0.639
MOD_CDK_SPxK_1	333	339	PF00069	0.642
MOD_CDK_SPxK_1	488	494	PF00069	0.638
MOD_CK1_1	184	190	PF00069	0.642
MOD_CK2_1	475	481	PF00069	0.601
MOD_CK2_1	79	85	PF00069	0.605
MOD_GlcNHglycan	239	242	PF01048	0.770
MOD_GlcNHglycan	477	480	PF01048	0.626
MOD_GlcNHglycan	558	561	PF01048	0.633
MOD_GSK3_1	314	321	PF00069	0.677
MOD_GSK3_1	440	447	PF00069	0.599
MOD_GSK3_1	475	482	PF00069	0.620
MOD_GSK3_1	488	495	PF00069	0.455
MOD_GSK3_1	550	557	PF00069	0.470
MOD_N-GLC_1	267	272	PF02516	0.559
MOD_N-GLC_1	345	350	PF02516	0.579
MOD_N-GLC_1	73	78	PF02516	0.657
MOD_N-GLC_2	450	452	PF02516	0.547
MOD_NEK2_1	189	194	PF00069	0.615
MOD_NEK2_1	299	304	PF00069	0.554
MOD_NEK2_1	34	39	PF00069	0.671
MOD_NEK2_1	382	387	PF00069	0.726
MOD_NEK2_1	444	449	PF00069	0.539
MOD_NEK2_1	610	615	PF00069	0.648
MOD_NEK2_1	73	78	PF00069	0.657
MOD_NEK2_2	208	213	PF00069	0.642
MOD_NEK2_2	479	484	PF00069	0.656
MOD_NEK2_2	492	497	PF00069	0.542
MOD_PIKK_1	459	465	PF00454	0.629
MOD_PKA_2	338	344	PF00069	0.638
MOD_PKA_2	49	55	PF00069	0.601
MOD_PKA_2	562	568	PF00069	0.598
MOD_Plk_1	318	324	PF00069	0.644
MOD_Plk_1	34	40	PF00069	0.569
MOD_Plk_1	345	351	PF00069	0.581
MOD_Plk_4	4	10	PF00069	0.482
MOD_Plk_4	440	446	PF00069	0.622
MOD_Plk_4	562	568	PF00069	0.559
MOD_ProDKin_1	267	273	PF00069	0.566
MOD_ProDKin_1	333	339	PF00069	0.642
MOD_ProDKin_1	457	463	PF00069	0.519
MOD_ProDKin_1	488	494	PF00069	0.511
MOD_SUMO_for_1	602	605	PF00179	0.537
MOD_SUMO_rev_2	149	155	PF00179	0.797
MOD_SUMO_rev_2	283	289	PF00179	0.600
MOD_SUMO_rev_2	35	43	PF00179	0.733
MOD_SUMO_rev_2	53	58	PF00179	0.469
TRG_DiLeu_BaEn_4	83	89	PF01217	0.704
TRG_DiLeu_BaLyEn_6	606	611	PF01217	0.590
TRG_ENDOCYTIC_2	199	202	PF00928	0.642
TRG_ENDOCYTIC_2	255	258	PF00928	0.773
TRG_ENDOCYTIC_2	296	299	PF00928	0.660
TRG_ENDOCYTIC_2	44	47	PF00928	0.497
TRG_ENDOCYTIC_2	490	493	PF00928	0.520
TRG_ENDOCYTIC_2	534	537	PF00928	0.564
TRG_ENDOCYTIC_2	545	548	PF00928	0.435
TRG_ENDOCYTIC_2	75	78	PF00928	0.563
TRG_ER_diArg_1	112	115	PF00400	0.723
TRG_ER_diArg_1	143	145	PF00400	0.734
TRG_ER_diArg_1	354	356	PF00400	0.645
TRG_ER_diArg_1	49	51	PF00400	0.652
TRG_ER_diArg_1	614	617	PF00400	0.652
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.790

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMQ3	Leptomonas seymouri	72%	72%
A0A0S4IX72	Bodo saltans	35%	84%
A0A1X0P281	Trypanosomatidae	47%	79%
A0A3R7N4R9	Trypanosoma rangeli	46%	80%
A4HI65	Leishmania braziliensis	91%	100%
A4I5E2	Leishmania infantum	100%	100%
C9ZQS2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	82%
E9B0P0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q7J2	Leishmania major	99%	100%
V5B929	Trypanosoma cruzi	48%	83%