Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X383_LEIDO

TriTrypDb:

LdBPK_300860.1 , LdCL_300013700 , LDHU3_30.1080

Length:

198

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 4
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3S7X383

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X383

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	136	138	PF00675	0.707
CLV_NRD_NRD_1	182	184	PF00675	0.454
CLV_PCSK_KEX2_1	193	195	PF00082	0.514
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.457
DEG_Nend_UBRbox_1	1	4	PF02207	0.599
DEG_SPOP_SBC_1	112	116	PF00917	0.334
DEG_SPOP_SBC_1	26	30	PF00917	0.469
DOC_PP1_RVXF_1	73	80	PF00149	0.373
DOC_PP2B_LxvP_1	172	175	PF13499	0.642
DOC_PP2B_LxvP_1	177	180	PF13499	0.650
DOC_USP7_MATH_1	104	108	PF00917	0.395
DOC_USP7_MATH_1	144	148	PF00917	0.447
DOC_USP7_MATH_1	26	30	PF00917	0.607
DOC_USP7_MATH_1	73	77	PF00917	0.403
DOC_WW_Pin1_4	117	122	PF00397	0.474
DOC_WW_Pin1_4	138	143	PF00397	0.539
DOC_WW_Pin1_4	27	32	PF00397	0.442
LIG_14-3-3_CanoR_1	194	198	PF00244	0.763
LIG_14-3-3_CanoR_1	75	80	PF00244	0.365
LIG_Actin_WH2_2	95	112	PF00022	0.403
LIG_BRCT_BRCA1_1	75	79	PF00533	0.354
LIG_Clathr_ClatBox_1	99	103	PF01394	0.423
LIG_FHA_1	11	17	PF00498	0.545
LIG_FHA_1	117	123	PF00498	0.437
LIG_FHA_1	32	38	PF00498	0.500
LIG_FHA_1	60	66	PF00498	0.400
LIG_FHA_1	72	78	PF00498	0.366
LIG_FHA_1	90	96	PF00498	0.450
LIG_IRF3_LxIS_1	121	127	PF10401	0.407
LIG_LIR_Gen_1	76	87	PF02991	0.371
LIG_LIR_Nem_3	76	82	PF02991	0.312
LIG_MAD2	167	175	PF02301	0.680
LIG_PCNA_yPIPBox_3	46	58	PF02747	0.360
LIG_SH2_CRK	22	26	PF00017	0.378
LIG_SH2_PTP2	52	55	PF00017	0.338
LIG_SH2_STAT5	22	25	PF00017	0.418
LIG_SH2_STAT5	52	55	PF00017	0.338
LIG_SH3_3	90	96	PF00018	0.404
LIG_Sin3_3	149	156	PF02671	0.312
LIG_SUMO_SIM_par_1	167	173	PF11976	0.727
LIG_SUMO_SIM_par_1	90	97	PF11976	0.378
LIG_TYR_ITIM	20	25	PF00017	0.367
LIG_TYR_ITIM	50	55	PF00017	0.263
LIG_WRC_WIRS_1	186	191	PF05994	0.666
MOD_CK1_1	111	117	PF00069	0.439
MOD_CK1_1	127	133	PF00069	0.361
MOD_CK1_1	147	153	PF00069	0.404
MOD_CK1_1	188	194	PF00069	0.662
MOD_CK1_1	5	11	PF00069	0.418
MOD_CK1_1	85	91	PF00069	0.455
MOD_CK2_1	127	133	PF00069	0.431
MOD_GlcNHglycan	110	113	PF01048	0.632
MOD_GlcNHglycan	146	149	PF01048	0.362
MOD_GlcNHglycan	67	70	PF01048	0.614
MOD_GlcNHglycan	84	87	PF01048	0.626
MOD_GSK3_1	104	111	PF00069	0.378
MOD_GSK3_1	112	119	PF00069	0.413
MOD_GSK3_1	140	147	PF00069	0.497
MOD_GSK3_1	185	192	PF00069	0.703
MOD_GSK3_1	2	9	PF00069	0.530
MOD_GSK3_1	27	34	PF00069	0.478
MOD_GSK3_1	71	78	PF00069	0.339
MOD_GSK3_1	81	88	PF00069	0.331
MOD_NEK2_1	102	107	PF00069	0.417
MOD_NEK2_1	124	129	PF00069	0.346
MOD_NEK2_1	189	194	PF00069	0.700
MOD_NEK2_1	25	30	PF00069	0.588
MOD_NEK2_1	71	76	PF00069	0.321
MOD_PK_1	167	173	PF00069	0.676
MOD_Plk_1	89	95	PF00069	0.446
MOD_Plk_4	10	16	PF00069	0.554
MOD_Plk_4	104	110	PF00069	0.398
MOD_Plk_4	167	173	PF00069	0.647
MOD_ProDKin_1	117	123	PF00069	0.473
MOD_ProDKin_1	138	144	PF00069	0.538
MOD_ProDKin_1	27	33	PF00069	0.440
TRG_ENDOCYTIC_2	22	25	PF00928	0.375
TRG_ENDOCYTIC_2	52	55	PF00928	0.315
TRG_NES_CRM1_1	35	48	PF08389	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM14	Leptomonas seymouri	46%	100%
A0A1X0P359	Trypanosomatidae	33%	100%
A0A422P4T9	Trypanosoma rangeli	33%	100%
A4HI36	Leishmania braziliensis	79%	100%
A4I5B2	Leishmania infantum	99%	100%
C9ZQP6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B0K8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q7M4	Leishmania major	92%	100%