RING-type E3 ubiquitin transferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania donovani

UniProt:

A0A3S7X380_LEIDO

TriTrypDb:

LdBPK_301290.1 , LdCL_300018100 , LDHU3_30.1670

Length:

723

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X380

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X380

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0072344	rescue of stalled ribosome	6	12
GO:1901576	organic substance biosynthetic process	3	12
GO:0006807	nitrogen compound metabolic process	2	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004842	ubiquitin-protein transferase activity	4	12
GO:0005488	binding	1	5
GO:0016740	transferase activity	2	12
GO:0019787	ubiquitin-like protein transferase activity	3	12
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0061630	ubiquitin protein ligase activity	5	12
GO:0061659	ubiquitin-like protein ligase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0043022	ribosome binding	4	1
GO:0044877	protein-containing complex binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.590
CLV_NRD_NRD_1	360	362	PF00675	0.667
CLV_NRD_NRD_1	546	548	PF00675	0.575
CLV_NRD_NRD_1	590	592	PF00675	0.703
CLV_NRD_NRD_1	705	707	PF00675	0.664
CLV_NRD_NRD_1	73	75	PF00675	0.433
CLV_PCSK_KEX2_1	103	105	PF00082	0.590
CLV_PCSK_KEX2_1	213	215	PF00082	0.585
CLV_PCSK_KEX2_1	360	362	PF00082	0.665
CLV_PCSK_KEX2_1	705	707	PF00082	0.663
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.585
CLV_PCSK_SKI1_1	104	108	PF00082	0.514
CLV_PCSK_SKI1_1	173	177	PF00082	0.365
CLV_PCSK_SKI1_1	460	464	PF00082	0.443
CLV_PCSK_SKI1_1	592	596	PF00082	0.694
CLV_PCSK_SKI1_1	597	601	PF00082	0.642
CLV_PCSK_SKI1_1	75	79	PF00082	0.415
DEG_APCC_KENBOX_2	351	355	PF00400	0.740
DEG_SPOP_SBC_1	404	408	PF00917	0.700
DEG_SPOP_SBC_1	422	426	PF00917	0.550
DEG_SPOP_SBC_1	634	638	PF00917	0.708
DOC_ANK_TNKS_1	704	711	PF00023	0.571
DOC_CKS1_1	669	674	PF01111	0.643
DOC_MAPK_gen_1	74	82	PF00069	0.389
DOC_PP1_RVXF_1	297	303	PF00149	0.557
DOC_PP4_FxxP_1	497	500	PF00568	0.550
DOC_USP7_MATH_1	134	138	PF00917	0.482
DOC_USP7_MATH_1	310	314	PF00917	0.625
DOC_USP7_MATH_1	319	323	PF00917	0.555
DOC_USP7_MATH_1	325	329	PF00917	0.656
DOC_USP7_MATH_1	404	408	PF00917	0.691
DOC_USP7_MATH_1	414	418	PF00917	0.706
DOC_USP7_MATH_1	423	427	PF00917	0.647
DOC_USP7_MATH_1	567	571	PF00917	0.640
DOC_USP7_MATH_1	577	581	PF00917	0.519
DOC_USP7_MATH_1	626	630	PF00917	0.755
DOC_USP7_MATH_1	635	639	PF00917	0.682
DOC_USP7_MATH_1	642	646	PF00917	0.640
DOC_USP7_MATH_1	661	665	PF00917	0.490
DOC_USP7_MATH_1	673	677	PF00917	0.627
DOC_WW_Pin1_4	115	120	PF00397	0.499
DOC_WW_Pin1_4	22	27	PF00397	0.605
DOC_WW_Pin1_4	300	305	PF00397	0.593
DOC_WW_Pin1_4	461	466	PF00397	0.575
DOC_WW_Pin1_4	578	583	PF00397	0.785
DOC_WW_Pin1_4	584	589	PF00397	0.709
DOC_WW_Pin1_4	668	673	PF00397	0.740
DOC_WW_Pin1_4	678	683	PF00397	0.702
LIG_14-3-3_CanoR_1	103	112	PF00244	0.524
LIG_14-3-3_CanoR_1	200	204	PF00244	0.572
LIG_14-3-3_CanoR_1	240	246	PF00244	0.503
LIG_14-3-3_CanoR_1	419	423	PF00244	0.701
LIG_14-3-3_CanoR_1	61	66	PF00244	0.433
LIG_Actin_WH2_2	98	115	PF00022	0.527
LIG_AP2alpha_2	145	147	PF02296	0.515
LIG_APCC_ABBA_1	24	29	PF00400	0.566
LIG_BIR_II_1	1	5	PF00653	0.754
LIG_BRCT_BRCA1_1	387	391	PF00533	0.492
LIG_BRCT_BRCA1_1	424	428	PF00533	0.708
LIG_BRCT_BRCA1_1	664	668	PF00533	0.615
LIG_eIF4E_1	219	225	PF01652	0.389
LIG_EVH1_2	207	211	PF00568	0.444
LIG_FHA_1	130	136	PF00498	0.463
LIG_FHA_1	232	238	PF00498	0.412
LIG_FHA_1	318	324	PF00498	0.635
LIG_FHA_1	393	399	PF00498	0.582
LIG_FHA_1	511	517	PF00498	0.410
LIG_FHA_1	533	539	PF00498	0.618
LIG_FHA_1	82	88	PF00498	0.424
LIG_LIR_Apic_2	130	134	PF02991	0.352
LIG_LIR_Apic_2	495	500	PF02991	0.545
LIG_LIR_Gen_1	145	153	PF02991	0.467
LIG_LIR_Gen_1	162	170	PF02991	0.381
LIG_LIR_Gen_1	336	343	PF02991	0.561
LIG_LIR_Gen_1	467	474	PF02991	0.564
LIG_LIR_Gen_1	486	497	PF02991	0.365
LIG_LIR_Nem_3	162	168	PF02991	0.382
LIG_LIR_Nem_3	244	248	PF02991	0.389
LIG_LIR_Nem_3	336	340	PF02991	0.532
LIG_LIR_Nem_3	388	394	PF02991	0.476
LIG_LIR_Nem_3	467	471	PF02991	0.562
LIG_LIR_Nem_3	485	491	PF02991	0.320
LIG_LIR_Nem_3	505	510	PF02991	0.333
LIG_LIR_Nem_3	693	699	PF02991	0.624
LIG_LRP6_Inhibitor_1	699	705	PF00058	0.664
LIG_NRP_CendR_1	722	723	PF00754	0.761
LIG_PCNA_PIPBox_1	150	159	PF02747	0.396
LIG_PCNA_yPIPBox_3	519	527	PF02747	0.448
LIG_Pex14_1	139	143	PF04695	0.477
LIG_Pex14_2	243	247	PF04695	0.539
LIG_Pex14_2	337	341	PF04695	0.653
LIG_Pex14_2	503	507	PF04695	0.399
LIG_SH2_CRK	131	135	PF00017	0.418
LIG_SH2_CRK	489	493	PF00017	0.402
LIG_SH2_SRC	143	146	PF00017	0.518
LIG_SH2_STAP1	183	187	PF00017	0.451
LIG_SH2_STAP1	233	237	PF00017	0.516
LIG_SH2_STAP1	27	31	PF00017	0.504
LIG_SH2_STAP1	474	478	PF00017	0.511
LIG_SH2_STAP1	489	493	PF00017	0.530
LIG_SH2_STAT5	131	134	PF00017	0.336
LIG_SH2_STAT5	165	168	PF00017	0.341
LIG_SH2_STAT5	233	236	PF00017	0.517
LIG_SH2_STAT5	385	388	PF00017	0.529
LIG_SH2_STAT5	474	477	PF00017	0.526
LIG_SH2_STAT5	53	56	PF00017	0.362
LIG_SH3_3	370	376	PF00018	0.544
LIG_SH3_3	459	465	PF00018	0.621
LIG_SH3_3	666	672	PF00018	0.676
LIG_SH3_3	676	682	PF00018	0.634
LIG_SH3_3	694	700	PF00018	0.535
LIG_SUMO_SIM_anti_2	283	288	PF11976	0.525
LIG_SUMO_SIM_par_1	507	513	PF11976	0.379
LIG_TRAF2_1	375	378	PF00917	0.580
LIG_TRAF2_1	522	525	PF00917	0.537
LIG_TRAF2_1	541	544	PF00917	0.384
LIG_TRAF2_1	88	91	PF00917	0.570
LIG_TRAF2_2	620	625	PF00917	0.756
LIG_TYR_ITIM	163	168	PF00017	0.338
MOD_CDK_SPxxK_3	584	591	PF00069	0.749
MOD_CK1_1	201	207	PF00069	0.530
MOD_CK1_1	25	31	PF00069	0.596
MOD_CK1_1	311	317	PF00069	0.648
MOD_CK1_1	397	403	PF00069	0.665
MOD_CK1_1	417	423	PF00069	0.729
MOD_CK1_1	464	470	PF00069	0.478
MOD_CK1_1	570	576	PF00069	0.751
MOD_CK1_1	664	670	PF00069	0.639
MOD_CK2_1	85	91	PF00069	0.591
MOD_CK2_1	92	98	PF00069	0.579
MOD_Cter_Amidation	358	361	PF01082	0.687
MOD_GlcNHglycan	14	17	PF01048	0.595
MOD_GlcNHglycan	18	21	PF01048	0.530
MOD_GlcNHglycan	309	313	PF01048	0.673
MOD_GlcNHglycan	387	390	PF01048	0.604
MOD_GlcNHglycan	407	410	PF01048	0.742
MOD_GlcNHglycan	420	423	PF01048	0.682
MOD_GlcNHglycan	425	428	PF01048	0.676
MOD_GlcNHglycan	480	483	PF01048	0.445
MOD_GlcNHglycan	617	620	PF01048	0.777
MOD_GlcNHglycan	625	629	PF01048	0.680
MOD_GlcNHglycan	637	640	PF01048	0.675
MOD_GlcNHglycan	664	667	PF01048	0.662
MOD_GlcNHglycan	675	678	PF01048	0.653
MOD_GlcNHglycan	94	97	PF01048	0.511
MOD_GSK3_1	12	19	PF00069	0.698
MOD_GSK3_1	243	250	PF00069	0.516
MOD_GSK3_1	319	326	PF00069	0.682
MOD_GSK3_1	413	420	PF00069	0.710
MOD_GSK3_1	478	485	PF00069	0.493
MOD_GSK3_1	604	611	PF00069	0.669
MOD_GSK3_1	626	633	PF00069	0.706
MOD_GSK3_1	664	671	PF00069	0.701
MOD_GSK3_1	673	680	PF00069	0.637
MOD_GSK3_1	81	88	PF00069	0.463
MOD_LATS_1	470	476	PF00433	0.444
MOD_N-GLC_1	16	21	PF02516	0.705
MOD_N-GLC_1	417	422	PF02516	0.750
MOD_N-GLC_1	577	582	PF02516	0.669
MOD_NEK2_1	243	248	PF00069	0.437
MOD_NEK2_1	394	399	PF00069	0.597
MOD_NEK2_1	478	483	PF00069	0.469
MOD_NEK2_1	613	618	PF00069	0.779
MOD_NEK2_2	51	56	PF00069	0.433
MOD_NEK2_2	642	647	PF00069	0.777
MOD_OFUCOSY	133	138	PF10250	0.474
MOD_OFUCOSY	50	55	PF10250	0.423
MOD_PIKK_1	532	538	PF00454	0.609
MOD_PIKK_1	75	81	PF00454	0.386
MOD_PKA_2	199	205	PF00069	0.550
MOD_PKA_2	414	420	PF00069	0.682
MOD_PKA_2	66	72	PF00069	0.272
MOD_Plk_1	198	204	PF00069	0.521
MOD_Plk_1	692	698	PF00069	0.735
MOD_Plk_1	75	81	PF00069	0.351
MOD_Plk_4	220	226	PF00069	0.512
MOD_Plk_4	664	670	PF00069	0.617
MOD_ProDKin_1	115	121	PF00069	0.494
MOD_ProDKin_1	22	28	PF00069	0.593
MOD_ProDKin_1	300	306	PF00069	0.594
MOD_ProDKin_1	461	467	PF00069	0.571
MOD_ProDKin_1	578	584	PF00069	0.787
MOD_ProDKin_1	668	674	PF00069	0.741
MOD_ProDKin_1	678	684	PF00069	0.705
MOD_SUMO_rev_2	545	555	PF00179	0.568
TRG_DiLeu_LyEn_5	505	510	PF01217	0.313
TRG_ENDOCYTIC_2	165	168	PF00928	0.341
TRG_ENDOCYTIC_2	468	471	PF00928	0.549
TRG_ENDOCYTIC_2	488	491	PF00928	0.267
TRG_ER_diArg_1	102	104	PF00400	0.515
TRG_ER_diArg_1	704	706	PF00400	0.703
TRG_NES_CRM1_1	149	162	PF08389	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA72	Leptomonas seymouri	65%	100%
A0A0S4KKN7	Bodo saltans	39%	100%
A0A1X0P1Y0	Trypanosomatidae	43%	100%
A0A422P542	Trypanosoma rangeli	41%	100%
A4HI75	Leishmania braziliensis	81%	100%
A4I5F4	Leishmania infantum	100%	100%
C9ZQU0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B0Q2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q7I1	Leishmania major	94%	100%
V5BYZ6	Trypanosoma cruzi	36%	100%