Transmembrane protein 107

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transmembrane protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X379_LEIDO

TriTrypDb:

LdBPK_301240.1 , LdCL_300017600 , LDHU3_30.1620

Length:

166

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3S7X379

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X379

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0030030	cell projection organization	4	9
GO:0071840	cellular component organization or biogenesis	2	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.521
CLV_PCSK_KEX2_1	12	14	PF00082	0.521
CLV_PCSK_SKI1_1	28	32	PF00082	0.382
CLV_PCSK_SKI1_1	75	79	PF00082	0.589
DEG_MDM2_SWIB_1	90	97	PF02201	0.381
DOC_CYCLIN_RxL_1	97	107	PF00134	0.582
DOC_MAPK_MEF2A_6	12	21	PF00069	0.673
DOC_PP1_RVXF_1	98	105	PF00149	0.582
DOC_SPAK_OSR1_1	103	107	PF12202	0.582
LIG_14-3-3_CanoR_1	12	17	PF00244	0.725
LIG_14-3-3_CanoR_1	58	63	PF00244	0.355
LIG_Actin_WH2_2	89	105	PF00022	0.437
LIG_FHA_1	127	133	PF00498	0.387
LIG_FHA_1	82	88	PF00498	0.474
LIG_FHA_1	97	103	PF00498	0.515
LIG_FHA_2	145	151	PF00498	0.362
LIG_LIR_Gen_1	68	77	PF02991	0.352
LIG_LIR_Gen_1	84	93	PF02991	0.366
LIG_LIR_Nem_3	15	21	PF02991	0.641
LIG_LIR_Nem_3	68	74	PF02991	0.300
LIG_LIR_Nem_3	84	89	PF02991	0.345
LIG_Pex14_1	136	140	PF04695	0.254
LIG_Pex14_1	39	43	PF04695	0.474
LIG_Pex14_2	86	90	PF04695	0.348
LIG_SH2_PTP2	71	74	PF00017	0.382
LIG_SH2_STAT5	140	143	PF00017	0.340
LIG_SH2_STAT5	18	21	PF00017	0.674
LIG_SH2_STAT5	71	74	PF00017	0.318
LIG_SH3_3	14	20	PF00018	0.705
LIG_SH3_3	27	33	PF00018	0.582
LIG_SUMO_SIM_par_1	1	7	PF11976	0.629
LIG_SUMO_SIM_par_1	119	125	PF11976	0.437
MOD_CK2_1	144	150	PF00069	0.362
MOD_GSK3_1	122	129	PF00069	0.448
MOD_GSK3_1	140	147	PF00069	0.423
MOD_GSK3_1	150	157	PF00069	0.347
MOD_N-GLC_2	79	81	PF02516	0.474
MOD_NEK2_1	110	115	PF00069	0.387
MOD_NEK2_1	122	127	PF00069	0.365
MOD_NEK2_1	154	159	PF00069	0.450
MOD_NEK2_1	82	87	PF00069	0.362
MOD_NEK2_2	126	131	PF00069	0.388
MOD_PKA_1	12	18	PF00069	0.686
MOD_PKA_2	12	18	PF00069	0.690
MOD_PKA_2	50	56	PF00069	0.357
MOD_PKA_2	57	63	PF00069	0.346
MOD_Plk_4	154	160	PF00069	0.489
MOD_Plk_4	42	48	PF00069	0.465
MOD_Plk_4	82	88	PF00069	0.337
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.688
TRG_ENDOCYTIC_2	18	21	PF00928	0.649
TRG_ENDOCYTIC_2	71	74	PF00928	0.324
TRG_ER_diArg_1	11	13	PF00400	0.723

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4KEE0	Bodo saltans	39%	100%
A0A1X0P1Z3	Trypanosomatidae	49%	100%
A0A3R7MXG9	Trypanosoma rangeli	52%	100%
A4I5E9	Leishmania infantum	100%	100%
C9ZQT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B0P7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q7I5	Leishmania major	93%	100%