Succinate dehydrogenase assembly factor 2, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flavinator of succinate dehydrogenase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X377_LEIDO

TriTrypDb:

LdBPK_301130.1 , LdCL_300016500 , LDHU3_30.1460

Length:

234

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	7
GO:0031974	membrane-enclosed lumen	2	7
GO:0043233	organelle lumen	3	7
GO:0070013	intracellular organelle lumen	4	7
GO:0110165	cellular anatomical entity	1	7
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A0A3S7X377

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X377

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	7
GO:0006121	mitochondrial electron transport, succinate to ubiquinone	7	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009060	aerobic respiration	6	7
GO:0009987	cellular process	1	7
GO:0015980	energy derivation by oxidation of organic compounds	4	7
GO:0018293	protein-FAD linkage	5	7
GO:0019538	protein metabolic process	3	7
GO:0019646	aerobic electron transport chain	6	7
GO:0022900	electron transport chain	4	7
GO:0022904	respiratory electron transport chain	5	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0045333	cellular respiration	5	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0006099	tricarboxylic acid cycle	3	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0033108	mitochondrial respiratory chain complex assembly	6	1
GO:0034552	respiratory chain complex II assembly	6	1
GO:0034553	mitochondrial respiratory chain complex II assembly	7	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	130	134	PF00656	0.494
CLV_C14_Caspase3-7	175	179	PF00656	0.508
CLV_C14_Caspase3-7	43	47	PF00656	0.521
CLV_NRD_NRD_1	148	150	PF00675	0.279
CLV_NRD_NRD_1	220	222	PF00675	0.278
CLV_PCSK_KEX2_1	146	148	PF00082	0.430
CLV_PCSK_KEX2_1	220	222	PF00082	0.329
CLV_PCSK_KEX2_1	85	87	PF00082	0.469
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.405
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.469
CLV_PCSK_SKI1_1	221	225	PF00082	0.360
CLV_PCSK_SKI1_1	4	8	PF00082	0.717
CLV_PCSK_SKI1_1	74	78	PF00082	0.464
DEG_APCC_DBOX_1	170	178	PF00400	0.466
DOC_MAPK_gen_1	155	164	PF00069	0.466
DOC_MAPK_MEF2A_6	157	166	PF00069	0.466
DOC_USP7_MATH_1	107	111	PF00917	0.562
DOC_USP7_MATH_1	139	143	PF00917	0.463
DOC_USP7_MATH_1	52	56	PF00917	0.524
DOC_WW_Pin1_4	74	79	PF00397	0.493
DOC_WW_Pin1_4	90	95	PF00397	0.579
LIG_14-3-3_CanoR_1	35	41	PF00244	0.619
LIG_BIR_III_4	46	50	PF00653	0.515
LIG_BRCT_BRCA1_1	193	197	PF00533	0.466
LIG_BRCT_BRCA1_1	66	70	PF00533	0.493
LIG_EH_1	50	54	PF12763	0.532
LIG_FHA_1	226	232	PF00498	0.433
LIG_FHA_1	52	58	PF00498	0.606
LIG_FHA_1	79	85	PF00498	0.479
LIG_FHA_2	128	134	PF00498	0.576
LIG_FHA_2	58	64	PF00498	0.521
LIG_FHA_2	75	81	PF00498	0.479
LIG_LIR_Gen_1	183	192	PF02991	0.465
LIG_LIR_Gen_1	67	78	PF02991	0.509
LIG_LIR_Nem_3	163	169	PF02991	0.489
LIG_LIR_Nem_3	183	188	PF02991	0.391
LIG_LIR_Nem_3	194	200	PF02991	0.468
LIG_LIR_Nem_3	67	73	PF02991	0.532
LIG_PCNA_PIPBox_1	162	171	PF02747	0.466
LIG_Pex14_2	66	70	PF04695	0.517
LIG_SH2_CRK	185	189	PF00017	0.466
LIG_SH2_STAP1	185	189	PF00017	0.466
LIG_SH3_3	133	139	PF00018	0.481
LIG_SH3_3	201	207	PF00018	0.508
LIG_SH3_3	95	101	PF00018	0.563
LIG_SUMO_SIM_par_1	18	23	PF11976	0.540
MOD_CDK_SPK_2	74	79	PF00069	0.493
MOD_CDK_SPK_2	94	99	PF00069	0.471
MOD_CK1_1	25	31	PF00069	0.653
MOD_CK1_1	38	44	PF00069	0.562
MOD_CK2_1	107	113	PF00069	0.571
MOD_CK2_1	57	63	PF00069	0.517
MOD_CK2_1	74	80	PF00069	0.567
MOD_GlcNHglycan	27	30	PF01048	0.579
MOD_GlcNHglycan	54	57	PF01048	0.556
MOD_GSK3_1	103	110	PF00069	0.606
MOD_GSK3_1	123	130	PF00069	0.537
MOD_GSK3_1	173	180	PF00069	0.480
MOD_GSK3_1	23	30	PF00069	0.688
MOD_GSK3_1	35	42	PF00069	0.539
MOD_GSK3_1	64	71	PF00069	0.503
MOD_GSK3_1	74	81	PF00069	0.527
MOD_GSK3_1	86	93	PF00069	0.518
MOD_NEK2_1	131	136	PF00069	0.550
MOD_NEK2_1	177	182	PF00069	0.474
MOD_NEK2_1	20	25	PF00069	0.528
MOD_NEK2_1	5	10	PF00069	0.555
MOD_PIKK_1	30	36	PF00454	0.524
MOD_PIKK_1	64	70	PF00454	0.503
MOD_PKA_2	131	137	PF00069	0.492
MOD_Plk_1	139	145	PF00069	0.432
MOD_Plk_1	177	183	PF00069	0.474
MOD_Plk_1	68	74	PF00069	0.474
MOD_Plk_4	177	183	PF00069	0.476
MOD_ProDKin_1	74	80	PF00069	0.489
MOD_ProDKin_1	90	96	PF00069	0.576
MOD_SUMO_for_1	223	226	PF00179	0.393
TRG_DiLeu_BaEn_1	184	189	PF01217	0.466
TRG_DiLeu_BaEn_1	226	231	PF01217	0.421
TRG_DiLeu_BaEn_2	217	223	PF01217	0.466
TRG_DiLeu_BaLyEn_6	146	151	PF01217	0.299
TRG_ENDOCYTIC_2	156	159	PF00928	0.480
TRG_ENDOCYTIC_2	185	188	PF00928	0.468
TRG_ER_diArg_1	147	149	PF00400	0.299
TRG_ER_diArg_1	219	221	PF00400	0.534
TRG_NES_CRM1_1	191	205	PF08389	0.466
TRG_NLS_MonoCore_2	145	150	PF00514	0.394
TRG_Pf-PMV_PEXEL_1	148	153	PF00026	0.266
TRG_Pf-PMV_PEXEL_1	221	225	PF00026	0.361
TRG_Pf-PMV_PEXEL_1	59	63	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P987	Leptomonas seymouri	68%	100%
A4HI62	Leishmania braziliensis	74%	97%
A4I5D8	Leishmania infantum	100%	100%
E9B0N6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q7J6	Leishmania major	88%	99%