Dolichyl pyrophosphate phosphatase, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PAP2 family protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X373_LEIDO

TriTrypDb:

LdBPK_300410.1 , LdCL_300009200 , LDHU3_30.0580

Length:

272

Annotations

LeishMANIAdb annotations

Involved in N-glycan biogenesis, conserved eukaryotic protein.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3S7X373

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X373

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:0006486	protein glycosylation	4	6
GO:0006487	protein N-linked glycosylation	5	6
GO:0006629	lipid metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	6
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0019538	protein metabolic process	3	6
GO:0030258	lipid modification	4	1
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0043413	macromolecule glycosylation	3	6
GO:0044237	cellular metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0046839	phospholipid dephosphorylation	5	1
GO:0070085	glycosylation	2	6
GO:1901564	organonitrogen compound metabolic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0008195	phosphatidate phosphatase activity	6	4
GO:0016787	hydrolase activity	2	10
GO:0016788	hydrolase activity, acting on ester bonds	3	5
GO:0016791	phosphatase activity	5	5
GO:0042578	phosphoric ester hydrolase activity	4	5
GO:0016462	pyrophosphatase activity	5	6
GO:0016817	hydrolase activity, acting on acid anhydrides	3	6
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	6
GO:0042392	sphingosine-1-phosphate phosphatase activity	7	1
GO:0042577	lipid phosphatase activity	6	1
GO:0047874	dolichyldiphosphatase activity	6	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	161	163	PF00675	0.257
CLV_NRD_NRD_1	167	169	PF00675	0.271
CLV_NRD_NRD_1	173	175	PF00675	0.277
CLV_NRD_NRD_1	181	183	PF00675	0.147
CLV_NRD_NRD_1	22	24	PF00675	0.511
CLV_NRD_NRD_1	99	101	PF00675	0.377
CLV_PCSK_FUR_1	165	169	PF00082	0.279
CLV_PCSK_FUR_1	97	101	PF00082	0.391
CLV_PCSK_KEX2_1	161	163	PF00082	0.297
CLV_PCSK_KEX2_1	167	169	PF00082	0.308
CLV_PCSK_KEX2_1	173	175	PF00082	0.312
CLV_PCSK_KEX2_1	22	24	PF00082	0.511
CLV_PCSK_KEX2_1	99	101	PF00082	0.377
CLV_PCSK_SKI1_1	247	251	PF00082	0.361
DEG_SPOP_SBC_1	192	196	PF00917	0.479
DOC_CYCLIN_yClb5_NLxxxL_5	101	110	PF00134	0.532
DOC_MAPK_gen_1	97	106	PF00069	0.541
DOC_MAPK_MEF2A_6	255	262	PF00069	0.540
DOC_MAPK_MEF2A_6	99	108	PF00069	0.484
DOC_PP1_RVXF_1	6	12	PF00149	0.409
DOC_USP7_MATH_1	134	138	PF00917	0.294
DOC_USP7_MATH_1	185	189	PF00917	0.507
DOC_USP7_MATH_1	192	196	PF00917	0.398
DOC_USP7_MATH_1	42	46	PF00917	0.559
DOC_WW_Pin1_4	123	128	PF00397	0.302
DOC_WW_Pin1_4	193	198	PF00397	0.545
DOC_WW_Pin1_4	44	49	PF00397	0.463
LIG_14-3-3_CanoR_1	167	176	PF00244	0.477
LIG_14-3-3_CanoR_1	182	191	PF00244	0.538
LIG_14-3-3_CanoR_1	193	197	PF00244	0.365
LIG_14-3-3_CanoR_1	247	252	PF00244	0.561
LIG_Actin_WH2_2	105	123	PF00022	0.457
LIG_BIR_II_1	1	5	PF00653	0.393
LIG_BRCT_BRCA1_1	70	74	PF00533	0.332
LIG_EH1_1	73	81	PF00400	0.379
LIG_eIF4E_1	198	204	PF01652	0.457
LIG_eIF4E_1	64	70	PF01652	0.447
LIG_FHA_1	206	212	PF00498	0.434
LIG_FHA_1	240	246	PF00498	0.410
LIG_FHA_1	266	272	PF00498	0.544
LIG_FHA_1	4	10	PF00498	0.406
LIG_FHA_1	58	64	PF00498	0.436
LIG_FHA_2	38	44	PF00498	0.486
LIG_FHA_2	45	51	PF00498	0.428
LIG_GBD_Chelix_1	201	209	PF00786	0.282
LIG_LIR_Apic_2	139	145	PF02991	0.322
LIG_LIR_Gen_1	12	21	PF02991	0.404
LIG_LIR_Gen_1	137	145	PF02991	0.302
LIG_LIR_Gen_1	195	206	PF02991	0.525
LIG_LIR_Nem_3	12	16	PF02991	0.405
LIG_LIR_Nem_3	137	141	PF02991	0.302
LIG_LIR_Nem_3	195	201	PF02991	0.502
LIG_LIR_Nem_3	208	213	PF02991	0.246
LIG_LYPXL_SIV_4	197	205	PF13949	0.379
LIG_NRBOX	199	205	PF00104	0.457
LIG_Pex14_2	151	155	PF04695	0.340
LIG_Pex14_2	206	210	PF04695	0.359
LIG_RPA_C_Fungi	27	39	PF08784	0.660
LIG_SH2_CRK	138	142	PF00017	0.355
LIG_SH2_CRK	198	202	PF00017	0.375
LIG_SH2_CRK	220	224	PF00017	0.372
LIG_SH2_NCK_1	138	142	PF00017	0.379
LIG_SH2_NCK_1	198	202	PF00017	0.457
LIG_SH2_STAP1	138	142	PF00017	0.379
LIG_SH2_STAP1	198	202	PF00017	0.379
LIG_SH2_STAT5	109	112	PF00017	0.415
LIG_SH2_STAT5	13	16	PF00017	0.573
LIG_SH2_STAT5	138	141	PF00017	0.380
LIG_SH2_STAT5	158	161	PF00017	0.415
LIG_SH3_3	121	127	PF00018	0.388
LIG_SH3_3	253	259	PF00018	0.472
LIG_SH3_3	45	51	PF00018	0.720
LIG_TYR_ITIM	107	112	PF00017	0.415
LIG_WRC_WIRS_1	263	268	PF05994	0.510
MOD_CDK_SPK_2	123	128	PF00069	0.372
MOD_CK1_1	137	143	PF00069	0.322
MOD_CK2_1	14	20	PF00069	0.570
MOD_CK2_1	37	43	PF00069	0.620
MOD_CK2_1	44	50	PF00069	0.556
MOD_CMANNOS	54	57	PF00535	0.548
MOD_GlcNHglycan	16	19	PF01048	0.569
MOD_GlcNHglycan	185	188	PF01048	0.444
MOD_GlcNHglycan	43	47	PF01048	0.680
MOD_GlcNHglycan	92	95	PF01048	0.436
MOD_GSK3_1	37	44	PF00069	0.639
MOD_GSK3_1	53	60	PF00069	0.454
MOD_N-GLC_1	168	173	PF02516	0.333
MOD_NEK2_1	110	115	PF00069	0.389
MOD_NEK2_1	120	125	PF00069	0.332
MOD_NEK2_1	136	141	PF00069	0.268
MOD_NEK2_1	191	196	PF00069	0.393
MOD_NEK2_1	205	210	PF00069	0.234
MOD_NEK2_1	238	243	PF00069	0.410
MOD_NEK2_1	262	267	PF00069	0.473
MOD_NEK2_1	3	8	PF00069	0.593
MOD_NEK2_1	74	79	PF00069	0.316
MOD_NEK2_2	153	158	PF00069	0.419
MOD_PKA_1	161	167	PF00069	0.334
MOD_PKA_1	174	180	PF00069	0.403
MOD_PKA_2	161	167	PF00069	0.387
MOD_PKA_2	192	198	PF00069	0.285
MOD_Plk_1	11	17	PF00069	0.415
MOD_Plk_4	137	143	PF00069	0.402
MOD_Plk_4	205	211	PF00069	0.331
MOD_Plk_4	262	268	PF00069	0.431
MOD_Plk_4	75	81	PF00069	0.306
MOD_ProDKin_1	123	129	PF00069	0.372
MOD_ProDKin_1	193	199	PF00069	0.433
MOD_ProDKin_1	44	50	PF00069	0.597
TRG_DiLeu_BaEn_1	5	10	PF01217	0.519
TRG_ENDOCYTIC_2	109	112	PF00928	0.415
TRG_ENDOCYTIC_2	13	16	PF00928	0.573
TRG_ENDOCYTIC_2	138	141	PF00928	0.353
TRG_ENDOCYTIC_2	176	179	PF00928	0.440
TRG_ENDOCYTIC_2	198	201	PF00928	0.412
TRG_ENDOCYTIC_2	220	223	PF00928	0.415
TRG_ER_diArg_1	160	162	PF00400	0.366
TRG_ER_diArg_1	165	168	PF00400	0.379
TRG_ER_diArg_1	21	23	PF00400	0.387
TRG_ER_diArg_1	99	101	PF00400	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGH8	Leptomonas seymouri	54%	100%
A0A1X0P264	Trypanosomatidae	35%	100%
A0A422NMI8	Trypanosoma rangeli	34%	100%
A4HHZ1	Leishmania braziliensis	79%	100%
A4I568	Leishmania infantum	99%	100%
B0CM95	Papio anubis	30%	100%
B0KWE9	Callithrix jacchus	30%	100%
B1MTH4	Plecturocebus moloch	30%	100%
B2KI79	Rhinolophus ferrumequinum	30%	100%
C9ZQJ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B0G5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
P53223	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
Q4Q7R8	Leishmania major	88%	100%
Q86YN1	Homo sapiens	30%	100%
Q9JMF7	Mus musculus	29%	100%