RF-1_domain_containing_protein_putative/Pfam:PF00 472

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RF-1 domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X372_LEIDO

TriTrypDb:

LdBPK_301120.1 , LdCL_300016400 , LDHU3_30.1450

Length:

202

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000315	organellar large ribosomal subunit	5	1
GO:0005762	mitochondrial large ribosomal subunit	3	1
GO:0015934	large ribosomal subunit	4	1
GO:0032991	protein-containing complex	1	1
GO:0044391	ribosomal subunit	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S7X372

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X372

Function

Biological processes
Term	Name	Level	Count
GO:0006415	translational termination	6	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022411	cellular component disassembly	4	1
GO:0032984	protein-containing complex disassembly	5	1
GO:0043933	protein-containing complex organization	4	1
GO:0070126	mitochondrial translational termination	7	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003747	translation release factor activity	5	12
GO:0005488	binding	1	12
GO:0008079	translation termination factor activity	4	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003824	catalytic activity	1	1
GO:0004045	aminoacyl-tRNA hydrolase activity	5	1
GO:0016150	translation release factor activity, codon nonspecific	6	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0052689	carboxylic ester hydrolase activity	4	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	116	118	PF00675	0.331
CLV_NRD_NRD_1	149	151	PF00675	0.259
CLV_NRD_NRD_1	15	17	PF00675	0.587
CLV_NRD_NRD_1	184	186	PF00675	0.251
CLV_PCSK_KEX2_1	116	118	PF00082	0.331
CLV_PCSK_KEX2_1	15	17	PF00082	0.587
CLV_PCSK_KEX2_1	183	185	PF00082	0.261
CLV_PCSK_SKI1_1	139	143	PF00082	0.355
CLV_PCSK_SKI1_1	4	8	PF00082	0.599
DOC_ANK_TNKS_1	77	84	PF00023	0.445
DOC_CYCLIN_RxL_1	12	22	PF00134	0.529
DOC_USP7_MATH_1	123	127	PF00917	0.430
DOC_WW_Pin1_4	19	24	PF00397	0.600
LIG_14-3-3_CanoR_1	150	156	PF00244	0.538
LIG_14-3-3_CanoR_1	192	202	PF00244	0.645
LIG_BIR_II_1	1	5	PF00653	0.620
LIG_BRCT_BRCA1_1	103	107	PF00533	0.457
LIG_FHA_1	127	133	PF00498	0.506
LIG_FHA_1	32	38	PF00498	0.620
LIG_LIR_Apic_2	160	164	PF02991	0.445
LIG_LIR_Nem_3	53	59	PF02991	0.589
LIG_MLH1_MIPbox_1	103	107	PF16413	0.506
LIG_NRBOX	151	157	PF00104	0.531
LIG_PCNA_PIPBox_1	100	109	PF02747	0.506
LIG_RPA_C_Fungi	112	124	PF08784	0.406
LIG_SH2_STAP1	13	17	PF00017	0.502
LIG_SH2_STAT3	57	60	PF00017	0.694
LIG_SH3_1	15	21	PF00018	0.494
LIG_SH3_3	15	21	PF00018	0.632
LIG_SH3_3	167	173	PF00018	0.445
LIG_SUMO_SIM_par_1	129	134	PF11976	0.317
MOD_CK1_1	126	132	PF00069	0.338
MOD_CK1_1	196	202	PF00069	0.709
MOD_CK2_1	131	137	PF00069	0.335
MOD_CK2_1	36	42	PF00069	0.681
MOD_GlcNHglycan	139	142	PF01048	0.333
MOD_GlcNHglycan	195	198	PF01048	0.680
MOD_GlcNHglycan	79	82	PF01048	0.355
MOD_GSK3_1	122	129	PF00069	0.355
MOD_GSK3_1	171	178	PF00069	0.315
MOD_GSK3_1	19	26	PF00069	0.628
MOD_GSK3_1	73	80	PF00069	0.347
MOD_GSK3_1	84	91	PF00069	0.300
MOD_N-GLC_1	87	92	PF02516	0.271
MOD_NEK2_1	193	198	PF00069	0.594
MOD_NEK2_1	77	82	PF00069	0.364
MOD_PKA_1	185	191	PF00069	0.630
MOD_PKA_2	171	177	PF00069	0.368
MOD_PKA_2	191	197	PF00069	0.391
MOD_PKA_2	77	83	PF00069	0.359
MOD_PKB_1	183	191	PF00069	0.715
MOD_Plk_4	127	133	PF00069	0.383
MOD_Plk_4	151	157	PF00069	0.322
MOD_Plk_4	171	177	PF00069	0.186
MOD_ProDKin_1	19	25	PF00069	0.605
MOD_SUMO_rev_2	174	182	PF00179	0.445
TRG_DiLeu_BaEn_2	170	176	PF01217	0.445
TRG_DiLeu_BaLyEn_6	1	6	PF01217	0.631
TRG_ENDOCYTIC_2	56	59	PF00928	0.595
TRG_ER_diArg_1	115	117	PF00400	0.411
TRG_ER_diArg_1	15	17	PF00400	0.590
TRG_ER_diArg_1	183	185	PF00400	0.438
TRG_NLS_MonoExtN_4	183	189	PF00514	0.303

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3M0	Leptomonas seymouri	77%	100%
A0A0S4IXK6	Bodo saltans	49%	96%
A0A1X0P1Z5	Trypanosomatidae	54%	74%
A0A422P522	Trypanosoma rangeli	50%	78%
A4HI61	Leishmania braziliensis	80%	100%
A4I5D7	Leishmania infantum	99%	100%
C9ZQR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	89%
E9B0N5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
P40711	Escherichia coli (strain K12)	30%	100%
Q4Q7J7	Leishmania major	96%	100%
V5BZ05	Trypanosoma cruzi	49%	77%