Protein kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X363_LEIDO

TriTrypDb:

LdBPK_301060.1 , LdCL_300015800 , LDHU3_30.1380

Length:

611

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3S7X363

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X363

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	13
GO:0006793	phosphorus metabolic process	3	13
GO:0006796	phosphate-containing compound metabolic process	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0007165	signal transduction	2	1
GO:0008152	metabolic process	1	13
GO:0009987	cellular process	1	13
GO:0016310	phosphorylation	5	13
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0004672	protein kinase activity	3	13
GO:0004674	protein serine/threonine kinase activity	4	3
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0016301	kinase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	13
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	13

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.566
CLV_C14_Caspase3-7	269	273	PF00656	0.696
CLV_C14_Caspase3-7	380	384	PF00656	0.441
CLV_NRD_NRD_1	292	294	PF00675	0.614
CLV_NRD_NRD_1	303	305	PF00675	0.294
CLV_NRD_NRD_1	393	395	PF00675	0.452
CLV_NRD_NRD_1	429	431	PF00675	0.477
CLV_NRD_NRD_1	452	454	PF00675	0.634
CLV_PCSK_FUR_1	290	294	PF00082	0.742
CLV_PCSK_FUR_1	301	305	PF00082	0.427

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMI5	Leptomonas seymouri	56%	99%
A0A0S4IZ51	Bodo saltans	39%	100%
A0A0S4JI27	Bodo saltans	24%	85%
A0A1X0P290	Trypanosomatidae	45%	100%
A0A422P4X7	Trypanosoma rangeli	38%	100%
A4HI55	Leishmania braziliensis	79%	100%
A4I5D1	Leishmania infantum	100%	100%
C9ZQR3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B0M9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q7K3	Leishmania major	94%	100%

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