Protein kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X363_LEIDO

TriTrypDb:

LdBPK_301060.1 , LdCL_300015800 , LDHU3_30.1380

Length:

611

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X363

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X363

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	13
GO:0006793	phosphorus metabolic process	3	13
GO:0006796	phosphate-containing compound metabolic process	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009987	cellular process	1	13
GO:0016310	phosphorylation	5	13
GO:0019538	protein metabolic process	3	13
GO:0036211	protein modification process	4	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043412	macromolecule modification	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:0007165	signal transduction	2	1
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0035556	intracellular signal transduction	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0004672	protein kinase activity	3	13
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0016301	kinase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	13
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	13
GO:0017076	purine nucleotide binding	4	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:0140096	catalytic activity, acting on a protein	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13
GO:0004674	protein serine/threonine kinase activity	4	3
GO:0106310	protein serine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.566
CLV_C14_Caspase3-7	269	273	PF00656	0.696
CLV_C14_Caspase3-7	380	384	PF00656	0.441
CLV_NRD_NRD_1	292	294	PF00675	0.614
CLV_NRD_NRD_1	303	305	PF00675	0.294
CLV_NRD_NRD_1	393	395	PF00675	0.452
CLV_NRD_NRD_1	429	431	PF00675	0.477
CLV_NRD_NRD_1	452	454	PF00675	0.634
CLV_PCSK_FUR_1	290	294	PF00082	0.742
CLV_PCSK_FUR_1	301	305	PF00082	0.427
CLV_PCSK_FUR_1	450	454	PF00082	0.626
CLV_PCSK_KEX2_1	174	176	PF00082	0.361
CLV_PCSK_KEX2_1	290	292	PF00082	0.616
CLV_PCSK_KEX2_1	303	305	PF00082	0.331
CLV_PCSK_KEX2_1	393	395	PF00082	0.450
CLV_PCSK_KEX2_1	412	414	PF00082	0.178
CLV_PCSK_KEX2_1	429	431	PF00082	0.461
CLV_PCSK_KEX2_1	452	454	PF00082	0.632
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.349
CLV_PCSK_PC1ET2_1	412	414	PF00082	0.450
CLV_PCSK_SKI1_1	174	178	PF00082	0.322
CLV_PCSK_SKI1_1	216	220	PF00082	0.273
CLV_PCSK_SKI1_1	292	296	PF00082	0.628
CLV_PCSK_SKI1_1	430	434	PF00082	0.536
DEG_COP1_1	153	161	PF00400	0.449
DEG_Nend_UBRbox_3	1	3	PF02207	0.670
DEG_SPOP_SBC_1	180	184	PF00917	0.541
DEG_SPOP_SBC_1	285	289	PF00917	0.541
DOC_CKS1_1	564	569	PF01111	0.761
DOC_CYCLIN_RxL_1	184	193	PF00134	0.541
DOC_MAPK_gen_1	216	225	PF00069	0.471
DOC_MAPK_gen_1	228	236	PF00069	0.471
DOC_MAPK_gen_1	290	296	PF00069	0.654
DOC_MAPK_JIP1_4	20	26	PF00069	0.539
DOC_MAPK_MEF2A_6	369	378	PF00069	0.418
DOC_MAPK_MEF2A_6	46	55	PF00069	0.500
DOC_PP1_RVXF_1	185	192	PF00149	0.520
DOC_PP4_FxxP_1	511	514	PF00568	0.537
DOC_USP7_MATH_1	12	16	PF00917	0.635
DOC_USP7_MATH_1	136	140	PF00917	0.522
DOC_USP7_MATH_1	164	168	PF00917	0.574
DOC_USP7_MATH_1	180	184	PF00917	0.445
DOC_USP7_MATH_1	268	272	PF00917	0.727
DOC_USP7_MATH_1	285	289	PF00917	0.709
DOC_USP7_MATH_1	31	35	PF00917	0.491
DOC_USP7_MATH_1	487	491	PF00917	0.706
DOC_USP7_MATH_1	498	502	PF00917	0.425
DOC_USP7_MATH_1	546	550	PF00917	0.755
DOC_USP7_MATH_1	552	556	PF00917	0.713
DOC_USP7_MATH_1	568	572	PF00917	0.734
DOC_USP7_UBL2_3	58	62	PF12436	0.471
DOC_WW_Pin1_4	142	147	PF00397	0.549
DOC_WW_Pin1_4	314	319	PF00397	0.336
DOC_WW_Pin1_4	350	355	PF00397	0.450
DOC_WW_Pin1_4	5	10	PF00397	0.643
DOC_WW_Pin1_4	563	568	PF00397	0.715
LIG_14-3-3_CanoR_1	291	297	PF00244	0.596
LIG_14-3-3_CanoR_1	304	310	PF00244	0.294
LIG_14-3-3_CanoR_1	522	530	PF00244	0.638
LIG_Actin_WH2_2	33	48	PF00022	0.522
LIG_APCC_ABBA_1	414	419	PF00400	0.488
LIG_APCC_ABBA_1	508	513	PF00400	0.465
LIG_APCC_ABBAyCdc20_2	413	419	PF00400	0.394
LIG_BIR_III_2	526	530	PF00653	0.549
LIG_BIR_III_4	381	385	PF00653	0.394
LIG_BIR_III_4	479	483	PF00653	0.630
LIG_Clathr_ClatBox_1	233	237	PF01394	0.480
LIG_deltaCOP1_diTrp_1	323	333	PF00928	0.391
LIG_EH_1	527	531	PF12763	0.512
LIG_FHA_1	152	158	PF00498	0.438
LIG_FHA_1	196	202	PF00498	0.483
LIG_FHA_1	236	242	PF00498	0.548
LIG_FHA_1	564	570	PF00498	0.752
LIG_FHA_2	351	357	PF00498	0.480
LIG_FHA_2	533	539	PF00498	0.664
LIG_FXI_DFP_1	233	237	PF00024	0.280
LIG_LIR_Apic_2	312	318	PF02991	0.323
LIG_LIR_Gen_1	190	199	PF02991	0.496
LIG_LIR_Gen_1	353	362	PF02991	0.367
LIG_LIR_Gen_1	392	402	PF02991	0.286
LIG_LIR_Gen_1	504	514	PF02991	0.458
LIG_LIR_Nem_3	101	107	PF02991	0.562
LIG_LIR_Nem_3	190	194	PF02991	0.496
LIG_LIR_Nem_3	353	358	PF02991	0.446
LIG_LIR_Nem_3	371	376	PF02991	0.296
LIG_LIR_Nem_3	392	398	PF02991	0.309
LIG_LIR_Nem_3	504	509	PF02991	0.431
LIG_LIR_Nem_3	513	519	PF02991	0.394
LIG_LIR_Nem_3	601	607	PF02991	0.706
LIG_PCNA_yPIPBox_3	62	75	PF02747	0.562
LIG_Pex14_2	105	109	PF04695	0.577
LIG_Pex14_2	530	534	PF04695	0.682
LIG_SH2_CRK	506	510	PF00017	0.434
LIG_SH2_NCK_1	340	344	PF00017	0.391
LIG_SH2_PTP2	315	318	PF00017	0.352
LIG_SH2_STAP1	340	344	PF00017	0.394
LIG_SH2_STAP1	516	520	PF00017	0.447
LIG_SH2_STAT3	121	124	PF00017	0.577
LIG_SH2_STAT5	104	107	PF00017	0.407
LIG_SH2_STAT5	121	124	PF00017	0.477
LIG_SH2_STAT5	315	318	PF00017	0.336
LIG_SH2_STAT5	366	369	PF00017	0.439
LIG_SH2_STAT5	519	522	PF00017	0.464
LIG_SH2_STAT5	595	598	PF00017	0.699
LIG_SH2_STAT5	603	606	PF00017	0.583
LIG_SH2_STAT5	89	92	PF00017	0.513
LIG_SH3_3	242	248	PF00018	0.609
LIG_SH3_3	251	257	PF00018	0.565
LIG_SH3_3	48	54	PF00018	0.523
LIG_SH3_3	561	567	PF00018	0.751
LIG_SH3_3	6	12	PF00018	0.663
LIG_SUMO_SIM_par_1	201	206	PF11976	0.554
LIG_SxIP_EBH_1	174	185	PF03271	0.577
LIG_TYR_ITIM	338	343	PF00017	0.370
LIG_WRC_WIRS_1	446	451	PF05994	0.551
MOD_CK1_1	139	145	PF00069	0.550
MOD_CK1_1	167	173	PF00069	0.554
MOD_CK1_1	286	292	PF00069	0.653
MOD_CK1_1	3	9	PF00069	0.678
MOD_CK1_1	327	333	PF00069	0.336
MOD_CK1_1	350	356	PF00069	0.450
MOD_CK1_1	459	465	PF00069	0.670
MOD_CK1_1	481	487	PF00069	0.718
MOD_CK1_1	501	507	PF00069	0.437
MOD_CK2_1	350	356	PF00069	0.441
MOD_CK2_1	362	368	PF00069	0.418
MOD_CK2_1	568	574	PF00069	0.706
MOD_CK2_1	96	102	PF00069	0.464
MOD_GlcNHglycan	165	169	PF01048	0.359
MOD_GlcNHglycan	33	36	PF01048	0.294
MOD_GlcNHglycan	349	352	PF01048	0.388
MOD_GlcNHglycan	462	465	PF01048	0.644
MOD_GlcNHglycan	479	483	PF01048	0.714
MOD_GlcNHglycan	484	487	PF01048	0.600
MOD_GlcNHglycan	497	501	PF01048	0.458
MOD_GlcNHglycan	554	557	PF01048	0.713
MOD_GlcNHglycan	558	561	PF01048	0.648
MOD_GSK3_1	166	173	PF00069	0.527
MOD_GSK3_1	305	312	PF00069	0.405
MOD_GSK3_1	31	38	PF00069	0.500
MOD_GSK3_1	455	462	PF00069	0.630
MOD_GSK3_1	463	470	PF00069	0.674
MOD_GSK3_1	474	481	PF00069	0.716
MOD_GSK3_1	532	539	PF00069	0.656
MOD_GSK3_1	552	559	PF00069	0.459
MOD_NEK2_1	294	299	PF00069	0.564
MOD_NEK2_1	309	314	PF00069	0.315
MOD_NEK2_1	423	428	PF00069	0.457
MOD_NEK2_1	456	461	PF00069	0.651
MOD_NEK2_1	593	598	PF00069	0.738
MOD_NEK2_1	93	98	PF00069	0.480
MOD_PIKK_1	294	300	PF00454	0.657
MOD_PIKK_1	35	41	PF00454	0.535
MOD_PIKK_1	532	538	PF00454	0.769
MOD_PK_1	70	76	PF00069	0.562
MOD_PKA_1	174	180	PF00069	0.563
MOD_PKA_1	292	298	PF00069	0.599
MOD_PKA_1	303	309	PF00069	0.287
MOD_PKA_2	174	180	PF00069	0.563
MOD_PKA_2	292	298	PF00069	0.597
MOD_PKA_2	303	309	PF00069	0.321
MOD_PKA_2	521	527	PF00069	0.621
MOD_PKB_1	290	298	PF00069	0.710
MOD_PKB_1	301	309	PF00069	0.383
MOD_Plk_1	423	429	PF00069	0.455
MOD_Plk_2-3	574	580	PF00069	0.715
MOD_Plk_4	362	368	PF00069	0.394
MOD_Plk_4	574	580	PF00069	0.744
MOD_Plk_4	70	76	PF00069	0.562
MOD_ProDKin_1	142	148	PF00069	0.549
MOD_ProDKin_1	314	320	PF00069	0.336
MOD_ProDKin_1	350	356	PF00069	0.450
MOD_ProDKin_1	5	11	PF00069	0.640
MOD_ProDKin_1	563	569	PF00069	0.714
MOD_SUMO_for_1	218	221	PF00179	0.471
MOD_SUMO_rev_2	317	327	PF00179	0.450
TRG_DiLeu_BaLyEn_6	48	53	PF01217	0.522
TRG_ENDOCYTIC_2	104	107	PF00928	0.480
TRG_ENDOCYTIC_2	340	343	PF00928	0.336
TRG_ENDOCYTIC_2	506	509	PF00928	0.444
TRG_ER_diArg_1	290	293	PF00400	0.661
TRG_ER_diArg_1	301	304	PF00400	0.579
TRG_ER_diArg_1	393	395	PF00400	0.450
TRG_ER_diArg_1	428	430	PF00400	0.536
TRG_ER_diArg_1	449	452	PF00400	0.598
TRG_NES_CRM1_1	193	206	PF08389	0.554
TRG_Pf-PMV_PEXEL_1	216	221	PF00026	0.280

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMI5	Leptomonas seymouri	56%	99%
A0A0S4IZ51	Bodo saltans	39%	100%
A0A0S4JI27	Bodo saltans	24%	85%
A0A1X0P290	Trypanosomatidae	45%	100%
A0A422P4X7	Trypanosoma rangeli	38%	100%
A4HI55	Leishmania braziliensis	79%	100%
A4I5D1	Leishmania infantum	100%	100%
C9ZQR3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B0M9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q7K3	Leishmania major	94%	100%
V5BU83	Trypanosoma cruzi	41%	100%