Autophagy protein 5 (ATG5)

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

autophagy protein 5

Species:

Leishmania donovani

UniProt:

A0A3S7X356_LEIDO

TriTrypDb:

LdBPK_301040.1 , LdCL_300015600 , LDHU3_30.1360

Length:

460

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X356

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X356

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	423	425	PF00675	0.492
CLV_PCSK_KEX2_1	423	425	PF00082	0.494
CLV_PCSK_SKI1_1	225	229	PF00082	0.689
CLV_PCSK_SKI1_1	357	361	PF00082	0.757
CLV_PCSK_SKI1_1	452	456	PF00082	0.563
CLV_PCSK_SKI1_1	7	11	PF00082	0.498
DEG_Nend_Nbox_1	1	3	PF02207	0.507
DEG_SPOP_SBC_1	63	67	PF00917	0.551
DOC_CDC14_PxL_1	300	308	PF14671	0.539
DOC_CKS1_1	227	232	PF01111	0.650
DOC_CKS1_1	436	441	PF01111	0.662
DOC_CYCLIN_RxL_1	222	229	PF00134	0.753
DOC_CYCLIN_yCln2_LP_2	12	18	PF00134	0.577
DOC_CYCLIN_yCln2_LP_2	160	166	PF00134	0.639
DOC_CYCLIN_yCln2_LP_2	86	92	PF00134	0.663
DOC_MAPK_gen_1	398	408	PF00069	0.621
DOC_MAPK_MEF2A_6	264	273	PF00069	0.757
DOC_MAPK_MEF2A_6	401	408	PF00069	0.607
DOC_MAPK_MEF2A_6	452	460	PF00069	0.553
DOC_MAPK_NFAT4_5	401	409	PF00069	0.570
DOC_PP1_RVXF_1	237	243	PF00149	0.683
DOC_PP1_RVXF_1	421	428	PF00149	0.583
DOC_PP4_FxxP_1	211	214	PF00568	0.755
DOC_PP4_FxxP_1	301	304	PF00568	0.536
DOC_SPAK_OSR1_1	426	430	PF12202	0.673
DOC_USP7_MATH_1	250	254	PF00917	0.697
DOC_USP7_MATH_1	317	321	PF00917	0.699
DOC_USP7_MATH_1	323	327	PF00917	0.702
DOC_USP7_MATH_1	412	416	PF00917	0.739
DOC_USP7_MATH_1	69	73	PF00917	0.615
DOC_USP7_UBL2_3	127	131	PF12436	0.545
DOC_WW_Pin1_4	197	202	PF00397	0.719
DOC_WW_Pin1_4	210	215	PF00397	0.514
DOC_WW_Pin1_4	226	231	PF00397	0.426
DOC_WW_Pin1_4	31	36	PF00397	0.542
DOC_WW_Pin1_4	319	324	PF00397	0.710
DOC_WW_Pin1_4	370	375	PF00397	0.648
DOC_WW_Pin1_4	415	420	PF00397	0.615
DOC_WW_Pin1_4	435	440	PF00397	0.563
DOC_WW_Pin1_4	65	70	PF00397	0.669
LIG_14-3-3_CanoR_1	264	271	PF00244	0.651
LIG_BRCT_BRCA1_1	205	209	PF00533	0.663
LIG_CtBP_PxDLS_1	89	93	PF00389	0.521
LIG_FHA_1	106	112	PF00498	0.639
LIG_FHA_1	22	28	PF00498	0.602
LIG_FHA_1	358	364	PF00498	0.655
LIG_FHA_2	274	280	PF00498	0.723
LIG_FHA_2	284	290	PF00498	0.507
LIG_FHA_2	371	377	PF00498	0.677
LIG_LIR_Apic_2	37	41	PF02991	0.536
LIG_LIR_Gen_1	219	228	PF02991	0.688
LIG_LIR_Gen_1	338	349	PF02991	0.545
LIG_LIR_Nem_3	135	141	PF02991	0.551
LIG_LIR_Nem_3	219	223	PF02991	0.682
LIG_LIR_Nem_3	25	31	PF02991	0.501
LIG_LIR_Nem_3	254	260	PF02991	0.695
LIG_LIR_Nem_3	338	344	PF02991	0.558
LIG_NRBOX	223	229	PF00104	0.753
LIG_PCNA_yPIPBox_3	221	231	PF02747	0.628
LIG_PDZ_Class_2	455	460	PF00595	0.647
LIG_PTB_Apo_2	189	196	PF02174	0.737
LIG_PTB_Phospho_1	189	195	PF10480	0.736
LIG_SH2_CRK	134	138	PF00017	0.568
LIG_SH2_CRK	205	209	PF00017	0.668
LIG_SH2_CRK	220	224	PF00017	0.638
LIG_SH2_CRK	341	345	PF00017	0.551
LIG_SH2_GRB2like	112	115	PF00017	0.566
LIG_SH2_GRB2like	48	51	PF00017	0.539
LIG_SH2_NCK_1	205	209	PF00017	0.700
LIG_SH2_NCK_1	352	356	PF00017	0.693
LIG_SH2_SRC	352	355	PF00017	0.573
LIG_SH2_STAP1	134	138	PF00017	0.568
LIG_SH2_STAP1	16	20	PF00017	0.585
LIG_SH2_STAT5	112	115	PF00017	0.566
LIG_SH2_STAT5	134	137	PF00017	0.565
LIG_SH2_STAT5	141	144	PF00017	0.535
LIG_SH2_STAT5	215	218	PF00017	0.735
LIG_SH2_STAT5	236	239	PF00017	0.587
LIG_SH2_STAT5	257	260	PF00017	0.700
LIG_SH2_STAT5	48	51	PF00017	0.539
LIG_SH3_3	371	377	PF00018	0.625
LIG_SUMO_SIM_par_1	87	93	PF11976	0.563
LIG_TRAF2_1	167	170	PF00917	0.621
LIG_TYR_ITIM	113	118	PF00017	0.554
LIG_WRPW_2	13	16	PF00400	0.682
LIG_WRPW_2	161	164	PF00400	0.599
LIG_WW_3	354	358	PF00397	0.732
MOD_CDK_SPK_2	226	231	PF00069	0.633
MOD_CK1_1	196	202	PF00069	0.684
MOD_CK1_1	322	328	PF00069	0.791
MOD_CK1_1	415	421	PF00069	0.650
MOD_CK1_1	62	68	PF00069	0.710
MOD_CK1_1	84	90	PF00069	0.633
MOD_CK2_1	273	279	PF00069	0.720
MOD_CK2_1	283	289	PF00069	0.484
MOD_CK2_1	332	338	PF00069	0.724
MOD_CK2_1	370	376	PF00069	0.788
MOD_CK2_1	438	444	PF00069	0.580
MOD_CMANNOS	380	383	PF00535	0.587
MOD_Cter_Amidation	421	424	PF01082	0.576
MOD_GlcNHglycan	149	152	PF01048	0.580
MOD_GlcNHglycan	182	185	PF01048	0.634
MOD_GlcNHglycan	205	208	PF01048	0.767
MOD_GlcNHglycan	254	257	PF01048	0.641
MOD_GlcNHglycan	265	268	PF01048	0.612
MOD_GlcNHglycan	325	328	PF01048	0.751
MOD_GlcNHglycan	329	332	PF01048	0.735
MOD_GlcNHglycan	414	417	PF01048	0.644
MOD_GlcNHglycan	61	64	PF01048	0.735
MOD_GlcNHglycan	71	74	PF01048	0.607
MOD_GSK3_1	193	200	PF00069	0.717
MOD_GSK3_1	27	34	PF00069	0.523
MOD_GSK3_1	271	278	PF00069	0.672
MOD_GSK3_1	317	324	PF00069	0.738
MOD_GSK3_1	434	441	PF00069	0.656
MOD_GSK3_1	59	66	PF00069	0.625
MOD_GSK3_1	77	84	PF00069	0.581
MOD_GSK3_1	97	104	PF00069	0.629
MOD_LATS_1	316	322	PF00433	0.619
MOD_N-GLC_1	139	144	PF02516	0.524
MOD_N-GLC_2	50	52	PF02516	0.541
MOD_NEK2_1	105	110	PF00069	0.513
MOD_NEK2_1	182	187	PF00069	0.697
MOD_NEK2_1	209	214	PF00069	0.738
MOD_NEK2_1	271	276	PF00069	0.780
MOD_NEK2_1	344	349	PF00069	0.509
MOD_NEK2_1	369	374	PF00069	0.796
MOD_NEK2_1	61	66	PF00069	0.737
MOD_NEK2_1	77	82	PF00069	0.597
MOD_NEK2_1	90	95	PF00069	0.529
MOD_NEK2_2	139	144	PF00069	0.557
MOD_PIKK_1	22	28	PF00454	0.508
MOD_PKA_2	263	269	PF00069	0.654
MOD_PKA_2	317	323	PF00069	0.609
MOD_Plk_1	139	145	PF00069	0.488
MOD_Plk_1	22	28	PF00069	0.536
MOD_Plk_1	337	343	PF00069	0.678
MOD_Plk_1	90	96	PF00069	0.504
MOD_Plk_4	132	138	PF00069	0.557
MOD_Plk_4	139	145	PF00069	0.510
MOD_Plk_4	34	40	PF00069	0.635
MOD_Plk_4	438	444	PF00069	0.580
MOD_Plk_4	81	87	PF00069	0.629
MOD_ProDKin_1	197	203	PF00069	0.721
MOD_ProDKin_1	210	216	PF00069	0.512
MOD_ProDKin_1	226	232	PF00069	0.422
MOD_ProDKin_1	31	37	PF00069	0.541
MOD_ProDKin_1	319	325	PF00069	0.706
MOD_ProDKin_1	370	376	PF00069	0.644
MOD_ProDKin_1	415	421	PF00069	0.617
MOD_ProDKin_1	435	441	PF00069	0.570
MOD_ProDKin_1	65	71	PF00069	0.669
MOD_SUMO_rev_2	119	129	PF00179	0.649
TRG_DiLeu_BaEn_1	219	224	PF01217	0.739
TRG_DiLeu_BaLyEn_6	365	370	PF01217	0.707
TRG_ENDOCYTIC_2	115	118	PF00928	0.551
TRG_ENDOCYTIC_2	134	137	PF00928	0.565
TRG_ENDOCYTIC_2	161	164	PF00928	0.550
TRG_ENDOCYTIC_2	220	223	PF00928	0.629
TRG_ENDOCYTIC_2	341	344	PF00928	0.532
TRG_ER_diArg_1	423	426	PF00400	0.499
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8W7	Leptomonas seymouri	57%	86%
A4HI53	Leishmania braziliensis	84%	100%
A4I5C9	Leishmania infantum	100%	100%
E9B0M7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q7K5	Leishmania major	94%	100%