Protein kinase, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X353_LEIDO

TriTrypDb:

LdBPK_300620.1 , LdCL_300011300 , LDHU3_30.0800

Length:

928

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X353

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X353

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0007165	signal transduction	2	1
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	355	361	PF00089	0.304
CLV_NRD_NRD_1	107	109	PF00675	0.594
CLV_NRD_NRD_1	136	138	PF00675	0.606
CLV_NRD_NRD_1	212	214	PF00675	0.620
CLV_NRD_NRD_1	35	37	PF00675	0.588
CLV_NRD_NRD_1	409	411	PF00675	0.304
CLV_NRD_NRD_1	605	607	PF00675	0.303
CLV_NRD_NRD_1	632	634	PF00675	0.664
CLV_NRD_NRD_1	804	806	PF00675	0.717
CLV_NRD_NRD_1	846	848	PF00675	0.697

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILR5	Leptomonas seymouri	55%	99%
A4HI11	Leishmania braziliensis	80%	100%
A4I588	Leishmania infantum	99%	100%
E9B0I5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q7P6	Leishmania major	95%	100%

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