AdoMet dependent proline di-methyltransferase/O-methyltransferase/Methyltransferase domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AdoMet dependent proline di-methyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X350_LEIDO

TriTrypDb:

LdBPK_300880.1 , LdCL_300013900 , LDHU3_30.1100

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X350

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X350

PDB structure(s): 1xtp_A

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	13
GO:0006480	N-terminal protein amino acid methylation	5	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0008213	protein alkylation	5	13
GO:0009987	cellular process	1	13
GO:0019538	protein metabolic process	3	13
GO:0031365	N-terminal protein amino acid modification	5	13
GO:0032259	methylation	2	13
GO:0036211	protein modification process	4	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043412	macromolecule modification	4	13
GO:0043414	macromolecule methylation	3	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044260	obsolete cellular macromolecule metabolic process	3	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0008168	methyltransferase activity	4	13
GO:0008276	protein methyltransferase activity	3	13
GO:0016740	transferase activity	2	13
GO:0016741	transferase activity, transferring one-carbon groups	3	13
GO:0140096	catalytic activity, acting on a protein	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	129	131	PF00082	0.314
CLV_PCSK_KEX2_1	218	220	PF00082	0.251
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.314
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.251
CLV_PCSK_SKI1_1	102	106	PF00082	0.249
CLV_PCSK_SKI1_1	139	143	PF00082	0.251
CLV_PCSK_SKI1_1	174	178	PF00082	0.260
CLV_PCSK_SKI1_1	218	222	PF00082	0.238
CLV_PCSK_SKI1_1	227	231	PF00082	0.238
DEG_APCC_KENBOX_2	191	195	PF00400	0.238
DOC_CYCLIN_RxL_1	102	109	PF00134	0.286
DOC_CYCLIN_RxL_1	212	224	PF00134	0.345
DOC_CYCLIN_yClb5_NLxxxL_5	105	111	PF00134	0.391
DOC_CYCLIN_yCln2_LP_2	117	123	PF00134	0.366
DOC_MAPK_DCC_7	236	246	PF00069	0.133
DOC_MAPK_gen_1	129	137	PF00069	0.314
DOC_SPAK_OSR1_1	200	204	PF12202	0.311
DOC_USP7_MATH_1	58	62	PF00917	0.251
DOC_WW_Pin1_4	181	186	PF00397	0.267
LIG_14-3-3_CanoR_1	24	30	PF00244	0.581
LIG_BRCT_BRCA1_1	77	81	PF00533	0.238
LIG_deltaCOP1_diTrp_1	235	242	PF00928	0.291
LIG_eIF4E_1	112	118	PF01652	0.286
LIG_FHA_1	113	119	PF00498	0.283
LIG_FHA_1	145	151	PF00498	0.247
LIG_FHA_1	152	158	PF00498	0.245
LIG_FHA_1	33	39	PF00498	0.586
LIG_FHA_2	166	172	PF00498	0.251
LIG_FHA_2	209	215	PF00498	0.258
LIG_GBD_Chelix_1	103	111	PF00786	0.369
LIG_LIR_Gen_1	154	160	PF02991	0.248
LIG_LIR_Gen_1	169	176	PF02991	0.238
LIG_LIR_Nem_3	154	158	PF02991	0.289
LIG_LIR_Nem_3	169	175	PF02991	0.280
LIG_LIR_Nem_3	214	220	PF02991	0.271
LIG_LIR_Nem_3	51	56	PF02991	0.345
LIG_Pex14_1	162	166	PF04695	0.238
LIG_Pex14_2	172	176	PF04695	0.345
LIG_Pex14_2	233	237	PF04695	0.345
LIG_REV1ctd_RIR_1	173	181	PF16727	0.311
LIG_REV1ctd_RIR_1	188	196	PF16727	0.155
LIG_SH2_CRK	155	159	PF00017	0.238
LIG_SH2_CRK	217	221	PF00017	0.238
LIG_SH2_STAP1	155	159	PF00017	0.238
LIG_SH2_STAT5	166	169	PF00017	0.238
LIG_SH2_STAT5	188	191	PF00017	0.251
LIG_SUMO_SIM_anti_2	156	161	PF11976	0.238
LIG_TRAF2_1	232	235	PF00917	0.290
LIG_TYR_ITIM	215	220	PF00017	0.391
MOD_CK1_1	144	150	PF00069	0.251
MOD_CK1_1	208	214	PF00069	0.238
MOD_CK2_1	22	28	PF00069	0.548
MOD_CK2_1	77	83	PF00069	0.230
MOD_GlcNHglycan	13	16	PF01048	0.628
MOD_GlcNHglycan	223	226	PF01048	0.394
MOD_GlcNHglycan	60	63	PF01048	0.238
MOD_GSK3_1	11	18	PF00069	0.602
MOD_GSK3_1	141	148	PF00069	0.242
MOD_GSK3_1	19	26	PF00069	0.650
MOD_GSK3_1	206	213	PF00069	0.244
MOD_GSK3_1	52	59	PF00069	0.288
MOD_GSK3_1	77	84	PF00069	0.385
MOD_N-GLC_1	193	198	PF02516	0.326
MOD_N-GLC_1	221	226	PF02516	0.242
MOD_NEK2_1	145	150	PF00069	0.262
MOD_NEK2_1	221	226	PF00069	0.348
MOD_NEK2_1	81	86	PF00069	0.300
MOD_PKA_2	15	21	PF00069	0.544
MOD_PKA_2	23	29	PF00069	0.637
MOD_Plk_1	145	151	PF00069	0.335
MOD_Plk_1	205	211	PF00069	0.238
MOD_ProDKin_1	181	187	PF00069	0.267
MOD_SUMO_for_1	128	131	PF00179	0.251
TRG_ENDOCYTIC_2	155	158	PF00928	0.238
TRG_ENDOCYTIC_2	188	191	PF00928	0.251
TRG_ENDOCYTIC_2	217	220	PF00928	0.238
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEJ3	Leptomonas seymouri	81%	100%
A0A0S4J7U1	Bodo saltans	61%	99%
A0A1X0P231	Trypanosomatidae	69%	99%
A0A422P4V7	Trypanosoma rangeli	71%	99%
A2XMJ1	Oryza sativa subsp. indica	42%	81%
A4HI37	Leishmania braziliensis	90%	100%
A4I5B4	Leishmania infantum	99%	100%
A8WVR2	Caenorhabditis briggsae	38%	100%
B1H2P7	Xenopus tropicalis	37%	100%
B2RXM4	Mus musculus	35%	88%
B8JM82	Danio rerio	32%	90%
C9ZQP7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
C9ZQQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
D2H163	Ailuropoda melanoleuca	38%	100%
D3ZVR1	Rattus norvegicus	34%	88%
E9B0L0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O13748	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	100%
P38340	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	100%
Q10CT5	Oryza sativa subsp. japonica	42%	81%
Q2T9N3	Bos taurus	38%	100%
Q4KL94	Xenopus laevis	36%	100%
Q4KLE6	Xenopus laevis	37%	100%
Q4Q7M2	Leishmania major	96%	100%
Q55DH6	Dictyostelium discoideum	40%	93%
Q5BJX0	Rattus norvegicus	36%	100%
Q5PP70	Arabidopsis thaliana	40%	91%
Q5VVY1	Homo sapiens	33%	88%
Q6NN40	Drosophila melanogaster	39%	91%
Q6NWX7	Danio rerio	35%	100%
Q8R2U4	Mus musculus	36%	100%
Q9BV86	Homo sapiens	37%	100%
Q9N4D9	Caenorhabditis elegans	38%	100%
V5B946	Trypanosoma cruzi	71%	99%