Mitochondrial oligo U binding protein TBRGG1, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial oligo_U binding protein TBRGG1, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X349_LEIDO

TriTrypDb:

LdBPK_300830.1 , LdCL_300013400 , LDHU3_30.1040

Length:

677

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X349

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X349

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0032774	RNA biosynthetic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.769
CLV_NRD_NRD_1	126	128	PF00675	0.725
CLV_NRD_NRD_1	152	154	PF00675	0.687
CLV_NRD_NRD_1	190	192	PF00675	0.514
CLV_PCSK_KEX2_1	101	103	PF00082	0.769
CLV_PCSK_KEX2_1	126	128	PF00082	0.725
CLV_PCSK_KEX2_1	152	154	PF00082	0.695
CLV_PCSK_KEX2_1	190	192	PF00082	0.587
CLV_PCSK_SKI1_1	174	178	PF00082	0.561
CLV_PCSK_SKI1_1	190	194	PF00082	0.516
CLV_PCSK_SKI1_1	4	8	PF00082	0.740
CLV_PCSK_SKI1_1	448	452	PF00082	0.522
CLV_PCSK_SKI1_1	522	526	PF00082	0.596
CLV_PCSK_SKI1_1	600	604	PF00082	0.414
DEG_APCC_DBOX_1	599	607	PF00400	0.424
DEG_Nend_Nbox_1	1	3	PF02207	0.783
DOC_CDC14_PxL_1	370	378	PF14671	0.400
DOC_MAPK_MEF2A_6	278	287	PF00069	0.511
DOC_PP1_RVXF_1	481	488	PF00149	0.497
DOC_PP4_FxxP_1	218	221	PF00568	0.570
DOC_PP4_FxxP_1	444	447	PF00568	0.411
DOC_SPAK_OSR1_1	182	186	PF12202	0.569
DOC_USP7_MATH_1	272	276	PF00917	0.467
DOC_USP7_MATH_1	313	317	PF00917	0.497
DOC_USP7_MATH_1	457	461	PF00917	0.514
DOC_USP7_MATH_1	512	516	PF00917	0.505
DOC_USP7_MATH_1	529	533	PF00917	0.686
DOC_USP7_MATH_1	659	663	PF00917	0.592
DOC_USP7_UBL2_3	170	174	PF12436	0.486
DOC_WW_Pin1_4	239	244	PF00397	0.450
DOC_WW_Pin1_4	254	259	PF00397	0.418
DOC_WW_Pin1_4	595	600	PF00397	0.527
DOC_WW_Pin1_4	644	649	PF00397	0.607
LIG_14-3-3_CanoR_1	133	138	PF00244	0.745
LIG_14-3-3_CanoR_1	147	151	PF00244	0.713
LIG_14-3-3_CanoR_1	16	22	PF00244	0.644
LIG_14-3-3_CanoR_1	389	396	PF00244	0.427
LIG_14-3-3_CanoR_1	4	9	PF00244	0.718
LIG_14-3-3_CanoR_1	413	419	PF00244	0.560
LIG_14-3-3_CanoR_1	492	498	PF00244	0.397
LIG_14-3-3_CanoR_1	519	529	PF00244	0.534
LIG_14-3-3_CanoR_1	564	568	PF00244	0.535
LIG_14-3-3_CanoR_1	600	609	PF00244	0.488
LIG_14-3-3_CanoR_1	619	627	PF00244	0.295
LIG_Actin_WH2_2	179	196	PF00022	0.474
LIG_Actin_WH2_2	579	594	PF00022	0.580
LIG_BRCT_BRCA1_1	553	557	PF00533	0.534
LIG_FHA_1	215	221	PF00498	0.486
LIG_FHA_1	389	395	PF00498	0.519
LIG_FHA_1	422	428	PF00498	0.542
LIG_FHA_1	497	503	PF00498	0.551
LIG_FHA_1	602	608	PF00498	0.454
LIG_FHA_2	194	200	PF00498	0.521
LIG_FHA_2	434	440	PF00498	0.562
LIG_FHA_2	557	563	PF00498	0.504
LIG_FHA_2	583	589	PF00498	0.552
LIG_IRF3_LxIS_1	560	566	PF10401	0.436
LIG_LIR_Apic_2	217	221	PF02991	0.566
LIG_LIR_Apic_2	442	447	PF02991	0.412
LIG_LIR_Gen_1	228	238	PF02991	0.562
LIG_LIR_Nem_3	181	186	PF02991	0.476
LIG_LIR_Nem_3	481	485	PF02991	0.497
LIG_LIR_Nem_3	554	560	PF02991	0.437
LIG_PCNA_PIPBox_1	304	313	PF02747	0.560
LIG_PCNA_yPIPBox_3	262	270	PF02747	0.522
LIG_PCNA_yPIPBox_3	380	389	PF02747	0.503
LIG_SH2_CRK	18	22	PF00017	0.690
LIG_SH2_GRB2like	81	84	PF00017	0.803
LIG_SH2_GRB2like	88	91	PF00017	0.827
LIG_SH2_NCK_1	456	460	PF00017	0.556
LIG_SH2_SRC	456	459	PF00017	0.553
LIG_SH2_SRC	88	91	PF00017	0.820
LIG_SH2_STAP1	18	22	PF00017	0.704
LIG_SH2_STAP1	553	557	PF00017	0.433
LIG_SH2_STAT3	158	161	PF00017	0.602
LIG_SH2_STAT3	57	60	PF00017	0.702
LIG_SH2_STAT5	158	161	PF00017	0.602
LIG_SH2_STAT5	95	98	PF00017	0.754
LIG_SH3_3	413	419	PF00018	0.558
LIG_SH3_3	459	465	PF00018	0.491
LIG_SH3_3	515	521	PF00018	0.534
LIG_SUMO_SIM_anti_2	207	212	PF11976	0.468
LIG_SUMO_SIM_anti_2	284	290	PF11976	0.401
LIG_SUMO_SIM_anti_2	365	371	PF11976	0.407
LIG_SUMO_SIM_anti_2	506	512	PF11976	0.488
LIG_TRAF2_1	426	429	PF00917	0.529
LIG_TRAF2_1	467	470	PF00917	0.550
LIG_UBA3_1	166	174	PF00899	0.457
LIG_UBA3_1	434	440	PF00899	0.516
LIG_UBA3_1	493	501	PF00899	0.538
LIG_WRC_WIRS_1	479	484	PF05994	0.568
LIG_WW_3	50	54	PF00397	0.754
LIG_WW_3	519	523	PF00397	0.526
MOD_CDK_SPK_2	595	600	PF00069	0.527
MOD_CK1_1	334	340	PF00069	0.619
MOD_CK1_1	417	423	PF00069	0.560
MOD_CK1_1	496	502	PF00069	0.543
MOD_CK1_1	644	650	PF00069	0.540
MOD_CK2_1	199	205	PF00069	0.485
MOD_CK2_1	254	260	PF00069	0.490
MOD_CK2_1	306	312	PF00069	0.494
MOD_CK2_1	433	439	PF00069	0.552
MOD_CK2_1	457	463	PF00069	0.579
MOD_CK2_1	556	562	PF00069	0.510
MOD_CK2_1	582	588	PF00069	0.532
MOD_GlcNHglycan	148	151	PF01048	0.765
MOD_GlcNHglycan	406	409	PF01048	0.445
MOD_GlcNHglycan	441	444	PF01048	0.507
MOD_GlcNHglycan	448	451	PF01048	0.399
MOD_GlcNHglycan	465	468	PF01048	0.343
MOD_GlcNHglycan	503	506	PF01048	0.576
MOD_GlcNHglycan	522	525	PF01048	0.450
MOD_GlcNHglycan	663	666	PF01048	0.570
MOD_GSK3_1	321	328	PF00069	0.458
MOD_GSK3_1	417	424	PF00069	0.588
MOD_GSK3_1	429	436	PF00069	0.457
MOD_GSK3_1	468	475	PF00069	0.463
MOD_N-GLC_1	512	517	PF02516	0.546
MOD_N-GLC_1	619	624	PF02516	0.500
MOD_NEK2_1	193	198	PF00069	0.538
MOD_NEK2_1	376	381	PF00069	0.524
MOD_NEK2_1	472	477	PF00069	0.532
MOD_NEK2_1	493	498	PF00069	0.527
MOD_NEK2_1	582	587	PF00069	0.458
MOD_NEK2_1	654	659	PF00069	0.562
MOD_PIKK_1	117	123	PF00454	0.601
MOD_PIKK_1	157	163	PF00454	0.583
MOD_PIKK_1	199	205	PF00454	0.485
MOD_PIKK_1	376	382	PF00454	0.540
MOD_PIKK_1	496	502	PF00454	0.537
MOD_PKA_2	146	152	PF00069	0.724
MOD_PKA_2	193	199	PF00069	0.562
MOD_PKA_2	388	394	PF00069	0.486
MOD_PKA_2	563	569	PF00069	0.537
MOD_PKB_1	14	22	PF00069	0.676
MOD_PKB_1	72	80	PF00069	0.698
MOD_Plk_1	204	210	PF00069	0.443
MOD_Plk_1	512	518	PF00069	0.553
MOD_Plk_4	17	23	PF00069	0.663
MOD_Plk_4	272	278	PF00069	0.518
MOD_Plk_4	325	331	PF00069	0.479
MOD_Plk_4	472	478	PF00069	0.428
MOD_Plk_4	506	512	PF00069	0.418
MOD_ProDKin_1	239	245	PF00069	0.443
MOD_ProDKin_1	254	260	PF00069	0.423
MOD_ProDKin_1	595	601	PF00069	0.520
MOD_ProDKin_1	644	650	PF00069	0.596
MOD_SUMO_for_1	222	225	PF00179	0.585
MOD_SUMO_rev_2	257	264	PF00179	0.458
TRG_DiLeu_BaEn_1	188	193	PF01217	0.508
TRG_DiLeu_BaEn_1	365	370	PF01217	0.404
TRG_DiLeu_BaEn_4	298	304	PF01217	0.509
TRG_DiLeu_BaLyEn_6	162	167	PF01217	0.468
TRG_DiLeu_LyEn_5	188	193	PF01217	0.547
TRG_ENDOCYTIC_2	18	21	PF00928	0.696
TRG_ER_diArg_1	13	16	PF00400	0.760
TRG_ER_diArg_1	151	153	PF00400	0.753
TRG_ER_diArg_1	190	192	PF00400	0.495
TRG_NES_CRM1_1	279	293	PF08389	0.456
TRG_Pf-PMV_PEXEL_1	584	588	PF00026	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I169	Leptomonas seymouri	44%	100%
A0A0S4JB89	Bodo saltans	25%	91%
A0A1X0P251	Trypanosomatidae	38%	100%
A0A422P4U2	Trypanosoma rangeli	37%	100%
A4HI33	Leishmania braziliensis	80%	100%
A4I5A9	Leishmania infantum	100%	100%
C9ZQP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	91%
E9B0K5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q7M7	Leishmania major	92%	97%