Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X346_LEIDO

TriTrypDb:

LdBPK_300840.1 , LdCL_300013500 , LDHU3_30.1050

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X346

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X346

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.514
CLV_C14_Caspase3-7	128	132	PF00656	0.495
CLV_C14_Caspase3-7	151	155	PF00656	0.624
CLV_NRD_NRD_1	194	196	PF00675	0.593
CLV_NRD_NRD_1	214	216	PF00675	0.490
CLV_NRD_NRD_1	247	249	PF00675	0.549
CLV_NRD_NRD_1	333	335	PF00675	0.628
CLV_NRD_NRD_1	350	352	PF00675	0.551
CLV_NRD_NRD_1	358	360	PF00675	0.516
CLV_NRD_NRD_1	58	60	PF00675	0.635
CLV_PCSK_FUR_1	245	249	PF00082	0.544
CLV_PCSK_KEX2_1	247	249	PF00082	0.549
CLV_PCSK_KEX2_1	333	335	PF00082	0.602
CLV_PCSK_KEX2_1	349	351	PF00082	0.552
CLV_PCSK_KEX2_1	358	360	PF00082	0.508
CLV_PCSK_KEX2_1	419	421	PF00082	0.548
CLV_PCSK_KEX2_1	42	44	PF00082	0.578
CLV_PCSK_KEX2_1	423	425	PF00082	0.548
CLV_PCSK_PC1ET2_1	419	421	PF00082	0.548
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.578
CLV_PCSK_PC1ET2_1	423	425	PF00082	0.548
CLV_PCSK_PC7_1	243	249	PF00082	0.543
CLV_PCSK_PC7_1	329	335	PF00082	0.587
CLV_PCSK_SKI1_1	162	166	PF00082	0.606
CLV_PCSK_SKI1_1	216	220	PF00082	0.640
CLV_PCSK_SKI1_1	371	375	PF00082	0.640
CLV_PCSK_SKI1_1	42	46	PF00082	0.585
CLV_Separin_Metazoa	159	163	PF03568	0.602
DEG_APCC_DBOX_1	350	358	PF00400	0.530
DEG_SCF_FBW7_2	150	156	PF00400	0.627
DOC_CKS1_1	150	155	PF01111	0.629
DOC_MAPK_gen_1	349	357	PF00069	0.534
DOC_MAPK_gen_1	358	365	PF00069	0.435
DOC_MAPK_RevD_3	29	43	PF00069	0.554
DOC_PP2B_LxvP_1	138	141	PF13499	0.587
DOC_USP7_MATH_1	141	145	PF00917	0.639
DOC_USP7_MATH_1	17	21	PF00917	0.615
DOC_USP7_MATH_2	310	316	PF00917	0.589
DOC_USP7_UBL2_3	419	423	PF12436	0.553
DOC_WW_Pin1_4	149	154	PF00397	0.639
DOC_WW_Pin1_4	202	207	PF00397	0.708
DOC_WW_Pin1_4	316	321	PF00397	0.699
LIG_14-3-3_CanoR_1	135	141	PF00244	0.604
LIG_14-3-3_CanoR_1	204	212	PF00244	0.652
LIG_14-3-3_CanoR_1	224	234	PF00244	0.713
LIG_14-3-3_CanoR_1	247	256	PF00244	0.589
LIG_14-3-3_CanoR_1	409	417	PF00244	0.440
LIG_14-3-3_CanoR_1	43	47	PF00244	0.644
LIG_APCC_ABBA_1	61	66	PF00400	0.645
LIG_BIR_II_1	1	5	PF00653	0.561
LIG_BRCT_BRCA1_1	222	226	PF00533	0.676
LIG_BRCT_BRCA1_1	314	318	PF00533	0.594
LIG_FHA_1	155	161	PF00498	0.550
LIG_FHA_1	236	242	PF00498	0.727
LIG_FHA_1	249	255	PF00498	0.543
LIG_FHA_1	279	285	PF00498	0.660
LIG_FHA_1	30	36	PF00498	0.572
LIG_FHA_1	330	336	PF00498	0.679
LIG_FHA_1	394	400	PF00498	0.503
LIG_FHA_2	198	204	PF00498	0.645
LIG_FHA_2	311	317	PF00498	0.640
LIG_FHA_2	341	347	PF00498	0.558
LIG_FHA_2	46	52	PF00498	0.649
LIG_LIR_Gen_1	125	134	PF02991	0.608
LIG_LIR_Gen_1	379	388	PF02991	0.477
LIG_LIR_Nem_3	125	130	PF02991	0.663
LIG_LIR_Nem_3	182	188	PF02991	0.550
LIG_LIR_Nem_3	2	7	PF02991	0.766
LIG_LIR_Nem_3	379	383	PF02991	0.464
LIG_Pex14_3	160	165	PF04695	0.599
LIG_RPA_C_Fungi	354	366	PF08784	0.447
LIG_SH2_STAP1	188	192	PF00017	0.548
LIG_SH2_STAP1	99	103	PF00017	0.541
LIG_SH2_STAT5	111	114	PF00017	0.742
LIG_SH2_STAT5	201	204	PF00017	0.688
LIG_SH2_STAT5	360	363	PF00017	0.519
LIG_SH3_3	147	153	PF00018	0.640
LIG_SH3_3	228	234	PF00018	0.661
LIG_SH3_3	314	320	PF00018	0.545
LIG_SUMO_SIM_anti_2	156	163	PF11976	0.600
LIG_SUMO_SIM_anti_2	352	358	PF11976	0.524
LIG_TRAF2_1	48	51	PF00917	0.651
LIG_WRC_WIRS_1	4	9	PF05994	0.572
MOD_CK1_1	139	145	PF00069	0.597
MOD_CK1_1	205	211	PF00069	0.680
MOD_CK1_1	225	231	PF00069	0.768
MOD_CK1_1	235	241	PF00069	0.518
MOD_CK1_1	285	291	PF00069	0.600
MOD_CK1_1	90	96	PF00069	0.615
MOD_CK2_1	122	128	PF00069	0.591
MOD_CK2_1	254	260	PF00069	0.668
MOD_CK2_1	286	292	PF00069	0.585
MOD_CK2_1	3	9	PF00069	0.569
MOD_CK2_1	310	316	PF00069	0.603
MOD_CK2_1	340	346	PF00069	0.563
MOD_CK2_1	45	51	PF00069	0.649
MOD_Cter_Amidation	245	248	PF01082	0.545
MOD_Cter_Amidation	421	424	PF01082	0.562
MOD_Cter_Amidation	57	60	PF01082	0.663
MOD_GlcNHglycan	1	4	PF01048	0.560
MOD_GlcNHglycan	11	14	PF01048	0.574
MOD_GlcNHglycan	141	144	PF01048	0.619
MOD_GlcNHglycan	19	22	PF01048	0.580
MOD_GlcNHglycan	302	305	PF01048	0.546
MOD_GlcNHglycan	320	323	PF01048	0.573
MOD_GSK3_1	222	229	PF00069	0.614
MOD_GSK3_1	261	268	PF00069	0.644
MOD_GSK3_1	278	285	PF00069	0.511
MOD_GSK3_1	300	307	PF00069	0.558
MOD_GSK3_1	312	319	PF00069	0.701
MOD_GSK3_1	336	343	PF00069	0.623
MOD_GSK3_1	388	395	PF00069	0.504
MOD_GSK3_1	86	93	PF00069	0.598
MOD_N-GLC_1	335	340	PF02516	0.504
MOD_N-GLC_1	388	393	PF02516	0.498
MOD_NEK2_1	226	231	PF00069	0.673
MOD_NEK2_1	261	266	PF00069	0.654
MOD_NEK2_1	29	34	PF00069	0.622
MOD_NEK2_1	337	342	PF00069	0.584
MOD_NEK2_1	415	420	PF00069	0.406
MOD_NEK2_1	88	93	PF00069	0.598
MOD_NEK2_2	3	8	PF00069	0.594
MOD_PIKK_1	29	35	PF00454	0.731
MOD_PIKK_1	310	316	PF00454	0.603
MOD_PIKK_1	394	400	PF00454	0.433
MOD_PIKK_1	88	94	PF00454	0.644
MOD_PKA_1	247	253	PF00069	0.556
MOD_PKA_1	42	48	PF00069	0.643
MOD_PKA_2	174	180	PF00069	0.631
MOD_PKA_2	190	196	PF00069	0.512
MOD_PKA_2	226	232	PF00069	0.709
MOD_PKA_2	247	253	PF00069	0.583
MOD_PKA_2	415	421	PF00069	0.409
MOD_PKA_2	42	48	PF00069	0.643
MOD_PKB_1	245	253	PF00069	0.640
MOD_Plk_1	279	285	PF00069	0.632
MOD_Plk_1	388	394	PF00069	0.505
MOD_Plk_1	401	407	PF00069	0.412
MOD_Plk_2-3	154	160	PF00069	0.602
MOD_Plk_2-3	197	203	PF00069	0.568
MOD_Plk_4	279	285	PF00069	0.584
MOD_ProDKin_1	149	155	PF00069	0.635
MOD_ProDKin_1	202	208	PF00069	0.708
MOD_ProDKin_1	316	322	PF00069	0.698
MOD_SUMO_for_1	399	402	PF00179	0.507
TRG_DiLeu_BaEn_1	156	161	PF01217	0.597
TRG_DiLeu_BaEn_1	352	357	PF01217	0.525
TRG_DiLeu_BaEn_4	352	358	PF01217	0.524
TRG_ENDOCYTIC_2	360	363	PF00928	0.457
TRG_ENDOCYTIC_2	380	383	PF00928	0.341
TRG_ER_diArg_1	244	247	PF00400	0.568
TRG_ER_diArg_1	333	335	PF00400	0.602
TRG_ER_diArg_1	348	351	PF00400	0.553
TRG_ER_diArg_1	357	359	PF00400	0.517
TRG_NES_CRM1_1	25	40	PF08389	0.624
TRG_Pf-PMV_PEXEL_1	371	375	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I5B0	Leishmania infantum	100%	100%
C6K3W7	Leptomonas seymouri	30%	100%
E9B0K6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q7M6	Leishmania major	88%	100%