Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X345_LEIDO

TriTrypDb:

LdBPK_300870.1 , LdCL_300013800 , LDHU3_30.1090

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3S7X345

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X345

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.721
CLV_C14_Caspase3-7	177	181	PF00656	0.725
CLV_NRD_NRD_1	135	137	PF00675	0.482
CLV_PCSK_KEX2_1	135	137	PF00082	0.486
DEG_Nend_UBRbox_3	1	3	PF02207	0.540
DOC_CKS1_1	182	187	PF01111	0.691
DOC_CYCLIN_yCln2_LP_2	232	238	PF00134	0.799
DOC_PP2B_LxvP_1	222	225	PF13499	0.824
DOC_PP2B_LxvP_1	232	235	PF13499	0.671
DOC_USP7_MATH_1	225	229	PF00917	0.795
DOC_USP7_MATH_1	40	44	PF00917	0.724
DOC_USP7_MATH_1	71	75	PF00917	0.532
DOC_USP7_MATH_1	9	13	PF00917	0.524
DOC_WW_Pin1_4	181	186	PF00397	0.815
LIG_14-3-3_CanoR_1	105	109	PF00244	0.735
LIG_14-3-3_CanoR_1	136	146	PF00244	0.693
LIG_14-3-3_CanoR_1	211	218	PF00244	0.747
LIG_APCC_ABBA_1	99	104	PF00400	0.537
LIG_BRCT_BRCA1_1	56	60	PF00533	0.524
LIG_FHA_1	224	230	PF00498	0.826
LIG_FHA_1	243	249	PF00498	0.601
LIG_FHA_2	138	144	PF00498	0.689
LIG_LIR_Apic_2	216	221	PF02991	0.827
LIG_LIR_Gen_1	174	183	PF02991	0.726
LIG_LIR_Nem_3	107	112	PF02991	0.733
LIG_LIR_Nem_3	13	19	PF02991	0.524
LIG_LIR_Nem_3	174	179	PF02991	0.758
LIG_LIR_Nem_3	187	192	PF02991	0.738
LIG_LIR_Nem_3	48	54	PF02991	0.524
LIG_NRBOX	24	30	PF00104	0.399
LIG_PDZ_Class_2	244	249	PF00595	0.820
LIG_Pex14_1	96	100	PF04695	0.524
LIG_Pex14_2	47	51	PF04695	0.524
LIG_SH2_CRK	16	20	PF00017	0.524
LIG_SH2_CRK	218	222	PF00017	0.831
LIG_SH2_NCK_1	139	143	PF00017	0.799
LIG_SH2_STAT3	236	239	PF00017	0.798
LIG_SH2_STAT5	100	103	PF00017	0.664
LIG_SH2_STAT5	108	111	PF00017	0.674
LIG_SH2_STAT5	137	140	PF00017	0.792
LIG_SH2_STAT5	192	195	PF00017	0.803
LIG_SH2_STAT5	236	239	PF00017	0.798
LIG_SH3_3	179	185	PF00018	0.689
LIG_SUMO_SIM_par_1	220	226	PF11976	0.826
LIG_UBA3_1	25	34	PF00899	0.678
MOD_CK1_1	213	219	PF00069	0.813
MOD_CK1_1	242	248	PF00069	0.819
MOD_CK2_1	171	177	PF00069	0.728
MOD_GlcNHglycan	114	117	PF01048	0.467
MOD_GlcNHglycan	12	15	PF01048	0.358
MOD_GlcNHglycan	131	134	PF01048	0.505
MOD_GlcNHglycan	157	160	PF01048	0.519
MOD_GlcNHglycan	171	174	PF01048	0.431
MOD_GlcNHglycan	213	216	PF01048	0.579
MOD_GSK3_1	151	158	PF00069	0.722
MOD_GSK3_1	165	172	PF00069	0.629
MOD_GSK3_1	50	57	PF00069	0.524
MOD_NEK2_1	167	172	PF00069	0.676
MOD_NEK2_1	50	55	PF00069	0.524
MOD_PIKK_1	184	190	PF00454	0.823
MOD_PK_1	151	157	PF00069	0.722
MOD_PKA_2	104	110	PF00069	0.727
MOD_PKA_2	210	216	PF00069	0.744
MOD_Plk_1	239	245	PF00069	0.821
MOD_Plk_4	104	110	PF00069	0.647
MOD_Plk_4	213	219	PF00069	0.821
MOD_Plk_4	54	60	PF00069	0.524
MOD_ProDKin_1	181	187	PF00069	0.815
TRG_DiLeu_BaEn_1	75	80	PF01217	0.432
TRG_ENDOCYTIC_2	16	19	PF00928	0.524
TRG_ER_diArg_1	135	137	PF00400	0.791

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I5B3	Leishmania infantum	100%	100%
E9B0K9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q7M3	Leishmania major	90%	100%