Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X342_LEIDO

TriTrypDb:

LdBPK_300780.1 , LdCL_300012900 , LDHU3_30.0990

Length:

171

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X342

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X342

PDB structure(s): 7ane_n

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.522
CLV_NRD_NRD_1	43	45	PF00675	0.397
CLV_NRD_NRD_1	46	48	PF00675	0.409
CLV_NRD_NRD_1	53	55	PF00675	0.429
CLV_PCSK_KEX2_1	101	103	PF00082	0.363
CLV_PCSK_KEX2_1	27	29	PF00082	0.428
CLV_PCSK_KEX2_1	3	5	PF00082	0.522
CLV_PCSK_KEX2_1	43	45	PF00082	0.391
CLV_PCSK_KEX2_1	53	55	PF00082	0.429
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.363
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.436
CLV_PCSK_SKI1_1	27	31	PF00082	0.409
DEG_Nend_Nbox_1	1	3	PF02207	0.538
DOC_PP2B_LxvP_1	65	68	PF13499	0.436
DOC_PP4_FxxP_1	81	84	PF00568	0.409
DOC_USP7_MATH_1	20	24	PF00917	0.547
DOC_USP7_UBL2_3	115	119	PF12436	0.379
DOC_USP7_UBL2_3	27	31	PF12436	0.416
DOC_WW_Pin1_4	126	131	PF00397	0.426
LIG_14-3-3_CanoR_1	102	108	PF00244	0.346
LIG_14-3-3_CanoR_1	117	122	PF00244	0.391
LIG_14-3-3_CanoR_1	3	11	PF00244	0.591
LIG_Actin_WH2_2	18	33	PF00022	0.593
LIG_BRCT_BRCA1_1	77	81	PF00533	0.419
LIG_deltaCOP1_diTrp_1	92	98	PF00928	0.382
LIG_eIF4E_1	163	169	PF01652	0.341
LIG_LIR_Apic_2	78	84	PF02991	0.410
LIG_LIR_Nem_3	120	124	PF02991	0.402
LIG_LIR_Nem_3	35	40	PF02991	0.363
LIG_Pex14_1	93	97	PF04695	0.401
LIG_Pex14_2	121	125	PF04695	0.407
LIG_REV1ctd_RIR_1	95	106	PF16727	0.366
LIG_SH2_STAT3	105	108	PF00017	0.353
LIG_SH2_STAT5	105	108	PF00017	0.353
LIG_SH2_STAT5	163	166	PF00017	0.377
LIG_SH2_STAT5	40	43	PF00017	0.381
LIG_SH2_STAT5	69	72	PF00017	0.383
LIG_SH2_STAT5	88	91	PF00017	0.387
MOD_CDC14_SPxK_1	129	132	PF00782	0.474
MOD_CDK_SPxK_1	126	132	PF00069	0.425
MOD_CK1_1	120	126	PF00069	0.397
MOD_CK1_1	72	78	PF00069	0.369
MOD_CK2_1	120	126	PF00069	0.378
MOD_GlcNHglycan	111	114	PF01048	0.427
MOD_GlcNHglycan	22	25	PF01048	0.530
MOD_GlcNHglycan	6	9	PF01048	0.594
MOD_GSK3_1	87	94	PF00069	0.404
MOD_NEK2_1	97	102	PF00069	0.357
MOD_PIKK_1	57	63	PF00454	0.571
MOD_PIKK_1	75	81	PF00454	0.266
MOD_Plk_4	120	126	PF00069	0.397
MOD_Plk_4	77	83	PF00069	0.421
MOD_ProDKin_1	126	132	PF00069	0.432
TRG_ER_diArg_1	2	4	PF00400	0.519
TRG_ER_diArg_1	53	55	PF00400	0.436
TRG_NLS_MonoExtC_3	156	162	PF00514	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7E7	Leptomonas seymouri	88%	100%
A0A0S4JBB3	Bodo saltans	69%	84%
A0A1X0P373	Trypanosomatidae	83%	99%
A0A3R7P4T8	Trypanosoma rangeli	82%	99%
A4HI27	Leishmania braziliensis	92%	100%
A4I5A4	Leishmania infantum	99%	100%
C9ZQN7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	80%	99%
E9B0K0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q7N2	Leishmania major	99%	100%