LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania donovani
UniProt:
A0A3S7X330_LEIDO
TriTrypDb:
LdBPK_300390.1 , LdCL_300009000 , LDHU3_30.0560
Length:
250

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 4
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

A0A3S7X330
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X330

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 186 190 PF00656 0.805
CLV_C14_Caspase3-7 220 224 PF00656 0.681
CLV_C14_Caspase3-7 65 69 PF00656 0.482
CLV_NRD_NRD_1 242 244 PF00675 0.592
CLV_NRD_NRD_1 246 248 PF00675 0.539
CLV_PCSK_KEX2_1 242 244 PF00082 0.521
CLV_PCSK_SKI1_1 16 20 PF00082 0.425
CLV_PCSK_SKI1_1 81 85 PF00082 0.595
DEG_Kelch_Keap1_1 145 150 PF01344 0.698
DEG_Nend_Nbox_1 1 3 PF02207 0.662
DEG_SCF_FBW7_1 215 222 PF00400 0.711
DEG_SCF_TRCP1_1 68 74 PF00400 0.509
DEG_SPOP_SBC_1 45 49 PF00917 0.428
DOC_CKS1_1 161 166 PF01111 0.721
DOC_MAPK_MEF2A_6 11 19 PF00069 0.601
DOC_MAPK_MEF2A_6 95 103 PF00069 0.320
DOC_PP2B_LxvP_1 211 214 PF13499 0.692
DOC_PP4_FxxP_1 212 215 PF00568 0.803
DOC_PP4_MxPP_1 169 172 PF00568 0.687
DOC_USP7_MATH_1 45 49 PF00917 0.444
DOC_WW_Pin1_4 160 165 PF00397 0.740
DOC_WW_Pin1_4 2 7 PF00397 0.625
DOC_WW_Pin1_4 215 220 PF00397 0.783
DOC_WW_Pin1_4 46 51 PF00397 0.459
DOC_WW_Pin1_4 71 76 PF00397 0.536
LIG_14-3-3_CanoR_1 235 239 PF00244 0.725
LIG_Actin_WH2_2 5 22 PF00022 0.604
LIG_BRCT_BRCA1_1 206 210 PF00533 0.702
LIG_DCNL_PONY_1 1 4 PF03556 0.638
LIG_deltaCOP1_diTrp_1 85 96 PF00928 0.431
LIG_FHA_1 132 138 PF00498 0.726
LIG_FHA_1 177 183 PF00498 0.713
LIG_FHA_2 126 132 PF00498 0.694
LIG_FHA_2 63 69 PF00498 0.447
LIG_LIR_Apic_2 209 215 PF02991 0.805
LIG_LIR_Gen_1 207 215 PF02991 0.751
LIG_LIR_Gen_1 86 97 PF02991 0.397
LIG_LIR_Nem_3 122 126 PF02991 0.647
LIG_LIR_Nem_3 207 213 PF02991 0.724
LIG_LIR_Nem_3 86 92 PF02991 0.443
LIG_LIR_Nem_3 93 99 PF02991 0.288
LIG_NRBOX 8 14 PF00104 0.558
LIG_NRP_CendR_1 247 250 PF00754 0.487
LIG_Pex14_2 96 100 PF04695 0.385
LIG_SH2_CRK 161 165 PF00017 0.667
LIG_SH2_STAT5 119 122 PF00017 0.618
LIG_SH3_1 167 173 PF00018 0.682
LIG_SH3_3 167 173 PF00018 0.783
LIG_SH3_3 72 78 PF00018 0.606
LIG_SUMO_SIM_par_1 33 38 PF11976 0.385
LIG_TRAF2_1 183 186 PF00917 0.705
LIG_UBA3_1 12 16 PF00899 0.588
MOD_CDK_SPK_2 160 165 PF00069 0.722
MOD_CDK_SPxxK_3 160 167 PF00069 0.721
MOD_CK1_1 129 135 PF00069 0.711
MOD_CK1_1 136 142 PF00069 0.693
MOD_CK1_1 143 149 PF00069 0.649
MOD_CK1_1 151 157 PF00069 0.646
MOD_CK1_1 204 210 PF00069 0.772
MOD_CK1_1 234 240 PF00069 0.687
MOD_CK1_1 38 44 PF00069 0.488
MOD_CK1_1 48 54 PF00069 0.451
MOD_CK1_1 5 11 PF00069 0.592
MOD_CK1_1 58 64 PF00069 0.392
MOD_CK1_1 66 72 PF00069 0.467
MOD_CK1_1 76 82 PF00069 0.476
MOD_CK2_1 129 135 PF00069 0.762
MOD_CK2_1 144 150 PF00069 0.645
MOD_CK2_1 151 157 PF00069 0.716
MOD_GlcNHglycan 147 150 PF01048 0.554
MOD_GlcNHglycan 154 157 PF01048 0.542
MOD_GlcNHglycan 37 40 PF01048 0.652
MOD_GlcNHglycan 55 58 PF01048 0.609
MOD_GlcNHglycan 68 71 PF01048 0.625
MOD_GSK3_1 125 132 PF00069 0.692
MOD_GSK3_1 136 143 PF00069 0.667
MOD_GSK3_1 144 151 PF00069 0.618
MOD_GSK3_1 201 208 PF00069 0.734
MOD_GSK3_1 215 222 PF00069 0.755
MOD_GSK3_1 234 241 PF00069 0.706
MOD_GSK3_1 35 42 PF00069 0.576
MOD_GSK3_1 44 51 PF00069 0.441
MOD_GSK3_1 58 65 PF00069 0.499
MOD_N-GLC_1 204 209 PF02516 0.603
MOD_N-GLC_1 90 95 PF02516 0.613
MOD_NEK2_1 238 243 PF00069 0.699
MOD_NEK2_1 44 49 PF00069 0.539
MOD_NEK2_2 90 95 PF00069 0.374
MOD_PIKK_1 140 146 PF00454 0.712
MOD_PIKK_1 199 205 PF00454 0.702
MOD_PKA_2 139 145 PF00069 0.672
MOD_PKA_2 234 240 PF00069 0.717
MOD_Plk_1 63 69 PF00069 0.567
MOD_Plk_1 90 96 PF00069 0.413
MOD_ProDKin_1 160 166 PF00069 0.740
MOD_ProDKin_1 2 8 PF00069 0.622
MOD_ProDKin_1 215 221 PF00069 0.786
MOD_ProDKin_1 46 52 PF00069 0.461
MOD_ProDKin_1 71 77 PF00069 0.535
TRG_DiLeu_BaEn_2 205 211 PF01217 0.704
TRG_DiLeu_BaLyEn_6 79 84 PF01217 0.408
TRG_DiLeu_BaLyEn_6 8 13 PF01217 0.645
TRG_ENDOCYTIC_2 123 126 PF00928 0.665
TRG_ER_diArg_1 164 167 PF00400 0.721

Homologs

Protein Taxonomy Sequence identity Coverage
A4HHY6 Leishmania braziliensis 64% 100%
A4I566 Leishmania infantum 98% 100%
E9B0G3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 100%
Q4Q7S0 Leishmania major 84% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS