LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X327_LEIDO
TriTrypDb:
LdBPK_300670.1 , LdCL_300011800 , LDHU3_30.0860
Length:
397

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S7X327
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X327

PDB structure(s): 7ane_aj

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 171 175 PF00656 0.491
CLV_NRD_NRD_1 264 266 PF00675 0.395
CLV_NRD_NRD_1 7 9 PF00675 0.619
CLV_PCSK_KEX2_1 389 391 PF00082 0.616
CLV_PCSK_KEX2_1 7 9 PF00082 0.619
CLV_PCSK_PC1ET2_1 389 391 PF00082 0.616
CLV_PCSK_SKI1_1 179 183 PF00082 0.444
CLV_PCSK_SKI1_1 184 188 PF00082 0.486
CLV_PCSK_SKI1_1 218 222 PF00082 0.404
CLV_PCSK_SKI1_1 257 261 PF00082 0.373
CLV_PCSK_SKI1_1 265 269 PF00082 0.371
CLV_PCSK_SKI1_1 7 11 PF00082 0.651
DEG_APCC_DBOX_1 217 225 PF00400 0.442
DEG_APCC_KENBOX_2 289 293 PF00400 0.445
DEG_Nend_Nbox_1 1 3 PF02207 0.595
DEG_SCF_FBW7_2 92 99 PF00400 0.465
DOC_CKS1_1 196 201 PF01111 0.492
DOC_CKS1_1 93 98 PF01111 0.462
DOC_CYCLIN_RxL_1 254 264 PF00134 0.375
DOC_CYCLIN_RxL_1 3 13 PF00134 0.620
DOC_CYCLIN_yCln2_LP_2 48 54 PF00134 0.631
DOC_MAPK_gen_1 265 272 PF00069 0.407
DOC_PP1_RVXF_1 263 270 PF00149 0.391
DOC_PP1_RVXF_1 312 319 PF00149 0.466
DOC_PP2B_LxvP_1 285 288 PF13499 0.453
DOC_PP2B_LxvP_1 48 51 PF13499 0.615
DOC_PP4_FxxP_1 196 199 PF00568 0.504
DOC_USP7_MATH_1 369 373 PF00917 0.698
DOC_USP7_MATH_1 54 58 PF00917 0.502
DOC_WW_Pin1_4 10 15 PF00397 0.508
DOC_WW_Pin1_4 105 110 PF00397 0.463
DOC_WW_Pin1_4 17 22 PF00397 0.440
DOC_WW_Pin1_4 190 195 PF00397 0.402
DOC_WW_Pin1_4 309 314 PF00397 0.441
DOC_WW_Pin1_4 318 323 PF00397 0.466
DOC_WW_Pin1_4 328 333 PF00397 0.476
DOC_WW_Pin1_4 92 97 PF00397 0.461
LIG_14-3-3_CanoR_1 271 275 PF00244 0.397
LIG_14-3-3_CanoR_1 40 45 PF00244 0.513
LIG_Actin_WH2_2 255 273 PF00022 0.537
LIG_BRCT_BRCA1_1 387 391 PF00533 0.689
LIG_Clathr_ClatBox_1 76 80 PF01394 0.536
LIG_deltaCOP1_diTrp_1 118 125 PF00928 0.439
LIG_deltaCOP1_diTrp_1 177 182 PF00928 0.444
LIG_deltaCOP1_diTrp_1 188 196 PF00928 0.356
LIG_deltaCOP1_diTrp_1 377 384 PF00928 0.564
LIG_eIF4E_1 254 260 PF01652 0.388
LIG_FHA_1 181 187 PF00498 0.526
LIG_FHA_2 271 277 PF00498 0.441
LIG_LIR_Apic_2 193 199 PF02991 0.508
LIG_LIR_Gen_1 102 111 PF02991 0.503
LIG_LIR_Gen_1 198 208 PF02991 0.368
LIG_LIR_Gen_1 273 282 PF02991 0.431
LIG_LIR_Nem_3 102 107 PF02991 0.474
LIG_LIR_Nem_3 175 181 PF02991 0.422
LIG_LIR_Nem_3 198 204 PF02991 0.393
LIG_LIR_Nem_3 273 277 PF02991 0.392
LIG_LIR_Nem_3 293 299 PF02991 0.199
LIG_LIR_Nem_3 367 373 PF02991 0.608
LIG_LIR_Nem_3 377 382 PF02991 0.594
LIG_PCNA_yPIPBox_3 90 101 PF02747 0.537
LIG_Pex14_1 178 182 PF04695 0.375
LIG_SH2_CRK 12 16 PF00017 0.502
LIG_SH2_CRK 252 256 PF00017 0.456
LIG_SH2_CRK 32 36 PF00017 0.267
LIG_SH2_NCK_1 12 16 PF00017 0.502
LIG_SH2_NCK_1 32 36 PF00017 0.267
LIG_SH2_SRC 52 55 PF00017 0.617
LIG_SH2_STAP1 241 245 PF00017 0.463
LIG_SH2_STAP1 359 363 PF00017 0.593
LIG_SH2_STAP1 364 368 PF00017 0.608
LIG_SH2_STAT5 12 15 PF00017 0.511
LIG_SH2_STAT5 192 195 PF00017 0.405
LIG_SH2_STAT5 203 206 PF00017 0.388
LIG_SH2_STAT5 254 257 PF00017 0.381
LIG_SH2_STAT5 258 261 PF00017 0.368
LIG_SH2_STAT5 317 320 PF00017 0.454
LIG_SH2_STAT5 357 360 PF00017 0.519
LIG_SH3_1 90 96 PF00018 0.462
LIG_SH3_3 11 17 PF00018 0.499
LIG_SH3_3 155 161 PF00018 0.473
LIG_SH3_3 48 54 PF00018 0.631
LIG_SH3_3 90 96 PF00018 0.462
LIG_TRAF2_1 374 377 PF00917 0.581
LIG_TYR_ITIM 10 15 PF00017 0.522
LIG_TYR_ITIM 272 277 PF00017 0.415
LIG_UBA3_1 259 266 PF00899 0.447
LIG_WW_2 158 161 PF00397 0.457
MOD_CDK_SPK_2 309 314 PF00069 0.450
MOD_CDK_SPxxK_3 328 335 PF00069 0.617
MOD_CK1_1 195 201 PF00069 0.541
MOD_CK1_1 328 334 PF00069 0.696
MOD_CK2_1 130 136 PF00069 0.494
MOD_GlcNHglycan 132 135 PF01048 0.453
MOD_GlcNHglycan 152 156 PF01048 0.592
MOD_GlcNHglycan 174 177 PF01048 0.434
MOD_GlcNHglycan 327 330 PF01048 0.669
MOD_GlcNHglycan 393 396 PF01048 0.699
MOD_GSK3_1 168 175 PF00069 0.436
MOD_GSK3_1 195 202 PF00069 0.460
MOD_GSK3_1 320 327 PF00069 0.554
MOD_GSK3_1 40 47 PF00069 0.557
MOD_N-GLC_1 190 195 PF02516 0.396
MOD_N-GLC_1 291 296 PF02516 0.537
MOD_N-GLC_1 44 49 PF02516 0.516
MOD_NEK2_1 130 135 PF00069 0.515
MOD_NEK2_1 168 173 PF00069 0.373
MOD_NEK2_1 2 7 PF00069 0.599
MOD_NEK2_1 204 209 PF00069 0.387
MOD_NEK2_1 23 28 PF00069 0.518
MOD_NEK2_1 270 275 PF00069 0.417
MOD_NEK2_1 325 330 PF00069 0.578
MOD_NEK2_2 301 306 PF00069 0.389
MOD_PIKK_1 23 29 PF00454 0.437
MOD_PIKK_1 320 326 PF00454 0.558
MOD_PK_1 40 46 PF00069 0.571
MOD_PKA_2 270 276 PF00069 0.415
MOD_PKA_2 39 45 PF00069 0.588
MOD_Plk_1 291 297 PF00069 0.542
MOD_Plk_1 44 50 PF00069 0.514
MOD_Plk_4 291 297 PF00069 0.542
MOD_ProDKin_1 10 16 PF00069 0.500
MOD_ProDKin_1 105 111 PF00069 0.456
MOD_ProDKin_1 17 23 PF00069 0.437
MOD_ProDKin_1 190 196 PF00069 0.397
MOD_ProDKin_1 309 315 PF00069 0.444
MOD_ProDKin_1 318 324 PF00069 0.475
MOD_ProDKin_1 328 334 PF00069 0.473
MOD_ProDKin_1 92 98 PF00069 0.465
TRG_DiLeu_BaEn_1 215 220 PF01217 0.461
TRG_DiLeu_BaEn_1 235 240 PF01217 0.479
TRG_DiLeu_BaLyEn_6 106 111 PF01217 0.478
TRG_DiLeu_BaLyEn_6 5 10 PF01217 0.713
TRG_ENDOCYTIC_2 12 15 PF00928 0.511
TRG_ENDOCYTIC_2 252 255 PF00928 0.367
TRG_ENDOCYTIC_2 274 277 PF00928 0.374
TRG_ENDOCYTIC_2 62 65 PF00928 0.414
TRG_ER_diArg_1 7 9 PF00400 0.621
TRG_Pf-PMV_PEXEL_1 314 319 PF00026 0.475

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I176 Leptomonas seymouri 84% 100%
A0A0S4KKK6 Bodo saltans 49% 100%
A0A1X0P238 Trypanosomatidae 73% 100%
A0A422NIE7 Trypanosoma rangeli 71% 100%
A4HI16 Leishmania braziliensis 95% 100%
A4I593 Leishmania infantum 100% 100%
C9ZQM4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 70% 100%
E9B0J0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
Q4Q7Q8 Leishmania major 98% 100%
V5D870 Trypanosoma cruzi 72% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS