Sad1 / UNC-like C-terminal, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sad1 / UNC-like C-terminal, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X320_LEIDO

TriTrypDb:

LdBPK_300320.1 , LdCL_300008300 , LDHU3_30.0460

Length:

586

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 4, no: 3
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3S7X320

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X320

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.490
CLV_C14_Caspase3-7	320	324	PF00656	0.469
CLV_NRD_NRD_1	101	103	PF00675	0.480
CLV_NRD_NRD_1	157	159	PF00675	0.564
CLV_PCSK_KEX2_1	157	159	PF00082	0.564
CLV_PCSK_KEX2_1	327	329	PF00082	0.723
CLV_PCSK_KEX2_1	48	50	PF00082	0.709
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.707
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.717
CLV_PCSK_SKI1_1	131	135	PF00082	0.560
CLV_PCSK_SKI1_1	172	176	PF00082	0.582
CLV_PCSK_SKI1_1	454	458	PF00082	0.658
CLV_PCSK_SKI1_1	92	96	PF00082	0.484
DEG_APCC_DBOX_1	233	241	PF00400	0.479
DEG_APCC_DBOX_1	474	482	PF00400	0.417
DOC_CKS1_1	241	246	PF01111	0.505
DOC_CKS1_1	388	393	PF01111	0.487
DOC_CKS1_1	399	404	PF01111	0.464
DOC_CYCLIN_RxL_1	451	459	PF00134	0.438
DOC_CYCLIN_yCln2_LP_2	304	310	PF00134	0.616
DOC_MAPK_gen_1	102	109	PF00069	0.323
DOC_MAPK_gen_1	168	176	PF00069	0.387
DOC_PP1_RVXF_1	168	174	PF00149	0.291
DOC_PP2B_LxvP_1	304	307	PF13499	0.566
DOC_PP4_FxxP_1	20	23	PF00568	0.597
DOC_PP4_FxxP_1	235	238	PF00568	0.566
DOC_USP7_MATH_1	220	224	PF00917	0.599
DOC_USP7_MATH_1	253	257	PF00917	0.557
DOC_USP7_MATH_1	326	330	PF00917	0.615
DOC_USP7_MATH_1	331	335	PF00917	0.443
DOC_USP7_MATH_1	343	347	PF00917	0.460
DOC_USP7_MATH_1	409	413	PF00917	0.549
DOC_USP7_MATH_1	417	421	PF00917	0.425
DOC_USP7_MATH_1	506	510	PF00917	0.515
DOC_USP7_MATH_1	521	525	PF00917	0.212
DOC_USP7_MATH_1	70	74	PF00917	0.365
DOC_WW_Pin1_4	226	231	PF00397	0.593
DOC_WW_Pin1_4	240	245	PF00397	0.467
DOC_WW_Pin1_4	327	332	PF00397	0.547
DOC_WW_Pin1_4	387	392	PF00397	0.545
DOC_WW_Pin1_4	398	403	PF00397	0.533
DOC_WW_Pin1_4	40	45	PF00397	0.581
LIG_14-3-3_CanoR_1	131	136	PF00244	0.360
LIG_14-3-3_CanoR_1	261	271	PF00244	0.451
LIG_14-3-3_CanoR_1	33	41	PF00244	0.492
LIG_14-3-3_CanoR_1	357	362	PF00244	0.430
LIG_14-3-3_CanoR_1	427	436	PF00244	0.460
LIG_14-3-3_CanoR_1	454	464	PF00244	0.337
LIG_14-3-3_CanoR_1	49	56	PF00244	0.475
LIG_14-3-3_CanoR_1	6	10	PF00244	0.424
LIG_BIR_III_4	218	222	PF00653	0.475
LIG_deltaCOP1_diTrp_1	185	193	PF00928	0.283
LIG_EVH1_1	240	244	PF00568	0.484
LIG_FHA_1	10	16	PF00498	0.440
LIG_FHA_1	143	149	PF00498	0.382
LIG_FHA_1	314	320	PF00498	0.543
LIG_FHA_1	330	336	PF00498	0.470
LIG_FHA_1	421	427	PF00498	0.460
LIG_FHA_1	451	457	PF00498	0.473
LIG_FHA_2	203	209	PF00498	0.420
LIG_FHA_2	241	247	PF00498	0.529
LIG_FHA_2	362	368	PF00498	0.519
LIG_FHA_2	430	436	PF00498	0.414
LIG_FHA_2	465	471	PF00498	0.364
LIG_LIR_Gen_1	143	154	PF02991	0.364
LIG_LIR_Gen_1	185	195	PF02991	0.283
LIG_LIR_Gen_1	383	391	PF02991	0.468
LIG_LIR_Gen_1	524	533	PF02991	0.426
LIG_LIR_Gen_1	59	70	PF02991	0.397
LIG_LIR_Nem_3	143	149	PF02991	0.287
LIG_LIR_Nem_3	185	190	PF02991	0.283
LIG_LIR_Nem_3	191	196	PF02991	0.280
LIG_LIR_Nem_3	383	388	PF02991	0.468
LIG_LIR_Nem_3	458	464	PF02991	0.383
LIG_LIR_Nem_3	524	528	PF02991	0.426
LIG_LIR_Nem_3	551	556	PF02991	0.727
LIG_LIR_Nem_3	59	65	PF02991	0.389
LIG_MYND_1	238	242	PF01753	0.533
LIG_MYND_1	574	578	PF01753	0.775
LIG_NRBOX	421	427	PF00104	0.460
LIG_NRBOX	9	15	PF00104	0.510
LIG_NRP_CendR_1	584	586	PF00754	0.571
LIG_Pex14_1	178	182	PF04695	0.364
LIG_Pex14_1	553	557	PF04695	0.757
LIG_SH2_CRK	62	66	PF00017	0.355
LIG_SH2_GRB2like	556	559	PF00017	0.716
LIG_SH2_STAP1	62	66	PF00017	0.317
LIG_SH2_STAT5	162	165	PF00017	0.364
LIG_SH2_STAT5	17	20	PF00017	0.466
LIG_SH2_STAT5	66	69	PF00017	0.339
LIG_SH2_STAT5	93	96	PF00017	0.364
LIG_SH3_3	235	241	PF00018	0.509
LIG_SH3_3	244	250	PF00018	0.514
LIG_SH3_3	385	391	PF00018	0.608
LIG_SH3_3	396	402	PF00018	0.422
LIG_SH3_3	543	549	PF00018	0.715
LIG_SH3_3	572	578	PF00018	0.738
LIG_SH3_3	91	97	PF00018	0.389
LIG_SUMO_SIM_anti_2	435	440	PF11976	0.458
LIG_SUMO_SIM_anti_2	5	12	PF11976	0.534
LIG_SUMO_SIM_par_1	21	28	PF11976	0.542
LIG_TRFH_1	93	97	PF08558	0.364
LIG_WRC_WIRS_1	190	195	PF05994	0.280
LIG_WRC_WIRS_1	522	527	PF05994	0.377
MOD_CDC14_SPxK_1	45	48	PF00782	0.560
MOD_CDK_SPxK_1	42	48	PF00069	0.558
MOD_CDK_SPxxK_3	398	405	PF00069	0.525
MOD_CDK_SPxxK_3	42	49	PF00069	0.555
MOD_CK1_1	313	319	PF00069	0.517
MOD_CK1_1	329	335	PF00069	0.458
MOD_CK1_1	380	386	PF00069	0.563
MOD_CK1_1	398	404	PF00069	0.599
MOD_CK1_1	42	48	PF00069	0.520
MOD_CK1_1	420	426	PF00069	0.434
MOD_CK1_1	509	515	PF00069	0.585
MOD_CK1_1	51	57	PF00069	0.487
MOD_CK1_1	539	545	PF00069	0.725
MOD_CK2_1	240	246	PF00069	0.529
MOD_CK2_1	429	435	PF00069	0.506
MOD_CK2_1	464	470	PF00069	0.485
MOD_GlcNHglycan	127	130	PF01048	0.526
MOD_GlcNHglycan	20	23	PF01048	0.630
MOD_GlcNHglycan	222	225	PF01048	0.749
MOD_GlcNHglycan	255	258	PF01048	0.797
MOD_GlcNHglycan	265	268	PF01048	0.654
MOD_GlcNHglycan	312	315	PF01048	0.706
MOD_GlcNHglycan	349	352	PF01048	0.721
MOD_GlcNHglycan	35	38	PF01048	0.670
MOD_GlcNHglycan	379	382	PF01048	0.646
MOD_GlcNHglycan	392	395	PF01048	0.780
MOD_GlcNHglycan	407	410	PF01048	0.694
MOD_GlcNHglycan	415	418	PF01048	0.606
MOD_GlcNHglycan	508	511	PF01048	0.746
MOD_GlcNHglycan	53	56	PF01048	0.580
MOD_GlcNHglycan	550	553	PF01048	0.536
MOD_GlcNHglycan	562	565	PF01048	0.435
MOD_GlcNHglycan	567	570	PF01048	0.549
MOD_GSK3_1	131	138	PF00069	0.323
MOD_GSK3_1	253	260	PF00069	0.515
MOD_GSK3_1	288	295	PF00069	0.571
MOD_GSK3_1	313	320	PF00069	0.548
MOD_GSK3_1	327	334	PF00069	0.541
MOD_GSK3_1	343	350	PF00069	0.540
MOD_GSK3_1	357	364	PF00069	0.526
MOD_GSK3_1	376	383	PF00069	0.543
MOD_GSK3_1	386	393	PF00069	0.528
MOD_GSK3_1	397	404	PF00069	0.493
MOD_GSK3_1	405	412	PF00069	0.536
MOD_GSK3_1	413	420	PF00069	0.428
MOD_GSK3_1	5	12	PF00069	0.422
MOD_GSK3_1	509	516	PF00069	0.541
MOD_GSK3_1	536	543	PF00069	0.619
MOD_GSK3_1	57	64	PF00069	0.336
MOD_GSK3_1	70	77	PF00069	0.375
MOD_N-GLC_1	131	136	PF02516	0.526
MOD_N-GLC_1	347	352	PF02516	0.780
MOD_N-GLC_1	357	362	PF02516	0.673
MOD_N-GLC_1	450	455	PF02516	0.642
MOD_NEK2_1	135	140	PF00069	0.318
MOD_NEK2_1	252	257	PF00069	0.566
MOD_NEK2_1	337	342	PF00069	0.523
MOD_NEK2_1	397	402	PF00069	0.451
MOD_NEK2_1	407	412	PF00069	0.492
MOD_NEK2_1	450	455	PF00069	0.458
MOD_NEK2_1	536	541	PF00069	0.630
MOD_NEK2_2	409	414	PF00069	0.526
MOD_PIKK_1	317	323	PF00454	0.587
MOD_PK_1	357	363	PF00069	0.429
MOD_PKA_1	48	54	PF00069	0.503
MOD_PKA_2	32	38	PF00069	0.444
MOD_PKA_2	429	435	PF00069	0.465
MOD_PKA_2	48	54	PF00069	0.460
MOD_PKA_2	5	11	PF00069	0.500
MOD_PKA_2	560	566	PF00069	0.727
MOD_Plk_1	131	137	PF00069	0.326
MOD_Plk_1	357	363	PF00069	0.514
MOD_Plk_1	366	372	PF00069	0.507
MOD_Plk_1	383	389	PF00069	0.525
MOD_Plk_1	434	440	PF00069	0.382
MOD_Plk_1	450	456	PF00069	0.328
MOD_Plk_4	142	148	PF00069	0.364
MOD_Plk_4	25	31	PF00069	0.619
MOD_Plk_4	409	415	PF00069	0.434
MOD_Plk_4	417	423	PF00069	0.385
MOD_Plk_4	434	440	PF00069	0.294
MOD_Plk_4	5	11	PF00069	0.508
MOD_Plk_4	509	515	PF00069	0.525
MOD_Plk_4	61	67	PF00069	0.389
MOD_ProDKin_1	226	232	PF00069	0.591
MOD_ProDKin_1	240	246	PF00069	0.469
MOD_ProDKin_1	327	333	PF00069	0.548
MOD_ProDKin_1	387	393	PF00069	0.544
MOD_ProDKin_1	398	404	PF00069	0.530
MOD_ProDKin_1	40	46	PF00069	0.581
MOD_SUMO_rev_2	320	329	PF00179	0.488
TRG_DiLeu_BaEn_1	435	440	PF01217	0.413
TRG_ENDOCYTIC_2	162	165	PF00928	0.364
TRG_ENDOCYTIC_2	17	20	PF00928	0.641
TRG_ENDOCYTIC_2	556	559	PF00928	0.798
TRG_ENDOCYTIC_2	62	65	PF00928	0.343
TRG_ER_diArg_1	157	160	PF00400	0.366
TRG_ER_diArg_1	167	170	PF00400	0.292
TRG_ER_diArg_1	452	455	PF00400	0.434
TRG_NES_CRM1_1	476	490	PF08389	0.400
TRG_Pf-PMV_PEXEL_1	444	448	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	454	459	PF00026	0.595
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P2C6	Trypanosomatidae	28%	100%
A0A3R7NHR9	Trypanosoma rangeli	30%	100%
A4HHX6	Leishmania braziliensis	68%	98%
A4I526	Leishmania infantum	100%	100%
E9B0F6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q7S7	Leishmania major	90%	100%