Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X313_LEIDO

TriTrypDb:

LdBPK_300480.1 , LdCL_300009900 , LDHU3_30.0660

Length:

548

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X313

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X313

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.573
CLV_C14_Caspase3-7	309	313	PF00656	0.766
CLV_NRD_NRD_1	195	197	PF00675	0.460
CLV_NRD_NRD_1	254	256	PF00675	0.579
CLV_NRD_NRD_1	424	426	PF00675	0.500
CLV_NRD_NRD_1	463	465	PF00675	0.504
CLV_NRD_NRD_1	507	509	PF00675	0.523
CLV_NRD_NRD_1	520	522	PF00675	0.582
CLV_NRD_NRD_1	526	528	PF00675	0.373
CLV_PCSK_FUR_1	192	196	PF00082	0.572
CLV_PCSK_KEX2_1	194	196	PF00082	0.457
CLV_PCSK_KEX2_1	223	225	PF00082	0.563
CLV_PCSK_KEX2_1	253	255	PF00082	0.518
CLV_PCSK_KEX2_1	424	426	PF00082	0.500
CLV_PCSK_KEX2_1	463	465	PF00082	0.457
CLV_PCSK_KEX2_1	507	509	PF00082	0.488
CLV_PCSK_KEX2_1	520	522	PF00082	0.536
CLV_PCSK_KEX2_1	528	530	PF00082	0.645
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.563
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.532
CLV_PCSK_PC1ET2_1	528	530	PF00082	0.689
CLV_PCSK_SKI1_1	115	119	PF00082	0.638
DEG_APCC_DBOX_1	428	436	PF00400	0.501
DEG_Nend_Nbox_1	1	3	PF02207	0.534
DEG_ODPH_VHL_1	397	410	PF01847	0.553
DEG_SCF_FBW7_2	235	242	PF00400	0.564
DEG_SPOP_SBC_1	320	324	PF00917	0.810
DOC_CKS1_1	117	122	PF01111	0.719
DOC_CKS1_1	350	355	PF01111	0.695
DOC_CYCLIN_RxL_1	112	119	PF00134	0.635
DOC_CYCLIN_RxL_1	368	379	PF00134	0.473
DOC_CYCLIN_yCln2_LP_2	118	124	PF00134	0.637
DOC_MAPK_DCC_7	195	205	PF00069	0.473
DOC_MAPK_DCC_7	378	388	PF00069	0.573
DOC_MAPK_gen_1	128	137	PF00069	0.671
DOC_MAPK_gen_1	463	471	PF00069	0.526
DOC_MAPK_gen_1	524	534	PF00069	0.694
DOC_PP1_RVXF_1	40	47	PF00149	0.413
DOC_PP2B_LxvP_1	118	121	PF13499	0.638
DOC_PP2B_LxvP_1	13	16	PF13499	0.502
DOC_USP7_MATH_1	310	314	PF00917	0.784
DOC_USP7_MATH_1	316	320	PF00917	0.785
DOC_USP7_MATH_1	321	325	PF00917	0.801
DOC_USP7_MATH_1	341	345	PF00917	0.753
DOC_USP7_MATH_1	448	452	PF00917	0.587
DOC_USP7_UBL2_3	249	253	PF12436	0.393
DOC_USP7_UBL2_3	441	445	PF12436	0.565
DOC_USP7_UBL2_3	524	528	PF12436	0.582
DOC_WW_Pin1_4	116	121	PF00397	0.713
DOC_WW_Pin1_4	210	215	PF00397	0.415
DOC_WW_Pin1_4	235	240	PF00397	0.555
DOC_WW_Pin1_4	284	289	PF00397	0.671
DOC_WW_Pin1_4	314	319	PF00397	0.705
DOC_WW_Pin1_4	333	338	PF00397	0.800
DOC_WW_Pin1_4	349	354	PF00397	0.641
DOC_WW_Pin1_4	444	449	PF00397	0.615
LIG_14-3-3_CanoR_1	140	145	PF00244	0.527
LIG_14-3-3_CanoR_1	254	260	PF00244	0.521
LIG_14-3-3_CanoR_1	424	432	PF00244	0.480
LIG_APCC_ABBA_1	66	71	PF00400	0.538
LIG_BRCT_BRCA1_1	408	412	PF00533	0.575
LIG_Clathr_ClatBox_1	383	387	PF01394	0.554
LIG_CtBP_PxDLS_1	385	389	PF00389	0.592
LIG_CtBP_PxDLS_1	431	435	PF00389	0.525
LIG_FHA_1	15	21	PF00498	0.341
LIG_FHA_1	210	216	PF00498	0.475
LIG_FHA_1	272	278	PF00498	0.557
LIG_FHA_1	350	356	PF00498	0.656
LIG_FHA_1	372	378	PF00498	0.501
LIG_FHA_1	417	423	PF00498	0.508
LIG_FHA_1	8	14	PF00498	0.406
LIG_FHA_1	91	97	PF00498	0.517
LIG_FHA_2	148	154	PF00498	0.511
LIG_FHA_2	307	313	PF00498	0.739
LIG_LIR_Gen_1	148	155	PF02991	0.453
LIG_LIR_Gen_1	17	26	PF02991	0.458
LIG_LIR_Gen_1	184	193	PF02991	0.453
LIG_LIR_Gen_1	238	247	PF02991	0.486
LIG_LIR_Gen_1	280	290	PF02991	0.650
LIG_LIR_LC3C_4	55	59	PF02991	0.469
LIG_LIR_Nem_3	10	14	PF02991	0.414
LIG_LIR_Nem_3	148	152	PF02991	0.410
LIG_LIR_Nem_3	162	168	PF02991	0.444
LIG_LIR_Nem_3	17	22	PF02991	0.394
LIG_LIR_Nem_3	184	189	PF02991	0.443
LIG_LIR_Nem_3	238	244	PF02991	0.461
LIG_LIR_Nem_3	258	262	PF02991	0.205
LIG_LIR_Nem_3	280	285	PF02991	0.595
LIG_LIR_Nem_3	367	372	PF02991	0.427
LIG_MAD2	115	123	PF02301	0.639
LIG_MYND_1	198	202	PF01753	0.491
LIG_Pex14_1	365	369	PF04695	0.525
LIG_Pex14_2	165	169	PF04695	0.486
LIG_Pex14_2	408	412	PF04695	0.585
LIG_Pex14_2	46	50	PF04695	0.519
LIG_PTB_Apo_2	360	367	PF02174	0.436
LIG_PTB_Phospho_1	360	366	PF10480	0.528
LIG_Rb_LxCxE_1	100	110	PF01857	0.610
LIG_REV1ctd_RIR_1	44	50	PF16727	0.445
LIG_SH2_CRK	372	376	PF00017	0.496
LIG_SH2_CRK	439	443	PF00017	0.526
LIG_SH2_GRB2like	168	171	PF00017	0.588
LIG_SH2_NCK_1	439	443	PF00017	0.585
LIG_SH2_STAT5	14	17	PF00017	0.412
LIG_SH2_STAT5	168	171	PF00017	0.477
LIG_SH2_STAT5	19	22	PF00017	0.388
LIG_SH2_STAT5	356	359	PF00017	0.496
LIG_SH2_STAT5	407	410	PF00017	0.407
LIG_SH2_STAT5	95	98	PF00017	0.425
LIG_SH3_3	117	123	PF00018	0.644
LIG_SH3_3	282	288	PF00018	0.643
LIG_SH3_3	327	333	PF00018	0.771
LIG_SH3_3	347	353	PF00018	0.723
LIG_SH3_3	492	498	PF00018	0.555
LIG_SH3_3	93	99	PF00018	0.502
LIG_SUMO_SIM_anti_2	55	61	PF11976	0.575
LIG_SUMO_SIM_par_1	201	207	PF11976	0.479
LIG_SUMO_SIM_par_1	530	535	PF11976	0.392
LIG_SUMO_SIM_par_1	55	61	PF11976	0.575
LIG_TRAF2_1	154	157	PF00917	0.569
LIG_TRAF2_1	3	6	PF00917	0.477
LIG_TRAF2_1	413	416	PF00917	0.633
LIG_TRAF2_1	499	502	PF00917	0.607
LIG_UBA3_1	175	181	PF00899	0.510
LIG_WRC_WIRS_1	19	24	PF05994	0.394
LIG_WRC_WIRS_1	256	261	PF05994	0.446
MOD_CK1_1	286	292	PF00069	0.637
MOD_CK1_1	314	320	PF00069	0.719
MOD_CK1_1	322	328	PF00069	0.723
MOD_CK1_1	344	350	PF00069	0.766
MOD_CK2_1	155	161	PF00069	0.513
MOD_GlcNHglycan	292	295	PF01048	0.739
MOD_GlcNHglycan	299	302	PF01048	0.750
MOD_GlcNHglycan	312	316	PF01048	0.677
MOD_GlcNHglycan	318	321	PF01048	0.689
MOD_GlcNHglycan	343	346	PF01048	0.690
MOD_GlcNHglycan	347	350	PF01048	0.648
MOD_GlcNHglycan	390	393	PF01048	0.591
MOD_GlcNHglycan	450	453	PF01048	0.604
MOD_GlcNHglycan	60	63	PF01048	0.630
MOD_GSK3_1	14	21	PF00069	0.527
MOD_GSK3_1	206	213	PF00069	0.440
MOD_GSK3_1	266	273	PF00069	0.456
MOD_GSK3_1	286	293	PF00069	0.397
MOD_GSK3_1	306	313	PF00069	0.521
MOD_GSK3_1	316	323	PF00069	0.715
MOD_GSK3_1	341	348	PF00069	0.725
MOD_GSK3_1	388	395	PF00069	0.597
MOD_GSK3_1	444	451	PF00069	0.601
MOD_GSK3_1	541	548	PF00069	0.712
MOD_NEK2_1	155	160	PF00069	0.547
MOD_NEK2_1	277	282	PF00069	0.516
MOD_NEK2_1	388	393	PF00069	0.555
MOD_NEK2_1	541	546	PF00069	0.709
MOD_PIKK_1	322	328	PF00454	0.807
MOD_PKA_1	424	430	PF00069	0.498
MOD_PKA_1	520	526	PF00069	0.678
MOD_PKA_2	310	316	PF00069	0.751
MOD_PKA_2	388	394	PF00069	0.521
MOD_PKA_2	424	430	PF00069	0.498
MOD_PKA_2	520	526	PF00069	0.675
MOD_Plk_1	147	153	PF00069	0.513
MOD_Plk_1	155	161	PF00069	0.477
MOD_Plk_1	206	212	PF00069	0.504
MOD_Plk_1	541	547	PF00069	0.702
MOD_Plk_2-3	157	163	PF00069	0.510
MOD_Plk_2-3	206	212	PF00069	0.570
MOD_Plk_4	14	20	PF00069	0.345
MOD_Plk_4	24	30	PF00069	0.309
MOD_Plk_4	277	283	PF00069	0.530
MOD_Plk_4	7	13	PF00069	0.384
MOD_Plk_4	91	97	PF00069	0.565
MOD_ProDKin_1	116	122	PF00069	0.714
MOD_ProDKin_1	210	216	PF00069	0.420
MOD_ProDKin_1	235	241	PF00069	0.559
MOD_ProDKin_1	284	290	PF00069	0.675
MOD_ProDKin_1	314	320	PF00069	0.706
MOD_ProDKin_1	333	339	PF00069	0.802
MOD_ProDKin_1	349	355	PF00069	0.634
MOD_ProDKin_1	444	450	PF00069	0.614
MOD_SUMO_for_1	97	100	PF00179	0.519
MOD_SUMO_rev_2	516	526	PF00179	0.596
TRG_DiLeu_BaEn_1	217	222	PF01217	0.540
TRG_ENDOCYTIC_2	19	22	PF00928	0.408
TRG_ENDOCYTIC_2	241	244	PF00928	0.424
TRG_ENDOCYTIC_2	256	259	PF00928	0.416
TRG_ENDOCYTIC_2	366	369	PF00928	0.442
TRG_ENDOCYTIC_2	372	375	PF00928	0.478
TRG_ENDOCYTIC_2	407	410	PF00928	0.445
TRG_ENDOCYTIC_2	439	442	PF00928	0.463
TRG_ER_diArg_1	127	130	PF00400	0.667
TRG_ER_diArg_1	192	195	PF00400	0.427
TRG_ER_diArg_1	254	256	PF00400	0.576
TRG_ER_diArg_1	40	43	PF00400	0.488
TRG_ER_diArg_1	423	425	PF00400	0.483
TRG_ER_diArg_1	462	464	PF00400	0.491
TRG_ER_diArg_1	506	508	PF00400	0.506
TRG_ER_diArg_1	526	529	PF00400	0.680
TRG_NLS_MonoExtC_3	252	257	PF00514	0.583
TRG_Pf-PMV_PEXEL_1	476	480	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	507	511	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7T4	Leptomonas seymouri	57%	89%
A0A0S4IL03	Bodo saltans	40%	94%
A0A1X0NR90	Trypanosomatidae	28%	76%
A0A1X0P2A9	Trypanosomatidae	46%	87%
A0A422N566	Trypanosoma rangeli	47%	90%
A0A422NYX8	Trypanosoma rangeli	26%	81%
A4HHZ8	Leishmania braziliensis	83%	100%
A4I575	Leishmania infantum	99%	100%
C9ZQK1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	91%
D0A8B9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	82%
E9B0H2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q7R1	Leishmania major	96%	100%
V5B7S2	Trypanosoma cruzi	48%	90%
V5BJS6	Trypanosoma cruzi	27%	81%