AMP-binding_enzyme_putative/Pfam:PF00501

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AMP-binding enzyme, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X311_LEIDO

TriTrypDb:

LdBPK_300600.1 , LdCL_300011100 , LDHU3_30.0780

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X311

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X311

PDB structure(s): 7aih_Ai , 7ane_Ai

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	466	470	PF00656	0.508
CLV_NRD_NRD_1	194	196	PF00675	0.404
CLV_NRD_NRD_1	211	213	PF00675	0.378
CLV_NRD_NRD_1	28	30	PF00675	0.372
CLV_NRD_NRD_1	322	324	PF00675	0.392
CLV_NRD_NRD_1	51	53	PF00675	0.294
CLV_PCSK_FUR_1	209	213	PF00082	0.379
CLV_PCSK_KEX2_1	211	213	PF00082	0.399
CLV_PCSK_SKI1_1	195	199	PF00082	0.382
CLV_PCSK_SKI1_1	34	38	PF00082	0.341
CLV_PCSK_SKI1_1	392	396	PF00082	0.323
CLV_PCSK_SKI1_1	45	49	PF00082	0.307
DEG_ODPH_VHL_1	280	293	PF01847	0.342
DOC_CDC14_PxL_1	150	158	PF14671	0.368
DOC_CYCLIN_RxL_1	366	375	PF00134	0.284
DOC_MAPK_gen_1	323	331	PF00069	0.307
DOC_MAPK_RevD_3	14	30	PF00069	0.354
DOC_PP1_RVXF_1	107	113	PF00149	0.307
DOC_PP1_RVXF_1	194	201	PF00149	0.388
DOC_PP4_FxxP_1	379	382	PF00568	0.307
DOC_SPAK_OSR1_1	264	268	PF12202	0.307
DOC_USP7_MATH_1	285	289	PF00917	0.342
DOC_USP7_MATH_1	457	461	PF00917	0.527
DOC_USP7_UBL2_3	30	34	PF12436	0.380
DOC_WW_Pin1_4	10	15	PF00397	0.450
DOC_WW_Pin1_4	189	194	PF00397	0.400
LIG_14-3-3_CanoR_1	211	219	PF00244	0.386
LIG_14-3-3_CanoR_1	413	421	PF00244	0.364
LIG_Actin_WH2_2	161	179	PF00022	0.370
LIG_APCC_ABBA_1	293	298	PF00400	0.323
LIG_APCC_ABBA_1	401	406	PF00400	0.323
LIG_BRCT_BRCA1_1	169	173	PF00533	0.354
LIG_BRCT_BRCA1_1	296	300	PF00533	0.323
LIG_eIF4E_1	441	447	PF01652	0.307
LIG_FHA_1	11	17	PF00498	0.439
LIG_FHA_1	271	277	PF00498	0.352
LIG_FHA_1	446	452	PF00498	0.307
LIG_FHA_1	81	87	PF00498	0.323
LIG_FHA_2	457	463	PF00498	0.382
LIG_LIR_Gen_1	126	133	PF02991	0.381
LIG_LIR_Gen_1	147	158	PF02991	0.362
LIG_LIR_Gen_1	326	334	PF02991	0.308
LIG_LIR_Gen_1	340	350	PF02991	0.310
LIG_LIR_Gen_1	35	44	PF02991	0.350
LIG_LIR_Nem_3	126	130	PF02991	0.371
LIG_LIR_Nem_3	147	153	PF02991	0.347
LIG_LIR_Nem_3	170	176	PF02991	0.351
LIG_LIR_Nem_3	326	330	PF02991	0.305
LIG_LIR_Nem_3	340	345	PF02991	0.274
LIG_LIR_Nem_3	35	39	PF02991	0.330
LIG_LIR_Nem_3	390	394	PF02991	0.324
LIG_NRBOX	212	218	PF00104	0.402
LIG_Pex14_1	146	150	PF04695	0.353
LIG_SH2_CRK	150	154	PF00017	0.356
LIG_SH2_CRK	283	287	PF00017	0.307
LIG_SH2_GRB2like	113	116	PF00017	0.307
LIG_SH2_GRB2like	23	26	PF00017	0.337
LIG_SH2_GRB2like	363	366	PF00017	0.376
LIG_SH2_GRB2like	440	443	PF00017	0.307
LIG_SH2_NCK_1	150	154	PF00017	0.356
LIG_SH2_NCK_1	441	445	PF00017	0.307
LIG_SH2_PTP2	23	26	PF00017	0.337
LIG_SH2_SRC	23	26	PF00017	0.337
LIG_SH2_STAP1	206	210	PF00017	0.387
LIG_SH2_STAT3	160	163	PF00017	0.396
LIG_SH2_STAT3	205	208	PF00017	0.407
LIG_SH2_STAT5	113	116	PF00017	0.307
LIG_SH2_STAT5	175	178	PF00017	0.404
LIG_SH2_STAT5	23	26	PF00017	0.337
LIG_SH2_STAT5	363	366	PF00017	0.307
LIG_SH2_STAT5	377	380	PF00017	0.307
LIG_SH3_3	196	202	PF00018	0.385
LIG_SH3_3	216	222	PF00018	0.201
LIG_SUMO_SIM_anti_2	469	475	PF11976	0.556
LIG_SUMO_SIM_par_1	220	228	PF11976	0.374
LIG_TYR_ITSM	146	153	PF00017	0.435
LIG_UBA3_1	252	260	PF00899	0.307
MOD_CDK_SPxK_1	189	195	PF00069	0.402
MOD_CDK_SPxxK_3	189	196	PF00069	0.400
MOD_CK2_1	201	207	PF00069	0.396
MOD_CK2_1	456	462	PF00069	0.382
MOD_Cter_Amidation	321	324	PF01082	0.307
MOD_GlcNHglycan	105	108	PF01048	0.342
MOD_GlcNHglycan	213	216	PF01048	0.389
MOD_GlcNHglycan	287	290	PF01048	0.323
MOD_GlcNHglycan	474	477	PF01048	0.606
MOD_GSK3_1	294	301	PF00069	0.323
MOD_GSK3_1	383	390	PF00069	0.409
MOD_N-GLC_1	469	474	PF02516	0.495
MOD_NEK2_1	145	150	PF00069	0.387
MOD_NEK2_1	156	161	PF00069	0.349
MOD_NEK2_1	237	242	PF00069	0.378
MOD_NEK2_1	251	256	PF00069	0.323
MOD_NEK2_1	367	372	PF00069	0.358
MOD_NEK2_1	456	461	PF00069	0.377
MOD_NEK2_1	62	67	PF00069	0.307
MOD_PIKK_1	167	173	PF00454	0.361
MOD_PIKK_1	251	257	PF00454	0.369
MOD_PIKK_1	395	401	PF00454	0.454
MOD_PKA_1	211	217	PF00069	0.389
MOD_PKA_1	395	401	PF00069	0.454
MOD_PKA_1	52	58	PF00069	0.307
MOD_PKA_2	211	217	PF00069	0.389
MOD_PKA_2	412	418	PF00069	0.307
MOD_PKB_1	209	217	PF00069	0.384
MOD_Plk_1	383	389	PF00069	0.384
MOD_Plk_1	469	475	PF00069	0.506
MOD_Plk_2-3	298	304	PF00069	0.323
MOD_Plk_4	145	151	PF00069	0.426
MOD_Plk_4	316	322	PF00069	0.428
MOD_Plk_4	383	389	PF00069	0.422
MOD_Plk_4	80	86	PF00069	0.307
MOD_ProDKin_1	10	16	PF00069	0.442
MOD_ProDKin_1	189	195	PF00069	0.402
MOD_SUMO_for_1	259	262	PF00179	0.323
MOD_SUMO_rev_2	228	237	PF00179	0.417
MOD_SUMO_rev_2	412	421	PF00179	0.380
MOD_SUMO_rev_2	5	10	PF00179	0.424
TRG_DiLeu_BaEn_1	316	321	PF01217	0.428
TRG_ENDOCYTIC_2	150	153	PF00928	0.349
TRG_ENDOCYTIC_2	23	26	PF00928	0.174
TRG_ENDOCYTIC_2	283	286	PF00928	0.307
TRG_ENDOCYTIC_2	33	36	PF00928	0.362
TRG_ENDOCYTIC_2	4	7	PF00928	0.490
TRG_ER_diArg_1	209	212	PF00400	0.399
TRG_NES_CRM1_1	362	375	PF08389	0.307
TRG_Pf-PMV_PEXEL_1	72	77	PF00026	0.307

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7F1	Leptomonas seymouri	91%	91%
A0A0S4JH74	Bodo saltans	78%	96%
A0A1X0P289	Trypanosomatidae	80%	93%
A0A3R7LXH8	Trypanosoma rangeli	80%	93%
A4HI09	Leishmania braziliensis	96%	100%
A4I586	Leishmania infantum	100%	100%
C9ZQL5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	80%	92%
E9B0I3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
O31826	Bacillus subtilis (strain 168)	23%	87%
Q0P4F7	Danio rerio	22%	79%
Q17QJ1	Bos taurus	22%	78%
Q499N5	Rattus norvegicus	23%	78%
Q4Q7P8	Leishmania major	99%	100%
Q4R4Z9	Macaca fascicularis	22%	78%
Q4WR83	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	81%
Q5R9G9	Pongo abelii	21%	78%
Q8VCW8	Mus musculus	23%	78%
Q96CM8	Homo sapiens	22%	78%
V5BC74	Trypanosoma cruzi	81%	93%