Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X310_LEIDO

TriTrypDb:

LdBPK_300200.1 , LdCL_300007000 , LDHU3_30.0320

Length:

119

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3S7X310

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X310

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.436
CLV_NRD_NRD_1	32	34	PF00675	0.405
CLV_PCSK_KEX2_1	32	34	PF00082	0.388
CLV_PCSK_SKI1_1	32	36	PF00082	0.411
DEG_Nend_Nbox_1	1	3	PF02207	0.614
DEG_SPOP_SBC_1	15	19	PF00917	0.603
DOC_CKS1_1	27	32	PF01111	0.663
DOC_CKS1_1	59	64	PF01111	0.438
DOC_CYCLIN_yCln2_LP_2	59	65	PF00134	0.586
DOC_MAPK_gen_1	32	40	PF00069	0.613
DOC_USP7_MATH_1	14	18	PF00917	0.618
DOC_USP7_MATH_1	75	79	PF00917	0.389
DOC_WW_Pin1_4	26	31	PF00397	0.640
DOC_WW_Pin1_4	58	63	PF00397	0.446
LIG_14-3-3_CanoR_1	16	22	PF00244	0.637
LIG_14-3-3_CanoR_1	32	40	PF00244	0.522
LIG_BRCT_BRCA1_1	30	34	PF00533	0.666
LIG_BRCT_BRCA1_1	43	47	PF00533	0.410
LIG_FHA_1	33	39	PF00498	0.563
LIG_FHA_1	50	56	PF00498	0.279
LIG_LIR_Gen_1	53	63	PF02991	0.355
LIG_LIR_Nem_3	53	59	PF02991	0.355
LIG_LIR_Nem_3	92	97	PF02991	0.279
LIG_MLH1_MIPbox_1	43	47	PF16413	0.222
LIG_MYND_1	10	14	PF01753	0.628
LIG_NRBOX	54	60	PF00104	0.410
LIG_SH3_3	19	25	PF00018	0.651
LIG_SH3_3	59	65	PF00018	0.581
LIG_SUMO_SIM_par_1	24	29	PF11976	0.612
MOD_CDK_SPxK_1	26	32	PF00069	0.664
MOD_CDK_SPxxK_3	26	33	PF00069	0.653
MOD_CK1_1	42	48	PF00069	0.367
MOD_CK1_1	50	56	PF00069	0.307
MOD_CK2_1	109	115	PF00069	0.468
MOD_GlcNHglycan	18	21	PF01048	0.443
MOD_GlcNHglycan	77	80	PF01048	0.549
MOD_GSK3_1	28	35	PF00069	0.626
MOD_GSK3_1	41	48	PF00069	0.225
MOD_GSK3_1	71	78	PF00069	0.395
MOD_GSK3_1	85	92	PF00069	0.454
MOD_N-GLC_1	89	94	PF02516	0.496
MOD_NEK2_1	39	44	PF00069	0.336
MOD_NEK2_1	47	52	PF00069	0.274
MOD_NEK2_1	89	94	PF00069	0.296
MOD_OFUCOSY	43	49	PF10250	0.410
MOD_PIKK_1	109	115	PF00454	0.599
MOD_PKA_1	32	38	PF00069	0.614
MOD_PKA_2	15	21	PF00069	0.653
MOD_PKA_2	32	38	PF00069	0.553
MOD_Plk_4	42	48	PF00069	0.319
MOD_ProDKin_1	26	32	PF00069	0.639
MOD_ProDKin_1	58	64	PF00069	0.444
TRG_ER_diArg_1	32	34	PF00400	0.628
TRG_ER_FFAT_2	42	52	PF00635	0.222

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMG4	Leptomonas seymouri	70%	100%
A0A0S4JM96	Bodo saltans	56%	100%
A0A1X0P2D6	Trypanosomatidae	59%	100%
A0A422N153	Trypanosoma rangeli	61%	100%
A4HHW4	Leishmania braziliensis	91%	100%
A4I514	Leishmania infantum	100%	100%
C9ZQG9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9B0E4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q7V0	Leishmania major	94%	100%