Diacylglycerol kinase catalytic domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Diacylglycerol kinase catalytic domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X308_LEIDO

TriTrypDb:

LdBPK_300430.1 , LdCL_300009400 , LDHU3_30.0600

Length:

366

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X308

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X308

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	4
GO:0006796	phosphate-containing compound metabolic process	4	4
GO:0008152	metabolic process	1	4
GO:0009987	cellular process	1	4
GO:0016310	phosphorylation	5	4
GO:0044237	cellular metabolic process	2	4
GO:0006066	alcohol metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006643	membrane lipid metabolic process	4	1
GO:0006665	sphingolipid metabolic process	4	1
GO:0006670	sphingosine metabolic process	6	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0019751	polyol metabolic process	4	1
GO:0030148	sphingolipid biosynthetic process	5	1
GO:0034311	diol metabolic process	5	1
GO:0034312	diol biosynthetic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046165	alcohol biosynthetic process	4	1
GO:0046173	polyol biosynthetic process	5	1
GO:0046467	membrane lipid biosynthetic process	4	1
GO:0046512	sphingosine biosynthetic process	5	1
GO:0046519	sphingoid metabolic process	5	1
GO:0046520	sphingoid biosynthetic process	6	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901615	organic hydroxy compound metabolic process	3	1
GO:1901617	organic hydroxy compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016301	kinase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0001727	lipid kinase activity	5	1
GO:0003951	NAD+ kinase activity	5	1
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	175	177	PF00675	0.458
CLV_NRD_NRD_1	257	259	PF00675	0.478
CLV_PCSK_KEX2_1	175	177	PF00082	0.397
CLV_PCSK_KEX2_1	257	259	PF00082	0.522
CLV_PCSK_KEX2_1	5	7	PF00082	0.481
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.481
CLV_PCSK_SKI1_1	258	262	PF00082	0.448
CLV_PCSK_SKI1_1	6	10	PF00082	0.400
DEG_APCC_DBOX_1	137	145	PF00400	0.402
DEG_SCF_FBW7_1	249	254	PF00400	0.408
DOC_CYCLIN_yCln2_LP_2	105	111	PF00134	0.279
DOC_MAPK_gen_1	5	11	PF00069	0.353
DOC_PP1_RVXF_1	301	307	PF00149	0.476
DOC_PP1_SILK_1	25	30	PF00149	0.227
DOC_PP2B_LxvP_1	105	108	PF13499	0.324
DOC_USP7_MATH_1	127	131	PF00917	0.327
DOC_USP7_MATH_1	225	229	PF00917	0.533
DOC_USP7_MATH_1	307	311	PF00917	0.561
DOC_USP7_MATH_1	316	320	PF00917	0.717
DOC_USP7_MATH_1	347	351	PF00917	0.539
DOC_USP7_MATH_1	81	85	PF00917	0.365
DOC_USP7_MATH_1	94	98	PF00917	0.485
DOC_WW_Pin1_4	247	252	PF00397	0.407
LIG_14-3-3_CanoR_1	126	132	PF00244	0.284
LIG_14-3-3_CanoR_1	159	165	PF00244	0.312
LIG_14-3-3_CanoR_1	257	263	PF00244	0.445
LIG_14-3-3_CanoR_1	318	322	PF00244	0.628
LIG_Clathr_ClatBox_1	336	340	PF01394	0.410
LIG_FHA_1	212	218	PF00498	0.442
LIG_FHA_2	120	126	PF00498	0.360
LIG_FHA_2	202	208	PF00498	0.448
LIG_GBD_Chelix_1	49	57	PF00786	0.312
LIG_LIR_Gen_1	185	194	PF02991	0.471
LIG_LIR_Gen_1	23	32	PF02991	0.227
LIG_LIR_LC3C_4	129	133	PF02991	0.400
LIG_LIR_LC3C_4	334	339	PF02991	0.399
LIG_LIR_Nem_3	23	27	PF02991	0.227
LIG_MYND_1	241	245	PF01753	0.447
LIG_RPA_C_Fungi	9	21	PF08784	0.312
LIG_SH2_STAP1	170	174	PF00017	0.352
LIG_SH2_STAT5	164	167	PF00017	0.309
LIG_SH2_STAT5	187	190	PF00017	0.490
LIG_SH2_STAT5	286	289	PF00017	0.503
LIG_SH2_STAT5	31	34	PF00017	0.319
LIG_SH3_3	134	140	PF00018	0.399
LIG_SH3_3	146	152	PF00018	0.570
LIG_SH3_3	185	191	PF00018	0.525
LIG_SH3_3	341	347	PF00018	0.511
LIG_SH3_3	39	45	PF00018	0.400
LIG_SH3_3	90	96	PF00018	0.388
LIG_SUMO_SIM_anti_2	334	340	PF11976	0.428
LIG_SUMO_SIM_anti_2	350	358	PF11976	0.274
LIG_SUMO_SIM_par_1	212	218	PF11976	0.325
LIG_SUMO_SIM_par_1	334	340	PF11976	0.507
LIG_TRAF2_1	294	297	PF00917	0.445
LIG_TRFH_1	247	251	PF08558	0.357
MOD_CK1_1	114	120	PF00069	0.323
MOD_CK1_1	350	356	PF00069	0.378
MOD_CK2_1	119	125	PF00069	0.448
MOD_CK2_1	201	207	PF00069	0.443
MOD_CK2_1	94	100	PF00069	0.368
MOD_GlcNHglycan	14	17	PF01048	0.349
MOD_GlcNHglycan	333	336	PF01048	0.522
MOD_GlcNHglycan	73	76	PF01048	0.498
MOD_GlcNHglycan	84	87	PF01048	0.405
MOD_GSK3_1	111	118	PF00069	0.279
MOD_GSK3_1	160	167	PF00069	0.380
MOD_GSK3_1	211	218	PF00069	0.461
MOD_GSK3_1	221	228	PF00069	0.318
MOD_GSK3_1	247	254	PF00069	0.399
MOD_GSK3_1	263	270	PF00069	0.393
MOD_GSK3_1	350	357	PF00069	0.408
MOD_GSK3_1	94	101	PF00069	0.372
MOD_LATS_1	256	262	PF00433	0.459
MOD_N-GLC_1	12	17	PF02516	0.379
MOD_N-GLC_1	221	226	PF02516	0.406
MOD_NEK2_1	111	116	PF00069	0.284
MOD_NEK2_1	119	124	PF00069	0.284
MOD_NEK2_1	235	240	PF00069	0.377
MOD_NEK2_1	260	265	PF00069	0.354
MOD_NEK2_2	170	175	PF00069	0.342
MOD_PIKK_1	235	241	PF00454	0.357
MOD_PIKK_1	307	313	PF00454	0.593
MOD_PIKK_1	317	323	PF00454	0.709
MOD_PKA_2	317	323	PF00069	0.740
MOD_Plk_1	211	217	PF00069	0.521
MOD_Plk_1	267	273	PF00069	0.445
MOD_Plk_1	357	363	PF00069	0.496
MOD_Plk_4	127	133	PF00069	0.400
MOD_Plk_4	160	166	PF00069	0.303
MOD_Plk_4	211	217	PF00069	0.439
MOD_Plk_4	23	29	PF00069	0.282
MOD_Plk_4	350	356	PF00069	0.448
MOD_Plk_4	94	100	PF00069	0.379
MOD_ProDKin_1	247	253	PF00069	0.405
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.442
TRG_DiLeu_LyEn_5	100	105	PF01217	0.360
TRG_ENDOCYTIC_2	153	156	PF00928	0.503
TRG_ENDOCYTIC_2	187	190	PF00928	0.511
TRG_ER_diArg_1	174	176	PF00400	0.449
TRG_ER_diArg_1	271	274	PF00400	0.429
TRG_Pf-PMV_PEXEL_1	300	305	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHE5	Leptomonas seymouri	56%	95%
A0A1X0P2A6	Trypanosomatidae	40%	100%
A0A3R7L399	Trypanosoma rangeli	34%	100%
A4HHZ3	Leishmania braziliensis	77%	100%
A4I570	Leishmania infantum	100%	100%
C9ZQJ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B0G7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q7R6	Leishmania major	91%	100%