Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X301_LEIDO

TriTrypDb:

LdBPK_300500.1 , LdCL_300010100 , LDHU3_30.0680

Length:

716

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X301

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X301

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	235	239	PF00656	0.609
CLV_NRD_NRD_1	12	14	PF00675	0.563
CLV_NRD_NRD_1	284	286	PF00675	0.575
CLV_NRD_NRD_1	484	486	PF00675	0.502
CLV_NRD_NRD_1	585	587	PF00675	0.402
CLV_NRD_NRD_1	623	625	PF00675	0.461
CLV_NRD_NRD_1	670	672	PF00675	0.415
CLV_NRD_NRD_1	673	675	PF00675	0.429
CLV_NRD_NRD_1	93	95	PF00675	0.679
CLV_PCSK_FUR_1	668	672	PF00082	0.416
CLV_PCSK_KEX2_1	12	14	PF00082	0.528
CLV_PCSK_KEX2_1	284	286	PF00082	0.585
CLV_PCSK_KEX2_1	484	486	PF00082	0.502
CLV_PCSK_KEX2_1	527	529	PF00082	0.618
CLV_PCSK_KEX2_1	584	586	PF00082	0.438
CLV_PCSK_KEX2_1	614	616	PF00082	0.517
CLV_PCSK_KEX2_1	625	627	PF00082	0.443
CLV_PCSK_KEX2_1	670	672	PF00082	0.415
CLV_PCSK_KEX2_1	677	679	PF00082	0.436
CLV_PCSK_KEX2_1	688	690	PF00082	0.443
CLV_PCSK_KEX2_1	697	699	PF00082	0.316
CLV_PCSK_KEX2_1	93	95	PF00082	0.679
CLV_PCSK_PC1ET2_1	527	529	PF00082	0.596
CLV_PCSK_PC1ET2_1	584	586	PF00082	0.438
CLV_PCSK_PC1ET2_1	614	616	PF00082	0.517
CLV_PCSK_PC1ET2_1	625	627	PF00082	0.443
CLV_PCSK_PC1ET2_1	677	679	PF00082	0.436
CLV_PCSK_PC1ET2_1	688	690	PF00082	0.513
CLV_PCSK_PC1ET2_1	697	699	PF00082	0.360
CLV_PCSK_SKI1_1	175	179	PF00082	0.569
CLV_PCSK_SKI1_1	484	488	PF00082	0.455
CLV_PCSK_SKI1_1	569	573	PF00082	0.456
CLV_PCSK_SKI1_1	586	590	PF00082	0.459
CLV_PCSK_SKI1_1	697	701	PF00082	0.440
DEG_APCC_DBOX_1	19	27	PF00400	0.567
DEG_SPOP_SBC_1	100	104	PF00917	0.619
DOC_CYCLIN_RxL_1	481	491	PF00134	0.422
DOC_CYCLIN_RxL_1	552	562	PF00134	0.489
DOC_MAPK_gen_1	272	279	PF00069	0.581
DOC_MAPK_gen_1	584	595	PF00069	0.431
DOC_MAPK_gen_1	597	605	PF00069	0.318
DOC_MAPK_gen_1	688	695	PF00069	0.481
DOC_PP4_FxxP_1	505	508	PF00568	0.530
DOC_PP4_FxxP_1	87	90	PF00568	0.534
DOC_USP7_MATH_1	119	123	PF00917	0.670
DOC_USP7_MATH_1	127	131	PF00917	0.636
DOC_USP7_MATH_1	177	181	PF00917	0.756
DOC_USP7_MATH_1	182	186	PF00917	0.682
DOC_USP7_MATH_1	297	301	PF00917	0.621
DOC_USP7_MATH_1	407	411	PF00917	0.637
DOC_USP7_MATH_1	413	417	PF00917	0.753
DOC_USP7_MATH_1	445	449	PF00917	0.763
DOC_USP7_MATH_1	538	542	PF00917	0.619
DOC_USP7_MATH_1	567	571	PF00917	0.502
DOC_WW_Pin1_4	130	135	PF00397	0.699
DOC_WW_Pin1_4	164	169	PF00397	0.606
DOC_WW_Pin1_4	187	192	PF00397	0.683
DOC_WW_Pin1_4	218	223	PF00397	0.579
DOC_WW_Pin1_4	298	303	PF00397	0.677
DOC_WW_Pin1_4	311	316	PF00397	0.566
DOC_WW_Pin1_4	323	328	PF00397	0.611
DOC_WW_Pin1_4	373	378	PF00397	0.598
DOC_WW_Pin1_4	68	73	PF00397	0.643
DOC_WW_Pin1_4	708	713	PF00397	0.601
DOC_WW_Pin1_4	74	79	PF00397	0.622
DOC_WW_Pin1_4	86	91	PF00397	0.486
LIG_14-3-3_CanoR_1	196	204	PF00244	0.616
LIG_14-3-3_CanoR_1	272	278	PF00244	0.570
LIG_14-3-3_CanoR_1	334	344	PF00244	0.609
LIG_14-3-3_CanoR_1	585	589	PF00244	0.456
LIG_14-3-3_CanoR_1	698	706	PF00244	0.552
LIG_14-3-3_CterR_2	714	716	PF00244	0.684
LIG_Actin_WH2_2	675	690	PF00022	0.487
LIG_BIR_II_1	1	5	PF00653	0.632
LIG_BRCT_BRCA1_1	101	105	PF00533	0.608
LIG_BRCT_BRCA1_1	81	85	PF00533	0.685
LIG_DLG_GKlike_1	318	326	PF00625	0.592
LIG_FHA_1	102	108	PF00498	0.627
LIG_FHA_1	340	346	PF00498	0.608
LIG_FHA_1	399	405	PF00498	0.684
LIG_FHA_1	431	437	PF00498	0.664
LIG_FHA_1	554	560	PF00498	0.466
LIG_FHA_1	688	694	PF00498	0.451
LIG_FHA_1	698	704	PF00498	0.511
LIG_FHA_2	276	282	PF00498	0.649
LIG_FHA_2	384	390	PF00498	0.648
LIG_FHA_2	456	462	PF00498	0.619
LIG_FHA_2	538	544	PF00498	0.494
LIG_LIR_Apic_2	503	508	PF02991	0.594
LIG_LIR_Gen_1	659	665	PF02991	0.410
LIG_LIR_Nem_3	347	352	PF02991	0.552
LIG_LIR_Nem_3	480	486	PF02991	0.431
LIG_LIR_Nem_3	659	664	PF02991	0.410
LIG_LYPXL_yS_3	349	352	PF13949	0.543
LIG_MYND_1	222	226	PF01753	0.515
LIG_SH2_CRK	483	487	PF00017	0.430
LIG_SH2_NCK_1	24	28	PF00017	0.526
LIG_SH2_SRC	232	235	PF00017	0.564
LIG_SH2_STAP1	630	634	PF00017	0.479
LIG_SH2_STAT5	495	498	PF00017	0.474
LIG_SH3_1	704	710	PF00018	0.559
LIG_SH3_2	191	196	PF14604	0.671
LIG_SH3_2	709	714	PF14604	0.608
LIG_SH3_3	145	151	PF00018	0.630
LIG_SH3_3	188	194	PF00018	0.765
LIG_SH3_3	296	302	PF00018	0.545
LIG_SH3_3	704	710	PF00018	0.559
LIG_SH3_CIN85_PxpxPR_1	506	511	PF14604	0.599
LIG_SUMO_SIM_anti_2	659	667	PF11976	0.407
LIG_SUMO_SIM_par_1	485	491	PF11976	0.425
LIG_TRAF2_1	367	370	PF00917	0.569
LIG_TRAF2_1	386	389	PF00917	0.546
LIG_TRAF2_1	510	513	PF00917	0.583
LIG_TRAF2_1	643	646	PF00917	0.516
LIG_UBA3_1	486	494	PF00899	0.503
LIG_WW_3	711	715	PF00397	0.593
MOD_CDC14_SPxK_1	172	175	PF00782	0.673
MOD_CDC14_SPxK_1	711	714	PF00782	0.589
MOD_CDK_SPK_2	218	223	PF00069	0.566
MOD_CDK_SPxK_1	169	175	PF00069	0.671
MOD_CDK_SPxK_1	708	714	PF00069	0.583
MOD_CDK_SPxxK_3	311	318	PF00069	0.681
MOD_CDK_SPxxK_3	86	93	PF00069	0.544
MOD_CK1_1	112	118	PF00069	0.625
MOD_CK1_1	130	136	PF00069	0.632
MOD_CK1_1	164	170	PF00069	0.731
MOD_CK1_1	181	187	PF00069	0.569
MOD_CK1_1	2	8	PF00069	0.606
MOD_CK1_1	237	243	PF00069	0.789
MOD_CK1_1	321	327	PF00069	0.640
MOD_CK1_1	398	404	PF00069	0.669
MOD_CK1_1	414	420	PF00069	0.606
MOD_CK1_1	439	445	PF00069	0.759
MOD_CK2_1	119	125	PF00069	0.614
MOD_CK2_1	203	209	PF00069	0.651
MOD_CK2_1	298	304	PF00069	0.574
MOD_CK2_1	382	388	PF00069	0.642
MOD_CK2_1	393	399	PF00069	0.696
MOD_CK2_1	455	461	PF00069	0.544
MOD_CK2_1	537	543	PF00069	0.517
MOD_Cter_Amidation	582	585	PF01082	0.492
MOD_GlcNHglycan	1	4	PF01048	0.598
MOD_GlcNHglycan	112	115	PF01048	0.657
MOD_GlcNHglycan	121	124	PF01048	0.596
MOD_GlcNHglycan	163	166	PF01048	0.601
MOD_GlcNHglycan	180	183	PF01048	0.655
MOD_GlcNHglycan	184	187	PF01048	0.663
MOD_GlcNHglycan	205	208	PF01048	0.706
MOD_GlcNHglycan	290	293	PF01048	0.532
MOD_GlcNHglycan	323	326	PF01048	0.648
MOD_GlcNHglycan	36	39	PF01048	0.689
MOD_GlcNHglycan	411	414	PF01048	0.817
MOD_GlcNHglycan	419	422	PF01048	0.777
MOD_GlcNHglycan	438	441	PF01048	0.662
MOD_GlcNHglycan	463	466	PF01048	0.607
MOD_GlcNHglycan	471	474	PF01048	0.578
MOD_GlcNHglycan	52	55	PF01048	0.523
MOD_GlcNHglycan	549	552	PF01048	0.443
MOD_GlcNHglycan	627	633	PF01048	0.473
MOD_GSK3_1	115	122	PF00069	0.634
MOD_GSK3_1	177	184	PF00069	0.744
MOD_GSK3_1	208	215	PF00069	0.672
MOD_GSK3_1	335	342	PF00069	0.666
MOD_GSK3_1	373	380	PF00069	0.614
MOD_GSK3_1	383	390	PF00069	0.673
MOD_GSK3_1	394	401	PF00069	0.668
MOD_GSK3_1	405	412	PF00069	0.768
MOD_GSK3_1	413	420	PF00069	0.549
MOD_GSK3_1	445	452	PF00069	0.639
MOD_GSK3_1	453	460	PF00069	0.571
MOD_GSK3_1	652	659	PF00069	0.409
MOD_N-GLC_1	110	115	PF02516	0.618
MOD_N-GLC_1	430	435	PF02516	0.608
MOD_NEK2_1	1	6	PF00069	0.581
MOD_NEK2_1	161	166	PF00069	0.639
MOD_NEK2_1	178	183	PF00069	0.607
MOD_NEK2_1	449	454	PF00069	0.684
MOD_NEK2_2	567	572	PF00069	0.500
MOD_PIKK_1	2	8	PF00454	0.606
MOD_PIKK_1	365	371	PF00454	0.608
MOD_PIKK_1	697	703	PF00454	0.457
MOD_PKA_1	527	533	PF00069	0.549
MOD_PKA_1	584	590	PF00069	0.456
MOD_PKA_1	697	703	PF00069	0.457
MOD_PKA_2	178	184	PF00069	0.680
MOD_PKA_2	195	201	PF00069	0.503
MOD_PKA_2	333	339	PF00069	0.628
MOD_PKA_2	527	533	PF00069	0.549
MOD_PKA_2	547	553	PF00069	0.444
MOD_PKA_2	584	590	PF00069	0.456
MOD_PKA_2	697	703	PF00069	0.521
MOD_Plk_1	387	393	PF00069	0.722
MOD_Plk_1	553	559	PF00069	0.490
MOD_Plk_2-3	388	394	PF00069	0.688
MOD_Plk_4	449	455	PF00069	0.482
MOD_Plk_4	657	663	PF00069	0.406
MOD_ProDKin_1	130	136	PF00069	0.696
MOD_ProDKin_1	164	170	PF00069	0.607
MOD_ProDKin_1	187	193	PF00069	0.682
MOD_ProDKin_1	218	224	PF00069	0.578
MOD_ProDKin_1	298	304	PF00069	0.678
MOD_ProDKin_1	311	317	PF00069	0.566
MOD_ProDKin_1	323	329	PF00069	0.612
MOD_ProDKin_1	373	379	PF00069	0.603
MOD_ProDKin_1	68	74	PF00069	0.637
MOD_ProDKin_1	708	714	PF00069	0.607
MOD_ProDKin_1	86	92	PF00069	0.482
MOD_SUMO_rev_2	230	237	PF00179	0.619
TRG_DiLeu_BaLyEn_6	482	487	PF01217	0.494
TRG_DiLeu_BaLyEn_6	599	604	PF01217	0.549
TRG_ENDOCYTIC_2	349	352	PF00928	0.543
TRG_ENDOCYTIC_2	483	486	PF00928	0.440
TRG_ER_diArg_1	12	14	PF00400	0.563
TRG_ER_diArg_1	283	285	PF00400	0.505
TRG_ER_diArg_1	359	362	PF00400	0.550
TRG_ER_diArg_1	483	485	PF00400	0.502
TRG_ER_diArg_1	545	548	PF00400	0.455
TRG_ER_diArg_1	623	626	PF00400	0.502
TRG_ER_diArg_1	670	672	PF00400	0.415
TRG_ER_diArg_1	92	94	PF00400	0.669
TRG_NES_CRM1_1	652	667	PF08389	0.408
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	362	366	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	485	490	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	507	512	PF00026	0.653
TRG_Pf-PMV_PEXEL_1	516	520	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	586	590	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	591	596	PF00026	0.400
TRG_Pf-PMV_PEXEL_1	602	606	PF00026	0.366
TRG_Pf-PMV_PEXEL_1	614	618	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDA1	Leptomonas seymouri	44%	100%
A4HI00	Leishmania braziliensis	75%	99%
A4I577	Leishmania infantum	100%	100%
E9B0H4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	97%
Q4Q7Q7	Leishmania major	91%	100%