Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X2Z5_LEIDO

TriTrypDb:

LdBPK_292720.1 , LdCL_290033300 , LDHU3_29.4000

Length:

719

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X2Z5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2Z5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	249	253	PF00656	0.546
CLV_NRD_NRD_1	377	379	PF00675	0.678
CLV_NRD_NRD_1	400	402	PF00675	0.644
CLV_NRD_NRD_1	656	658	PF00675	0.576
CLV_NRD_NRD_1	681	683	PF00675	0.578
CLV_PCSK_KEX2_1	28	30	PF00082	0.637
CLV_PCSK_KEX2_1	377	379	PF00082	0.678
CLV_PCSK_KEX2_1	400	402	PF00082	0.711
CLV_PCSK_KEX2_1	656	658	PF00082	0.576
CLV_PCSK_KEX2_1	681	683	PF00082	0.578
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.637
CLV_PCSK_SKI1_1	267	271	PF00082	0.677
CLV_PCSK_SKI1_1	326	330	PF00082	0.633
CLV_PCSK_SKI1_1	356	360	PF00082	0.616
CLV_PCSK_SKI1_1	362	366	PF00082	0.580
CLV_PCSK_SKI1_1	537	541	PF00082	0.558
CLV_PCSK_SKI1_1	657	661	PF00082	0.448
CLV_PCSK_SKI1_1	711	715	PF00082	0.598
DEG_APCC_DBOX_1	536	544	PF00400	0.580
DEG_APCC_DBOX_1	655	663	PF00400	0.656
DEG_APCC_DBOX_1	693	701	PF00400	0.652
DEG_SCF_FBW7_1	568	574	PF00400	0.737
DOC_CKS1_1	568	573	PF01111	0.736
DOC_CKS1_1	637	642	PF01111	0.571
DOC_CYCLIN_RxL_1	534	542	PF00134	0.674
DOC_CYCLIN_yCln2_LP_2	102	108	PF00134	0.634
DOC_MAPK_gen_1	353	361	PF00069	0.685
DOC_MAPK_MEF2A_6	235	243	PF00069	0.695
DOC_MAPK_MEF2A_6	688	697	PF00069	0.446
DOC_PP2B_LxvP_1	102	105	PF13499	0.593
DOC_PP2B_LxvP_1	168	171	PF13499	0.723
DOC_PP4_FxxP_1	4	7	PF00568	0.678
DOC_USP7_MATH_1	111	115	PF00917	0.737
DOC_USP7_MATH_1	160	164	PF00917	0.609
DOC_USP7_MATH_1	183	187	PF00917	0.686
DOC_USP7_MATH_1	205	209	PF00917	0.600
DOC_USP7_MATH_1	213	217	PF00917	0.590
DOC_USP7_MATH_1	285	289	PF00917	0.662
DOC_USP7_MATH_1	317	321	PF00917	0.643
DOC_USP7_MATH_1	366	370	PF00917	0.720
DOC_USP7_MATH_1	383	387	PF00917	0.556
DOC_USP7_MATH_1	581	585	PF00917	0.676
DOC_USP7_MATH_2	176	182	PF00917	0.696
DOC_USP7_UBL2_3	246	250	PF12436	0.511
DOC_WW_Pin1_4	179	184	PF00397	0.697
DOC_WW_Pin1_4	274	279	PF00397	0.747
DOC_WW_Pin1_4	567	572	PF00397	0.662
DOC_WW_Pin1_4	636	641	PF00397	0.564
DOC_WW_Pin1_4	91	96	PF00397	0.714
LIG_14-3-3_CanoR_1	128	136	PF00244	0.653
LIG_14-3-3_CanoR_1	240	244	PF00244	0.685
LIG_14-3-3_CanoR_1	262	269	PF00244	0.612
LIG_14-3-3_CanoR_1	505	510	PF00244	0.630
LIG_14-3-3_CanoR_1	537	546	PF00244	0.599
LIG_14-3-3_CanoR_1	657	663	PF00244	0.573
LIG_14-3-3_CanoR_1	681	689	PF00244	0.554
LIG_14-3-3_CanoR_1	79	85	PF00244	0.665
LIG_Actin_WH2_2	225	242	PF00022	0.616
LIG_Actin_WH2_2	347	364	PF00022	0.589
LIG_Actin_WH2_2	398	415	PF00022	0.560
LIG_Actin_WH2_2	56	72	PF00022	0.755
LIG_BIR_II_1	1	5	PF00653	0.685
LIG_BRCT_BRCA1_1	454	458	PF00533	0.581
LIG_BRCT_BRCA1_2	454	460	PF00533	0.578
LIG_CSL_BTD_1	174	177	PF09270	0.708
LIG_FHA_1	240	246	PF00498	0.676
LIG_FHA_1	525	531	PF00498	0.608
LIG_FHA_1	539	545	PF00498	0.537
LIG_FHA_1	592	598	PF00498	0.567
LIG_FHA_1	637	643	PF00498	0.676
LIG_FHA_1	64	70	PF00498	0.667
LIG_FHA_2	268	274	PF00498	0.540
LIG_FHA_2	39	45	PF00498	0.661
LIG_FHA_2	454	460	PF00498	0.578
LIG_FHA_2	53	59	PF00498	0.689
LIG_FHA_2	548	554	PF00498	0.643
LIG_FHA_2	673	679	PF00498	0.677
LIG_FHA_2	681	687	PF00498	0.527
LIG_Integrin_isoDGR_2	305	307	PF01839	0.731
LIG_LIR_Apic_2	2	7	PF02991	0.678
LIG_LIR_Apic_2	564	568	PF02991	0.669
LIG_LIR_Gen_1	22	31	PF02991	0.696
LIG_LIR_Gen_1	32	38	PF02991	0.591
LIG_LIR_Gen_1	531	540	PF02991	0.569
LIG_LIR_Gen_1	557	566	PF02991	0.626
LIG_LIR_Gen_1	74	85	PF02991	0.658
LIG_LIR_Nem_3	22	27	PF02991	0.711
LIG_LIR_Nem_3	30	36	PF02991	0.595
LIG_LIR_Nem_3	531	536	PF02991	0.595
LIG_LIR_Nem_3	557	561	PF02991	0.623
LIG_MLH1_MIPbox_1	454	458	PF16413	0.581
LIG_NRBOX	436	442	PF00104	0.577
LIG_NRBOX	539	545	PF00104	0.580
LIG_PCNA_PIPBox_1	451	460	PF02747	0.638
LIG_PCNA_yPIPBox_3	299	312	PF02747	0.608
LIG_SH2_NCK_1	546	550	PF00017	0.563
LIG_SH2_PTP2	337	340	PF00017	0.588
LIG_SH2_SRC	565	568	PF00017	0.654
LIG_SH2_STAT3	224	227	PF00017	0.690
LIG_SH2_STAT5	337	340	PF00017	0.588
LIG_SH2_STAT5	343	346	PF00017	0.594
LIG_SH2_STAT5	360	363	PF00017	0.563
LIG_SH2_STAT5	457	460	PF00017	0.575
LIG_SH3_1	565	571	PF00018	0.765
LIG_SH3_3	11	17	PF00018	0.691
LIG_SH3_3	177	183	PF00018	0.566
LIG_SH3_3	486	492	PF00018	0.637
LIG_SH3_3	565	571	PF00018	0.765
LIG_SH3_3	634	640	PF00018	0.590
LIG_SUMO_SIM_par_1	241	247	PF11976	0.509
LIG_TRAF2_1	208	211	PF00917	0.612
LIG_TRAF2_1	661	664	PF00917	0.653
LIG_TRAF2_1	683	686	PF00917	0.658
LIG_TRAF2_1	9	12	PF00917	0.785
LIG_TYR_ITIM	335	340	PF00017	0.597
LIG_WRC_WIRS_1	432	437	PF05994	0.607
LIG_WW_1	16	19	PF00397	0.700
MOD_CK1_1	100	106	PF00069	0.722
MOD_CK1_1	114	120	PF00069	0.460
MOD_CK1_1	146	152	PF00069	0.657
MOD_CK1_1	182	188	PF00069	0.631
MOD_CK1_1	228	234	PF00069	0.564
MOD_CK1_1	274	280	PF00069	0.732
MOD_CK1_1	281	287	PF00069	0.599
MOD_CK1_1	386	392	PF00069	0.786
MOD_CK1_1	547	553	PF00069	0.606
MOD_CK1_1	577	583	PF00069	0.763
MOD_CK1_1	93	99	PF00069	0.719
MOD_CK2_1	205	211	PF00069	0.606
MOD_CK2_1	267	273	PF00069	0.533
MOD_CK2_1	366	372	PF00069	0.725
MOD_CK2_1	38	44	PF00069	0.656
MOD_CK2_1	453	459	PF00069	0.577
MOD_CK2_1	52	58	PF00069	0.693
MOD_CK2_1	658	664	PF00069	0.666
MOD_CK2_1	672	678	PF00069	0.477
MOD_CK2_1	680	686	PF00069	0.529
MOD_GlcNHglycan	113	116	PF01048	0.713
MOD_GlcNHglycan	133	136	PF01048	0.401
MOD_GlcNHglycan	146	149	PF01048	0.674
MOD_GlcNHglycan	215	218	PF01048	0.611
MOD_GlcNHglycan	273	276	PF01048	0.747
MOD_GlcNHglycan	283	286	PF01048	0.625
MOD_GlcNHglycan	331	334	PF01048	0.611
MOD_GlcNHglycan	367	371	PF01048	0.734
MOD_GlcNHglycan	381	384	PF01048	0.649
MOD_GlcNHglycan	388	391	PF01048	0.657
MOD_GlcNHglycan	413	416	PF01048	0.653
MOD_GlcNHglycan	421	424	PF01048	0.555
MOD_GlcNHglycan	461	464	PF01048	0.572
MOD_GlcNHglycan	47	50	PF01048	0.708
MOD_GlcNHglycan	557	561	PF01048	0.693
MOD_GlcNHglycan	571	574	PF01048	0.786
MOD_GlcNHglycan	576	579	PF01048	0.718
MOD_GlcNHglycan	667	672	PF01048	0.490
MOD_GSK3_1	127	134	PF00069	0.655
MOD_GSK3_1	146	153	PF00069	0.462
MOD_GSK3_1	178	185	PF00069	0.719
MOD_GSK3_1	267	274	PF00069	0.684
MOD_GSK3_1	277	284	PF00069	0.655
MOD_GSK3_1	379	386	PF00069	0.803
MOD_GSK3_1	421	428	PF00069	0.634
MOD_GSK3_1	524	531	PF00069	0.583
MOD_GSK3_1	567	574	PF00069	0.666
MOD_GSK3_1	577	584	PF00069	0.717
MOD_GSK3_1	591	598	PF00069	0.482
MOD_GSK3_1	663	670	PF00069	0.689
MOD_GSK3_1	69	76	PF00069	0.737
MOD_GSK3_1	93	100	PF00069	0.725
MOD_N-GLC_1	425	430	PF02516	0.636
MOD_N-GLC_2	445	447	PF02516	0.669
MOD_NEK2_1	144	149	PF00069	0.745
MOD_NEK2_1	315	320	PF00069	0.709
MOD_NEK2_1	329	334	PF00069	0.537
MOD_NEK2_1	37	42	PF00069	0.651
MOD_NEK2_1	453	458	PF00069	0.574
MOD_NEK2_1	511	516	PF00069	0.690
MOD_NEK2_1	544	549	PF00069	0.579
MOD_NEK2_1	63	68	PF00069	0.710
MOD_NEK2_1	672	677	PF00069	0.636
MOD_NEK2_1	713	718	PF00069	0.585
MOD_NEK2_1	73	78	PF00069	0.620
MOD_PIKK_1	114	120	PF00454	0.657
MOD_PIKK_1	127	133	PF00454	0.496
MOD_PIKK_1	244	250	PF00454	0.632
MOD_PIKK_1	315	321	PF00454	0.736
MOD_PIKK_1	384	390	PF00454	0.761
MOD_PIKK_1	528	534	PF00454	0.614
MOD_PIKK_1	581	587	PF00454	0.761
MOD_PIKK_1	706	712	PF00454	0.531
MOD_PK_1	505	511	PF00069	0.630
MOD_PKA_1	400	406	PF00069	0.640
MOD_PKA_1	681	687	PF00069	0.576
MOD_PKA_2	127	133	PF00069	0.657
MOD_PKA_2	239	245	PF00069	0.618
MOD_PKA_2	261	267	PF00069	0.606
MOD_PKA_2	38	44	PF00069	0.656
MOD_PKA_2	400	406	PF00069	0.653
MOD_PKA_2	45	51	PF00069	0.705
MOD_PKA_2	649	655	PF00069	0.472
MOD_PKA_2	680	686	PF00069	0.578
MOD_PKA_2	69	75	PF00069	0.722
MOD_PKA_2	78	84	PF00069	0.604
MOD_Plk_1	425	431	PF00069	0.703
MOD_Plk_1	479	485	PF00069	0.589
MOD_Plk_1	519	525	PF00069	0.662
MOD_Plk_1	556	562	PF00069	0.653
MOD_Plk_1	667	673	PF00069	0.685
MOD_Plk_1	73	79	PF00069	0.746
MOD_Plk_2-3	479	485	PF00069	0.626
MOD_Plk_4	104	110	PF00069	0.618
MOD_Plk_4	160	166	PF00069	0.723
MOD_Plk_4	339	345	PF00069	0.518
MOD_Plk_4	428	434	PF00069	0.699
MOD_Plk_4	453	459	PF00069	0.577
MOD_Plk_4	519	525	PF00069	0.592
MOD_Plk_4	73	79	PF00069	0.746
MOD_Plk_4	93	99	PF00069	0.471
MOD_ProDKin_1	179	185	PF00069	0.688
MOD_ProDKin_1	274	280	PF00069	0.748
MOD_ProDKin_1	567	573	PF00069	0.663
MOD_ProDKin_1	636	642	PF00069	0.567
MOD_ProDKin_1	91	97	PF00069	0.716
MOD_SUMO_for_1	27	30	PF00179	0.743
MOD_SUMO_rev_2	564	571	PF00179	0.737
MOD_SUMO_rev_2	599	604	PF00179	0.622
TRG_DiLeu_BaEn_1	557	562	PF01217	0.540
TRG_DiLeu_BaEn_4	303	309	PF01217	0.731
TRG_DiLeu_BaEn_4	349	355	PF01217	0.685
TRG_DiLeu_BaLyEn_6	436	441	PF01217	0.678
TRG_DiLeu_BaLyEn_6	637	642	PF01217	0.593
TRG_ENDOCYTIC_2	24	27	PF00928	0.760
TRG_ENDOCYTIC_2	337	340	PF00928	0.588
TRG_ER_diArg_1	400	402	PF00400	0.644
TRG_ER_diArg_1	655	657	PF00400	0.576
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	485	490	PF00026	0.743
TRG_Pf-PMV_PEXEL_1	537	542	PF00026	0.679

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I841	Leptomonas seymouri	44%	97%
A4HHQ9	Leishmania braziliensis	72%	99%
A4I4T7	Leishmania infantum	99%	100%
E9AEC3	Leishmania major	90%	100%
E9ALG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%