Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X2Z1_LEIDO

TriTrypDb:

LdBPK_300030.1 , LdCL_300005300 , LDHU3_30.0080

Length:

238

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X2Z1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2Z1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	228	232	PF00656	0.489
CLV_NRD_NRD_1	116	118	PF00675	0.525
CLV_NRD_NRD_1	154	156	PF00675	0.579
CLV_NRD_NRD_1	196	198	PF00675	0.583
CLV_NRD_NRD_1	2	4	PF00675	0.707
CLV_NRD_NRD_1	203	205	PF00675	0.527
CLV_NRD_NRD_1	6	8	PF00675	0.735
CLV_NRD_NRD_1	90	92	PF00675	0.548
CLV_PCSK_KEX2_1	116	118	PF00082	0.525
CLV_PCSK_KEX2_1	156	158	PF00082	0.581
CLV_PCSK_KEX2_1	196	198	PF00082	0.610
CLV_PCSK_KEX2_1	2	4	PF00082	0.707
CLV_PCSK_KEX2_1	234	236	PF00082	0.675
CLV_PCSK_KEX2_1	6	8	PF00082	0.735
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.581
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.675
CLV_PCSK_PC7_1	2	8	PF00082	0.740
CLV_PCSK_SKI1_1	174	178	PF00082	0.601
CLV_PCSK_SKI1_1	6	10	PF00082	0.667
CLV_PCSK_SKI1_1	68	72	PF00082	0.487
DEG_Nend_UBRbox_1	1	4	PF02207	0.635
DOC_CDC14_PxL_1	34	42	PF14671	0.562
DOC_CKS1_1	110	115	PF01111	0.499
DOC_CYCLIN_yCln2_LP_2	141	144	PF00134	0.494
DOC_MAPK_gen_1	196	202	PF00069	0.550
DOC_MAPK_gen_1	73	81	PF00069	0.590
DOC_PP1_RVXF_1	24	31	PF00149	0.587
DOC_PP2B_LxvP_1	141	144	PF13499	0.470
DOC_USP7_UBL2_3	230	234	PF12436	0.633
DOC_WW_Pin1_4	10	15	PF00397	0.714
DOC_WW_Pin1_4	109	114	PF00397	0.495
DOC_WW_Pin1_4	74	79	PF00397	0.551
LIG_14-3-3_CanoR_1	6	15	PF00244	0.732
LIG_14-3-3_CanoR_1	97	101	PF00244	0.606
LIG_CtBP_PxDLS_1	143	147	PF00389	0.528
LIG_deltaCOP1_diTrp_1	160	168	PF00928	0.617
LIG_EH1_1	64	72	PF00400	0.569
LIG_eIF4E_1	131	137	PF01652	0.453
LIG_FHA_2	103	109	PF00498	0.517
LIG_LIR_Gen_1	102	109	PF02991	0.545
LIG_LIR_Gen_1	130	137	PF02991	0.453
LIG_LIR_Gen_1	148	159	PF02991	0.570
LIG_LIR_Nem_3	102	106	PF02991	0.526
LIG_LIR_Nem_3	112	118	PF02991	0.457
LIG_LIR_Nem_3	148	154	PF02991	0.618
LIG_Pex14_1	114	118	PF04695	0.488
LIG_Pex14_1	53	57	PF04695	0.486
LIG_Pex14_2	202	206	PF04695	0.467
LIG_SH2_STAP1	220	224	PF00017	0.531
LIG_SH2_STAT5	175	178	PF00017	0.547
LIG_SUMO_SIM_par_1	77	82	PF11976	0.548
LIG_TRAF2_1	105	108	PF00917	0.528
LIG_TRAF2_1	48	51	PF00917	0.613
MOD_CDK_SPxK_1	10	16	PF00069	0.649
MOD_CDK_SPxxK_3	109	116	PF00069	0.505
MOD_CK1_1	10	16	PF00069	0.678
MOD_CK1_1	145	151	PF00069	0.624
MOD_CK1_1	169	175	PF00069	0.599
MOD_CK1_1	96	102	PF00069	0.570
MOD_CK2_1	101	107	PF00069	0.538
MOD_CK2_1	74	80	PF00069	0.508
MOD_GlcNHglycan	138	141	PF01048	0.602
MOD_GlcNHglycan	220	223	PF01048	0.564
MOD_GlcNHglycan	9	12	PF01048	0.643
MOD_GSK3_1	95	102	PF00069	0.581
MOD_NEK2_1	136	141	PF00069	0.592
MOD_NEK2_1	209	214	PF00069	0.552
MOD_PKA_2	96	102	PF00069	0.607
MOD_Plk_1	49	55	PF00069	0.584
MOD_Plk_2-3	166	172	PF00069	0.607
MOD_ProDKin_1	10	16	PF00069	0.715
MOD_ProDKin_1	109	115	PF00069	0.494
MOD_ProDKin_1	74	80	PF00069	0.546
MOD_SUMO_rev_2	201	206	PF00179	0.546
MOD_SUMO_rev_2	84	94	PF00179	0.538
TRG_DiLeu_BaEn_1	132	137	PF01217	0.447
TRG_ENDOCYTIC_2	131	134	PF00928	0.456
TRG_ENDOCYTIC_2	151	154	PF00928	0.381
TRG_ENDOCYTIC_2	191	194	PF00928	0.564
TRG_ENDOCYTIC_2	199	202	PF00928	0.494
TRG_ER_diArg_1	1	3	PF00400	0.708
TRG_ER_diArg_1	115	117	PF00400	0.531
TRG_ER_diArg_1	154	157	PF00400	0.584
TRG_ER_diArg_1	6	8	PF00400	0.735
TRG_NLS_MonoExtC_3	154	160	PF00514	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I128	Leptomonas seymouri	83%	100%
A0A0S4IVT3	Bodo saltans	51%	93%
A0A1X0P3S5	Trypanosomatidae	74%	100%
A4HHU8	Leishmania braziliensis	92%	100%
A4I4Z8	Leishmania infantum	100%	100%
C9ZQE7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
E9B0C8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q7V6	Leishmania major	96%	100%