Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X2Z0_LEIDO

TriTrypDb:

LdBPK_300240.1 , LdCL_300007500 , LDHU3_30.0380

Length:

596

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X2Z0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2Z0

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016539	intein-mediated protein splicing	7	1
GO:0019538	protein metabolic process	3	1
GO:0030908	protein splicing	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	98	102	PF00656	0.506
CLV_NRD_NRD_1	171	173	PF00675	0.374
CLV_NRD_NRD_1	191	193	PF00675	0.212
CLV_NRD_NRD_1	209	211	PF00675	0.354
CLV_NRD_NRD_1	330	332	PF00675	0.481
CLV_NRD_NRD_1	556	558	PF00675	0.433
CLV_NRD_NRD_1	579	581	PF00675	0.481
CLV_NRD_NRD_1	86	88	PF00675	0.414
CLV_PCSK_KEX2_1	171	173	PF00082	0.507
CLV_PCSK_KEX2_1	191	193	PF00082	0.212
CLV_PCSK_KEX2_1	2	4	PF00082	0.675
CLV_PCSK_KEX2_1	209	211	PF00082	0.286
CLV_PCSK_KEX2_1	247	249	PF00082	0.390
CLV_PCSK_KEX2_1	267	269	PF00082	0.271
CLV_PCSK_KEX2_1	330	332	PF00082	0.426
CLV_PCSK_KEX2_1	362	364	PF00082	0.446
CLV_PCSK_KEX2_1	556	558	PF00082	0.422
CLV_PCSK_KEX2_1	578	580	PF00082	0.487
CLV_PCSK_KEX2_1	94	96	PF00082	0.522
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.507
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.543
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.390
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.271
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.446
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.522
CLV_PCSK_PC7_1	326	332	PF00082	0.492
CLV_PCSK_SKI1_1	134	138	PF00082	0.542
CLV_PCSK_SKI1_1	164	168	PF00082	0.314
CLV_PCSK_SKI1_1	226	230	PF00082	0.319
CLV_PCSK_SKI1_1	248	252	PF00082	0.549
CLV_PCSK_SKI1_1	271	275	PF00082	0.382
CLV_PCSK_SKI1_1	335	339	PF00082	0.398
CLV_PCSK_SKI1_1	363	367	PF00082	0.424
CLV_PCSK_SKI1_1	531	535	PF00082	0.543
CLV_PCSK_SKI1_1	54	58	PF00082	0.467
DEG_Nend_UBRbox_1	1	4	PF02207	0.647
DEG_SCF_FBW7_1	198	205	PF00400	0.473
DEG_SPOP_SBC_1	538	542	PF00917	0.491
DOC_CDC14_PxL_1	230	238	PF14671	0.494
DOC_CDC14_PxL_1	545	553	PF14671	0.502
DOC_CKS1_1	136	141	PF01111	0.452
DOC_CKS1_1	199	204	PF01111	0.484
DOC_CYCLIN_RxL_1	330	341	PF00134	0.465
DOC_CYCLIN_yCln2_LP_2	304	310	PF00134	0.503
DOC_MAPK_gen_1	191	198	PF00069	0.335
DOC_MAPK_gen_1	266	276	PF00069	0.351
DOC_MAPK_gen_1	330	340	PF00069	0.440
DOC_MAPK_gen_1	362	370	PF00069	0.481
DOC_MAPK_gen_1	556	567	PF00069	0.533
DOC_MAPK_MEF2A_6	267	276	PF00069	0.325
DOC_MAPK_MEF2A_6	305	312	PF00069	0.478
DOC_MAPK_MEF2A_6	560	569	PF00069	0.504
DOC_MAPK_RevD_3	565	580	PF00069	0.478
DOC_PP2B_LxvP_1	304	307	PF13499	0.514
DOC_PP2B_LxvP_1	495	498	PF13499	0.468
DOC_PP2B_LxvP_1	518	521	PF13499	0.605
DOC_PP4_FxxP_1	181	184	PF00568	0.338
DOC_PP4_FxxP_1	19	22	PF00568	0.691
DOC_USP7_MATH_1	519	523	PF00917	0.576
DOC_USP7_MATH_1	527	531	PF00917	0.651
DOC_USP7_MATH_1	538	542	PF00917	0.606
DOC_USP7_UBL2_3	31	35	PF12436	0.579
DOC_USP7_UBL2_3	362	366	PF12436	0.585
DOC_WW_Pin1_4	135	140	PF00397	0.538
DOC_WW_Pin1_4	18	23	PF00397	0.475
DOC_WW_Pin1_4	198	203	PF00397	0.337
DOC_WW_Pin1_4	5	10	PF00397	0.633
LIG_14-3-3_CanoR_1	213	223	PF00244	0.439
LIG_14-3-3_CanoR_1	226	231	PF00244	0.266
LIG_14-3-3_CanoR_1	248	257	PF00244	0.424
LIG_14-3-3_CanoR_1	26	34	PF00244	0.624
LIG_14-3-3_CanoR_1	434	441	PF00244	0.589
LIG_14-3-3_CanoR_1	87	96	PF00244	0.395
LIG_Clathr_ClatBox_1	337	341	PF01394	0.370
LIG_CSL_BTD_1	199	202	PF09270	0.347
LIG_DLG_GKlike_1	95	103	PF00625	0.515
LIG_FHA_1	199	205	PF00498	0.479
LIG_FHA_1	215	221	PF00498	0.508
LIG_FHA_1	312	318	PF00498	0.471
LIG_FHA_1	412	418	PF00498	0.641
LIG_FHA_2	123	129	PF00498	0.417
LIG_FHA_2	151	157	PF00498	0.336
LIG_FHA_2	489	495	PF00498	0.507
LIG_FHA_2	502	508	PF00498	0.413
LIG_HCF-1_HBM_1	259	262	PF13415	0.342
LIG_Integrin_RGD_1	387	389	PF01839	0.433
LIG_Integrin_RGD_1	580	582	PF01839	0.414
LIG_LIR_Apic_2	16	22	PF02991	0.652
LIG_LIR_Gen_1	104	113	PF02991	0.370
LIG_LIR_Gen_1	153	162	PF02991	0.354
LIG_LIR_Gen_1	403	409	PF02991	0.436
LIG_LIR_Gen_1	476	485	PF02991	0.477
LIG_LIR_Gen_1	590	596	PF02991	0.612
LIG_LIR_Nem_3	104	109	PF02991	0.338
LIG_LIR_Nem_3	130	136	PF02991	0.510
LIG_LIR_Nem_3	153	157	PF02991	0.300
LIG_LIR_Nem_3	403	407	PF02991	0.424
LIG_LIR_Nem_3	471	477	PF02991	0.359
LIG_LIR_Nem_3	590	595	PF02991	0.506
LIG_Pex14_1	473	477	PF04695	0.360
LIG_Pex14_2	74	78	PF04695	0.358
LIG_PTB_Apo_2	395	402	PF02174	0.403
LIG_PTB_Phospho_1	395	401	PF10480	0.403
LIG_SH2_CRK	477	481	PF00017	0.416
LIG_SH2_CRK	49	53	PF00017	0.465
LIG_SH2_GRB2like	147	150	PF00017	0.405
LIG_SH2_STAP1	401	405	PF00017	0.363
LIG_SH2_STAP1	477	481	PF00017	0.417
LIG_SH2_STAT3	147	150	PF00017	0.498
LIG_SH2_STAT5	154	157	PF00017	0.325
LIG_SH2_STAT5	203	206	PF00017	0.427
LIG_SH2_STAT5	235	238	PF00017	0.514
LIG_SH2_STAT5	275	278	PF00017	0.419
LIG_SH2_STAT5	51	54	PF00017	0.385
LIG_SH2_STAT5	545	548	PF00017	0.473
LIG_SH2_STAT5	550	553	PF00017	0.559
LIG_SH2_STAT5	572	575	PF00017	0.406
LIG_SH3_3	133	139	PF00018	0.548
LIG_SH3_3	4	10	PF00018	0.701
LIG_SH3_3	451	457	PF00018	0.632
LIG_SH3_3	518	524	PF00018	0.568
LIG_SH3_3	543	549	PF00018	0.558
LIG_SH3_3	63	69	PF00018	0.390
LIG_SH3_3	90	96	PF00018	0.380
LIG_SUMO_SIM_anti_2	566	571	PF11976	0.492
LIG_SUMO_SIM_par_1	336	341	PF11976	0.454
LIG_TRAF2_1	504	507	PF00917	0.443
LIG_WRC_WIRS_1	401	406	PF05994	0.427
MOD_CK1_1	214	220	PF00069	0.394
MOD_CK1_1	237	243	PF00069	0.381
MOD_CK1_1	311	317	PF00069	0.525
MOD_CK1_1	322	328	PF00069	0.525
MOD_CK1_1	411	417	PF00069	0.621
MOD_CK2_1	150	156	PF00069	0.347
MOD_CK2_1	488	494	PF00069	0.492
MOD_CK2_1	501	507	PF00069	0.505
MOD_CK2_1	584	590	PF00069	0.451
MOD_CMANNOS	285	288	PF00535	0.315
MOD_Cter_Amidation	554	557	PF01082	0.460
MOD_GlcNHglycan	22	25	PF01048	0.560
MOD_GlcNHglycan	410	413	PF01048	0.663
MOD_GlcNHglycan	426	429	PF01048	0.487
MOD_GlcNHglycan	531	534	PF01048	0.682
MOD_GlcNHglycan	553	556	PF01048	0.520
MOD_GlcNHglycan	561	564	PF01048	0.446
MOD_GlcNHglycan	63	66	PF01048	0.457
MOD_GSK3_1	198	205	PF00069	0.358
MOD_GSK3_1	322	329	PF00069	0.497
MOD_GSK3_1	353	360	PF00069	0.488
MOD_GSK3_1	411	418	PF00069	0.570
MOD_GSK3_1	527	534	PF00069	0.641
MOD_N-GLC_1	211	216	PF02516	0.476
MOD_N-GLC_1	357	362	PF02516	0.381
MOD_NEK2_1	109	114	PF00069	0.381
MOD_NEK2_1	122	127	PF00069	0.297
MOD_NEK2_1	253	258	PF00069	0.460
MOD_NEK2_1	287	292	PF00069	0.305
MOD_NEK2_1	353	358	PF00069	0.496
MOD_NEK2_1	400	405	PF00069	0.437
MOD_NEK2_1	499	504	PF00069	0.434
MOD_NEK2_1	551	556	PF00069	0.538
MOD_NEK2_2	203	208	PF00069	0.532
MOD_PIKK_1	248	254	PF00454	0.418
MOD_PIKK_1	436	442	PF00454	0.743
MOD_PIKK_1	501	507	PF00454	0.545
MOD_PKA_1	267	273	PF00069	0.401
MOD_PKA_1	87	93	PF00069	0.400
MOD_PKA_2	208	214	PF00069	0.422
MOD_PKA_2	25	31	PF00069	0.692
MOD_PKA_2	267	273	PF00069	0.401
MOD_PKA_2	381	387	PF00069	0.586
MOD_PKA_2	424	430	PF00069	0.695
MOD_PKA_2	433	439	PF00069	0.690
MOD_PKA_2	559	565	PF00069	0.531
MOD_Plk_1	211	217	PF00069	0.479
MOD_Plk_1	237	243	PF00069	0.379
MOD_Plk_1	279	285	PF00069	0.388
MOD_Plk_1	59	65	PF00069	0.479
MOD_Plk_4	150	156	PF00069	0.364
MOD_Plk_4	203	209	PF00069	0.375
MOD_Plk_4	237	243	PF00069	0.421
MOD_Plk_4	299	305	PF00069	0.608
MOD_Plk_4	400	406	PF00069	0.499
MOD_Plk_4	415	421	PF00069	0.654
MOD_Plk_4	476	482	PF00069	0.432
MOD_Plk_4	568	574	PF00069	0.469
MOD_Plk_4	68	74	PF00069	0.305
MOD_Plk_4	95	101	PF00069	0.408
MOD_ProDKin_1	135	141	PF00069	0.537
MOD_ProDKin_1	18	24	PF00069	0.474
MOD_ProDKin_1	198	204	PF00069	0.343
MOD_ProDKin_1	5	11	PF00069	0.630
MOD_SUMO_for_1	1	4	PF00179	0.620
MOD_SUMO_for_1	184	187	PF00179	0.400
MOD_SUMO_rev_2	126	136	PF00179	0.479
MOD_SUMO_rev_2	259	269	PF00179	0.363
TRG_DiLeu_BaEn_1	507	512	PF01217	0.326
TRG_DiLeu_BaEn_1	513	518	PF01217	0.374
TRG_DiLeu_BaEn_4	463	469	PF01217	0.399
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.467
TRG_ENDOCYTIC_2	106	109	PF00928	0.339
TRG_ENDOCYTIC_2	154	157	PF00928	0.343
TRG_ENDOCYTIC_2	401	404	PF00928	0.447
TRG_ENDOCYTIC_2	477	480	PF00928	0.534
TRG_ENDOCYTIC_2	49	52	PF00928	0.328
TRG_ER_diArg_1	208	210	PF00400	0.473
TRG_ER_diArg_1	213	216	PF00400	0.488
TRG_ER_diArg_1	330	333	PF00400	0.573
TRG_ER_diArg_1	370	373	PF00400	0.673
TRG_ER_diArg_1	556	558	PF00400	0.433
TRG_ER_diArg_1	577	580	PF00400	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8C2	Leptomonas seymouri	67%	100%
A0A1X0P2D9	Trypanosomatidae	41%	100%
A0A3S5IRH4	Trypanosoma rangeli	41%	100%
A4HHW8	Leishmania braziliensis	81%	100%
A4I518	Leishmania infantum	100%	100%
C9ZQH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B0E8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	98%
Q4Q7T5	Leishmania major	93%	100%
V5BLG2	Trypanosoma cruzi	43%	100%