LIM domain containing protein, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X2Y9_LEIDO

TriTrypDb:

LdBPK_300280.1 , LdCL_300007900 , LDHU3_30.0420

Length:

217

Annotations

Annotations by Jardim et al.

Metal Binding, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X2Y9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2Y9

PDB structure(s): 7aih_Ax , 7am2_Ax , 7ane_Ax

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	163	165	PF00675	0.438
CLV_NRD_NRD_1	181	183	PF00675	0.428
CLV_NRD_NRD_1	62	64	PF00675	0.549
CLV_PCSK_KEX2_1	163	165	PF00082	0.438
CLV_PCSK_KEX2_1	181	183	PF00082	0.428
CLV_PCSK_KEX2_1	62	64	PF00082	0.527
CLV_PCSK_PC7_1	177	183	PF00082	0.463
CLV_PCSK_SKI1_1	142	146	PF00082	0.408
DEG_Nend_Nbox_1	1	3	PF02207	0.696
DOC_MAPK_gen_1	204	211	PF00069	0.486
DOC_PP2B_LxvP_1	39	42	PF13499	0.682
DOC_PP4_FxxP_1	20	23	PF00568	0.738
DOC_USP7_MATH_1	23	27	PF00917	0.706
DOC_WW_Pin1_4	211	216	PF00397	0.544
DOC_WW_Pin1_4	6	11	PF00397	0.688
LIG_14-3-3_CanoR_1	182	188	PF00244	0.463
LIG_14-3-3_CanoR_1	24	32	PF00244	0.697
LIG_CSL_BTD_1	122	125	PF09270	0.335
LIG_FHA_1	183	189	PF00498	0.465
LIG_FHA_1	34	40	PF00498	0.677
LIG_FHA_1	89	95	PF00498	0.628
LIG_LIR_Gen_1	120	129	PF02991	0.336
LIG_LIR_Gen_1	3	11	PF02991	0.523
LIG_LIR_Nem_3	120	124	PF02991	0.330
LIG_LIR_Nem_3	3	7	PF02991	0.654
LIG_Pex14_1	147	151	PF04695	0.378
LIG_Pex14_1	183	187	PF04695	0.447
LIG_PTB_Apo_2	153	160	PF02174	0.378
LIG_PTB_Phospho_1	153	159	PF10480	0.378
LIG_REV1ctd_RIR_1	136	146	PF16727	0.408
LIG_SH2_CRK	151	155	PF00017	0.447
LIG_SH2_CRK	4	8	PF00017	0.685
LIG_SH2_GRB2like	187	190	PF00017	0.460
LIG_SH2_PTP2	121	124	PF00017	0.355
LIG_SH2_STAP1	90	94	PF00017	0.591
LIG_SH2_STAT5	121	124	PF00017	0.350
LIG_SH2_STAT5	137	140	PF00017	0.266
LIG_SH2_STAT5	187	190	PF00017	0.441
LIG_SH2_STAT5	90	93	PF00017	0.621
LIG_SH3_1	82	88	PF00018	0.551
LIG_SH3_3	119	125	PF00018	0.335
LIG_SH3_3	82	88	PF00018	0.537
LIG_SH3_3	91	97	PF00018	0.378
LIG_TRAF2_1	77	80	PF00917	0.656
MOD_CDK_SPK_2	211	216	PF00069	0.544
MOD_CDK_SPxxK_3	6	13	PF00069	0.524
MOD_CK1_1	195	201	PF00069	0.493
MOD_CK2_1	211	217	PF00069	0.556
MOD_GlcNHglycan	125	128	PF01048	0.408
MOD_GlcNHglycan	25	28	PF01048	0.732
MOD_GlcNHglycan	51	54	PF01048	0.670
MOD_GSK3_1	183	190	PF00069	0.462
MOD_GSK3_1	23	30	PF00069	0.673
MOD_LATS_1	47	53	PF00433	0.656
MOD_NEK2_1	32	37	PF00069	0.643
MOD_PIKK_1	55	61	PF00454	0.558
MOD_PKA_2	195	201	PF00069	0.472
MOD_PKA_2	23	29	PF00069	0.701
MOD_Plk_4	117	123	PF00069	0.355
MOD_Plk_4	183	189	PF00069	0.465
MOD_ProDKin_1	211	217	PF00069	0.556
MOD_ProDKin_1	6	12	PF00069	0.690
TRG_ENDOCYTIC_2	121	124	PF00928	0.348
TRG_ENDOCYTIC_2	151	154	PF00928	0.378
TRG_ENDOCYTIC_2	4	7	PF00928	0.689
TRG_ER_diArg_1	181	183	PF00400	0.453
TRG_ER_diArg_1	203	206	PF00400	0.555
TRG_ER_diArg_1	62	64	PF00400	0.549
TRG_ER_diArg_1	82	85	PF00400	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF24	Leptomonas seymouri	83%	100%
A0A0S4JZ50	Bodo saltans	62%	99%
A0A1X0P3Q2	Trypanosomatidae	75%	100%
A0A3R7L3B1	Trypanosoma rangeli	76%	100%
A4HHX2	Leishmania braziliensis	92%	100%
A4I522	Leishmania infantum	100%	100%
C9ZQI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	78%	100%
E9B0F2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q7T1	Leishmania major	95%	100%