Mitochondrial_carrier_protein_putative/Pfam:PF001 53

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X2Y8_LEIDO

TriTrypDb:

LdBPK_300230.1 , LdCL_300007400 , LDHU3_30.0370

Length:

351

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3S7X2Y8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2Y8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.514
CLV_NRD_NRD_1	166	168	PF00675	0.192
CLV_NRD_NRD_1	274	276	PF00675	0.349
CLV_NRD_NRD_1	347	349	PF00675	0.506
CLV_PCSK_KEX2_1	132	134	PF00082	0.513
CLV_PCSK_KEX2_1	166	168	PF00082	0.192
CLV_PCSK_KEX2_1	273	275	PF00082	0.349
CLV_PCSK_KEX2_1	83	85	PF00082	0.302
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.302
CLV_PCSK_SKI1_1	191	195	PF00082	0.354
CLV_PCSK_SKI1_1	266	270	PF00082	0.371
CLV_PCSK_SKI1_1	289	293	PF00082	0.276
CLV_PCSK_SKI1_1	89	93	PF00082	0.296
DEG_APCC_DBOX_1	247	255	PF00400	0.577
DOC_MAPK_gen_1	180	189	PF00069	0.476
DOC_MAPK_gen_1	95	105	PF00069	0.432
DOC_MAPK_MEF2A_6	180	189	PF00069	0.479
DOC_MAPK_MEF2A_6	221	228	PF00069	0.314
DOC_MAPK_NFAT4_5	221	229	PF00069	0.307
DOC_PP1_RVXF_1	198	205	PF00149	0.324
DOC_PP1_RVXF_1	87	93	PF00149	0.576
DOC_PP2B_LxvP_1	55	58	PF13499	0.423
DOC_USP7_MATH_1	243	247	PF00917	0.562
DOC_USP7_MATH_1	72	76	PF00917	0.556
DOC_WW_Pin1_4	16	21	PF00397	0.691
LIG_14-3-3_CanoR_1	156	162	PF00244	0.455
LIG_14-3-3_CanoR_1	191	196	PF00244	0.294
LIG_14-3-3_CanoR_1	28	38	PF00244	0.563
LIG_14-3-3_CanoR_1	309	317	PF00244	0.519
LIG_14-3-3_CanoR_1	7	15	PF00244	0.677
LIG_14-3-3_CanoR_1	77	87	PF00244	0.532
LIG_14-3-3_CanoR_1	98	103	PF00244	0.520
LIG_BIR_II_1	1	5	PF00653	0.683
LIG_BRCT_BRCA1_1	200	204	PF00533	0.377
LIG_DLG_GKlike_1	98	105	PF00625	0.392
LIG_EVH1_2	342	346	PF00568	0.663
LIG_FHA_1	113	119	PF00498	0.348
LIG_FHA_1	139	145	PF00498	0.378
LIG_FHA_1	192	198	PF00498	0.431
LIG_FHA_1	310	316	PF00498	0.523
LIG_FHA_1	324	330	PF00498	0.604
LIG_FHA_1	54	60	PF00498	0.485
LIG_LIR_Apic_2	18	24	PF02991	0.656
LIG_LIR_Apic_2	312	317	PF02991	0.546
LIG_LIR_Gen_1	101	109	PF02991	0.304
LIG_LIR_Gen_1	114	123	PF02991	0.306
LIG_LIR_Gen_1	149	159	PF02991	0.392
LIG_LIR_Nem_3	101	105	PF02991	0.321
LIG_LIR_Nem_3	114	119	PF02991	0.225
LIG_LIR_Nem_3	149	155	PF02991	0.392
LIG_LIR_Nem_3	217	223	PF02991	0.306
LIG_LIR_Nem_3	267	272	PF02991	0.500
LIG_LIR_Nem_3	279	285	PF02991	0.474
LIG_LIR_Nem_3	308	314	PF02991	0.552
LIG_LIR_Nem_3	63	68	PF02991	0.532
LIG_PCNA_yPIPBox_3	200	214	PF02747	0.385
LIG_Pex14_2	204	208	PF04695	0.289
LIG_Pex14_2	223	227	PF04695	0.289
LIG_Pex14_2	88	92	PF04695	0.493
LIG_Rb_pABgroove_1	276	284	PF01858	0.564
LIG_REV1ctd_RIR_1	283	289	PF16727	0.494
LIG_REV1ctd_RIR_1	85	93	PF16727	0.513
LIG_SH2_CRK	109	113	PF00017	0.377
LIG_SH2_CRK	152	156	PF00017	0.450
LIG_SH2_CRK	21	25	PF00017	0.726
LIG_SH2_CRK	216	220	PF00017	0.338
LIG_SH2_CRK	265	269	PF00017	0.581
LIG_SH2_NCK_1	145	149	PF00017	0.217
LIG_SH2_SRC	314	317	PF00017	0.588
LIG_SH2_STAP1	311	315	PF00017	0.527
LIG_SH2_STAT3	242	245	PF00017	0.540
LIG_SH2_STAT5	229	232	PF00017	0.275
LIG_SH2_STAT5	31	34	PF00017	0.547
LIG_SH2_STAT5	311	314	PF00017	0.530
LIG_SH2_STAT5	337	340	PF00017	0.676
LIG_SH2_STAT5	66	69	PF00017	0.502
LIG_SH3_2	162	167	PF14604	0.392
LIG_SH3_3	159	165	PF00018	0.503
LIG_SH3_3	329	335	PF00018	0.630
LIG_SUMO_SIM_anti_2	194	199	PF11976	0.406
LIG_TYR_ITIM	214	219	PF00017	0.344
LIG_WRC_WIRS_1	113	118	PF05994	0.377
LIG_WRC_WIRS_1	232	237	PF05994	0.388
LIG_WW_1	341	344	PF00397	0.656
MOD_CK1_1	2	8	PF00069	0.613
MOD_CK1_1	328	334	PF00069	0.652
MOD_GlcNHglycan	168	171	PF01048	0.303
MOD_GlcNHglycan	292	295	PF01048	0.278
MOD_GSK3_1	305	312	PF00069	0.500
MOD_GSK3_1	317	324	PF00069	0.604
MOD_N-GLC_1	254	259	PF02516	0.365
MOD_NEK2_1	111	116	PF00069	0.323
MOD_NEK2_1	144	149	PF00069	0.377
MOD_NEK2_1	198	203	PF00069	0.406
MOD_NEK2_1	3	8	PF00069	0.644
MOD_NEK2_2	243	248	PF00069	0.506
MOD_PIKK_1	31	37	PF00454	0.615
MOD_PIKK_1	323	329	PF00454	0.676
MOD_PKA_1	166	172	PF00069	0.392
MOD_PKA_2	155	161	PF00069	0.451
MOD_PKA_2	166	172	PF00069	0.451
MOD_PKA_2	9	15	PF00069	0.681
MOD_Plk_1	73	79	PF00069	0.582
MOD_Plk_2-3	124	130	PF00069	0.263
MOD_Plk_4	231	237	PF00069	0.321
MOD_ProDKin_1	16	22	PF00069	0.691
TRG_ENDOCYTIC_2	109	112	PF00928	0.335
TRG_ENDOCYTIC_2	152	155	PF00928	0.444
TRG_ENDOCYTIC_2	190	193	PF00928	0.275
TRG_ENDOCYTIC_2	211	214	PF00928	0.241
TRG_ENDOCYTIC_2	216	219	PF00928	0.322
TRG_ENDOCYTIC_2	220	223	PF00928	0.316
TRG_ENDOCYTIC_2	229	232	PF00928	0.213
TRG_ENDOCYTIC_2	265	268	PF00928	0.562
TRG_ENDOCYTIC_2	282	285	PF00928	0.409
TRG_ER_diArg_1	165	167	PF00400	0.392
TRG_ER_diArg_1	272	275	PF00400	0.484
TRG_ER_diArg_1	97	100	PF00400	0.467
TRG_Pf-PMV_PEXEL_1	266	271	PF00026	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD65	Leptomonas seymouri	68%	99%
A0A1X0P2B3	Trypanosomatidae	54%	98%
A4HHW7	Leishmania braziliensis	82%	100%
A4I517	Leishmania infantum	99%	100%
C9ZQH4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9B0E7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P04710	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
Q4Q7T6	Leishmania major	93%	100%
V5DD32	Trypanosoma cruzi	55%	100%