LeishMANIAdb
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ATP-dependent 6-phosphofructokinase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ATP-dependent 6-phosphofructokinase
Gene product:
ATP-dependent 6-phosphofructokinase, glycosomal
Species:
Leishmania donovani
UniProt:
A0A3S7X2Y4_LEIDO
TriTrypDb:
LdBPK_292620.1 , LdCL_290032300 , LDHU3_29.3880
Length:
486

Annotations

Annotations by Jardim et al.

Glycolysis Proteins, ATP-dependent 6-phosphofructokinase pfk

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 8
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 2
GO:0005777 peroxisome 6 10
GO:0016020 membrane 2 1
GO:0020015 glycosome 7 10
GO:0042579 microbody 5 10
GO:0043226 organelle 2 10
GO:0043227 membrane-bounded organelle 3 10
GO:0043229 intracellular organelle 3 10
GO:0043231 intracellular membrane-bounded organelle 4 10
GO:0110165 cellular anatomical entity 1 11
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Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3S7X2Y4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2Y4

Function

Biological processes
TermNameLevelCount
GO:0006002 fructose 6-phosphate metabolic process 4 12
GO:0006793 phosphorus metabolic process 3 12
GO:0006796 phosphate-containing compound metabolic process 4 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0019637 organophosphate metabolic process 3 12
GO:0044237 cellular metabolic process 2 12
GO:0071704 organic substance metabolic process 2 12
GO:1901135 carbohydrate derivative metabolic process 3 12
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Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 12
GO:0003872 6-phosphofructokinase activity 6 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 11
GO:0008443 phosphofructokinase activity 5 12
GO:0016301 kinase activity 4 12
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 12
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 386 390 PF00656 0.420
CLV_C14_Caspase3-7 65 69 PF00656 0.592
CLV_NRD_NRD_1 212 214 PF00675 0.209
CLV_NRD_NRD_1 309 311 PF00675 0.209
CLV_NRD_NRD_1 432 434 PF00675 0.294
CLV_NRD_NRD_1 465 467 PF00675 0.428
CLV_NRD_NRD_1 85 87 PF00675 0.421
CLV_PCSK_FUR_1 126 130 PF00082 0.269
CLV_PCSK_KEX2_1 128 130 PF00082 0.209
CLV_PCSK_KEX2_1 211 213 PF00082 0.209
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1PBL6 Leptomonas seymouri 90% 100%
A0A0S4IQ47 Bodo saltans 60% 98%
A0A1X0P916 Trypanosomatidae 72% 100%
A0A3R7N9H0 Trypanosoma rangeli 72% 100%
A2RE65 Streptococcus pyogenes serotype M5 (strain Manfredo) 25% 100%
A2RKA2 Lactococcus lactis subsp. cremoris (strain MG1363) 26% 100%
A3CM69 Streptococcus sanguinis (strain SK36) 25% 100%
A3N1C8 Actinobacillus pleuropneumoniae serotype 5b (strain L20) 29% 100%
A4HHQ0 Leishmania braziliensis 95% 100%
A4I4W5 Leishmania infantum 100% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS