Acyltransferase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X2X4_LEIDO

TriTrypDb:

LdBPK_292520.1 , LdCL_290031300 , LDHU3_29.3760

Length:

415

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 7
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3S7X2X4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2X4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008374	O-acyltransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11
GO:0005488	binding	1	2
GO:0005509	calcium ion binding	5	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	238	240	PF00675	0.438
CLV_NRD_NRD_1	277	279	PF00675	0.513
CLV_NRD_NRD_1	371	373	PF00675	0.470
CLV_PCSK_KEX2_1	277	279	PF00082	0.462
CLV_PCSK_KEX2_1	371	373	PF00082	0.509
CLV_PCSK_SKI1_1	146	150	PF00082	0.358
CLV_PCSK_SKI1_1	306	310	PF00082	0.420
CLV_PCSK_SKI1_1	402	406	PF00082	0.618
CLV_PCSK_SKI1_1	5	9	PF00082	0.376
DEG_APCC_KENBOX_2	239	243	PF00400	0.301
DOC_CKS1_1	12	17	PF01111	0.565
DOC_CKS1_1	122	127	PF01111	0.461
DOC_MAPK_gen_1	239	245	PF00069	0.262
DOC_PP1_RVXF_1	62	69	PF00149	0.283
DOC_PP2B_LxvP_1	26	29	PF13499	0.545
DOC_PP2B_LxvP_1	92	95	PF13499	0.591
DOC_USP7_MATH_1	206	210	PF00917	0.506
DOC_USP7_MATH_1	216	220	PF00917	0.371
DOC_USP7_MATH_1	264	268	PF00917	0.213
DOC_USP7_MATH_1	6	10	PF00917	0.572
DOC_WW_Pin1_4	11	16	PF00397	0.570
DOC_WW_Pin1_4	121	126	PF00397	0.477
LIG_14-3-3_CanoR_1	146	155	PF00244	0.365
LIG_14-3-3_CanoR_1	181	189	PF00244	0.446
LIG_14-3-3_CanoR_1	253	260	PF00244	0.270
LIG_14-3-3_CanoR_1	347	355	PF00244	0.230
LIG_14-3-3_CanoR_1	383	389	PF00244	0.390
LIG_14-3-3_CanoR_1	98	103	PF00244	0.557
LIG_APCC_ABBA_1	287	292	PF00400	0.206
LIG_BIR_II_1	1	5	PF00653	0.679
LIG_BRCT_BRCA1_1	243	247	PF00533	0.253
LIG_BRCT_BRCA1_1	348	352	PF00533	0.284
LIG_BRCT_BRCA1_1	56	60	PF00533	0.314
LIG_CaM_NSCaTE_8	35	42	PF13499	0.306
LIG_Clathr_ClatBox_1	83	87	PF01394	0.223
LIG_deltaCOP1_diTrp_1	223	233	PF00928	0.306
LIG_eIF4E_1	355	361	PF01652	0.276
LIG_FHA_1	12	18	PF00498	0.563
LIG_FHA_1	149	155	PF00498	0.337
LIG_FHA_1	158	164	PF00498	0.270
LIG_FHA_1	181	187	PF00498	0.465
LIG_FHA_1	271	277	PF00498	0.272
LIG_FHA_1	80	86	PF00498	0.321
LIG_FHA_2	110	116	PF00498	0.505
LIG_FHA_2	122	128	PF00498	0.507
LIG_FHA_2	205	211	PF00498	0.469
LIG_FHA_2	264	270	PF00498	0.214
LIG_FHA_2	365	371	PF00498	0.285
LIG_FHA_2	47	53	PF00498	0.372
LIG_LIR_Apic_2	121	125	PF02991	0.509
LIG_LIR_Apic_2	168	173	PF02991	0.349
LIG_LIR_Gen_1	127	137	PF02991	0.464
LIG_LIR_Gen_1	183	193	PF02991	0.377
LIG_LIR_Gen_1	223	234	PF02991	0.389
LIG_LIR_Gen_1	23	33	PF02991	0.462
LIG_LIR_Nem_3	127	132	PF02991	0.466
LIG_LIR_Nem_3	152	158	PF02991	0.302
LIG_LIR_Nem_3	183	188	PF02991	0.344
LIG_LIR_Nem_3	223	229	PF02991	0.352
LIG_LIR_Nem_3	23	28	PF02991	0.541
LIG_LIR_Nem_3	244	248	PF02991	0.341
LIG_LIR_Nem_3	349	355	PF02991	0.306
LIG_LIR_Nem_3	395	401	PF02991	0.278
LIG_LIR_Nem_3	403	408	PF02991	0.323
LIG_MLH1_MIPbox_1	243	247	PF16413	0.237
LIG_NRP_CendR_1	412	415	PF00754	0.537
LIG_PCNA_yPIPBox_3	375	389	PF02747	0.274
LIG_Pex14_1	174	178	PF04695	0.302
LIG_Pex14_1	68	72	PF04695	0.249
LIG_Pex14_2	144	148	PF04695	0.284
LIG_Pex14_2	155	159	PF04695	0.284
LIG_Pex14_2	327	331	PF04695	0.240
LIG_PTAP_UEV_1	281	286	PF05743	0.237
LIG_SH2_CRK	122	126	PF00017	0.518
LIG_SH2_CRK	36	40	PF00017	0.240
LIG_SH2_CRK	4	8	PF00017	0.539
LIG_SH2_NCK_1	122	126	PF00017	0.509
LIG_SH2_SRC	106	109	PF00017	0.557
LIG_SH2_SRC	170	173	PF00017	0.329
LIG_SH2_SRC	355	358	PF00017	0.325
LIG_SH2_STAT3	197	200	PF00017	0.308
LIG_SH2_STAT5	16	19	PF00017	0.581
LIG_SH2_STAT5	166	169	PF00017	0.351
LIG_SH2_STAT5	228	231	PF00017	0.306
LIG_SH2_STAT5	25	28	PF00017	0.547
LIG_SH2_STAT5	72	75	PF00017	0.321
LIG_SH3_3	279	285	PF00018	0.217
LIG_SH3_3	360	366	PF00018	0.271
LIG_SH3_3	9	15	PF00018	0.658
LIG_TRAF2_1	366	369	PF00917	0.312
LIG_TYR_ITIM	34	39	PF00017	0.262
LIG_TYR_ITIM	353	358	PF00017	0.326
LIG_WRC_WIRS_1	233	238	PF05994	0.206
MOD_CK1_1	180	186	PF00069	0.267
MOD_CK1_1	235	241	PF00069	0.259
MOD_CK1_1	394	400	PF00069	0.251
MOD_CK2_1	204	210	PF00069	0.519
MOD_CK2_1	235	241	PF00069	0.206
MOD_CK2_1	263	269	PF00069	0.292
MOD_CK2_1	364	370	PF00069	0.281
MOD_CK2_1	46	52	PF00069	0.403
MOD_GlcNHglycan	39	42	PF01048	0.453
MOD_GSK3_1	180	187	PF00069	0.348
MOD_GSK3_1	7	14	PF00069	0.598
MOD_N-GLC_1	216	221	PF02516	0.259
MOD_N-GLC_1	241	246	PF02516	0.501
MOD_N-GLC_1	391	396	PF02516	0.509
MOD_NEK2_1	137	142	PF00069	0.259
MOD_NEK2_1	148	153	PF00069	0.270
MOD_NEK2_1	159	164	PF00069	0.293
MOD_NEK2_1	376	381	PF00069	0.335
MOD_NEK2_1	384	389	PF00069	0.261
MOD_NEK2_1	79	84	PF00069	0.260
MOD_PKA_2	180	186	PF00069	0.301
MOD_PKA_2	252	258	PF00069	0.301
MOD_PKA_2	346	352	PF00069	0.286
MOD_Plk_1	216	222	PF00069	0.269
MOD_Plk_1	241	247	PF00069	0.301
MOD_Plk_1	394	400	PF00069	0.245
MOD_Plk_1	51	57	PF00069	0.283
MOD_Plk_4	232	238	PF00069	0.215
MOD_Plk_4	241	247	PF00069	0.206
MOD_Plk_4	254	260	PF00069	0.215
MOD_Plk_4	271	277	PF00069	0.262
MOD_Plk_4	384	390	PF00069	0.289
MOD_Plk_4	79	85	PF00069	0.298
MOD_ProDKin_1	11	17	PF00069	0.569
MOD_ProDKin_1	121	127	PF00069	0.474
MOD_SUMO_rev_2	209	214	PF00179	0.423
MOD_SUMO_rev_2	368	376	PF00179	0.379
MOD_SUMO_rev_2	394	404	PF00179	0.350
TRG_DiLeu_BaEn_1	210	215	PF01217	0.420
TRG_DiLeu_BaLyEn_6	356	361	PF01217	0.274
TRG_ENDOCYTIC_2	129	132	PF00928	0.453
TRG_ENDOCYTIC_2	202	205	PF00928	0.533
TRG_ENDOCYTIC_2	25	28	PF00928	0.553
TRG_ENDOCYTIC_2	324	327	PF00928	0.293
TRG_ENDOCYTIC_2	355	358	PF00928	0.325
TRG_ENDOCYTIC_2	36	39	PF00928	0.255
TRG_ENDOCYTIC_2	4	7	PF00928	0.593
TRG_ER_diArg_1	276	278	PF00400	0.313
TRG_ER_diLys_1	412	415	PF00400	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C8	Leptomonas seymouri	61%	99%
A0A0S4IPK1	Bodo saltans	45%	86%
A0A1X0P927	Trypanosomatidae	49%	88%
A0A3R7NZP9	Trypanosoma rangeli	49%	91%
A4HHP0	Leishmania braziliensis	82%	100%
A4I4V5	Leishmania infantum	100%	100%
C9ZL05	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	89%
E9AEA3	Leishmania major	94%	100%
E9ALI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q8BYI6	Mus musculus	31%	76%
Q8S8S2	Arabidopsis thaliana	30%	77%