Leucine-rich repeat protein, putative

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine-rich repeat, ribonuclease inhibitor subtype domain-containing protein

Species:

Leishmania donovani

UniProt:

A0A3S7X2X2_LEIDO

TriTrypDb:

LdBPK_300150.1 , LdCL_300006600 , LDHU3_30.0260

Length:

216

Annotations

LeishMANIAdb annotations

Leucine-rich repeat proteins with a hydrophobic terminal helix. Unlike its distant animal relatives, this cytoplasmic sensor protein might be anchored to the membrane.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	5
GO:0016020	membrane	2	4
GO:0042995	cell projection	2	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0110165	cellular anatomical entity	1	5
GO:0120025	plasma membrane bounded cell projection	3	5
GO:0005739	mitochondrion	5	1
GO:0005741	mitochondrial outer membrane	5	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

A0A3S7X2X2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2X2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	38	42	PF00656	0.627
CLV_PCSK_SKI1_1	110	114	PF00082	0.222
CLV_PCSK_SKI1_1	139	143	PF00082	0.318
CLV_PCSK_SKI1_1	164	168	PF00082	0.506
CLV_PCSK_SKI1_1	92	96	PF00082	0.427
DOC_MAPK_gen_1	4	13	PF00069	0.445
DOC_MAPK_MEF2A_6	4	13	PF00069	0.627
DOC_MAPK_MEF2A_6	63	71	PF00069	0.627
DOC_USP7_MATH_1	144	148	PF00917	0.705
DOC_USP7_UBL2_3	88	92	PF12436	0.627
LIG_14-3-3_CanoR_1	121	127	PF00244	0.784
LIG_14-3-3_CanoR_1	146	155	PF00244	0.700
LIG_14-3-3_CanoR_1	182	186	PF00244	0.808
LIG_14-3-3_CterR_2	213	216	PF00244	0.588
LIG_BIR_II_1	1	5	PF00653	0.627
LIG_BRCT_BRCA1_1	9	13	PF00533	0.627
LIG_DLG_GKlike_1	63	71	PF00625	0.627
LIG_FHA_1	140	146	PF00498	0.728
LIG_FHA_1	34	40	PF00498	0.627
LIG_FHA_2	127	133	PF00498	0.581
LIG_FHA_2	3	9	PF00498	0.627
LIG_FHA_2	93	99	PF00498	0.625
LIG_LIR_Apic_2	156	161	PF02991	0.805
LIG_LIR_Gen_1	10	19	PF02991	0.627
LIG_LIR_Gen_1	76	86	PF02991	0.568
LIG_LIR_Nem_3	10	16	PF02991	0.525
LIG_LIR_Nem_3	76	82	PF02991	0.581
LIG_SH2_CRK	158	162	PF00017	0.805
LIG_SH2_CRK	194	198	PF00017	0.518
LIG_SH2_NCK_1	172	176	PF00017	0.743
LIG_SH2_SRC	122	125	PF00017	0.786
LIG_SH2_STAP1	124	128	PF00017	0.627
LIG_SH2_STAT5	122	125	PF00017	0.786
LIG_SUMO_SIM_par_1	202	207	PF11976	0.390
LIG_SUMO_SIM_par_1	35	41	PF11976	0.627
LIG_TYR_ITIM	192	197	PF00017	0.518
MOD_CK1_1	147	153	PF00069	0.805
MOD_CK1_1	30	36	PF00069	0.627
MOD_CK1_1	59	65	PF00069	0.680
MOD_CK2_1	2	8	PF00069	0.627
MOD_CK2_1	59	65	PF00069	0.728
MOD_GlcNHglycan	59	62	PF01048	0.490
MOD_GSK3_1	122	129	PF00069	0.525
MOD_GSK3_1	144	151	PF00069	0.802
MOD_GSK3_1	33	40	PF00069	0.532
MOD_GSK3_1	59	66	PF00069	0.683
MOD_N-GLC_1	67	72	PF02516	0.318
MOD_NEK2_1	126	131	PF00069	0.627
MOD_NEK2_1	56	61	PF00069	0.787
MOD_NEK2_1	67	72	PF00069	0.479
MOD_NEK2_1	86	91	PF00069	0.798
MOD_NEK2_2	181	186	PF00069	0.808
MOD_NEK2_2	2	7	PF00069	0.445
MOD_PKA_2	145	151	PF00069	0.762
MOD_PKA_2	181	187	PF00069	0.805
MOD_Plk_1	67	73	PF00069	0.519
MOD_Plk_1	7	13	PF00069	0.627
MOD_Plk_4	187	193	PF00069	0.588
MOD_Plk_4	204	210	PF00069	0.301
MOD_SUMO_rev_2	173	180	PF00179	0.748
TRG_ENDOCYTIC_2	172	175	PF00928	0.740
TRG_ENDOCYTIC_2	194	197	PF00928	0.518
TRG_ER_diArg_1	210	213	PF00400	0.579
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	4	8	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I510	Leishmania infantum	99%	100%
E9B0E0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q7T8	Leishmania major	94%	100%