Disabled homolog 1-like

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X2X0_LEIDO

TriTrypDb:

LdBPK_292800.1 , LdCL_290034100 , LDHU3_29.4120

Length:

308

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X2X0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2X0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.599
CLV_NRD_NRD_1	5	7	PF00675	0.711
CLV_PCSK_SKI1_1	23	27	PF00082	0.721
DEG_Nend_UBRbox_2	1	3	PF02207	0.763
DOC_PP2B_LxvP_1	51	54	PF13499	0.751
DOC_PP4_FxxP_1	79	82	PF00568	0.794
DOC_PP4_MxPP_1	97	100	PF00568	0.769
DOC_USP7_MATH_1	114	118	PF00917	0.705
DOC_USP7_MATH_1	12	16	PF00917	0.649
DOC_USP7_MATH_1	181	185	PF00917	0.727
DOC_USP7_MATH_1	216	220	PF00917	0.752
DOC_USP7_MATH_1	238	242	PF00917	0.576
DOC_USP7_MATH_1	254	258	PF00917	0.723
DOC_USP7_MATH_1	275	279	PF00917	0.718
DOC_USP7_MATH_1	286	290	PF00917	0.725
DOC_USP7_MATH_1	52	56	PF00917	0.644
DOC_WW_Pin1_4	108	113	PF00397	0.738
DOC_WW_Pin1_4	142	147	PF00397	0.674
DOC_WW_Pin1_4	165	170	PF00397	0.706
DOC_WW_Pin1_4	185	190	PF00397	0.723
DOC_WW_Pin1_4	218	223	PF00397	0.732
DOC_WW_Pin1_4	269	274	PF00397	0.733
DOC_WW_Pin1_4	86	91	PF00397	0.635
LIG_BIR_III_2	34	38	PF00653	0.665
LIG_BRCT_BRCA1_1	191	195	PF00533	0.797
LIG_BRCT_BRCA1_1	26	30	PF00533	0.519
LIG_CSL_BTD_1	92	95	PF09270	0.700
LIG_EVH1_1	79	83	PF00568	0.717
LIG_FHA_1	186	192	PF00498	0.738
LIG_FHA_2	219	225	PF00498	0.689
LIG_LIR_Apic_2	132	136	PF02991	0.593
LIG_LYPXL_yS_3	64	67	PF13949	0.666
LIG_SH2_CRK	128	132	PF00017	0.678
LIG_SH2_CRK	133	137	PF00017	0.729
LIG_SH2_NCK_1	253	257	PF00017	0.765
LIG_SH2_STAP1	171	175	PF00017	0.743
LIG_SH2_STAT3	115	118	PF00017	0.754
LIG_SH2_STAT3	60	63	PF00017	0.637
LIG_SH2_STAT5	115	118	PF00017	0.773
LIG_SH2_STAT5	171	174	PF00017	0.818
LIG_SH3_3	175	181	PF00018	0.727
LIG_SH3_3	203	209	PF00018	0.736
LIG_SH3_3	212	218	PF00018	0.640
LIG_SH3_3	226	232	PF00018	0.721
LIG_SH3_3	77	83	PF00018	0.716
LIG_SH3_3	95	101	PF00018	0.633
LIG_SH3_4	161	168	PF00018	0.679
LIG_TYR_ITIM	126	131	PF00017	0.508
MOD_CDK_SPK_2	269	274	PF00069	0.733
MOD_CK1_1	200	206	PF00069	0.716
MOD_CK2_1	181	187	PF00069	0.646
MOD_CK2_1	218	224	PF00069	0.687
MOD_GlcNHglycan	158	161	PF01048	0.723
MOD_GlcNHglycan	183	186	PF01048	0.785
MOD_GlcNHglycan	199	202	PF01048	0.639
MOD_GlcNHglycan	256	259	PF01048	0.725
MOD_GlcNHglycan	26	29	PF01048	0.587
MOD_GlcNHglycan	305	308	PF01048	0.662
MOD_GSK3_1	165	172	PF00069	0.709
MOD_GSK3_1	181	188	PF00069	0.714
MOD_GSK3_1	196	203	PF00069	0.544
MOD_GSK3_1	248	255	PF00069	0.691
MOD_GSK3_1	275	282	PF00069	0.704
MOD_GSK3_1	82	89	PF00069	0.745
MOD_N-GLC_1	106	111	PF02516	0.792
MOD_N-GLC_1	201	206	PF02516	0.680
MOD_NEK2_1	131	136	PF00069	0.614
MOD_NEK2_1	139	144	PF00069	0.671
MOD_NEK2_1	150	155	PF00069	0.789
MOD_NEK2_1	196	201	PF00069	0.680
MOD_NEK2_1	223	228	PF00069	0.583
MOD_PIKK_1	114	120	PF00454	0.715
MOD_PIKK_1	248	254	PF00454	0.669
MOD_PIKK_1	286	292	PF00454	0.769
MOD_Plk_1	106	112	PF00069	0.792
MOD_Plk_1	223	229	PF00069	0.798
MOD_Plk_1	267	273	PF00069	0.726
MOD_ProDKin_1	108	114	PF00069	0.736
MOD_ProDKin_1	142	148	PF00069	0.677
MOD_ProDKin_1	165	171	PF00069	0.709
MOD_ProDKin_1	185	191	PF00069	0.722
MOD_ProDKin_1	218	224	PF00069	0.734
MOD_ProDKin_1	269	275	PF00069	0.735
MOD_ProDKin_1	86	92	PF00069	0.637
MOD_SUMO_rev_2	2	8	PF00179	0.703
TRG_ENDOCYTIC_2	128	131	PF00928	0.617
TRG_ENDOCYTIC_2	64	67	PF00928	0.642

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCA0	Leptomonas seymouri	51%	99%
A4HHS6	Leishmania braziliensis	69%	100%
A4I4X7	Leishmania infantum	100%	100%
E9AED1	Leishmania major	91%	100%
E9ALF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%