LeishMANIAdb
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Serine/threonine_protein_kinase_putative/GeneDB:L mjF.29.2720

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine/threonine_protein_kinase_putative/GeneDB:L mjF.29.2720
Gene product:
protein kinase, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X2W9_LEIDO
TriTrypDb:
LdBPK_292830.1 * , LdCL_290034400 , LDHU3_29.4150
Length:
323

Annotations

Annotations by Jardim et al.

Protein kinase, kinase Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

A0A3S7X2W9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2W9

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 10
GO:0006793 phosphorus metabolic process 3 10
GO:0006796 phosphate-containing compound metabolic process 4 10
GO:0006807 nitrogen compound metabolic process 2 10
GO:0008152 metabolic process 1 10
GO:0009987 cellular process 1 10
GO:0016310 phosphorylation 5 10
GO:0019538 protein metabolic process 3 10
GO:0036211 protein modification process 4 10
GO:0043170 macromolecule metabolic process 3 10
GO:0043412 macromolecule modification 4 10
GO:0044237 cellular metabolic process 2 10
GO:0044238 primary metabolic process 2 10
GO:0071704 organic substance metabolic process 2 10
GO:1901564 organonitrogen compound metabolic process 3 10
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0004672 protein kinase activity 3 11
GO:0004674 protein serine/threonine kinase activity 4 5
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016301 kinase activity 4 11
GO:0016740 transferase activity 2 11
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 11
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 11
GO:0017076 purine nucleotide binding 4 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11
GO:0004713 protein tyrosine kinase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 308 312 PF00656 0.567
CLV_NRD_NRD_1 162 164 PF00675 0.355
CLV_NRD_NRD_1 204 206 PF00675 0.386
CLV_NRD_NRD_1 271 273 PF00675 0.431
CLV_NRD_NRD_1 298 300 PF00675 0.473
CLV_PCSK_KEX2_1 162 164 PF00082 0.362
CLV_PCSK_KEX2_1 204 206 PF00082 0.356
CLV_PCSK_KEX2_1 271 273 PF00082 0.431
CLV_PCSK_KEX2_1 298 300 PF00082 0.498
CLV_PCSK_KEX2_1 68 70 PF00082 0.330
CLV_PCSK_PC1ET2_1 68 70 PF00082 0.330
CLV_PCSK_SKI1_1 106 110 PF00082 0.367
DOC_PP2B_LxvP_1 122 125 PF13499 0.458
DOC_USP7_MATH_1 18 22 PF00917 0.679
DOC_USP7_MATH_1 86 90 PF00917 0.407
DOC_WW_Pin1_4 205 210 PF00397 0.370
DOC_WW_Pin1_4 251 256 PF00397 0.376
DOC_WW_Pin1_4 317 322 PF00397 0.648
LIG_14-3-3_CanoR_1 17 27 PF00244 0.639
LIG_14-3-3_CanoR_1 286 294 PF00244 0.404
LIG_14-3-3_CanoR_1 40 49 PF00244 0.244
LIG_BIR_II_1 1 5 PF00653 0.654
LIG_BRCT_BRCA1_1 253 257 PF00533 0.425
LIG_deltaCOP1_diTrp_1 100 109 PF00928 0.356
LIG_eIF4E_1 206 212 PF01652 0.425
LIG_FHA_1 130 136 PF00498 0.444
LIG_FHA_2 235 241 PF00498 0.413
LIG_FHA_2 280 286 PF00498 0.518
LIG_LIR_Apic_2 203 209 PF02991 0.313
LIG_LIR_Gen_1 254 265 PF02991 0.425
LIG_LIR_Gen_1 274 284 PF02991 0.419
LIG_LIR_Gen_1 56 64 PF02991 0.360
LIG_LIR_Nem_3 192 197 PF02991 0.425
LIG_LIR_Nem_3 254 260 PF02991 0.357
LIG_LIR_Nem_3 274 279 PF02991 0.419
LIG_LIR_Nem_3 44 50 PF02991 0.301
LIG_LIR_Nem_3 56 60 PF02991 0.288
LIG_SH2_NCK_1 253 257 PF00017 0.354
LIG_SH2_STAT5 98 101 PF00017 0.332
LIG_SH3_3 215 221 PF00018 0.389
LIG_Sin3_3 257 264 PF02671 0.458
LIG_SUMO_SIM_par_1 25 30 PF11976 0.607
MOD_CDK_SPK_2 317 322 PF00069 0.609
MOD_CK1_1 129 135 PF00069 0.434
MOD_CK1_1 2 8 PF00069 0.690
MOD_CK1_1 243 249 PF00069 0.396
MOD_CK1_1 25 31 PF00069 0.589
MOD_CK1_1 43 49 PF00069 0.294
MOD_CK2_1 234 240 PF00069 0.382
MOD_CK2_1 279 285 PF00069 0.484
MOD_GlcNHglycan 245 248 PF01048 0.365
MOD_GlcNHglycan 273 276 PF01048 0.425
MOD_GlcNHglycan 4 7 PF01048 0.726
MOD_GSK3_1 18 25 PF00069 0.590
MOD_GSK3_1 236 243 PF00069 0.356
MOD_GSK3_1 30 37 PF00069 0.232
MOD_GSK3_1 316 323 PF00069 0.675
MOD_N-GLC_1 243 248 PF02516 0.399
MOD_NEK2_1 135 140 PF00069 0.348
MOD_NEK2_1 19 24 PF00069 0.631
MOD_NEK2_1 260 265 PF00069 0.425
MOD_PIKK_1 19 25 PF00454 0.669
MOD_PKA_1 271 277 PF00069 0.419
MOD_PKA_2 271 277 PF00069 0.386
MOD_PKA_2 30 36 PF00069 0.540
MOD_Plk_4 126 132 PF00069 0.423
MOD_Plk_4 166 172 PF00069 0.416
MOD_Plk_4 260 266 PF00069 0.410
MOD_ProDKin_1 205 211 PF00069 0.370
MOD_ProDKin_1 251 257 PF00069 0.376
MOD_ProDKin_1 317 323 PF00069 0.655
MOD_SUMO_for_1 155 158 PF00179 0.356
MOD_SUMO_rev_2 149 157 PF00179 0.410
TRG_DiLeu_BaLyEn_6 283 288 PF01217 0.553
TRG_ER_diArg_1 161 163 PF00400 0.408
TRG_ER_diArg_1 204 206 PF00400 0.386
TRG_ER_diArg_1 271 273 PF00400 0.434
TRG_ER_diArg_1 298 300 PF00400 0.509
TRG_Pf-PMV_PEXEL_1 163 168 PF00026 0.425
TRG_Pf-PMV_PEXEL_1 286 290 PF00026 0.626

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3N5 Leptomonas seymouri 23% 75%
A0A0N0P3Q8 Leptomonas seymouri 26% 90%
A0A0N0P953 Leptomonas seymouri 26% 67%
A0A0N1HT76 Leptomonas seymouri 25% 72%
A0A0N1I0G1 Leptomonas seymouri 27% 100%
A0A0N1I3G0 Leptomonas seymouri 25% 80%
A0A0N1I6T8 Leptomonas seymouri 26% 100%
A0A0N1IM47 Leptomonas seymouri 27% 88%
A0A0N1PC01 Leptomonas seymouri 68% 98%
A0A0N1PC31 Leptomonas seymouri 26% 83%
A0A0N1PD05 Leptomonas seymouri 25% 72%
A0A0S4IHW4 Bodo saltans 22% 72%
A0A0S4IQX7 Bodo saltans 24% 84%
A0A0S4IX86 Bodo saltans 25% 75%
A0A0S4J3Y5 Bodo saltans 26% 75%
A0A0S4J4B3 Bodo saltans 24% 72%
A0A0S4JCG2 Bodo saltans 26% 72%
A0A0S4JF22 Bodo saltans 24% 90%
A0A0S4JHA7 Bodo saltans 29% 70%
A0A0S4JU73 Bodo saltans 26% 68%
A0A0S4JUJ2 Bodo saltans 27% 100%
A0A0S4JVD7 Bodo saltans 26% 74%
A0A0S4KEA4 Bodo saltans 34% 80%
A0A0S4KFT7 Bodo saltans 27% 96%
A0A0S4KMV7 Bodo saltans 26% 100%
A0A0S4KN74 Bodo saltans 27% 99%
A0A1X0NIA0 Trypanosomatidae 26% 75%
A0A1X0NLC8 Trypanosomatidae 28% 68%
A0A1X0NM44 Trypanosomatidae 26% 94%
A0A1X0NQ63 Trypanosomatidae 24% 100%
A0A1X0NRZ9 Trypanosomatidae 25% 88%
A0A1X0NTR6 Trypanosomatidae 25% 92%
A0A1X0P1A2 Trypanosomatidae 23% 70%
A0A1X0P2H8 Trypanosomatidae 25% 80%
A0A1X0P3X8 Trypanosomatidae 26% 99%
A0A1X0P527 Trypanosomatidae 26% 73%
A0A1X0P549 Trypanosomatidae 28% 68%
A0A1X0P6E7 Trypanosomatidae 25% 82%
A0A1X0P919 Trypanosomatidae 26% 87%
A0A1X0P9V2 Trypanosomatidae 46% 89%
A0A3Q8IC87 Leishmania donovani 26% 87%
A0A3Q8IFW0 Leishmania donovani 23% 75%
A0A3Q8INQ4 Leishmania donovani 26% 83%
A0A3Q8IPR6 Leishmania donovani 25% 99%
A0A3R7KRP1 Trypanosoma rangeli 27% 68%
A0A3R7M5C7 Trypanosoma rangeli 25% 100%
A0A3R7MHW5 Trypanosoma rangeli 25% 81%
A0A3R7NKI8 Trypanosoma rangeli 24% 100%
A0A3S5H606 Leishmania donovani 26% 100%
A0A3S5H789 Leishmania donovani 24% 84%
A0A3S5IRC3 Trypanosoma rangeli 25% 86%
A0A3S7WP41 Leishmania donovani 28% 100%
A0A3S7X6T8 Leishmania donovani 23% 72%
A0A3S7X7Y2 Leishmania donovani 25% 84%
A0A422NDD2 Trypanosoma rangeli 24% 93%
A0A422NEU6 Trypanosoma rangeli 43% 95%
A0A422P292 Trypanosoma rangeli 29% 100%
A1D624 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) 28% 76%
A2XFC8 Oryza sativa subsp. indica 26% 88%
A4H4A1 Leishmania braziliensis 28% 100%
A4H539 Leishmania braziliensis 26% 100%
A4HAS1 Leishmania braziliensis 24% 84%
A4HCD7 Leishmania braziliensis 25% 76%
A4HFI2 Leishmania braziliensis 24% 98%
A4HHP8 Leishmania braziliensis 23% 72%
A4HHS9 Leishmania braziliensis 83% 100%
A4HJW2 Leishmania braziliensis 23% 75%
A4HLR0 Leishmania braziliensis 23% 72%
A4HSH7 Leishmania infantum 29% 100%
A4HTB4 Leishmania infantum 26% 100%
A4HYX6 Leishmania infantum 24% 84%
A4HZV1 Leishmania infantum 26% 87%
A4I1T4 Leishmania infantum 26% 83%
A4I4Y0 Leishmania infantum 100% 100%
A4I7C4 Leishmania infantum 23% 75%
A4I960 Leishmania infantum 23% 72%
A4I9Y5 Leishmania infantum 25% 84%
A4K2M3 Papio anubis 25% 66%
A4K2P5 Colobus guereza 25% 66%
A4K2Q5 Otolemur garnettii 25% 66%
A4K2S1 Lemur catta 25% 66%
A4K2T0 Macaca mulatta 25% 66%
A4K2W5 Aotus nancymaae 25% 66%
A4K2Y1 Chlorocebus aethiops 25% 66%
A9RWC9 Physcomitrium patens 24% 92%
B0LT89 Rattus norvegicus 24% 75%
C9ZKZ8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 68%
C9ZL78 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 77%
C9ZN29 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 22% 67%
C9ZSI7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
C9ZUD1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 22% 94%
C9ZUK8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
C9ZW68 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 92%
C9ZWI1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 75%
D0A3L9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 92%
D0A8X3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 88%
D0N4E2 Phytophthora infestans (strain T30-4) 25% 81%
E9AD33 Leishmania major 25% 99%
E9AEB1 Leishmania major 25% 72%
E9AED4 Leishmania major 94% 100%
E9AFZ2 Leishmania major 25% 68%
E9AHC6 Leishmania infantum 26% 99%
E9AKG1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9ALA7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9ALF2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
E9ALH5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 72%
E9ASL0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 66%
E9AVR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 87%
E9AXW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 83%
E9AYV7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 99%
E9B2B7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 75%
E9B436 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 72%
E9B4Z4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 84%
E9B745 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 68%
O00506 Homo sapiens 27% 76%
O14305 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 69%
O14733 Homo sapiens 26% 77%
O14757 Homo sapiens 25% 68%
O35280 Mus musculus 26% 68%
O43293 Homo sapiens 25% 71%
O54784 Mus musculus 25% 72%
O59790 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 91%
O61267 Drosophila melanogaster 25% 68%
O88764 Rattus norvegicus 25% 72%
O94768 Homo sapiens 26% 87%
P06245 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 85%
P06493 Homo sapiens 25% 100%
P11440 Mus musculus 25% 100%
P22517 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 72%
P23572 Drosophila melanogaster 23% 100%
P24923 Medicago sativa 29% 100%
P27466 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 72%
P35567 Xenopus laevis 25% 100%
P39951 Rattus norvegicus 25% 100%
P43294 Arabidopsis thaliana 25% 73%
P51955 Homo sapiens 26% 73%
P54665 Trypanosoma brucei brucei 22% 94%
P93101 Oxybasis rubra 25% 100%
Q00771 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 26% 78%
Q09170 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 29% 70%
Q10N20 Oryza sativa subsp. japonica 26% 88%
Q13043 Homo sapiens 25% 66%
Q20085 Caenorhabditis elegans 24% 69%
Q21307 Caenorhabditis elegans 27% 93%
Q24324 Drosophila melanogaster 28% 82%
Q2HJF7 Bos taurus 23% 66%
Q3SWY6 Bos taurus 27% 76%
Q40532 Nicotiana tabacum 25% 82%
Q41639 Vigna aconitifolia 26% 100%
Q4KSH7 Rattus norvegicus 30% 77%
Q4Q2Z2 Leishmania major 25% 84%
Q4Q3Y9 Leishmania major 23% 72%
Q4Q5T9 Leishmania major 22% 75%
Q4Q9K2 Leishmania major 26% 83%
Q4QA98 Leishmania major 26% 92%
Q4QBR6 Leishmania major 26% 87%
Q4QIJ7 Leishmania major 26% 100%
Q4QJE7 Leishmania major 29% 100%
Q4WYR6 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 28% 76%
Q54E34 Dictyostelium discoideum 29% 92%
Q54JG7 Dictyostelium discoideum 24% 67%
Q5E9L6 Bos taurus 25% 66%
Q5HZ38 Arabidopsis thaliana 25% 79%
Q5QN75 Oryza sativa subsp. japonica 24% 91%
Q5RCH1 Pongo abelii 24% 100%
Q5ZJK4 Gallus gallus 25% 66%
Q5ZKI0 Gallus gallus 23% 67%
Q64261 Mus musculus 28% 99%
Q6C3J2 Yarrowia lipolytica (strain CLIB 122 / E 150) 24% 87%
Q6CWQ4 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 24% 89%
Q6DE87 Xenopus laevis 27% 68%
Q6P3Q4 Xenopus tropicalis 25% 67%
Q6PA14 Xenopus laevis 25% 67%
Q6Z8C8 Oryza sativa subsp. japonica 24% 70%
Q86UX6 Homo sapiens 26% 66%
Q8BG48 Mus musculus 25% 87%
Q8GVC7 Phytophthora infestans 25% 81%
Q8MYQ1 Caenorhabditis elegans 27% 73%
Q91XS8 Rattus norvegicus 25% 87%
Q91ZN7 Rattus norvegicus 26% 68%
Q93V58 Arabidopsis thaliana 25% 82%
Q99KH8 Mus musculus 23% 75%
Q9DG02 Xenopus laevis 23% 68%
Q9JI11 Mus musculus 25% 66%
Q9JJX8 Mus musculus 22% 78%
Q9LT35 Arabidopsis thaliana 27% 78%
Q9NY57 Homo sapiens 22% 78%
Q9Y6E0 Homo sapiens 23% 73%
Q9Z2W1 Mus musculus 26% 76%
V5B8E0 Trypanosoma cruzi 29% 92%
V5B9R6 Trypanosoma cruzi 25% 92%
V5BG98 Trypanosoma cruzi 26% 100%
V5BJT8 Trypanosoma cruzi 23% 98%
V5BNV8 Trypanosoma cruzi 25% 100%
V5BP88 Trypanosoma cruzi 24% 70%
V5BQF4 Trypanosoma cruzi 25% 87%
V5BSM0 Trypanosoma cruzi 46% 77%
V5BWC2 Trypanosoma cruzi 27% 100%
V5DDT1 Trypanosoma cruzi 25% 92%
V5DTI8 Trypanosoma cruzi 25% 82%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS