UPF0602 protein C4orf47 homolog

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4586), putative

Species:

Leishmania donovani

UniProt:

A0A3S7X2W5_LEIDO

TriTrypDb:

LdBPK_292670.1 , LdCL_290032800 , LDHU3_29.3940

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	18
GO:0005815	microtubule organizing center	2	18
GO:0110165	cellular anatomical entity	1	18
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7X2W5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2W5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	30	34	PF00656	0.554
CLV_NRD_NRD_1	197	199	PF00675	0.366
CLV_NRD_NRD_1	248	250	PF00675	0.256
CLV_NRD_NRD_1	300	302	PF00675	0.291
CLV_NRD_NRD_1	337	339	PF00675	0.491
CLV_PCSK_FUR_1	195	199	PF00082	0.300
CLV_PCSK_KEX2_1	142	144	PF00082	0.270
CLV_PCSK_KEX2_1	197	199	PF00082	0.307
CLV_PCSK_KEX2_1	248	250	PF00082	0.290
CLV_PCSK_KEX2_1	252	254	PF00082	0.303
CLV_PCSK_KEX2_1	316	318	PF00082	0.329
CLV_PCSK_KEX2_1	337	339	PF00082	0.515
CLV_PCSK_KEX2_1	62	64	PF00082	0.380
CLV_PCSK_KEX2_1	84	86	PF00082	0.303
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.271
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.281
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.300
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.381
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.359
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.208
CLV_PCSK_SKI1_1	249	253	PF00082	0.329
CLV_PCSK_SKI1_1	297	301	PF00082	0.283
CLV_PCSK_SKI1_1	42	46	PF00082	0.270
CLV_PCSK_SKI1_1	62	66	PF00082	0.158
CLV_PCSK_SKI1_1	84	88	PF00082	0.339
DOC_CYCLIN_yCln2_LP_2	209	215	PF00134	0.537
DOC_PP2B_LxvP_1	209	212	PF13499	0.508
DOC_PP4_FxxP_1	11	14	PF00568	0.463
DOC_PP4_FxxP_1	213	216	PF00568	0.465
DOC_USP7_MATH_1	109	113	PF00917	0.498
DOC_USP7_MATH_1	216	220	PF00917	0.449
DOC_USP7_MATH_1	241	245	PF00917	0.449
DOC_USP7_MATH_1	271	275	PF00917	0.435
DOC_USP7_MATH_1	34	38	PF00917	0.540
DOC_USP7_UBL2_3	138	142	PF12436	0.442
DOC_USP7_UBL2_3	248	252	PF12436	0.441
DOC_USP7_UBL2_3	302	306	PF12436	0.479
DOC_USP7_UBL2_3	91	95	PF12436	0.422
LIG_14-3-3_CanoR_1	322	327	PF00244	0.504
LIG_14-3-3_CanoR_1	63	68	PF00244	0.417
LIG_APCC_ABBA_1	286	291	PF00400	0.449
LIG_BIR_III_2	33	37	PF00653	0.578
LIG_deltaCOP1_diTrp_1	319	326	PF00928	0.513
LIG_EH_1	280	284	PF12763	0.449
LIG_eIF4E_1	168	174	PF01652	0.534
LIG_FHA_1	327	333	PF00498	0.499
LIG_FHA_2	145	151	PF00498	0.538
LIG_LIR_Apic_2	167	171	PF02991	0.440
LIG_LIR_Gen_1	61	68	PF02991	0.425
LIG_LIR_Nem_3	102	108	PF02991	0.537
LIG_LIR_Nem_3	117	122	PF02991	0.491
LIG_LIR_Nem_3	167	173	PF02991	0.453
LIG_LIR_Nem_3	232	238	PF02991	0.537
LIG_LIR_Nem_3	5	10	PF02991	0.450
LIG_LIR_Nem_3	61	67	PF02991	0.425
LIG_LYPXL_yS_3	170	173	PF13949	0.523
LIG_Pex14_1	184	188	PF04695	0.523
LIG_Pex14_2	283	287	PF04695	0.434
LIG_Pex14_2	60	64	PF04695	0.473
LIG_PTB_Apo_2	121	128	PF02174	0.481
LIG_PTB_Apo_2	174	181	PF02174	0.442
LIG_PTB_Phospho_1	121	127	PF10480	0.523
LIG_PTB_Phospho_1	174	180	PF10480	0.442
LIG_SH2_CRK	168	172	PF00017	0.451
LIG_SH2_CRK	7	11	PF00017	0.466
LIG_SH2_NCK_1	188	192	PF00017	0.436
LIG_SH2_NCK_1	238	242	PF00017	0.501
LIG_SH2_SRC	80	83	PF00017	0.495
LIG_SH2_STAP1	180	184	PF00017	0.484
LIG_SH2_STAT5	16	19	PF00017	0.515
LIG_SH2_STAT5	222	225	PF00017	0.486
LIG_SH2_STAT5	39	42	PF00017	0.437
LIG_SH2_STAT5	59	62	PF00017	0.358
LIG_SH3_3	317	323	PF00018	0.450
LIG_TRAF2_1	147	150	PF00917	0.437
LIG_TRAF2_2	52	57	PF00917	0.449
MOD_CK1_1	176	182	PF00069	0.433
MOD_CK1_1	330	336	PF00069	0.537
MOD_CK2_1	104	110	PF00069	0.521
MOD_CK2_1	144	150	PF00069	0.462
MOD_CK2_1	96	102	PF00069	0.534
MOD_GlcNHglycan	231	234	PF01048	0.265
MOD_GlcNHglycan	243	246	PF01048	0.267
MOD_GlcNHglycan	269	272	PF01048	0.263
MOD_GlcNHglycan	273	276	PF01048	0.229
MOD_GSK3_1	110	117	PF00069	0.488
MOD_GSK3_1	160	167	PF00069	0.458
MOD_GSK3_1	267	274	PF00069	0.463
MOD_GSK3_1	322	329	PF00069	0.452
MOD_GSK3_1	63	70	PF00069	0.582
MOD_GSK3_1	80	87	PF00069	0.372
MOD_N-GLC_1	271	276	PF02516	0.323
MOD_N-GLC_1	42	47	PF02516	0.323
MOD_NEK2_1	103	108	PF00069	0.556
MOD_NEK2_1	173	178	PF00069	0.540
MOD_NEK2_1	267	272	PF00069	0.433
MOD_NEK2_1	326	331	PF00069	0.545
MOD_PIKK_1	290	296	PF00454	0.565
MOD_PKA_1	141	147	PF00069	0.483
MOD_PKA_1	164	170	PF00069	0.461
MOD_PKA_1	84	90	PF00069	0.444
MOD_PKA_2	142	148	PF00069	0.525
MOD_PKA_2	84	90	PF00069	0.433
MOD_Plk_1	2	8	PF00069	0.285
MOD_Plk_1	42	48	PF00069	0.523
MOD_Plk_4	114	120	PF00069	0.515
MOD_Plk_4	2	8	PF00069	0.294
MOD_Plk_4	218	224	PF00069	0.548
MOD_Plk_4	257	263	PF00069	0.511
MOD_Plk_4	327	333	PF00069	0.466
MOD_SUMO_for_1	251	254	PF00179	0.449
MOD_SUMO_rev_2	132	139	PF00179	0.480
MOD_SUMO_rev_2	18	26	PF00179	0.436
MOD_SUMO_rev_2	27	34	PF00179	0.452
MOD_SUMO_rev_2	79	86	PF00179	0.401
TRG_DiLeu_BaEn_4	150	156	PF01217	0.449
TRG_ENDOCYTIC_2	119	122	PF00928	0.500
TRG_ENDOCYTIC_2	127	130	PF00928	0.480
TRG_ENDOCYTIC_2	170	173	PF00928	0.499
TRG_ENDOCYTIC_2	7	10	PF00928	0.474
TRG_ER_diArg_1	195	198	PF00400	0.454
TRG_ER_diArg_1	336	338	PF00400	0.496
TRG_NLS_MonoCore_2	139	144	PF00514	0.461
TRG_NLS_MonoExtC_3	247	252	PF00514	0.446
TRG_NLS_MonoExtN_4	138	145	PF00514	0.445
TRG_NLS_MonoExtN_4	248	253	PF00514	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6K0	Leptomonas seymouri	67%	98%
A0A0S4IPI4	Bodo saltans	37%	100%
A0A1X0P929	Trypanosomatidae	50%	97%
A0A3Q8IGT8	Leishmania donovani	30%	100%
A0A3R7NAQ1	Trypanosoma rangeli	47%	99%
A4HGN9	Leishmania braziliensis	30%	100%
A4HHQ4	Leishmania braziliensis	81%	99%
A4I3R2	Leishmania infantum	30%	100%
A4I4W9	Leishmania infantum	100%	100%
C9ZKZ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	85%
D0A995	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AEB8	Leishmania major	96%	100%
E9ALG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9B005	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
Q4Q880	Leishmania major	30%	100%
V5DTV3	Trypanosoma cruzi	48%	99%