FoP_duplication domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S7X2W4_LEIDO

TriTrypDb:

LdCL_300005900

Length:

227

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X2W4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2W4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.474
CLV_NRD_NRD_1	118	120	PF00675	0.470
CLV_NRD_NRD_1	123	125	PF00675	0.558
CLV_NRD_NRD_1	128	130	PF00675	0.456
CLV_NRD_NRD_1	134	136	PF00675	0.546
CLV_NRD_NRD_1	151	153	PF00675	0.547
CLV_NRD_NRD_1	158	160	PF00675	0.648
CLV_NRD_NRD_1	170	172	PF00675	0.510
CLV_NRD_NRD_1	176	178	PF00675	0.559
CLV_NRD_NRD_1	20	22	PF00675	0.546
CLV_NRD_NRD_1	32	34	PF00675	0.584
CLV_NRD_NRD_1	43	45	PF00675	0.613
CLV_NRD_NRD_1	50	52	PF00675	0.485
CLV_NRD_NRD_1	69	71	PF00675	0.571
CLV_NRD_NRD_1	81	83	PF00675	0.579
CLV_NRD_NRD_1	9	11	PF00675	0.686
CLV_NRD_NRD_1	90	92	PF00675	0.615
CLV_NRD_NRD_1	98	100	PF00675	0.463
CLV_PCSK_FUR_1	116	120	PF00082	0.461
CLV_PCSK_FUR_1	17	21	PF00082	0.707
CLV_PCSK_FUR_1	29	33	PF00082	0.579
CLV_PCSK_FUR_1	79	83	PF00082	0.719
CLV_PCSK_FUR_1	96	100	PF00082	0.541
CLV_PCSK_KEX2_1	108	110	PF00082	0.474
CLV_PCSK_KEX2_1	118	120	PF00082	0.470
CLV_PCSK_KEX2_1	123	125	PF00082	0.558
CLV_PCSK_KEX2_1	128	130	PF00082	0.456
CLV_PCSK_KEX2_1	134	136	PF00082	0.546
CLV_PCSK_KEX2_1	151	153	PF00082	0.547
CLV_PCSK_KEX2_1	158	160	PF00082	0.643
CLV_PCSK_KEX2_1	169	171	PF00082	0.570
CLV_PCSK_KEX2_1	176	178	PF00082	0.579
CLV_PCSK_KEX2_1	19	21	PF00082	0.539
CLV_PCSK_KEX2_1	31	33	PF00082	0.581
CLV_PCSK_KEX2_1	43	45	PF00082	0.596
CLV_PCSK_KEX2_1	50	52	PF00082	0.468
CLV_PCSK_KEX2_1	69	71	PF00082	0.594
CLV_PCSK_KEX2_1	8	10	PF00082	0.694
CLV_PCSK_KEX2_1	81	83	PF00082	0.560
CLV_PCSK_KEX2_1	90	92	PF00082	0.631
CLV_PCSK_KEX2_1	98	100	PF00082	0.463
CLV_PCSK_PC7_1	119	125	PF00082	0.728
CLV_PCSK_PC7_1	147	153	PF00082	0.703
CLV_PCSK_PC7_1	86	92	PF00082	0.681
CLV_PCSK_PC7_1	94	100	PF00082	0.579
CLV_PCSK_SKI1_1	86	90	PF00082	0.757
DEG_APCC_DBOX_1	7	15	PF00400	0.681
DOC_ANK_TNKS_1	151	158	PF00023	0.698
DOC_USP7_MATH_1	205	209	PF00917	0.647
DOC_USP7_MATH_1	62	66	PF00917	0.569
LIG_14-3-3_CanoR_1	44	54	PF00244	0.780
LIG_14-3-3_CanoR_1	81	89	PF00244	0.594
LIG_BRCT_BRCA1_1	79	83	PF00533	0.649
LIG_FHA_2	212	218	PF00498	0.748
LIG_FHA_2	50	56	PF00498	0.779
LIG_Integrin_RGD_1	119	121	PF01839	0.735
LIG_LIR_Apic_2	36	42	PF02991	0.777
LIG_LIR_Nem_3	110	115	PF02991	0.517
LIG_LIR_Nem_3	95	100	PF02991	0.647
LIG_RPA_C_Fungi	147	159	PF08784	0.697
LIG_SH2_CRK	39	43	PF00017	0.779
LIG_SH2_STAT5	45	48	PF00017	0.790
LIG_TRAF2_1	214	217	PF00917	0.746
MOD_CK2_1	211	217	PF00069	0.761
MOD_CK2_1	49	55	PF00069	0.777
MOD_Cter_Amidation	121	124	PF01082	0.703
MOD_Cter_Amidation	126	129	PF01082	0.613
MOD_Cter_Amidation	156	159	PF01082	0.707
MOD_Cter_Amidation	167	170	PF01082	0.622
MOD_Cter_Amidation	174	177	PF01082	0.553
MOD_GlcNHglycan	173	176	PF01048	0.830
MOD_GlcNHglycan	22	25	PF01048	0.741
MOD_GSK3_1	45	52	PF00069	0.784
MOD_GSK3_1	77	84	PF00069	0.637
MOD_NEK2_1	140	145	PF00069	0.811
MOD_PKA_1	20	26	PF00069	0.739
MOD_PKA_1	81	87	PF00069	0.772
MOD_PKA_2	140	146	PF00069	0.810
MOD_PKA_2	163	169	PF00069	0.729
MOD_PKA_2	20	26	PF00069	0.739
MOD_PKA_2	49	55	PF00069	0.699
MOD_PKA_2	81	87	PF00069	0.772
MOD_PKB_1	169	177	PF00069	0.755
MOD_PKB_1	79	87	PF00069	0.695
TRG_ER_diArg_1	115	118	PF00400	0.479
TRG_ER_diArg_1	123	125	PF00400	0.662
TRG_ER_diArg_1	128	130	PF00400	0.560
TRG_ER_diArg_1	134	137	PF00400	0.508
TRG_ER_diArg_1	138	141	PF00400	0.610
TRG_ER_diArg_1	158	161	PF00400	0.484
TRG_ER_diArg_1	169	171	PF00400	0.556
TRG_ER_diArg_1	17	20	PF00400	0.554
TRG_ER_diArg_1	31	33	PF00400	0.548
TRG_ER_diArg_1	42	44	PF00400	0.592
TRG_ER_diArg_1	50	53	PF00400	0.512
TRG_ER_diArg_1	68	70	PF00400	0.524
TRG_ER_diArg_1	78	81	PF00400	0.598
TRG_ER_diArg_1	8	10	PF00400	0.694
TRG_ER_diArg_1	89	91	PF00400	0.596
TRG_ER_diArg_1	97	99	PF00400	0.454
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.671

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HHV4	Leishmania braziliensis	61%	94%
A4I504	Leishmania infantum	97%	97%
E9B0D4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q7U6	Leishmania major	96%	100%