Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X2W2_LEIDO

TriTrypDb:

LdBPK_300060.1 , LdCL_300005600 , LDHU3_30.0110

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3S7X2W2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2W2

PDB structure(s): 7aih_Ap , 7am2_Ap , 7ane_Ap

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.534
CLV_NRD_NRD_1	190	192	PF00675	0.455
CLV_PCSK_KEX2_1	172	174	PF00082	0.420
CLV_PCSK_KEX2_1	93	95	PF00082	0.407
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.395
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.407
CLV_PCSK_SKI1_1	222	226	PF00082	0.643
CLV_PCSK_SKI1_1	60	64	PF00082	0.371
CLV_PCSK_SKI1_1	97	101	PF00082	0.365
DEG_APCC_DBOX_1	172	180	PF00400	0.363
DEG_APCC_DBOX_1	59	67	PF00400	0.451
DEG_Nend_UBRbox_3	1	3	PF02207	0.626
DEG_SCF_FBW7_1	13	19	PF00400	0.359
DEG_SPOP_SBC_1	184	188	PF00917	0.507
DOC_CKS1_1	13	18	PF01111	0.469
DOC_MAPK_gen_1	172	178	PF00069	0.538
DOC_MAPK_gen_1	57	66	PF00069	0.356
DOC_PP1_RVXF_1	207	213	PF00149	0.375
DOC_USP7_MATH_1	16	20	PF00917	0.519
DOC_USP7_MATH_2	72	78	PF00917	0.449
DOC_WW_Pin1_4	12	17	PF00397	0.454
DOC_WW_Pin1_4	232	237	PF00397	0.753
LIG_BRCT_BRCA1_1	160	164	PF00533	0.583
LIG_FHA_1	185	191	PF00498	0.400
LIG_FHA_1	53	59	PF00498	0.426
LIG_FHA_2	169	175	PF00498	0.484
LIG_LIR_Gen_1	106	116	PF02991	0.376
LIG_LIR_Gen_1	127	136	PF02991	0.408
LIG_LIR_Nem_3	106	111	PF02991	0.372
LIG_LIR_Nem_3	127	132	PF02991	0.449
LIG_LIR_Nem_3	144	149	PF02991	0.461
LIG_LIR_Nem_3	197	203	PF02991	0.370
LIG_PCNA_PIPBox_1	2	11	PF02747	0.546
LIG_SH2_CRK	146	150	PF00017	0.536
LIG_SH2_STAP1	160	164	PF00017	0.460
LIG_SH2_STAT3	68	71	PF00017	0.362
LIG_SH2_STAT5	200	203	PF00017	0.358
LIG_SH3_3	10	16	PF00018	0.400
LIG_TRAF2_1	30	33	PF00917	0.565
LIG_TYR_ITIM	201	206	PF00017	0.386
LIG_WRC_WIRS_1	108	113	PF05994	0.376
MOD_CDK_SPK_2	232	237	PF00069	0.516
MOD_CK1_1	158	164	PF00069	0.459
MOD_CK2_1	150	156	PF00069	0.469
MOD_CK2_1	160	166	PF00069	0.450
MOD_CK2_1	168	174	PF00069	0.390
MOD_CK2_1	74	80	PF00069	0.452
MOD_GlcNHglycan	146	149	PF01048	0.467
MOD_GlcNHglycan	152	155	PF01048	0.449
MOD_GlcNHglycan	156	160	PF01048	0.439
MOD_GSK3_1	12	19	PF00069	0.586
MOD_GSK3_1	150	157	PF00069	0.502
MOD_GSK3_1	218	225	PF00069	0.501
MOD_GSK3_1	232	239	PF00069	0.583
MOD_LATS_1	175	181	PF00433	0.561
MOD_N-GLC_1	36	41	PF02516	0.370
MOD_NEK2_1	62	67	PF00069	0.370
MOD_NEK2_2	160	165	PF00069	0.586
MOD_PKA_2	52	58	PF00069	0.473
MOD_Plk_1	155	161	PF00069	0.446
MOD_Plk_1	222	228	PF00069	0.661
MOD_Plk_1	36	42	PF00069	0.327
MOD_Plk_2-3	74	80	PF00069	0.452
MOD_Plk_4	62	68	PF00069	0.345
MOD_Plk_4	74	80	PF00069	0.445
MOD_ProDKin_1	12	18	PF00069	0.463
MOD_ProDKin_1	232	238	PF00069	0.755
TRG_DiLeu_BaEn_1	131	136	PF01217	0.510
TRG_DiLeu_BaEn_1	174	179	PF01217	0.562
TRG_DiLeu_LyEn_5	174	179	PF01217	0.562
TRG_ENDOCYTIC_2	146	149	PF00928	0.553
TRG_ENDOCYTIC_2	203	206	PF00928	0.383
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMG2	Leptomonas seymouri	85%	100%
A0A0N1PDB1	Leptomonas seymouri	28%	96%
A0A0S4IZI9	Bodo saltans	28%	100%
A0A0S4JXP9	Bodo saltans	58%	78%
A0A1X0NWE3	Trypanosomatidae	27%	97%
A0A1X0P2D2	Trypanosomatidae	65%	97%
A0A3S7WW24	Leishmania donovani	31%	100%
A0A422N627	Trypanosoma rangeli	63%	96%
A0A422NJN4	Trypanosoma rangeli	26%	95%
A4HHV1	Leishmania braziliensis	91%	100%
A4HYP5	Leishmania infantum	29%	100%
A4I501	Leishmania infantum	99%	100%
C9ZI86	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	98%
C9ZQF0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	79%
E9AIC3	Leishmania braziliensis	30%	100%
E9AUL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B0D1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q7V3	Leishmania major	98%	100%
Q4QCX4	Leishmania major	31%	100%
V5BCA8	Trypanosoma cruzi	64%	96%
V5BVG0	Trypanosoma cruzi	28%	99%