Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X2V8_LEIDO

TriTrypDb:

LdBPK_292730.1 , LdCL_290033400 , LDHU3_29.4010

Length:

122

Annotations

LeishMANIAdb annotations

A short, single-pass TM protein of unclear topology and function.. A highly conserved protein family in parazitic kinetoplastids.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A0A3S7X2V8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2V8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	116	118	PF00675	0.519
DOC_CKS1_1	19	24	PF01111	0.510
DOC_WW_Pin1_4	102	107	PF00397	0.688
DOC_WW_Pin1_4	12	17	PF00397	0.526
DOC_WW_Pin1_4	18	23	PF00397	0.510
DOC_WW_Pin1_4	34	39	PF00397	0.353
LIG_14-3-3_CterR_2	117	122	PF00244	0.751
LIG_BIR_II_1	1	5	PF00653	0.462
LIG_eIF4E_1	95	101	PF01652	0.619
LIG_FHA_1	19	25	PF00498	0.482
LIG_FHA_1	28	34	PF00498	0.404
LIG_FHA_1	46	52	PF00498	0.407
LIG_FHA_1	83	89	PF00498	0.687
LIG_LIR_LC3C_4	55	60	PF02991	0.441
LIG_SH2_CRK	97	101	PF00017	0.651
LIG_SH2_PTP2	19	22	PF00017	0.508
LIG_SH2_PTP2	69	72	PF00017	0.378
LIG_SH2_SRC	69	72	PF00017	0.378
LIG_SH2_STAT5	113	116	PF00017	0.713
LIG_SH2_STAT5	19	22	PF00017	0.508
LIG_SH2_STAT5	69	72	PF00017	0.355
LIG_SH3_3	103	109	PF00018	0.696
LIG_SUMO_SIM_anti_2	48	55	PF11976	0.386
LIG_SUMO_SIM_par_1	85	92	PF11976	0.679
MOD_CDK_SPxxK_3	18	25	PF00069	0.509
MOD_GlcNHglycan	54	57	PF01048	0.434
MOD_GSK3_1	27	34	PF00069	0.437
MOD_NEK2_1	100	105	PF00069	0.678
MOD_NEK2_1	47	52	PF00069	0.388
MOD_OFUCOSY	29	36	PF10250	0.594
MOD_Plk_4	108	114	PF00069	0.678
MOD_Plk_4	47	53	PF00069	0.279
MOD_ProDKin_1	102	108	PF00069	0.700
MOD_ProDKin_1	12	18	PF00069	0.522
MOD_ProDKin_1	34	40	PF00069	0.453
MOD_SUMO_rev_2	110	119	PF00179	0.687
TRG_ENDOCYTIC_2	69	72	PF00928	0.325
TRG_ENDOCYTIC_2	97	100	PF00928	0.629
TRG_Pf-PMV_PEXEL_1	117	122	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6I0	Leptomonas seymouri	70%	100%
A0A1X0P914	Trypanosomatidae	40%	100%
A0A3R7NJ38	Trypanosoma rangeli	46%	100%
A4HHR0	Leishmania braziliensis	84%	100%
A4I4T8	Leishmania infantum	100%	100%
C9ZKY3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	93%
E9AEC4	Leishmania major	93%	100%
E9ALG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
V5DU61	Trypanosoma cruzi	38%	100%