Alpha/beta hydrolase family/alpha/beta hydrolase fold, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase family, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X2V6_LEIDO

TriTrypDb:

LdBPK_300010.1 , LdCL_300005100 , LDHU3_30.0060

Length:

425

Annotations

LeishMANIAdb annotations

Posesses a conserved AB hydrolase domain. Due to the distribution of hydrophilic / hydrophobic amino acids, it likely only has a perimembrane helix, not a full TM one.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 25
NetGPI	no	yes: 0, no: 25

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3S7X2V6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2V6

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044255	cellular lipid metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016787	hydrolase activity	2	6
GO:0016298	lipase activity	4	3
GO:0016788	hydrolase activity, acting on ester bonds	3	3
GO:0034338	short-chain carboxylesterase activity	5	3
GO:0047372	acylglycerol lipase activity	5	3
GO:0052689	carboxylic ester hydrolase activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	251	255	PF00656	0.325
CLV_NRD_NRD_1	261	263	PF00675	0.450
CLV_NRD_NRD_1	281	283	PF00675	0.467
CLV_PCSK_KEX2_1	261	263	PF00082	0.368
CLV_PCSK_KEX2_1	281	283	PF00082	0.477
CLV_PCSK_SKI1_1	126	130	PF00082	0.503
CLV_PCSK_SKI1_1	189	193	PF00082	0.420
CLV_PCSK_SKI1_1	282	286	PF00082	0.498
CLV_PCSK_SKI1_1	321	325	PF00082	0.466
CLV_PCSK_SKI1_1	66	70	PF00082	0.497
DEG_SCF_FBW7_1	169	176	PF00400	0.293
DOC_CDC14_PxL_1	132	140	PF14671	0.278
DOC_CDC14_PxL_1	287	295	PF14671	0.335
DOC_CDC14_PxL_1	322	330	PF14671	0.335
DOC_CKS1_1	174	179	PF01111	0.285
DOC_CKS1_1	330	335	PF01111	0.307
DOC_MAPK_DCC_7	17	26	PF00069	0.414
DOC_MAPK_gen_1	126	135	PF00069	0.314
DOC_MAPK_gen_1	23	31	PF00069	0.538
DOC_MAPK_MEF2A_6	126	135	PF00069	0.313
DOC_MAPK_MEF2A_6	17	26	PF00069	0.601
DOC_MAPK_MEF2A_6	321	330	PF00069	0.335
DOC_PP1_RVXF_1	21	27	PF00149	0.500
DOC_PP2B_LxvP_1	133	136	PF13499	0.261
DOC_PP2B_LxvP_1	385	388	PF13499	0.251
DOC_PP2B_PxIxI_1	210	216	PF00149	0.354
DOC_PP4_FxxP_1	330	333	PF00568	0.273
DOC_PP4_FxxP_1	349	352	PF00568	0.123
DOC_USP7_MATH_1	368	372	PF00917	0.230
DOC_USP7_MATH_1	97	101	PF00917	0.343
DOC_USP7_UBL2_3	66	70	PF12436	0.230
DOC_WW_Pin1_4	169	174	PF00397	0.248
DOC_WW_Pin1_4	245	250	PF00397	0.258
DOC_WW_Pin1_4	291	296	PF00397	0.222
DOC_WW_Pin1_4	329	334	PF00397	0.288
DOC_WW_Pin1_4	338	343	PF00397	0.288
DOC_WW_Pin1_4	419	424	PF00397	0.271
LIG_14-3-3_CanoR_1	298	302	PF00244	0.329
LIG_14-3-3_CanoR_1	321	326	PF00244	0.327
LIG_Actin_WH2_2	28	44	PF00022	0.261
LIG_deltaCOP1_diTrp_1	344	349	PF00928	0.193
LIG_FHA_1	142	148	PF00498	0.279
LIG_FHA_1	174	180	PF00498	0.255
LIG_FHA_1	183	189	PF00498	0.231
LIG_FHA_1	404	410	PF00498	0.214
LIG_FHA_2	170	176	PF00498	0.311
LIG_FHA_2	313	319	PF00498	0.257
LIG_FHA_2	330	336	PF00498	0.200
LIG_FHA_2	406	412	PF00498	0.372
LIG_IRF3_LxIS_1	351	357	PF10401	0.199
LIG_LIR_Apic_2	327	333	PF02991	0.300
LIG_LIR_Gen_1	100	111	PF02991	0.250
LIG_LIR_Gen_1	148	155	PF02991	0.347
LIG_LIR_Gen_1	318	326	PF02991	0.287
LIG_LIR_Gen_1	334	343	PF02991	0.168
LIG_LIR_Nem_3	100	106	PF02991	0.385
LIG_LIR_Nem_3	148	153	PF02991	0.326
LIG_LIR_Nem_3	318	322	PF02991	0.286
LIG_LIR_Nem_3	334	340	PF02991	0.172
LIG_LIR_Nem_3	67	71	PF02991	0.243
LIG_MYND_1	291	295	PF01753	0.222
LIG_NRBOX	117	123	PF00104	0.194
LIG_NRP_CendR_1	424	425	PF00754	0.690
LIG_Pex14_1	345	349	PF04695	0.335
LIG_Pex14_2	155	159	PF04695	0.199
LIG_Pex14_2	32	36	PF04695	0.354
LIG_PTB_Apo_2	111	118	PF02174	0.361
LIG_PTB_Phospho_1	111	117	PF10480	0.234
LIG_REV1ctd_RIR_1	44	53	PF16727	0.435
LIG_REV1ctd_RIR_1	66	74	PF16727	0.232
LIG_SH2_CRK	103	107	PF00017	0.330
LIG_SH2_NCK_1	415	419	PF00017	0.261
LIG_SH2_NCK_1	79	83	PF00017	0.301
LIG_SH2_SRC	146	149	PF00017	0.335
LIG_SH2_SRC	268	271	PF00017	0.325
LIG_SH2_SRC	79	82	PF00017	0.376
LIG_SH2_STAP1	415	419	PF00017	0.261
LIG_SH2_STAT5	117	120	PF00017	0.371
LIG_SH2_STAT5	146	149	PF00017	0.250
LIG_SH2_STAT5	227	230	PF00017	0.272
LIG_SH2_STAT5	395	398	PF00017	0.299
LIG_SH3_3	103	109	PF00018	0.343
LIG_SH3_3	16	22	PF00018	0.568
LIG_SH3_3	243	249	PF00018	0.295
LIG_SUMO_SIM_anti_2	241	248	PF11976	0.199
LIG_TYR_ITIM	101	106	PF00017	0.381
MOD_CDK_SPK_2	173	178	PF00069	0.307
MOD_CDK_SPK_2	419	424	PF00069	0.271
MOD_CDK_SPxK_1	419	425	PF00069	0.273
MOD_CDK_SPxxK_3	291	298	PF00069	0.222
MOD_CK2_1	169	175	PF00069	0.315
MOD_CK2_1	338	344	PF00069	0.265
MOD_CK2_1	405	411	PF00069	0.333
MOD_CMANNOS	400	403	PF00535	0.525
MOD_GlcNHglycan	141	144	PF01048	0.475
MOD_GlcNHglycan	180	183	PF01048	0.472
MOD_GlcNHglycan	302	305	PF01048	0.501
MOD_GlcNHglycan	356	359	PF01048	0.498
MOD_GlcNHglycan	5	8	PF01048	0.468
MOD_GlcNHglycan	84	87	PF01048	0.494
MOD_GSK3_1	137	144	PF00069	0.213
MOD_GSK3_1	169	176	PF00069	0.264
MOD_GSK3_1	178	185	PF00069	0.264
MOD_GSK3_1	368	375	PF00069	0.363
MOD_GSK3_1	41	48	PF00069	0.552
MOD_GSK3_1	82	89	PF00069	0.287
MOD_NEK2_1	122	127	PF00069	0.358
MOD_NEK2_1	153	158	PF00069	0.315
MOD_NEK2_1	354	359	PF00069	0.286
MOD_NEK2_1	372	377	PF00069	0.144
MOD_NEK2_1	41	46	PF00069	0.488
MOD_NEK2_1	5	10	PF00069	0.675
MOD_PKA_1	261	267	PF00069	0.158
MOD_PKA_2	261	267	PF00069	0.334
MOD_PKA_2	297	303	PF00069	0.309
MOD_PKA_2	41	47	PF00069	0.592
MOD_Plk_4	405	411	PF00069	0.265
MOD_Plk_4	64	70	PF00069	0.334
MOD_Plk_4	87	93	PF00069	0.267
MOD_ProDKin_1	169	175	PF00069	0.248
MOD_ProDKin_1	245	251	PF00069	0.258
MOD_ProDKin_1	291	297	PF00069	0.222
MOD_ProDKin_1	329	335	PF00069	0.288
MOD_ProDKin_1	338	344	PF00069	0.288
MOD_ProDKin_1	419	425	PF00069	0.285
TRG_DiLeu_BaEn_1	175	180	PF01217	0.335
TRG_ENDOCYTIC_2	103	106	PF00928	0.332
TRG_ENDOCYTIC_2	337	340	PF00928	0.243
TRG_ER_diArg_1	261	263	PF00400	0.367
TRG_ER_diArg_1	423	425	PF00400	0.509
TRG_Pf-PMV_PEXEL_1	236	241	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5L7	Leptomonas seymouri	33%	93%
A0A0N1HZ60	Leptomonas seymouri	35%	92%
A0A0N1I523	Leptomonas seymouri	29%	96%
A0A0N1I5Q2	Leptomonas seymouri	31%	84%
A0A0N1I7U8	Leptomonas seymouri	66%	100%
A0A0S4JMS7	Bodo saltans	38%	98%
A0A0S4JTS9	Bodo saltans	38%	99%
A0A1X0NEW5	Trypanosomatidae	42%	100%
A0A1X0NSK7	Trypanosomatidae	42%	100%
A0A1X0NUZ6	Trypanosomatidae	27%	100%
A0A3S5H6J1	Leishmania donovani	32%	100%
A0A422NB49	Trypanosoma rangeli	45%	100%
A0A422NQC5	Trypanosoma rangeli	37%	97%
A4H6L0	Leishmania braziliensis	33%	100%
A4HHU6	Leishmania braziliensis	79%	100%
A4HUZ4	Leishmania infantum	32%	100%
A4I4Z6	Leishmania infantum	99%	100%
C9ZPB9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9ANM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9ANM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B0C6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P08910	Homo sapiens	26%	100%
P45524	Escherichia coli (strain K12)	29%	100%
P73879	Synechocystis sp. (strain PCC 6803 / Kazusa)	25%	100%
Q05AK6	Danio rerio	26%	100%
Q0VC00	Bos taurus	25%	100%
Q18610	Caenorhabditis elegans	24%	100%
Q24093	Drosophila melanogaster	24%	100%
Q3T0A0	Bos taurus	26%	100%
Q40863	Picea glauca	30%	93%
Q4Q7V8	Leishmania major	91%	100%
Q4QGZ4	Leishmania major	32%	100%
Q4QGZ5	Leishmania major	31%	100%
Q4R2Y9	Macaca fascicularis	26%	100%
Q54H38	Dictyostelium discoideum	28%	100%
Q5EA42	Bos taurus	26%	100%
Q5F2F2	Mus musculus	25%	93%
Q5RK23	Rattus norvegicus	26%	100%
Q6UXT9	Homo sapiens	25%	91%
Q802V6	Danio rerio	25%	98%
Q8WU67	Homo sapiens	26%	100%
Q91ZH7	Mus musculus	27%	100%
Q96SE0	Homo sapiens	26%	100%
Q9QXM0	Mus musculus	26%	100%
Q9QZC8	Mus musculus	25%	100%
V5AZF4	Trypanosoma cruzi	42%	100%
V5BBC2	Trypanosoma cruzi	37%	100%