Leucine rich repeat, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7X2V4_LEIDO

TriTrypDb:

LdBPK_131440.1 , LdBPK_292990.1 , LdCL_290036000 , LDHU3_29.4370

Length:

773

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	19
GO:0042995	cell projection	2	19
GO:0043226	organelle	2	19
GO:0043227	membrane-bounded organelle	3	19
GO:0110165	cellular anatomical entity	1	19
GO:0120025	plasma membrane bounded cell projection	3	19
GO:0000151	ubiquitin ligase complex	3	1
GO:0019005	SCF ubiquitin ligase complex	5	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7X2V4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2V4

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	1
GO:0006952	defense response	3	1
GO:0050896	response to stimulus	1	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	2
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	7	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0003824	catalytic activity	1	3
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.442
CLV_C14_Caspase3-7	357	361	PF00656	0.359
CLV_C14_Caspase3-7	492	496	PF00656	0.289
CLV_C14_Caspase3-7	537	541	PF00656	0.253
CLV_NRD_NRD_1	512	514	PF00675	0.320
CLV_NRD_NRD_1	707	709	PF00675	0.518
CLV_NRD_NRD_1	739	741	PF00675	0.668
CLV_PCSK_KEX2_1	512	514	PF00082	0.480
CLV_PCSK_KEX2_1	707	709	PF00082	0.353
CLV_PCSK_KEX2_1	739	741	PF00082	0.660
CLV_PCSK_SKI1_1	170	174	PF00082	0.373
CLV_PCSK_SKI1_1	182	186	PF00082	0.260
CLV_PCSK_SKI1_1	28	32	PF00082	0.410
CLV_PCSK_SKI1_1	347	351	PF00082	0.257
CLV_PCSK_SKI1_1	398	402	PF00082	0.356
CLV_PCSK_SKI1_1	470	474	PF00082	0.360
CLV_PCSK_SKI1_1	512	516	PF00082	0.380
CLV_PCSK_SKI1_1	557	561	PF00082	0.415
CLV_PCSK_SKI1_1	617	621	PF00082	0.325
CLV_PCSK_SKI1_1	682	686	PF00082	0.343
DEG_APCC_DBOX_1	27	35	PF00400	0.373
DEG_APCC_DBOX_1	397	405	PF00400	0.386
DEG_MDM2_SWIB_1	730	737	PF02201	0.422
DEG_Nend_UBRbox_1	1	4	PF02207	0.468
DEG_ODPH_VHL_1	517	528	PF01847	0.271
DEG_ODPH_VHL_1	607	618	PF01847	0.295
DOC_CDC14_PxL_1	271	279	PF14671	0.429
DOC_CDC14_PxL_1	385	393	PF14671	0.292
DOC_CDC14_PxL_1	520	528	PF14671	0.424
DOC_CDC14_PxL_1	655	663	PF14671	0.288
DOC_CYCLIN_RxL_1	496	505	PF00134	0.390
DOC_CYCLIN_yCln2_LP_2	199	205	PF00134	0.446
DOC_CYCLIN_yCln2_LP_2	33	39	PF00134	0.381
DOC_MAPK_gen_1	181	187	PF00069	0.433
DOC_MAPK_gen_1	589	598	PF00069	0.439
DOC_MAPK_gen_1	679	688	PF00069	0.410
DOC_MAPK_MEF2A_6	208	216	PF00069	0.503
DOC_MAPK_MEF2A_6	321	328	PF00069	0.282
DOC_MAPK_MEF2A_6	679	688	PF00069	0.410
DOC_PP1_RVXF_1	680	686	PF00149	0.414
DOC_PP1_RVXF_1	725	731	PF00149	0.405
DOC_PP2B_LxvP_1	15	18	PF13499	0.418
DOC_PP2B_LxvP_1	199	202	PF13499	0.317
DOC_USP7_MATH_1	112	116	PF00917	0.526
DOC_USP7_MATH_1	18	22	PF00917	0.450
DOC_USP7_MATH_1	203	207	PF00917	0.372
DOC_USP7_MATH_1	621	625	PF00917	0.418
DOC_USP7_MATH_1	711	715	PF00917	0.355
DOC_USP7_MATH_1	745	749	PF00917	0.640
DOC_USP7_MATH_1	80	84	PF00917	0.320
DOC_WW_Pin1_4	125	130	PF00397	0.453
DOC_WW_Pin1_4	247	252	PF00397	0.330
DOC_WW_Pin1_4	35	40	PF00397	0.426
DOC_WW_Pin1_4	430	435	PF00397	0.460
DOC_WW_Pin1_4	610	615	PF00397	0.436
DOC_WW_Pin1_4	700	705	PF00397	0.307
LIG_14-3-3_CanoR_1	119	123	PF00244	0.356
LIG_14-3-3_CanoR_1	132	139	PF00244	0.249
LIG_14-3-3_CanoR_1	155	161	PF00244	0.383
LIG_14-3-3_CanoR_1	300	305	PF00244	0.280
LIG_14-3-3_CanoR_1	347	352	PF00244	0.500
LIG_14-3-3_CanoR_1	378	383	PF00244	0.463
LIG_14-3-3_CanoR_1	390	395	PF00244	0.356
LIG_14-3-3_CanoR_1	46	56	PF00244	0.398
LIG_14-3-3_CanoR_1	470	479	PF00244	0.450
LIG_14-3-3_CanoR_1	512	518	PF00244	0.446
LIG_14-3-3_CanoR_1	602	608	PF00244	0.348
LIG_14-3-3_CanoR_1	648	653	PF00244	0.442
LIG_14-3-3_CanoR_1	692	698	PF00244	0.379
LIG_14-3-3_CanoR_1	79	85	PF00244	0.428
LIG_Actin_WH2_2	165	183	PF00022	0.407
LIG_Actin_WH2_2	387	404	PF00022	0.382
LIG_Actin_WH2_2	468	484	PF00022	0.391
LIG_Actin_WH2_2	556	574	PF00022	0.427
LIG_BRCT_BRCA1_1	15	19	PF00533	0.421
LIG_BRCT_BRCA1_1	369	373	PF00533	0.403
LIG_BRCT_BRCA1_1	414	418	PF00533	0.261
LIG_Clathr_ClatBox_1	683	687	PF01394	0.392
LIG_FHA_1	146	152	PF00498	0.347
LIG_FHA_1	235	241	PF00498	0.371
LIG_FHA_1	250	256	PF00498	0.328
LIG_FHA_1	265	271	PF00498	0.400
LIG_FHA_1	489	495	PF00498	0.437
LIG_FHA_1	558	564	PF00498	0.405
LIG_FHA_1	87	93	PF00498	0.314
LIG_FHA_2	535	541	PF00498	0.465
LIG_GBD_Chelix_1	26	34	PF00786	0.364
LIG_IBAR_NPY_1	223	225	PF08397	0.449
LIG_LIR_Gen_1	10	19	PF02991	0.419
LIG_LIR_Gen_1	193	203	PF02991	0.553
LIG_LIR_Gen_1	460	469	PF02991	0.337
LIG_LIR_Gen_1	731	737	PF02991	0.490
LIG_LIR_Nem_3	10	15	PF02991	0.421
LIG_LIR_Nem_3	136	142	PF02991	0.327
LIG_LIR_Nem_3	159	165	PF02991	0.407
LIG_LIR_Nem_3	193	199	PF02991	0.410
LIG_LIR_Nem_3	218	222	PF02991	0.670
LIG_LIR_Nem_3	460	466	PF02991	0.326
LIG_LIR_Nem_3	575	581	PF02991	0.344
LIG_LIR_Nem_3	731	737	PF02991	0.558
LIG_MAD2	527	535	PF02301	0.265
LIG_NRBOX	29	35	PF00104	0.369
LIG_PCNA_APIM_2	26	32	PF02747	0.377
LIG_Pex14_2	175	179	PF04695	0.464
LIG_Pex14_2	730	734	PF04695	0.414
LIG_SH2_CRK	106	110	PF00017	0.305
LIG_SH2_CRK	162	166	PF00017	0.436
LIG_SH2_CRK	196	200	PF00017	0.530
LIG_SH2_PTP2	12	15	PF00017	0.423
LIG_SH2_PTP2	732	735	PF00017	0.408
LIG_SH2_STAP1	134	138	PF00017	0.274
LIG_SH2_STAP1	196	200	PF00017	0.299
LIG_SH2_STAT3	225	228	PF00017	0.432
LIG_SH2_STAT5	12	15	PF00017	0.428
LIG_SH2_STAT5	174	177	PF00017	0.572
LIG_SH2_STAT5	196	199	PF00017	0.490
LIG_SH2_STAT5	330	333	PF00017	0.453
LIG_SH2_STAT5	348	351	PF00017	0.381
LIG_SH2_STAT5	732	735	PF00017	0.437
LIG_SH3_3	33	39	PF00018	0.381
LIG_SH3_3	55	61	PF00018	0.408
LIG_SH3_3	762	768	PF00018	0.517
LIG_SUMO_SIM_anti_2	303	308	PF11976	0.351
LIG_SUMO_SIM_par_1	147	152	PF11976	0.456
LIG_SUMO_SIM_par_1	534	540	PF11976	0.265
LIG_TRFH_1	220	224	PF08558	0.439
LIG_TRFH_1	225	229	PF08558	0.419
LIG_TYR_ITIM	104	109	PF00017	0.274
LIG_TYR_ITIM	160	165	PF00017	0.357
LIG_TYR_ITIM	346	351	PF00017	0.255
LIG_UBA3_1	30	35	PF00899	0.368
MOD_CDK_SPK_2	430	435	PF00069	0.243
MOD_CDK_SPK_2	610	615	PF00069	0.284
MOD_CDK_SPxxK_3	125	132	PF00069	0.445
MOD_CDK_SPxxK_3	430	437	PF00069	0.307
MOD_CDK_SPxxK_3	610	617	PF00069	0.283
MOD_CDK_SPxxK_3	700	707	PF00069	0.300
MOD_CK1_1	145	151	PF00069	0.554
MOD_CK1_1	264	270	PF00069	0.450
MOD_CK1_1	367	373	PF00069	0.243
MOD_CK1_1	52	58	PF00069	0.407
MOD_CK2_1	18	24	PF00069	0.498
MOD_CK2_1	204	210	PF00069	0.553
MOD_CK2_1	351	357	PF00069	0.283
MOD_CK2_1	441	447	PF00069	0.492
MOD_CK2_1	486	492	PF00069	0.278
MOD_CK2_1	588	594	PF00069	0.471
MOD_CK2_1	63	69	PF00069	0.376
MOD_CK2_1	666	672	PF00069	0.386
MOD_GlcNHglycan	116	119	PF01048	0.554
MOD_GlcNHglycan	129	132	PF01048	0.326
MOD_GlcNHglycan	150	154	PF01048	0.453
MOD_GlcNHglycan	175	178	PF01048	0.509
MOD_GlcNHglycan	182	185	PF01048	0.514
MOD_GlcNHglycan	192	195	PF01048	0.517
MOD_GlcNHglycan	394	397	PF01048	0.377
MOD_GlcNHglycan	414	417	PF01048	0.407
MOD_GlcNHglycan	430	433	PF01048	0.506
MOD_GlcNHglycan	443	446	PF01048	0.369
MOD_GlcNHglycan	475	478	PF01048	0.354
MOD_GlcNHglycan	488	491	PF01048	0.338
MOD_GlcNHglycan	610	613	PF01048	0.331
MOD_GlcNHglycan	623	626	PF01048	0.294
MOD_GlcNHglycan	668	671	PF01048	0.391
MOD_GlcNHglycan	674	677	PF01048	0.352
MOD_GlcNHglycan	700	703	PF01048	0.491
MOD_GlcNHglycan	713	716	PF01048	0.393
MOD_GlcNHglycan	723	727	PF01048	0.436
MOD_GlcNHglycan	92	95	PF01048	0.463
MOD_GSK3_1	114	121	PF00069	0.483
MOD_GSK3_1	145	152	PF00069	0.539
MOD_GSK3_1	18	25	PF00069	0.717
MOD_GSK3_1	190	197	PF00069	0.491
MOD_GSK3_1	243	250	PF00069	0.476
MOD_GSK3_1	347	354	PF00069	0.366
MOD_GSK3_1	390	397	PF00069	0.304
MOD_GSK3_1	412	419	PF00069	0.385
MOD_GSK3_1	457	464	PF00069	0.451
MOD_GSK3_1	486	493	PF00069	0.357
MOD_GSK3_1	502	509	PF00069	0.324
MOD_GSK3_1	576	583	PF00069	0.314
MOD_GSK3_1	59	66	PF00069	0.472
MOD_GSK3_1	644	651	PF00069	0.296
MOD_GSK3_1	698	705	PF00069	0.440
MOD_GSK3_1	7	14	PF00069	0.537
MOD_GSK3_1	80	87	PF00069	0.486
MOD_N-GLC_1	264	269	PF02516	0.512
MOD_N-GLC_1	506	511	PF02516	0.425
MOD_N-GLC_1	672	677	PF02516	0.396
MOD_N-GLC_1	711	716	PF02516	0.549
MOD_N-GLC_2	4	6	PF02516	0.422
MOD_N-GLC_2	49	51	PF02516	0.398
MOD_N-GLC_2	498	500	PF02516	0.307
MOD_N-GLC_2	633	635	PF02516	0.331
MOD_N-GLC_2	644	646	PF02516	0.308
MOD_N-GLC_2	665	667	PF02516	0.260
MOD_N-GLC_2	678	680	PF02516	0.298
MOD_NEK2_1	173	178	PF00069	0.533
MOD_NEK2_1	180	185	PF00069	0.520
MOD_NEK2_1	349	354	PF00069	0.433
MOD_NEK2_1	394	399	PF00069	0.332
MOD_NEK2_1	508	513	PF00069	0.382
MOD_NEK2_1	686	691	PF00069	0.327
MOD_NEK2_1	7	12	PF00069	0.432
MOD_OFUCOSY	57	63	PF10250	0.404
MOD_PK_1	22	28	PF00069	0.379
MOD_PK_1	660	666	PF00069	0.282
MOD_PKA_1	22	28	PF00069	0.379
MOD_PKA_1	512	518	PF00069	0.310
MOD_PKA_2	118	124	PF00069	0.353
MOD_PKA_2	234	240	PF00069	0.595
MOD_PKA_2	377	383	PF00069	0.499
MOD_PKA_2	512	518	PF00069	0.458
MOD_PKA_2	588	594	PF00069	0.458
MOD_PKA_2	644	650	PF00069	0.284
MOD_PKA_2	735	741	PF00069	0.595
MOD_PKA_2	90	96	PF00069	0.349
MOD_PKB_1	390	398	PF00069	0.279
MOD_Plk_1	264	270	PF00069	0.425
MOD_Plk_1	278	284	PF00069	0.395
MOD_Plk_1	574	580	PF00069	0.454
MOD_Plk_1	711	717	PF00069	0.496
MOD_Plk_2-3	364	370	PF00069	0.307
MOD_Plk_4	194	200	PF00069	0.367
MOD_Plk_4	302	308	PF00069	0.306
MOD_Plk_4	534	540	PF00069	0.395
MOD_Plk_4	558	564	PF00069	0.286
MOD_Plk_4	8	14	PF00069	0.449
MOD_Plk_4	80	86	PF00069	0.345
MOD_ProDKin_1	125	131	PF00069	0.445
MOD_ProDKin_1	247	253	PF00069	0.326
MOD_ProDKin_1	35	41	PF00069	0.427
MOD_ProDKin_1	430	436	PF00069	0.456
MOD_ProDKin_1	610	616	PF00069	0.432
MOD_ProDKin_1	700	706	PF00069	0.303
MOD_SUMO_rev_2	459	469	PF00179	0.468
TRG_DiLeu_BaEn_1	3	8	PF01217	0.426
TRG_DiLeu_BaEn_2	368	374	PF01217	0.212
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.364
TRG_ENDOCYTIC_2	106	109	PF00928	0.318
TRG_ENDOCYTIC_2	12	15	PF00928	0.423
TRG_ENDOCYTIC_2	134	137	PF00928	0.364
TRG_ENDOCYTIC_2	162	165	PF00928	0.425
TRG_ENDOCYTIC_2	196	199	PF00928	0.475
TRG_ENDOCYTIC_2	219	222	PF00928	0.587
TRG_ENDOCYTIC_2	348	351	PF00928	0.250
TRG_ENDOCYTIC_2	732	735	PF00928	0.408
TRG_ER_diArg_1	389	392	PF00400	0.431
TRG_ER_diArg_1	479	482	PF00400	0.279
TRG_ER_diArg_1	512	514	PF00400	0.391
TRG_ER_diArg_1	524	527	PF00400	0.278
TRG_ER_diArg_1	614	617	PF00400	0.296
TRG_ER_diArg_1	706	708	PF00400	0.577
TRG_ER_diArg_1	739	742	PF00400	0.618
TRG_NES_CRM1_1	357	369	PF08389	0.381
TRG_Pf-PMV_PEXEL_1	321	325	PF00026	0.292
TRG_Pf-PMV_PEXEL_1	499	504	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8N9	Leptomonas seymouri	33%	100%
A0A0N1P921	Leptomonas seymouri	27%	95%
A0A0S4J2Y5	Bodo saltans	23%	92%
A0A3S5H5M6	Leishmania donovani	28%	100%
A0A3S5ISR4	Trypanosoma rangeli	24%	92%
A4H3R1	Leishmania braziliensis	69%	100%
A4H4H0	Leishmania braziliensis	25%	100%
A4HSP5	Leishmania infantum	28%	100%
C9ZK22	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	95%
D0A4F4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	91%
E9AEF0	Leishmania major	87%	100%
E9AGT5	Leishmania infantum	28%	100%
E9AHJ6	Leishmania infantum	100%	100%
E9AKN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
Q4QJ77	Leishmania major	28%	100%
Q4QJ80	Leishmania major	28%	100%
V5BKI3	Trypanosoma cruzi	26%	93%