LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X2U9_LEIDO
TriTrypDb:
LdBPK_292880.1 , LdCL_290034900 , LDHU3_29.4200
Length:
204

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005730 nucleolus 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S7X2U9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X2U9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 183 185 PF00675 0.404
DEG_APCC_DBOX_1 99 107 PF00400 0.468
DOC_MAPK_JIP1_4 2 8 PF00069 0.525
DOC_WW_Pin1_4 113 118 PF00397 0.445
DOC_WW_Pin1_4 123 128 PF00397 0.375
DOC_WW_Pin1_4 13 18 PF00397 0.574
LIG_14-3-3_CanoR_1 141 147 PF00244 0.541
LIG_14-3-3_CanoR_1 184 190 PF00244 0.429
LIG_14-3-3_CterR_2 199 204 PF00244 0.664
LIG_APCC_ABBA_1 155 160 PF00400 0.521
LIG_APCC_ABBA_1 187 192 PF00400 0.552
LIG_FHA_1 110 116 PF00498 0.400
LIG_FHA_1 18 24 PF00498 0.455
LIG_FHA_1 79 85 PF00498 0.456
LIG_FHA_2 69 75 PF00498 0.404
LIG_LIR_Apic_2 112 117 PF02991 0.507
LIG_LIR_Gen_1 188 198 PF02991 0.584
LIG_LIR_Gen_1 60 67 PF02991 0.521
LIG_LIR_Gen_1 79 89 PF02991 0.494
LIG_LIR_Nem_3 60 64 PF02991 0.501
LIG_LIR_Nem_3 79 85 PF02991 0.496
LIG_PDZ_Class_1 199 204 PF00595 0.586
LIG_Pex14_1 28 32 PF04695 0.428
LIG_Pex14_2 190 194 PF04695 0.571
LIG_SH2_CRK 51 55 PF00017 0.559
LIG_SH2_CRK 82 86 PF00017 0.508
LIG_SH2_SRC 102 105 PF00017 0.555
LIG_SH2_STAP1 82 86 PF00017 0.508
LIG_SH2_STAT5 102 105 PF00017 0.555
LIG_SH3_3 114 120 PF00018 0.519
MOD_CDK_SPK_2 113 118 PF00069 0.524
MOD_CK1_1 175 181 PF00069 0.427
MOD_CK1_1 62 68 PF00069 0.531
MOD_CK1_1 77 83 PF00069 0.511
MOD_CK2_1 130 136 PF00069 0.488
MOD_CK2_1 68 74 PF00069 0.377
MOD_GlcNHglycan 149 152 PF01048 0.434
MOD_GlcNHglycan 177 180 PF01048 0.406
MOD_GSK3_1 109 116 PF00069 0.290
MOD_GSK3_1 13 20 PF00069 0.420
MOD_GSK3_1 140 147 PF00069 0.485
MOD_GSK3_1 168 175 PF00069 0.502
MOD_GSK3_1 28 35 PF00069 0.525
MOD_GSK3_1 39 46 PF00069 0.429
MOD_GSK3_1 74 81 PF00069 0.480
MOD_GSK3_1 91 98 PF00069 0.536
MOD_LATS_1 197 203 PF00433 0.648
MOD_NEK2_1 146 151 PF00069 0.500
MOD_NEK2_1 165 170 PF00069 0.455
MOD_NEK2_1 32 37 PF00069 0.359
MOD_PKA_2 140 146 PF00069 0.462
MOD_PKA_2 175 181 PF00069 0.427
MOD_Plk_1 59 65 PF00069 0.443
MOD_Plk_1 78 84 PF00069 0.490
MOD_Plk_4 109 115 PF00069 0.382
MOD_Plk_4 185 191 PF00069 0.501
MOD_Plk_4 28 34 PF00069 0.536
MOD_Plk_4 39 45 PF00069 0.430
MOD_Plk_4 8 14 PF00069 0.610
MOD_ProDKin_1 113 119 PF00069 0.452
MOD_ProDKin_1 123 129 PF00069 0.377
MOD_ProDKin_1 13 19 PF00069 0.564
TRG_ENDOCYTIC_2 51 54 PF00928 0.551
TRG_ENDOCYTIC_2 82 85 PF00928 0.507

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I852 Leptomonas seymouri 82% 100%
A0A1X0P9Y9 Trypanosomatidae 51% 93%
A0A3R7MK58 Trypanosoma rangeli 59% 100%
A4HHT4 Leishmania braziliensis 94% 100%
A4I4Z4 Leishmania infantum 100% 100%
C9ZKK3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 100%
E9AED9 Leishmania major 97% 100%
E9ALE7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
V5BCE2 Trypanosoma cruzi 57% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS